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G7TPJ0

- G7TPJ0_VIBCL

UniProt

G7TPJ0 - G7TPJ0_VIBCL

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Protein
Submitted name:

Isocitrate dehydrogenase

Gene

icd

Organism
Vibrio cholerae O1 str. 2010EL-1786
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Sitei257 – 2571Critical for catalysis
Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
Sitei422 – 4221Critical for catalysisUniRule annotation
Binding sitei549 – 5491SubstrateUniRule annotation
Metal bindingi550 – 5501Magnesium or manganeseUniRule annotation
Metal bindingi554 – 5541Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciVCHO914149:GHG2-645-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenaseImported (EC:1.1.1.42Imported)
Gene namesi
Name:icdImported
ORF Names:Vch1786_I0645Imported
OrganismiVibrio cholerae O1 str. 2010EL-1786Imported
Taxonomic identifieri914149 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000006802: Chromosome 1

Structurei

3D structure databases

ProteinModelPortaliG7TPJ0.
SMRiG7TPJ0. Positions 6-739.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

G7TPJ0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPTNKPTIIY TITDEAPALA TYSLLPIIQS FTASSGINVE TRDISLAGRI
60 70 80 90 100
LANFPEHLTE EQRISDALTE LGELAKTPEA NIIKLPNISA SVPQLKAAIK
110 120 130 140 150
ELQDKGYALP NYPEEPSSYE EEAIKATYDK IKGSAVNPVL REGNSDRRAP
160 170 180 190 200
ASVKNYAKKN PHSMGAWSKD SKSHVASMSD KDFFGSEKSM TVSGATKVAI
210 220 230 240 250
EFVGKEGAVK VLKKPFALQD KEIIDTSVMS KKALIAFFEK EIADAKAQDV
260 270 280 290 300
LFSLHMKATM MKVSDPVIFG HAVKVYYKAV FDKYGQLFDQ LGVDVNNGLG
310 320 330 340 350
DVYAKIQSLP EAQRAEIEAA IQAVYATQPA LAMVDSDRGI TNLHVPSDVI
360 370 380 390 400
VDASMPAMIR TSGQMWGPDG KQKDTKATIP DRCYAGVYQT VIDFCKQHGA
410 420 430 440 450
FDPTTMGSVP NVGLMAQKAE EYGSHDKTFI LDAEGVVRVI DEAGKVLLEQ
460 470 480 490 500
SVEAGDIFRM CQVKDAPIQD WVKLAVTRAR ASNTPAVFWL DPARAHDAEL
510 520 530 540 550
IKKVNQYLPN HDTSGLEIKI LSPIEATQYS LVRMKAGQDT ISVTGNVLRD
560 570 580 590 600
YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVQQVQKENH
610 620 630 640 650
LRWDSLGEFL ALAASLEHLS VVTGNRKAQV LADALDKATG KFLDMNKSPS
660 670 680 690 700
RRVGEIDNRG SHFYLATYWA QALAEQTADA DLAAEFAPIA KALEEKEAQI
710 720 730 740
VAELNGAQGK PGDLGGYYAP EFAKVAPLMR PSSTFNAIID R
Length:741
Mass (Da):80,531
Last modified:January 25, 2012 - v1
Checksum:i9442576499BA54A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003069 Genomic DNA. Translation: AET26253.1.
RefSeqiYP_004936807.1. NC_016445.1.

Genome annotation databases

EnsemblBacteriaiAET26253; AET26253; Vch1786_I0645.
GeneIDi11460464.
KEGGivce:Vch1786_I0645.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003069 Genomic DNA. Translation: AET26253.1 .
RefSeqi YP_004936807.1. NC_016445.1.

3D structure databases

ProteinModelPortali G7TPJ0.
SMRi G7TPJ0. Positions 6-739.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AET26253 ; AET26253 ; Vch1786_I0645 .
GeneIDi 11460464.
KEGGi vce:Vch1786_I0645.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci VCHO914149:GHG2-645-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2010EL-1786Imported.

Entry informationi

Entry nameiG7TPJ0_VIBCL
AccessioniPrimary (citable) accession number: G7TPJ0
Entry historyi
Integrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: October 29, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3