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Protein

Isocitrate dehydrogenase [NADP]

Gene

MTR_6g005470

Organism
Medicago truncatula (Barrel medic) (Medicago tribuloides)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei146 – 1461SubstrateUniRule annotation
Binding sitei151 – 1511NADPUniRule annotation
Binding sitei178 – 1781SubstrateUniRule annotation
Binding sitei201 – 2011SubstrateUniRule annotation
Sitei208 – 2081Critical for catalysisUniRule annotation
Sitei280 – 2801Critical for catalysisUniRule annotation
Metal bindingi320 – 3201Magnesium or manganeseUniRule annotation
Binding sitei328 – 3281NADPUniRule annotation
Metal bindingi343 – 3431Magnesium or manganeseUniRule annotation
Binding sitei396 – 3961NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi144 – 1463NADPUniRule annotation
Nucleotide bindingi378 – 3836NADPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:MTR_6g005470Imported
OrganismiMedicago truncatula (Barrel medic) (Medicago tribuloides)Imported
Taxonomic identifieri3880 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeTrifolieaeMedicago
ProteomesiUP000002051 Componenti: Chromosome 6

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni163 – 1697Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.
OMAiVMGMYNF.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G7KHI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRASSSSSL FRLTSTLTML SSSCSLRNPN NLLFHSTPSS SLFLPHPPNS
60 70 80 90 100
LSFHNHNHNP FIPLRCFASS TPIHVANPIV EMDGDEMTRI IWKMIKDKLI
110 120 130 140 150
FPYLDLNIKY FDLGVLNRDA TEDRVTVESA EATLKYNVAV KCATITPDET
160 170 180 190 200
RVKEFGLKSM WRSPNGTIRN ILNGTVFREP IICRNIPRII PGWKKPICIG
210 220 230 240 250
RHAFGDQYRA TDTVINGPGK LKLVFVPEDG DTPVELDVHD FKGPGVALAM
260 270 280 290 300
YNVDESIRAF AESSMSLAFT KKWPLYLSTK NTILKKYDGR FKDIFQEVYE
310 320 330 340 350
ERWRQKFEEH SIWYEHRLID DMVAYALKSE GGYVWACKNY DGDVQSDLLA
360 370 380 390 400
QGFGSLGLMT SVLLSSDGKT LEAEAAHGTV TRHFRFHQKG QETSTNSIAS
410 420 430 440 450
IFAWTRGLEH RAKLDKNEKL LDFADKLEAA CVETVESGKM TKDLALLIHG
460 470 480
PKVSREFYLN TEEFIDAVAS NLERKLREPA TV
Length:482
Mass (Da):54,523
Last modified:January 25, 2012 - v1
Checksum:i34FD52C6E39D13E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001222 Genomic DNA. Translation: AES74397.1.
RefSeqiXP_003618179.1. XM_003618131.1.
UniGeneiMtr.11394.

Genome annotation databases

EnsemblPlantsiAES74397; AES74397; MTR_6g005470.
GeneIDi11419675.
KEGGimtr:MTR_6g005470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001222 Genomic DNA. Translation: AES74397.1.
RefSeqiXP_003618179.1. XM_003618131.1.
UniGeneiMtr.11394.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAES74397; AES74397; MTR_6g005470.
GeneIDi11419675.
KEGGimtr:MTR_6g005470.

Phylogenomic databases

KOiK00031.
OMAiVMGMYNF.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Medicago genome provides insight into the evolution of rhizobial symbioses."
    Young N.D., Debelle F., Oldroyd G.E.D., Geurts R., Cannon S.B., Udvardi M.K., Benedito V.A., Mayer K.F.X., Gouzy J., Schoof H., Van de Peer Y., Proost S., Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S., Krishnakumar V.
    , Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D., Naoumkina M.A., Rosen B., Silverstein K.A.T., Tang H., Rombauts S., Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A., Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R., Deshpande S., Dai X., Doyle J.J., Dudez A.-M., Farmer A.D., Fouteau S., Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J., Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.-H., Jing Y., Jocker A., Kenton S.M., Kim D.-J., Klee K., Lai H., Lang C., Lin S., Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L., Mun J.-H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R., Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E., Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T., Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R., Sinharoy S., Sterck L., Viollet A., Wang B.-B., Wang K., Wang M., Wang X., Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B., Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A., Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F., Town C.D., Roe B.A.
    Nature 480:520-524(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A17Imported and cv. Jemalong A17Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A17.
  3. EnsemblPlants
    Submitted (APR-2015) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: cv. Jemalong A17Imported.

Entry informationi

Entry nameiG7KHI5_MEDTR
AccessioniPrimary (citable) accession number: G7KHI5
Entry historyi
Integrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: July 22, 2015
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.