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G7KHI5

- G7KHI5_MEDTR

UniProt

G7KHI5 - G7KHI5_MEDTR

Protein

Isocitrate dehydrogenase [NADP]

Gene

MTR_6g005470

Organism
Medicago truncatula (Barrel medic) (Medicago tribuloides)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (25 Jan 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei146 – 1461SubstrateUniRule annotation
    Binding sitei151 – 1511NADP
    Binding sitei178 – 1781SubstrateUniRule annotation
    Binding sitei201 – 2011SubstrateUniRule annotation
    Sitei208 – 2081Critical for catalysisUniRule annotation
    Sitei280 – 2801Critical for catalysisUniRule annotation
    Metal bindingi320 – 3201Magnesium or manganeseUniRule annotation
    Binding sitei328 – 3281NADP
    Metal bindingi343 – 3431Magnesium or manganeseUniRule annotation
    Binding sitei396 – 3961NADP; via amide nitrogen and carbonyl oxygen

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi144 – 1463NADP
    Nucleotide bindingi378 – 3836NADP

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:MTR_6g005470Imported
    OrganismiMedicago truncatula (Barrel medic) (Medicago tribuloides)Imported
    Taxonomic identifieri3880 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeTrifolieaeMedicago
    ProteomesiUP000002051: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. chloroplast stroma Source: EnsemblPlants/Gramene
    2. chloroplast thylakoid Source: EnsemblPlants/Gramene

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni163 – 1697Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.
    OMAiKVSREFY.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G7KHI5-1 [UniParc]FASTAAdd to Basket

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    MLRASSSSSL FRLTSTLTML SSSCSLRNPN NLLFHSTPSS SLFLPHPPNS    50
    LSFHNHNHNP FIPLRCFASS TPIHVANPIV EMDGDEMTRI IWKMIKDKLI 100
    FPYLDLNIKY FDLGVLNRDA TEDRVTVESA EATLKYNVAV KCATITPDET 150
    RVKEFGLKSM WRSPNGTIRN ILNGTVFREP IICRNIPRII PGWKKPICIG 200
    RHAFGDQYRA TDTVINGPGK LKLVFVPEDG DTPVELDVHD FKGPGVALAM 250
    YNVDESIRAF AESSMSLAFT KKWPLYLSTK NTILKKYDGR FKDIFQEVYE 300
    ERWRQKFEEH SIWYEHRLID DMVAYALKSE GGYVWACKNY DGDVQSDLLA 350
    QGFGSLGLMT SVLLSSDGKT LEAEAAHGTV TRHFRFHQKG QETSTNSIAS 400
    IFAWTRGLEH RAKLDKNEKL LDFADKLEAA CVETVESGKM TKDLALLIHG 450
    PKVSREFYLN TEEFIDAVAS NLERKLREPA TV 482
    Length:482
    Mass (Da):54,523
    Last modified:January 25, 2012 - v1
    Checksum:i34FD52C6E39D13E1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM001222 Genomic DNA. Translation: AES74397.1.
    RefSeqiXP_003618179.1. XM_003618131.1.
    UniGeneiMtr.11394.

    Genome annotation databases

    GeneIDi11419675.
    KEGGimtr:MTR_6g005470.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM001222 Genomic DNA. Translation: AES74397.1 .
    RefSeqi XP_003618179.1. XM_003618131.1.
    UniGenei Mtr.11394.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 11419675.
    KEGGi mtr:MTR_6g005470.

    Phylogenomic databases

    KOi K00031.
    OMAi KVSREFY.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Medicago genome provides insight into the evolution of rhizobial symbioses."
      Young N.D., Debelle F., Oldroyd G.E.D., Geurts R., Cannon S.B., Udvardi M.K., Benedito V.A., Mayer K.F.X., Gouzy J., Schoof H., Van de Peer Y., Proost S., Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S., Krishnakumar V.
      , Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D., Naoumkina M.A., Rosen B., Silverstein K.A.T., Tang H., Rombauts S., Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A., Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R., Deshpande S., Dai X., Doyle J.J., Dudez A.-M., Farmer A.D., Fouteau S., Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J., Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.-H., Jing Y., Jocker A., Kenton S.M., Kim D.-J., Klee K., Lai H., Lang C., Lin S., Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L., Mun J.-H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R., Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E., Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T., Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R., Sinharoy S., Sterck L., Viollet A., Wang B.-B., Wang K., Wang M., Wang X., Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B., Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A., Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F., Town C.D., Roe B.A.
      Nature 480:520-524(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: A17Imported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Jemalong A17Imported.

    Entry informationi

    Entry nameiG7KHI5_MEDTR
    AccessioniPrimary (citable) accession number: G7KHI5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 25, 2012
    Last sequence update: January 25, 2012
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3