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G7T560

- G7T560_SALPS

UniProt

G7T560 - G7T560_SALPS

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Protein

Phosphoribosylglycinamide formyltransferase 2

Gene

purT

Organism
Salmonella pullorum (strain RKS5078 / SGSC2294)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes two reactions: the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR; the second, a side reaction, is the production of acetyl phosphate and ADP from acetate and ATP.UniRule annotationSAAS annotation

Catalytic activityi

Formate + ATP + 5'-phospho-ribosylglycinamide = 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 8215'-phosphoribosylglycinamideUniRule annotation
Binding sitei114 – 1141ATPUniRule annotation
Binding sitei155 – 1551ATPUniRule annotation
Binding sitei203 – 2031ATPUniRule annotation
Metal bindingi267 – 2671MagnesiumUniRule annotation
Binding sitei267 – 2671ATPUniRule annotation
Metal bindingi279 – 2791MagnesiumUniRule annotation
Binding sitei279 – 2791ATPUniRule annotation
Binding sitei286 – 28615'-phosphoribosylglycinamideUniRule annotation
Binding sitei355 – 35515'-phosphoribosylglycinamideUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi160 – 1656ATPUniRule annotation
Nucleotide bindingi195 – 1984ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. biotin carboxylase activity Source: InterPro
  3. magnesium ion binding Source: InterPro
  4. phosphoribosylglycinamide formyltransferase 2 activity Source: UniProtKB-HAMAP
  5. phosphoribosylglycinamide formyltransferase activity Source: InterPro

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotation

Keywords - Biological processi

Purine biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT1081093:GJVO-1789-MONOMER.
UniPathwayiUPA00074; UER00127.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylglycinamide formyltransferase 2UniRule annotationSAAS annotation (EC:2.1.2.-UniRule annotationSAAS annotation)
Short name:
GART 2UniRule annotation
Alternative name(s):
5'-phosphoribosylglycinamide transformylase 2UniRule annotation
Formate-dependent GAR transformylaseUniRule annotation
GAR transformylase 2UniRule annotation
Gene namesi
Name:purTUniRule annotationImported
Ordered Locus Names:SPUL_1767Imported
OrganismiSalmonella pullorum (strain RKS5078 / SGSC2294)Imported
Taxonomic identifieri1081093 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000005873: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini119 – 308190ATP-graspUniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni22 – 2325'-phosphoribosylglycinamide bindingUniRule annotation
Regioni362 – 36325'-phosphoribosylglycinamide bindingUniRule annotation

Sequence similaritiesi

Belongs to the PurK/PurT family.UniRule annotation
Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

OMAiWDYAQQG.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPiMF_01643. PurT.
InterProiIPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011764. Biotin_carboxylation_dom.
IPR016185. PreATP-grasp_dom.
IPR005862. PurT.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF02222. ATP-grasp. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01142. purT. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G7T560-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLLGTALRP AATRVMLLGA GELGKEVAIE CQRLGIEVIA VDRYPDAPAM
60 70 80 90 100
HVAHRSHVIN MLDGEALRHV ITEEKPHYIV PEIEAIATDT LRELEDEGLN
110 120 130 140 150
VVPCARTTQL TMNREGIRRL AAEELGLPTS TYRFADSEAS FHDAVAAVGF
160 170 180 190 200
PCIVKPVMSS SGKGQSFIRS AEQLTQAWEY AQQGGRAGAG RVIVEGVVKF
210 220 230 240 250
DFEITLLTVS AVDGVHFCAP VGHRQQDGDY RESWQPQQMS ELALKRAQEI
260 270 280 290 300
ARHVVLALGG HGLFGVELFV CGDEVIFSEV SPRPHDTGMV TLISQDLSEF
310 320 330 340 350
ALHVRAFLGM PIGDIRQYGP AASAVILPQL TSQNVTFDNV HTAVGAGVQV
360 370 380 390
RLFGKPEIDG SRRLGVALAT GENVEEAVIR AKKAASRVTV KG
Length:392
Mass (Da):42,343
Last modified:January 25, 2012 - v1
Checksum:i4688A1B107D7C154
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003047 Genomic DNA. Translation: AET54103.1.
RefSeqiYP_005212933.1. NC_016831.1.

Genome annotation databases

EnsemblBacteriaiAET54103; AET54103; SPUL_1767.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003047 Genomic DNA. Translation: AET54103.1 .
RefSeqi YP_005212933.1. NC_016831.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AET54103 ; AET54103 ; SPUL_1767 .

Phylogenomic databases

OMAi WDYAQQG.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00127 .
BioCyci SENT1081093:GJVO-1789-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPi MF_01643. PurT.
InterProi IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011764. Biotin_carboxylation_dom.
IPR016185. PreATP-grasp_dom.
IPR005862. PurT.
IPR011054. Rudment_hybrid_motif.
[Graphical view ]
Pfami PF02222. ATP-grasp. 1 hit.
[Graphical view ]
SUPFAMi SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01142. purT. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Salmonella enterica serovar pullorum RKS5078."
    Feng Y., Xu H.F., Li Q.H., Zhang S.Y., Wang C.X., Zhu D.L., Cao F.L., Li Y.G., Johnston R.N., Zhou J., Liu G.R., Liu S.L.
    J. Bacteriol. 194:744-744(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RKS5078 / SGSC2294Imported.

Entry informationi

Entry nameiG7T560_SALPS
AccessioniPrimary (citable) accession number: G7T560
Entry historyi
Integrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: November 26, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3