SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

G7RM21

- G7RM21_ECOC1

UniProt

G7RM21 - G7RM21_ECOC1

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Acyl carrier protein
Gene
acpP, i14_1248
Organism
Escherichia coli (strain 'clone D i14')
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Carrier of the growing fatty acid chain in fatty acid biosynthesis By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371PhosphopantetheineImported

GO - Molecular functioni

  1. ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Biological processi

    Fatty acid biosynthesisUniRule annotationSAAS annotations, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciECOL885275:GJE6-1262-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acyl carrier proteinUniRule annotation
    Short name:
    ACPUniRule annotation
    Gene namesi
    Name:acpPUniRule annotationImported
    Ordered Locus Names:i14_1248Imported
    OrganismiEscherichia coli (strain 'clone D i14')Imported
    Taxonomic identifieri885275 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000005864: Chromosome

    Subcellular locationi

    Cytoplasm By similarity UniRule annotationSAAS annotations

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotations

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei37 – 371O-(pantetheine 4'-phosphoryl)serine By similarityUniRule annotation

    Post-translational modificationi

    4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group By similarity.UniRule annotation
    4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS By similarity.UniRule annotation

    Keywords - PTMi

    PhosphopantetheineUniRule annotationImported, PhosphoproteinUniRule annotationSAAS annotations

    Proteomic databases

    PRIDEiG7RM21.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-60690N.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4IHFX-ray2.10G/H/I/J/K/L1-78[»]
    4IHGX-ray2.89G/H/I/J/K/L1-78[»]
    4IHHX-ray2.13G/H/I/J/K/L1-78[»]
    ProteinModelPortaliG7RM21.
    SMRiG7RM21. Positions 2-78.

    Family & Domainsi

    Sequence similaritiesi

    Contains acyl carrier domain.SAAS annotations

    Phylogenomic databases

    KOiK02078.

    Family and domain databases

    Gene3Di1.10.1200.10. 1 hit.
    HAMAPiMF_01217. Acyl_carrier.
    InterProiIPR003231. Acyl_carrier.
    IPR009081. Acyl_carrier_prot-like.
    IPR006162. PPantetheine_attach_site.
    [Graphical view]
    PfamiPF00550. PP-binding. 1 hit.
    [Graphical view]
    ProDomiPD000887. PD000887. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF47336. SSF47336. 1 hit.
    TIGRFAMsiTIGR00517. acyl_carrier. 1 hit.
    PROSITEiPS50075. ACP_DOMAIN. 1 hit.
    PS00012. PHOSPHOPANTETHEINE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G7RM21-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTIEERVKK IIGEQLGVKQ EEVTNNASFV EDLGADSLDT VELVMALEEE   50
    FDTEIPDEEA EKITTVQAAI DYINGHQA 78
    Length:78
    Mass (Da):8,640
    Last modified:January 25, 2012 - v1
    Checksum:i41FCFC39D45BFEA1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002212 Genomic DNA. Translation: AER88748.1.
    RefSeqiYP_006153372.1. NC_017652.1.

    Genome annotation databases

    EnsemblBacteriaiAER88748; AER88748; i14_1248.
    GeneIDi12663967.
    KEGGielc:i14_1248.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002212 Genomic DNA. Translation: AER88748.1 .
    RefSeqi YP_006153372.1. NC_017652.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4IHF X-ray 2.10 G/H/I/J/K/L 1-78 [» ]
    4IHG X-ray 2.89 G/H/I/J/K/L 1-78 [» ]
    4IHH X-ray 2.13 G/H/I/J/K/L 1-78 [» ]
    ProteinModelPortali G7RM21.
    SMRi G7RM21. Positions 2-78.
    ModBasei Search...

    Protein-protein interaction databases

    DIPi DIP-60690N.

    Proteomic databases

    PRIDEi G7RM21.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AER88748 ; AER88748 ; i14_1248 .
    GeneIDi 12663967.
    KEGGi elc:i14_1248.

    Phylogenomic databases

    KOi K02078.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci ECOL885275:GJE6-1262-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1200.10. 1 hit.
    HAMAPi MF_01217. Acyl_carrier.
    InterProi IPR003231. Acyl_carrier.
    IPR009081. Acyl_carrier_prot-like.
    IPR006162. PPantetheine_attach_site.
    [Graphical view ]
    Pfami PF00550. PP-binding. 1 hit.
    [Graphical view ]
    ProDomi PD000887. PD000887. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF47336. SSF47336. 1 hit.
    TIGRFAMsi TIGR00517. acyl_carrier. 1 hit.
    PROSITEi PS50075. ACP_DOMAIN. 1 hit.
    PS00012. PHOSPHOPANTETHEINE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Rates of Mutation and Host Transmission for an Escherichia coli Clone over 3 Years."
      Reeves P.R., Liu B., Zhou Z., Li D., Guo D., Ren Y., Clabots C., Lan R., Johnson J.R., Wang L.
      PLoS ONE 6:E26907-E26907(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 'clone D i14'.
    2. "Chasing acyl carrier protein through a catalytic cycle of lipid A production."
      Masoudi A., Raetz C.R., Zhou P., Pemble C.W.
      Nature 505:422-426(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH PHOSPHOPANTETHEINE.

    Entry informationi

    Entry nameiG7RM21_ECOC1
    AccessioniPrimary (citable) accession number: G7RM21
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 25, 2012
    Last sequence update: January 25, 2012
    Last modified: July 9, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome

    External Data

    Dasty 3

    Similar proteinsi