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Protein

Ribonuclease PH

Gene

rph

Organism
Mycobacterium thermoresistibile (strain ATCC 19527 / DSM 44167 / CIP 105390 / JCM 6362 / NCTC 10409 / 316)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei88Phosphate (substrate) bindingUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotationSAAS annotationImported, RNA-binding, Transferase, tRNA-bindingUniRule annotationSAAS annotation
Biological processrRNA processingUniRule annotationSAAS annotation, tRNA processingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease PHUniRule annotationSAAS annotation (EC:2.7.7.56UniRule annotationSAAS annotation)
Short name:
RNase PHUniRule annotation
Alternative name(s):
tRNA nucleotidyltransferaseUniRule annotation
Gene namesi
Name:rphUniRule annotationImported
ORF Names:KEK_13023Imported
OrganismiMycobacterium thermoresistibile (strain ATCC 19527 / DSM 44167 / CIP 105390 / JCM 6362 / NCTC 10409 / 316)Imported
Taxonomic identifieri1078020 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000004915 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Homohexameric ring arranged as a trimer of dimers.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 142RNase_PHInterPro annotationAdd BLAST131
Domaini161 – 225RNase_PH_CInterPro annotationAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni126 – 128Phosphate (substrate) bindingUniRule annotation3

Sequence similaritiesi

Belongs to the RNase PH family.UniRule annotationSAAS annotation

Phylogenomic databases

OrthoDBiPOG091H03ML

Family and domain databases

CDDicd11362 RNase_PH_bact, 1 hit
Gene3Di3.30.230.70, 1 hit
HAMAPiMF_00564 RNase_PH, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR027408 PNPase/RNase_PH_dom_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR002381 RNase_PH_bac-type
IPR018336 RNase_PH_CS
PfamiView protein in Pfam
PF01138 RNase_PH, 1 hit
PF03725 RNase_PH_C, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55666 SSF55666, 1 hit
TIGRFAMsiTIGR01966 RNasePH, 1 hit
PROSITEiView protein in PROSITE
PS01277 RIBONUCLEASE_PH, 1 hit

Sequencei

Sequence statusi: Complete.

G7CL15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRREDGRLD DELRPVVITR GYTSHPAGSV LVEFGHTRVL CTASVLEGVP
60 70 80 90 100
RWRKGSGQGW LTAEYAMLPA ATHERSDRES VKGRLGGRTQ EISRLIGRSL
110 120 130 140 150
RACIDLNALG ENTIAIDCDV LQADGGTRTA AITGAYVALA DAVTYLAAAE
160 170 180 190 200
KLSDPWPLSC AIAAISVGVV DGRVRVDLPY SEDARAEVDM NVVATDTGTL
210 220 230 240 250
VEVQGTGEGA TFPRSTLDKM LDAALAACDQ LFAVQREALE LPYPGVLPAP
260
TSPPKKAFGS
Length:260
Mass (Da):27,594
Last modified:January 25, 2012 - v1
Checksum:i7E655D1AA6EFC808
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGVE01000046 Genomic DNA Translation: EHI11822.1
RefSeqiWP_003926086.1, NZ_AGVE01000046.1

Genome annotation databases

EnsemblBacteriaiEHI11822; EHI11822; KEK_13023
PATRICifig|1078020.3.peg.2560

Similar proteinsi

Entry informationi

Entry nameiG7CL15_MYCT3
AccessioniPrimary (citable) accession number: G7CL15
Entry historyiIntegrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: May 23, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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