Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Inward rectifier potassium channel 2

Gene

KCNJ2

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei172Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Voltage-gated channelUniRule annotationSAAS annotation
Biological processIon transport, Potassium transportUniRule annotationSAAS annotation, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Submitted name:
Inward rectifier potassium channel 2Imported
Gene namesi
Name:KCNJ2Imported
ORF Names:EGK_08925Imported
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei83 – 107HelicalSequence analysisAdd BLAST25
Transmembranei156 – 181HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMMUG00000014051.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiG7NJD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 47IRK_NInterPro annotationAdd BLAST47

Sequence similaritiesi

Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3827. Eukaryota.
ENOG410XQ62. LUCA.
KOiK04996.
OMAiVFSHNAT.
OrthoDBiEOG091G08HC.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiView protein in InterPro
IPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003271. K_chnl_inward-rec_Kir2.1.
IPR013518. K_chnl_inward-rec_Kir_cyto.
IPR013673. K_chnl_inward-rec_Kir_N.
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF67. PTHR11767:SF67. 1 hit.
PfamiView protein in Pfam
PF01007. IRK. 1 hit.
PF08466. IRK_N. 1 hit.
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01324. KIR21CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

G7NJD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSVRTNRYS IVSSEEDGMK LATMAVANGF GNGKSKVHTR QQCRSRFVKK
60 70 80 90 100
DGHCNVQFIN VGEKGQRYLA DIFTTCVDIR WRWMLVIFCL AFVLSWLFFG
110 120 130 140 150
CVFWLIALLH GDLDASKEGK ACVSEVNSFT AAFLFSIETQ TTIGYGFRCV
160 170 180 190 200
TDECPIAVFM VVFQSIVGCI IDAFIIGAVM AKMAKPKKRN ETLVFSHNAV
210 220 230 240 250
IAMRDGKLCL MWRVGNLRKS HLVEAHVRAQ LLKSRITSEG EYIPLDQIDI
260 270 280 290 300
NVGFDSGIDR IFLVSPITIV HEIDEDSPLY DLSKQDIDNA DFEIVVILEG
310 320 330 340 350
MVEATAMTTQ CRSSYLANEI LWGHRYEPVL FEEKHYYKVD YSRFHKTYEV
360 370 380 390 400
PNTPLCSARD LAEKKYILSN ANSFCYENEV ALTSKEEDDS ENGVPESTST
410 420
DTPPDIDLHN QASVPLEPRP LRRESEI
Length:427
Mass (Da):48,288
Last modified:January 25, 2012 - v1
Checksum:iAB37CAD4B99B4050
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JU334421 mRNA. Translation: AFE78174.1.
JU334422 mRNA. Translation: AFE78175.1.
JU334423 mRNA. Translation: AFE78176.1.
JU334424 mRNA. Translation: AFE78177.1.
JU475515 mRNA. Translation: AFH32319.1.
CM001268 Genomic DNA. Translation: EHH25153.1.
RefSeqiNP_001028031.1. NM_001032859.1.
XP_014975696.1. XM_015120210.1.
UniGeneiMmu.3525.

Genome annotation databases

GeneIDi574189.
KEGGimcc:574189.

Similar proteinsi

Entry informationi

Entry nameiG7NJD1_MACMU
AccessioniPrimary (citable) accession number: G7NJD1
Entry historyiIntegrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: September 27, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)