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G7R5K5

- G7R5K5_ECOC2

UniProt

G7R5K5 - G7R5K5_ECOC2

Protein

Glutamate decarboxylase

Gene

gadB

Organism
Escherichia coli (strain 'clone D i2')
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 13 (01 Oct 2014)
      Sequence version 1 (25 Jan 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glutamate decarboxylase activity Source: InterPro
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glutamate metabolic process Source: InterPro

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotation, Lyase

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciECOL885276:GJE7-1756-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
    Gene namesi
    Name:gadBImported
    Ordered Locus Names:i02_1744Imported
    OrganismiEscherichia coli (strain 'clone D i2')Imported
    Taxonomic identifieri885276 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000005865: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliG7R5K5.
    SMRiG7R5K5. Positions 27-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.UniRule annotation

    Phylogenomic databases

    KOiK01580.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR021115. Pyridoxal-P_BS.
    [Graphical view]
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
    PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G7R5K5-1 [UniParc]FASTAAdd to Basket

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    MHLLTLSINP TFLMRSNHFK EFKMDKKQVT DLRSELLDSR FGAKSISTIA    50
    ESKRFPLHEM RDDVAFQIIN DELYLDGNAR QNLATFCQTW DDDNVHKLMD 100
    LSINKNWIDK EEYPQSAAID LRCVNMVADL WHAPAPKNGQ AVGTNTIGSS 150
    EACMLGGMAM KWRWRKRMEA AGKPTNKPNL VCGPVQICWH KFARYWDVEL 200
    REIPMRPGQL FMDPKRMIEA CDENTIGVVP TFGVTYTGNY EFPQPLHDAL 250
    DKFQADTGID IDMHIDAASG GFLAPFVAPD IVWDFRLPRV KSISASGHKF 300
    GLAPLGCGWV IWRDEEALPQ ELVFNVDYLG GQIGTFAINF SRPAGQVIAQ 350
    YYEFLRLGRE GYTKVQNASY QVAAYLADEI AKLGPYEFIC TGRPDEGIPA 400
    VCFKLKDGED PGYTLYDLSE RLRLRGWQVP AFTLGGEATD IVVMRIMCRR 450
    GFEMDFAELL LEDYKASLKY LSDHPKLQGI AQQNSFKHT 489
    Length:489
    Mass (Da):55,440
    Last modified:January 25, 2012 - v1
    Checksum:iD885B97966EBCAF7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002211 Genomic DNA. Translation: AER84314.1.
    RefSeqiYP_006148938.1. NC_017651.1.

    Genome annotation databases

    EnsemblBacteriaiAER84314; AER84314; i02_1744.
    GeneIDi12669510.
    KEGGield:i02_1744.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002211 Genomic DNA. Translation: AER84314.1 .
    RefSeqi YP_006148938.1. NC_017651.1.

    3D structure databases

    ProteinModelPortali G7R5K5.
    SMRi G7R5K5. Positions 27-489.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AER84314 ; AER84314 ; i02_1744 .
    GeneIDi 12669510.
    KEGGi eld:i02_1744.

    Phylogenomic databases

    KOi K01580.

    Enzyme and pathway databases

    BioCyci ECOL885276:GJE7-1756-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR021115. Pyridoxal-P_BS.
    [Graphical view ]
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
    PROSITEi PS00392. DDC_GAD_HDC_YDC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rates of mutation and host transmission for an Escherichia coli clone over 3 years."
      Reeves P.R., Liu B., Zhou Z., Li D., Guo D., Ren Y., Clabots C., Lan R., Johnson J.R., Wang L.
      PLoS ONE 6:E26907-E26907(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 'clone D i2'Imported.

    Entry informationi

    Entry nameiG7R5K5_ECOC2
    AccessioniPrimary (citable) accession number: G7R5K5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 25, 2012
    Last sequence update: January 25, 2012
    Last modified: October 1, 2014
    This is version 13 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3