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G7T560 (G7T560_SALPS) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylglycinamide formyltransferase 2 HAMAP-Rule MF_01643

Short name=GART 2 HAMAP-Rule MF_01643
EC=2.1.2.- HAMAP-Rule MF_01643
Alternative name(s):
5'-phosphoribosylglycinamide transformylase 2 HAMAP-Rule MF_01643
Formate-dependent GAR transformylase HAMAP-Rule MF_01643
GAR transformylase 2 HAMAP-Rule MF_01643
Gene names
Name:purT HAMAP-Rule MF_01643 EMBL AET54103.1
Ordered Locus Names:SPUL_1767 EMBL AET54103.1
OrganismSalmonella pullorum (strain RKS5078 / SGSC2294) [Complete proteome] [HAMAP] EMBL AET54103.1
Taxonomic identifier1081093 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes two reactions: the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR; the second, a side reaction, is the production of acetyl phosphate and ADP from acetate and ATP By similarity. HAMAP-Rule MF_01643 SAAS SAAS011054

Catalytic activity

Formate + ATP + 5'-phospho-ribosylglycinamide = 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate. HAMAP-Rule MF_01643 SAAS SAAS011054

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (formate route): step 1/1. SAAS SAAS011054 HAMAP-Rule MF_01643

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01643 SAAS SAAS011054

Sequence similarities

Belongs to the PurK/PurT family. HAMAP-Rule MF_01643

Contains 1 ATP-grasp domain. HAMAP-Rule MF_01643

Contains ATP-grasp domain. SAAS SAAS003135

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain119 – 308190ATP-grasp By similarity HAMAP-Rule MF_01643
Nucleotide binding160 – 1656ATP By similarity HAMAP-Rule MF_01643
Nucleotide binding195 – 1984ATP By similarity HAMAP-Rule MF_01643
Region22 – 2325'-phosphoribosylglycinamide binding By similarity HAMAP-Rule MF_01643
Region362 – 36325'-phosphoribosylglycinamide binding By similarity HAMAP-Rule MF_01643

Sites

Metal binding2671Magnesium By similarity HAMAP-Rule MF_01643
Metal binding2791Magnesium By similarity HAMAP-Rule MF_01643
Binding site8215'-phosphoribosylglycinamide By similarity HAMAP-Rule MF_01643
Binding site1141ATP By similarity HAMAP-Rule MF_01643
Binding site1551ATP By similarity HAMAP-Rule MF_01643
Binding site2031ATP By similarity HAMAP-Rule MF_01643
Binding site2671ATP By similarity HAMAP-Rule MF_01643
Binding site2791ATP By similarity HAMAP-Rule MF_01643
Binding site28615'-phosphoribosylglycinamide By similarity HAMAP-Rule MF_01643
Binding site35515'-phosphoribosylglycinamide By similarity HAMAP-Rule MF_01643

Sequences

Sequence LengthMass (Da)Tools
G7T560 [UniParc].

Last modified January 25, 2012. Version 1.
Checksum: 4688A1B107D7C154

FASTA39242,343
        10         20         30         40         50         60 
MTLLGTALRP AATRVMLLGA GELGKEVAIE CQRLGIEVIA VDRYPDAPAM HVAHRSHVIN 

        70         80         90        100        110        120 
MLDGEALRHV ITEEKPHYIV PEIEAIATDT LRELEDEGLN VVPCARTTQL TMNREGIRRL 

       130        140        150        160        170        180 
AAEELGLPTS TYRFADSEAS FHDAVAAVGF PCIVKPVMSS SGKGQSFIRS AEQLTQAWEY 

       190        200        210        220        230        240 
AQQGGRAGAG RVIVEGVVKF DFEITLLTVS AVDGVHFCAP VGHRQQDGDY RESWQPQQMS 

       250        260        270        280        290        300 
ELALKRAQEI ARHVVLALGG HGLFGVELFV CGDEVIFSEV SPRPHDTGMV TLISQDLSEF 

       310        320        330        340        350        360 
ALHVRAFLGM PIGDIRQYGP AASAVILPQL TSQNVTFDNV HTAVGAGVQV RLFGKPEIDG 

       370        380        390 
SRRLGVALAT GENVEEAVIR AKKAASRVTV KG 

« Hide

References

[1]"Complete Genome Sequence of Salmonella enterica Serovar Pullorum RKS5078."
Feng Y., Xu H.F., Li Q.H., Zhang S.Y., Wang C.X., Zhu D.L., Cao F.L., Li Y.G., Johnston R.N., Zhou J., Liu G.R., Liu S.L.
J. Bacteriol. 194:744-744(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RKS5078 / SGSC2294.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003047 Genomic DNA. Translation: AET54103.1.
RefSeqYP_005212933.1. NC_016831.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAET54103; AET54103; SPUL_1767.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAGMVTMIT.

Enzyme and pathway databases

BioCycSENT1081093:GJVO-1789-MONOMER.
UniPathwayUPA00074; UER00127.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_01643. PurT.
InterProIPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011764. Biotin_carboxylation_dom.
IPR016185. PreATP-grasp_dom.
IPR005862. PurT.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PANTHERPTHR23047:SF2. PTHR23047:SF2. 1 hit.
PfamPF02222. ATP-grasp. 1 hit.
[Graphical view]
SUPFAMSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01142. purT. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG7T560_SALPS
AccessionPrimary (citable) accession number: G7T560
Entry history
Integrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: February 19, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)