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G7T560

- G7T560_SALPS

UniProt

G7T560 - G7T560_SALPS

Protein

Phosphoribosylglycinamide formyltransferase 2

Gene

purT

Organism
Salmonella pullorum (strain RKS5078 / SGSC2294)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (25 Jan 2012)
      Previous versions | rss
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    Functioni

    Catalyzes two reactions: the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR; the second, a side reaction, is the production of acetyl phosphate and ADP from acetate and ATP.UniRule annotationSAAS annotation

    Catalytic activityi

    Formate + ATP + 5'-phospho-ribosylglycinamide = 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei82 – 8215'-phosphoribosylglycinamideUniRule annotation
    Binding sitei114 – 1141ATPUniRule annotation
    Binding sitei155 – 1551ATPUniRule annotation
    Binding sitei203 – 2031ATPUniRule annotation
    Metal bindingi267 – 2671MagnesiumUniRule annotation
    Binding sitei267 – 2671ATPUniRule annotation
    Metal bindingi279 – 2791MagnesiumUniRule annotation
    Binding sitei279 – 2791ATPUniRule annotation
    Binding sitei286 – 28615'-phosphoribosylglycinamideUniRule annotation
    Binding sitei355 – 35515'-phosphoribosylglycinamideUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi160 – 1656ATPUniRule annotation
    Nucleotide bindingi195 – 1984ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. biotin carboxylase activity Source: InterPro
    3. magnesium ion binding Source: InterPro
    4. phosphoribosylglycinamide formyltransferase 2 activity Source: UniProtKB-HAMAP
    5. phosphoribosylglycinamide formyltransferase activity Source: InterPro

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    TransferaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Purine biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSENT1081093:GJVO-1789-MONOMER.
    UniPathwayiUPA00074; UER00127.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylglycinamide formyltransferase 2UniRule annotation (EC:2.1.2.-UniRule annotation)
    Short name:
    GART 2UniRule annotation
    Alternative name(s):
    5'-phosphoribosylglycinamide transformylase 2UniRule annotation
    Formate-dependent GAR transformylaseUniRule annotation
    GAR transformylase 2UniRule annotation
    Gene namesi
    Name:purTUniRule annotationImported
    Ordered Locus Names:SPUL_1767Imported
    OrganismiSalmonella pullorum (strain RKS5078 / SGSC2294)Imported
    Taxonomic identifieri1081093 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000005873: Chromosome

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini119 – 308190ATP-graspUniRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni22 – 2325'-phosphoribosylglycinamide bindingUniRule annotation
    Regioni362 – 36325'-phosphoribosylglycinamide bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PurK/PurT family.UniRule annotation
    Contains 1 ATP-grasp domain.UniRule annotation
    Contains ATP-grasp domain.SAAS annotation

    Phylogenomic databases

    OMAiWDYAQQG.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    HAMAPiMF_01643. PurT.
    InterProiIPR011761. ATP-grasp.
    IPR003135. ATP-grasp_carboxylate-amine.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR011764. Biotin_carboxylation_dom.
    IPR016185. PreATP-grasp_dom.
    IPR005862. PurT.
    IPR011054. Rudment_hybrid_motif.
    [Graphical view]
    PfamiPF02222. ATP-grasp. 1 hit.
    [Graphical view]
    SUPFAMiSSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    TIGRFAMsiTIGR01142. purT. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS50979. BC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G7T560-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLLGTALRP AATRVMLLGA GELGKEVAIE CQRLGIEVIA VDRYPDAPAM    50
    HVAHRSHVIN MLDGEALRHV ITEEKPHYIV PEIEAIATDT LRELEDEGLN 100
    VVPCARTTQL TMNREGIRRL AAEELGLPTS TYRFADSEAS FHDAVAAVGF 150
    PCIVKPVMSS SGKGQSFIRS AEQLTQAWEY AQQGGRAGAG RVIVEGVVKF 200
    DFEITLLTVS AVDGVHFCAP VGHRQQDGDY RESWQPQQMS ELALKRAQEI 250
    ARHVVLALGG HGLFGVELFV CGDEVIFSEV SPRPHDTGMV TLISQDLSEF 300
    ALHVRAFLGM PIGDIRQYGP AASAVILPQL TSQNVTFDNV HTAVGAGVQV 350
    RLFGKPEIDG SRRLGVALAT GENVEEAVIR AKKAASRVTV KG 392
    Length:392
    Mass (Da):42,343
    Last modified:January 25, 2012 - v1
    Checksum:i4688A1B107D7C154
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003047 Genomic DNA. Translation: AET54103.1.
    RefSeqiYP_005212933.1. NC_016831.1.

    Genome annotation databases

    EnsemblBacteriaiAET54103; AET54103; SPUL_1767.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003047 Genomic DNA. Translation: AET54103.1 .
    RefSeqi YP_005212933.1. NC_016831.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AET54103 ; AET54103 ; SPUL_1767 .

    Phylogenomic databases

    OMAi WDYAQQG.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00127 .
    BioCyci SENT1081093:GJVO-1789-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    HAMAPi MF_01643. PurT.
    InterProi IPR011761. ATP-grasp.
    IPR003135. ATP-grasp_carboxylate-amine.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR011764. Biotin_carboxylation_dom.
    IPR016185. PreATP-grasp_dom.
    IPR005862. PurT.
    IPR011054. Rudment_hybrid_motif.
    [Graphical view ]
    Pfami PF02222. ATP-grasp. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    TIGRFAMsi TIGR01142. purT. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS50979. BC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Salmonella enterica serovar pullorum RKS5078."
      Feng Y., Xu H.F., Li Q.H., Zhang S.Y., Wang C.X., Zhu D.L., Cao F.L., Li Y.G., Johnston R.N., Zhou J., Liu G.R., Liu S.L.
      J. Bacteriol. 194:744-744(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RKS5078 / SGSC2294Imported.

    Entry informationi

    Entry nameiG7T560_SALPS
    AccessioniPrimary (citable) accession number: G7T560
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 25, 2012
    Last sequence update: January 25, 2012
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3