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G7TPJ0

- G7TPJ0_VIBCL

UniProt

G7TPJ0 - G7TPJ0_VIBCL

Protein
Submitted name:

Isocitrate dehydrogenase

Gene

icd

Organism
Vibrio cholerae O1 str. 2010EL-1786
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (25 Jan 2012)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei147 – 1471SubstrateUniRule annotation
    Sitei257 – 2571Critical for catalysis
    Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
    Sitei422 – 4221Critical for catalysisUniRule annotation
    Binding sitei549 – 5491SubstrateUniRule annotation
    Metal bindingi550 – 5501Magnesium or manganeseUniRule annotation
    Metal bindingi554 – 5541Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciVCHO914149:GHG2-645-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenaseImported (EC:1.1.1.42Imported)
    Gene namesi
    Name:icdImported
    ORF Names:Vch1786_I0645Imported
    OrganismiVibrio cholerae O1 str. 2010EL-1786Imported
    Taxonomic identifieri914149 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000006802: Chromosome 1

    Structurei

    3D structure databases

    ProteinModelPortaliG7TPJ0.
    SMRiG7TPJ0. Positions 6-739.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni134 – 1418Substrate bindingUniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    G7TPJ0-1 [UniParc]FASTAAdd to Basket

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    MPTNKPTIIY TITDEAPALA TYSLLPIIQS FTASSGINVE TRDISLAGRI    50
    LANFPEHLTE EQRISDALTE LGELAKTPEA NIIKLPNISA SVPQLKAAIK 100
    ELQDKGYALP NYPEEPSSYE EEAIKATYDK IKGSAVNPVL REGNSDRRAP 150
    ASVKNYAKKN PHSMGAWSKD SKSHVASMSD KDFFGSEKSM TVSGATKVAI 200
    EFVGKEGAVK VLKKPFALQD KEIIDTSVMS KKALIAFFEK EIADAKAQDV 250
    LFSLHMKATM MKVSDPVIFG HAVKVYYKAV FDKYGQLFDQ LGVDVNNGLG 300
    DVYAKIQSLP EAQRAEIEAA IQAVYATQPA LAMVDSDRGI TNLHVPSDVI 350
    VDASMPAMIR TSGQMWGPDG KQKDTKATIP DRCYAGVYQT VIDFCKQHGA 400
    FDPTTMGSVP NVGLMAQKAE EYGSHDKTFI LDAEGVVRVI DEAGKVLLEQ 450
    SVEAGDIFRM CQVKDAPIQD WVKLAVTRAR ASNTPAVFWL DPARAHDAEL 500
    IKKVNQYLPN HDTSGLEIKI LSPIEATQYS LVRMKAGQDT ISVTGNVLRD 550
    YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVQQVQKENH 600
    LRWDSLGEFL ALAASLEHLS VVTGNRKAQV LADALDKATG KFLDMNKSPS 650
    RRVGEIDNRG SHFYLATYWA QALAEQTADA DLAAEFAPIA KALEEKEAQI 700
    VAELNGAQGK PGDLGGYYAP EFAKVAPLMR PSSTFNAIID R 741
    Length:741
    Mass (Da):80,531
    Last modified:January 25, 2012 - v1
    Checksum:i9442576499BA54A7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003069 Genomic DNA. Translation: AET26253.1.
    RefSeqiYP_004936807.1. NC_016445.1.

    Genome annotation databases

    EnsemblBacteriaiAET26253; AET26253; Vch1786_I0645.
    GeneIDi11460464.
    KEGGivce:Vch1786_I0645.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003069 Genomic DNA. Translation: AET26253.1 .
    RefSeqi YP_004936807.1. NC_016445.1.

    3D structure databases

    ProteinModelPortali G7TPJ0.
    SMRi G7TPJ0. Positions 6-739.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AET26253 ; AET26253 ; Vch1786_I0645 .
    GeneIDi 11460464.
    KEGGi vce:Vch1786_I0645.

    Phylogenomic databases

    KOi K00031.

    Enzyme and pathway databases

    BioCyci VCHO914149:GHG2-645-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2010EL-1786Imported.

    Entry informationi

    Entry nameiG7TPJ0_VIBCL
    AccessioniPrimary (citable) accession number: G7TPJ0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 25, 2012
    Last sequence update: January 25, 2012
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3