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G7KHI5

- G7KHI5_MEDTR

UniProt

G7KHI5 - G7KHI5_MEDTR

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Protein

Isocitrate dehydrogenase [NADP]

Gene

MTR_6g005470

Organism
Medicago truncatula (Barrel medic) (Medicago tribuloides)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei146 – 1461SubstrateUniRule annotation
Binding sitei178 – 1781SubstrateUniRule annotation
Binding sitei201 – 2011SubstrateUniRule annotation
Sitei208 – 2081Critical for catalysisUniRule annotation
Sitei280 – 2801Critical for catalysisUniRule annotation
Metal bindingi320 – 3201Magnesium or manganeseUniRule annotation
Metal bindingi343 – 3431Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: EnsemblPlants/Gramene
  3. NAD binding Source: EnsemblPlants/Gramene

GO - Biological processi

  1. isocitrate metabolic process Source: EnsemblPlants/Gramene
  2. response to stress Source: EnsemblPlants/Gramene
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:MTR_6g005470Imported
OrganismiMedicago truncatula (Barrel medic) (Medicago tribuloides)Imported
Taxonomic identifieri3880 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeTrifolieaeMedicago
ProteomesiUP000002051: Chromosome 6

Subcellular locationi

GO - Cellular componenti

  1. chloroplast stroma Source: EnsemblPlants/Gramene
  2. chloroplast thylakoid Source: EnsemblPlants/Gramene
  3. mitochondrion Source: EnsemblPlants/Gramene
Complete GO annotation...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni163 – 1697Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.
OMAiKVSREFY.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G7KHI5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRASSSSSL FRLTSTLTML SSSCSLRNPN NLLFHSTPSS SLFLPHPPNS
60 70 80 90 100
LSFHNHNHNP FIPLRCFASS TPIHVANPIV EMDGDEMTRI IWKMIKDKLI
110 120 130 140 150
FPYLDLNIKY FDLGVLNRDA TEDRVTVESA EATLKYNVAV KCATITPDET
160 170 180 190 200
RVKEFGLKSM WRSPNGTIRN ILNGTVFREP IICRNIPRII PGWKKPICIG
210 220 230 240 250
RHAFGDQYRA TDTVINGPGK LKLVFVPEDG DTPVELDVHD FKGPGVALAM
260 270 280 290 300
YNVDESIRAF AESSMSLAFT KKWPLYLSTK NTILKKYDGR FKDIFQEVYE
310 320 330 340 350
ERWRQKFEEH SIWYEHRLID DMVAYALKSE GGYVWACKNY DGDVQSDLLA
360 370 380 390 400
QGFGSLGLMT SVLLSSDGKT LEAEAAHGTV TRHFRFHQKG QETSTNSIAS
410 420 430 440 450
IFAWTRGLEH RAKLDKNEKL LDFADKLEAA CVETVESGKM TKDLALLIHG
460 470 480
PKVSREFYLN TEEFIDAVAS NLERKLREPA TV
Length:482
Mass (Da):54,523
Last modified:January 25, 2012 - v1
Checksum:i34FD52C6E39D13E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001222 Genomic DNA. Translation: AES74397.1.
RefSeqiXP_003618179.1. XM_003618131.1.
UniGeneiMtr.11394.

Genome annotation databases

GeneIDi11419675.
KEGGimtr:MTR_6g005470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001222 Genomic DNA. Translation: AES74397.1 .
RefSeqi XP_003618179.1. XM_003618131.1.
UniGenei Mtr.11394.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 11419675.
KEGGi mtr:MTR_6g005470.

Phylogenomic databases

KOi K00031.
OMAi KVSREFY.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The Medicago genome provides insight into the evolution of rhizobial symbioses."
    Young N.D., Debelle F., Oldroyd G.E.D., Geurts R., Cannon S.B., Udvardi M.K., Benedito V.A., Mayer K.F.X., Gouzy J., Schoof H., Van de Peer Y., Proost S., Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S., Krishnakumar V.
    , Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D., Naoumkina M.A., Rosen B., Silverstein K.A.T., Tang H., Rombauts S., Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A., Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R., Deshpande S., Dai X., Doyle J.J., Dudez A.-M., Farmer A.D., Fouteau S., Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J., Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.-H., Jing Y., Jocker A., Kenton S.M., Kim D.-J., Klee K., Lai H., Lang C., Lin S., Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L., Mun J.-H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R., Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E., Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T., Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R., Sinharoy S., Sterck L., Viollet A., Wang B.-B., Wang K., Wang M., Wang X., Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B., Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A., Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F., Town C.D., Roe B.A.
    Nature 480:520-524(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Jemalong A17Imported.

Entry informationi

Entry nameiG7KHI5_MEDTR
AccessioniPrimary (citable) accession number: G7KHI5
Entry historyi
Integrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: November 26, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3