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Protein

Histone deacetylase

Gene

11446252

Organism
Medicago truncatula (Barrel medic) (Medicago tribuloides)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei95SubstrateUniRule annotation1
Active sitei137Proton acceptorUniRule annotation1
Binding sitei145Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi172Divalent metal cationUniRule annotation1
Metal bindingi174Divalent metal cationUniRule annotation1
Metal bindingi261Divalent metal cationUniRule annotation1
Binding sitei300SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
Name:11446252Imported
Ordered Locus Names:MTR_4g055080Imported
OrganismiMedicago truncatula (Barrel medic) (Medicago tribuloides)Imported
Taxonomic identifieri3880 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeTrifolieaeMedicago
Proteomesi
  • UP000002051 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 315Hist_deacetylInterPro annotationAdd BLAST292

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

KOiK06067.
OMAiPRAWTHL.
OrthoDBiEOG093609CH.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
IPR037138. His_deacetylse_dom_sf.
IPR023696. Ureohydrolase_domain.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
SUPFAMiSSF52768. SSF52768. 1 hit.

Sequencei

Sequence statusi: Complete.

G7JKX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSKDRISYF YDGDVGSVYF GPNHPMKPHR LCMTHHLVLS YDLHKKMEVY
60 70 80 90 100
RPHKAYPVEL AQFHSADYVE FLHRITPDTQ HLFSDELAKY NLGEDCPVFD
110 120 130 140 150
NLFEFCQMYA GGTIDAARRL NNKLCDIAIN WAGGLHHAKK CEASGFCYIN
160 170 180 190 200
DLVLGILELL KHHPRVLYID IDVHHGDGVE EAFYFTDRVM TVSSHKYGDL
210 220 230 240 250
FFPGTGDAKE IGEREGKFYA INVPLKDGID DSSFTRLFKT IISKVVETYQ
260 270 280 290 300
PGAIVLQCGA DSLAGDRLGC FNLSIDGHAE CVRFVKKFNV PLLVTGGGGY
310 320 330 340 350
TKENVARCWT VETGVLLDTE LPNEIPENDY IKYFGPDFSL KIPNGFIENL
360 370 380 390 400
NSKSYLSTIK MQVMENLRCI QHAPSVQMQE VPPDFYIPDI DEDLQNPDER
410 420 430
NDQHTQDKHI QRDDEYYDGD NDNDHQMDLP
Length:430
Mass (Da):49,081
Last modified:January 25, 2012 - v1
Checksum:i82D792DA31E80FD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001220 Genomic DNA. Translation: AES88434.1.
RefSeqiXP_003606237.1. XM_003606189.2.

Genome annotation databases

EnsemblPlantsiAES88434; AES88434; MTR_4g055080.
GeneIDi11446252.
GrameneiAES88434; AES88434; MTR_4g055080.
KEGGimtr:MTR_4g055080.

Similar proteinsi

Entry informationi

Entry nameiG7JKX4_MEDTR
AccessioniPrimary (citable) accession number: G7JKX4
Entry historyiIntegrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: October 25, 2017
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported