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G7RM21

- G7RM21_ECOC1

UniProt

G7RM21 - G7RM21_ECOC1

Protein

Acyl carrier protein

Gene

acpP

Organism
Escherichia coli (strain 'clone D i14')
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Carrier of the growing fatty acid chain in fatty acid biosynthesis.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei37 – 371PhosphopantetheineImported

    GO - Molecular functioni

    1. ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Fatty acid biosynthesisUniRule annotationSAAS annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciECOL885275:GJE6-1262-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acyl carrier proteinUniRule annotation
    Short name:
    ACPUniRule annotation
    Gene namesi
    Name:acpPUniRule annotationImported
    Ordered Locus Names:i14_1248Imported
    OrganismiEscherichia coli (strain 'clone D i14')Imported
    Taxonomic identifieri885275 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000005864: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei37 – 371O-(pantetheine 4'-phosphoryl)serineUniRule annotation

    Post-translational modificationi

    4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.UniRule annotation
    4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.UniRule annotation

    Keywords - PTMi

    PhosphopantetheineUniRule annotationImported, PhosphoproteinUniRule annotationSAAS annotation

    Proteomic databases

    PRIDEiG7RM21.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-60690N.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4IHFX-ray2.10G/H/I/J/K/L1-78[»]
    4IHGX-ray2.89G/H/I/J/K/L1-78[»]
    4IHHX-ray2.13G/H/I/J/K/L1-78[»]
    ProteinModelPortaliG7RM21.
    SMRiG7RM21. Positions 2-78.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 acyl carrier domain.UniRule annotation
    Contains acyl carrier domain.SAAS annotation

    Phylogenomic databases

    KOiK02078.

    Family and domain databases

    Gene3Di1.10.1200.10. 1 hit.
    HAMAPiMF_01217. Acyl_carrier.
    InterProiIPR003231. Acyl_carrier.
    IPR009081. Acyl_carrier_prot-like.
    IPR006162. PPantetheine_attach_site.
    [Graphical view]
    PfamiPF00550. PP-binding. 1 hit.
    [Graphical view]
    ProDomiPD000887. PD000887. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF47336. SSF47336. 1 hit.
    TIGRFAMsiTIGR00517. acyl_carrier. 1 hit.
    PROSITEiPS50075. ACP_DOMAIN. 1 hit.
    PS00012. PHOSPHOPANTETHEINE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G7RM21-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTIEERVKK IIGEQLGVKQ EEVTNNASFV EDLGADSLDT VELVMALEEE   50
    FDTEIPDEEA EKITTVQAAI DYINGHQA 78
    Length:78
    Mass (Da):8,640
    Last modified:January 25, 2012 - v1
    Checksum:i41FCFC39D45BFEA1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002212 Genomic DNA. Translation: AER88748.1.
    RefSeqiYP_006153372.1. NC_017652.1.

    Genome annotation databases

    EnsemblBacteriaiAER88748; AER88748; i14_1248.
    GeneIDi12663967.
    KEGGielc:i14_1248.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002212 Genomic DNA. Translation: AER88748.1 .
    RefSeqi YP_006153372.1. NC_017652.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4IHF X-ray 2.10 G/H/I/J/K/L 1-78 [» ]
    4IHG X-ray 2.89 G/H/I/J/K/L 1-78 [» ]
    4IHH X-ray 2.13 G/H/I/J/K/L 1-78 [» ]
    ProteinModelPortali G7RM21.
    SMRi G7RM21. Positions 2-78.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60690N.

    Proteomic databases

    PRIDEi G7RM21.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AER88748 ; AER88748 ; i14_1248 .
    GeneIDi 12663967.
    KEGGi elc:i14_1248.

    Phylogenomic databases

    KOi K02078.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci ECOL885275:GJE6-1262-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1200.10. 1 hit.
    HAMAPi MF_01217. Acyl_carrier.
    InterProi IPR003231. Acyl_carrier.
    IPR009081. Acyl_carrier_prot-like.
    IPR006162. PPantetheine_attach_site.
    [Graphical view ]
    Pfami PF00550. PP-binding. 1 hit.
    [Graphical view ]
    ProDomi PD000887. PD000887. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF47336. SSF47336. 1 hit.
    TIGRFAMsi TIGR00517. acyl_carrier. 1 hit.
    PROSITEi PS50075. ACP_DOMAIN. 1 hit.
    PS00012. PHOSPHOPANTETHEINE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rates of mutation and host transmission for an Escherichia coli clone over 3 years."
      Reeves P.R., Liu B., Zhou Z., Li D., Guo D., Ren Y., Clabots C., Lan R., Johnson J.R., Wang L.
      PLoS ONE 6:E26907-E26907(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 'clone D i14'Imported.
    2. "Chasing acyl carrier protein through a catalytic cycle of lipid A production."
      Masoudi A., Raetz C.R., Zhou P., Pemble C.W.
      Nature 505:422-426(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH PHOSPHOPANTETHEINE.

    Entry informationi

    Entry nameiG7RM21_ECOC1
    AccessioniPrimary (citable) accession number: G7RM21
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 25, 2012
    Last sequence update: January 25, 2012
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3