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G7T560

- G7T560_SALPS

UniProt

G7T560 - G7T560_SALPS

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Protein

Phosphoribosylglycinamide formyltransferase 2

Gene
purT, SPUL_1767
Organism
Salmonella pullorum (strain RKS5078 / SGSC2294)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes two reactions: the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR; the second, a side reaction, is the production of acetyl phosphate and ADP from acetate and ATP By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Formate + ATP + 5'-phospho-ribosylglycinamide = 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 8215'-phosphoribosylglycinamide By similarityUniRule annotation
Binding sitei114 – 1141ATP By similarityUniRule annotation
Binding sitei155 – 1551ATP By similarityUniRule annotation
Binding sitei203 – 2031ATP By similarityUniRule annotation
Metal bindingi267 – 2671Magnesium By similarityUniRule annotation
Binding sitei267 – 2671ATP By similarityUniRule annotation
Metal bindingi279 – 2791Magnesium By similarityUniRule annotation
Binding sitei279 – 2791ATP By similarityUniRule annotation
Binding sitei286 – 28615'-phosphoribosylglycinamide By similarityUniRule annotation
Binding sitei355 – 35515'-phosphoribosylglycinamide By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi160 – 1656ATP By similarityUniRule annotation
Nucleotide bindingi195 – 1984ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. biotin carboxylase activity Source: InterPro
  3. magnesium ion binding Source: InterPro
  4. phosphoribosylglycinamide formyltransferase 2 activity Source: UniProtKB-HAMAP
  5. phosphoribosylglycinamide formyltransferase activity Source: InterPro

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Purine biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT1081093:GJVO-1789-MONOMER.
UniPathwayiUPA00074; UER00127.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylglycinamide formyltransferase 2UniRule annotation (EC:2.1.2.-UniRule annotation)
Short name:
GART 2UniRule annotation
Alternative name(s):
5'-phosphoribosylglycinamide transformylase 2
Formate-dependent GAR transformylase
GAR transformylase 2
Gene namesi
Name:purTUniRule annotationImported
Ordered Locus Names:SPUL_1767Imported
OrganismiSalmonella pullorum (strain RKS5078 / SGSC2294)Imported
Taxonomic identifieri1081093 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000005873: Chromosome

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini119 – 308190ATP-grasp By similarityUniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni22 – 2325'-phosphoribosylglycinamide binding By similarityUniRule annotation
Regioni362 – 36325'-phosphoribosylglycinamide binding By similarityUniRule annotation

Sequence similaritiesi

Belongs to the PurK/PurT family.UniRule annotation
Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotations

Phylogenomic databases

OMAiWDYAQQG.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPiMF_01643. PurT.
InterProiIPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011764. Biotin_carboxylation_dom.
IPR016185. PreATP-grasp_dom.
IPR005862. PurT.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF02222. ATP-grasp. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01142. purT. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G7T560-1 [UniParc]FASTAAdd to Basket

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MTLLGTALRP AATRVMLLGA GELGKEVAIE CQRLGIEVIA VDRYPDAPAM    50
HVAHRSHVIN MLDGEALRHV ITEEKPHYIV PEIEAIATDT LRELEDEGLN 100
VVPCARTTQL TMNREGIRRL AAEELGLPTS TYRFADSEAS FHDAVAAVGF 150
PCIVKPVMSS SGKGQSFIRS AEQLTQAWEY AQQGGRAGAG RVIVEGVVKF 200
DFEITLLTVS AVDGVHFCAP VGHRQQDGDY RESWQPQQMS ELALKRAQEI 250
ARHVVLALGG HGLFGVELFV CGDEVIFSEV SPRPHDTGMV TLISQDLSEF 300
ALHVRAFLGM PIGDIRQYGP AASAVILPQL TSQNVTFDNV HTAVGAGVQV 350
RLFGKPEIDG SRRLGVALAT GENVEEAVIR AKKAASRVTV KG 392
Length:392
Mass (Da):42,343
Last modified:January 25, 2012 - v1
Checksum:i4688A1B107D7C154
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003047 Genomic DNA. Translation: AET54103.1.
RefSeqiYP_005212933.1. NC_016831.1.

Genome annotation databases

EnsemblBacteriaiAET54103; AET54103; SPUL_1767.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003047 Genomic DNA. Translation: AET54103.1 .
RefSeqi YP_005212933.1. NC_016831.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AET54103 ; AET54103 ; SPUL_1767 .

Phylogenomic databases

OMAi WDYAQQG.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00127 .
BioCyci SENT1081093:GJVO-1789-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPi MF_01643. PurT.
InterProi IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011764. Biotin_carboxylation_dom.
IPR016185. PreATP-grasp_dom.
IPR005862. PurT.
IPR011054. Rudment_hybrid_motif.
[Graphical view ]
Pfami PF02222. ATP-grasp. 1 hit.
[Graphical view ]
SUPFAMi SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01142. purT. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete Genome Sequence of Salmonella enterica Serovar Pullorum RKS5078."
    Feng Y., Xu H.F., Li Q.H., Zhang S.Y., Wang C.X., Zhu D.L., Cao F.L., Li Y.G., Johnston R.N., Zhou J., Liu G.R., Liu S.L.
    J. Bacteriol. 194:744-744(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RKS5078 / SGSC2294.

Entry informationi

Entry nameiG7T560_SALPS
AccessioniPrimary (citable) accession number: G7T560
Entry historyi
Integrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: June 11, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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