ID   G7KMG0_MEDTR            Unreviewed;       339 AA.
AC   G7KMG0; A0A0C3VWL5;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 2.
DT   27-MAR-2024, entry version 76.
DE   SubName: Full=Histone-lysine N-methyltransferase {ECO:0000313|EMBL:AES75763.2, ECO:0000313|EMBL:RHN52125.1};
DE            EC=2.1.1.43 {ECO:0000313|EMBL:RHN52125.1};
GN   Name=11443283 {ECO:0000313|EnsemblPlants:AES75763};
GN   OrderedLocusNames=MTR_6g059310 {ECO:0000313|EMBL:AES75763.2};
GN   ORFNames=MtrunA17_Chr6g0477001 {ECO:0000313|EMBL:RHN52125.1};
OS   Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX   NCBI_TaxID=3880 {ECO:0000313|EMBL:AES75763.2, ECO:0000313|Proteomes:UP000002051};
RN   [1] {ECO:0000313|EMBL:AES75763.2, ECO:0000313|Proteomes:UP000002051}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A17 {ECO:0000313|EMBL:AES75763.2}, and cv. Jemalong A17
RC   {ECO:0000313|EnsemblPlants:AES75763,
RC   ECO:0000313|Proteomes:UP000002051};
RX   PubMed=22089132; DOI=10.1038/nature10625;
RA   Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA   Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA   Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA   Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA   Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA   Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA   Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA   Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA   Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA   Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA   Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA   Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA   Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA   Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA   Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA   Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA   Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA   Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA   Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA   Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA   Town C.D., Roe B.A.;
RT   "The Medicago genome provides insight into the evolution of rhizobial
RT   symbioses.";
RL   Nature 480:520-524(2011).
RN   [2] {ECO:0000313|EMBL:AES75763.2, ECO:0000313|Proteomes:UP000002051}
RP   GENOME REANNOTATION.
RC   STRAIN=A17 {ECO:0000313|EMBL:AES75763.2}, and cv. Jemalong A17
RC   {ECO:0000313|EnsemblPlants:AES75763,
RC   ECO:0000313|Proteomes:UP000002051};
RX   PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA   Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA   Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA   Schwartz D.C., Town C.D.;
RT   "An improved genome release (version Mt4.0) for the model legume Medicago
RT   truncatula.";
RL   BMC Genomics 15:312-312(2014).
RN   [3] {ECO:0000313|EnsemblPlants:AES75763}
RP   IDENTIFICATION.
RC   STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES75763};
RG   EnsemblPlants;
RL   Submitted (APR-2015) to UniProtKB.
RN   [4] {ECO:0000313|EMBL:RHN52125.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Leaves {ECO:0000313|EMBL:RHN52125.1};
RA   Pecrix Y., Gamas P., Carrere S.;
RT   "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL   Nat. Plants 0:0-0(2018).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; CM001222; AES75763.2; -; Genomic_DNA.
DR   EMBL; PSQE01000006; RHN52125.1; -; Genomic_DNA.
DR   RefSeq; XP_003619545.2; XM_003619497.2.
DR   AlphaFoldDB; G7KMG0; -.
DR   EnsemblPlants; AES75763; AES75763; MTR_6g059310.
DR   Gramene; AES75763; AES75763; MTR_6g059310.
DR   HOGENOM; CLU_020840_1_0_1; -.
DR   Proteomes; UP000002051; Chromosome 6.
DR   Proteomes; UP000265566; Chromosome 6.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd19175; SET_ASHR3-like; 1.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR047893; ASHR3-like_SET.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR025787; Hist-Lys_N-MeTrfase_SET2_plant.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   PANTHER; PTHR22884:SF498; HISTONE-LYSINE N-METHYLTRANSFERASE ASHH3; 1.
DR   PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS51578; SAM_MT43_SET2_2; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000313|EMBL:RHN52125.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002051};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:RHN52125.1}.
FT   DOMAIN          61..110
FT                   /note="AWS"
FT                   /evidence="ECO:0000259|PROSITE:PS51215"
FT   DOMAIN          112..229
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   DOMAIN          235..251
FT                   /note="Post-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50868"
SQ   SEQUENCE   339 AA;  38879 MW;  9A73FBA363DDFB44 CRC64;
     MPIMKKNSEQ NRFEAVFTKL MNNLGETVDF ELPDSIKNRT TQYTHIKRNV YVTKNRKRKS
     DDGIFCSCES SSDSTAVCGR DCHCGMLLSS CSSGCKCGIS CLNKAFQHRP VKKMKLVKTE
     KCGSGIVADE DIKLGEFVIE YVGEVIDDKT CEQRLWNMKD RGETNFYLCE INRDMVIDAT
     NKGNKSRYIN HSCCPNTEMQ KWIIDGETRI GIFASRDIKK GEHLTYDYQF VQFGADQDCH
     CGAVQCRRKL GARPTKPKLV AYQVYQNGGL QTGSSRVVDH SKCLLNCIDE VIMIKQLGNL
     RFGIIKWFDE YSRKHKIMFE DGCVEIYDMS KEDWELVRL
//