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Protein
Submitted name:

3-hydroxyisobutyryl-CoA hydrolase

Gene

KEK_02971

Organism
Mycobacterium thermoresistibile ATCC 19527
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi32 – 321Zinc 1; via pros nitrogenCombined sources
Metal bindingi46 – 461Zinc 2Combined sources
Metal bindingi83 – 831Zinc 1Combined sources
Metal bindingi97 – 971Zinc 2; via tele nitrogenCombined sources
Metal bindingi348 – 3481Zinc 2Combined sources

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseImported

Keywords - Ligandi

Metal-bindingCombined sources, ZincCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
3-hydroxyisobutyryl-CoA hydrolaseImported
Gene namesi
ORF Names:KEK_02971Imported
OrganismiMycobacterium thermoresistibile ATCC 19527Imported
Taxonomic identifieri1078020 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HDTX-ray1.60A2-350[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di1.10.12.10. 1 hit.
3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR014748. Crontonase_C.
IPR001753. Crotonase_core_superfam.
[Graphical view]
PfamiPF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 2 hits.

Sequencei

Sequence statusi: Complete.

G7CC99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAKNEDVLV NVEGGVGLLT LNRPKAINSL THGMVTTMAE RLAAWENDDS
60 70 80 90 100
VRAVLLTGAG ERGLCAGGDV VAIYHSAKAD GAEARRFWFD EYRLNAHIGR
110 120 130 140 150
YPKPYVSIMD GIVMGGGVGV GAHGNVRVVT DTTKMAMPEV GIGFIPDVGG
160 170 180 190 200
TYLLSRAPGK LGLHAALTGA PFSGADAIVM GFADHYVPHD KIDEFTRAVI
210 220 230 240 250
ADGVDAALAA HAQEPPASPL AEQRSWIDEC YTGDTVADII AALRAHDAPA
260 270 280 290 300
AGEAADLIAT RSPIALSVTL ESVRRAAKLQ SLEDTLRQEY RVSCASLKSH
310 320 330 340 350
DLVEGIRAQL VDKDRNPKWR PATLAEVTEA DVEAYFAPVD PELTFEGETQ
Length:350
Mass (Da):37,240
Last modified:January 25, 2012 - v1
Checksum:i03FF93D19FE338E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGVE01000017 Genomic DNA. Translation: EHI14362.1.

Genome annotation databases

EnsemblBacteriaiEHI14362; EHI14362; KEK_02971.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGVE01000017 Genomic DNA. Translation: EHI14362.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HDTX-ray1.60A2-350[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiEHI14362; EHI14362; KEK_02971.

Family and domain databases

Gene3Di1.10.12.10. 1 hit.
3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR014748. Crontonase_C.
IPR001753. Crotonase_core_superfam.
[Graphical view]
PfamiPF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. Tuberculosis Structural Genomics Consortium
    Ioerger T.R.
    Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC 19527Imported.
  2. "Crystal structure of a Carnitinyl-CoA dehydratase from Mycobacterium thermoresistibile."
    Seattle Structural Genomics Center for Infectious Disease (SSGCID)
    Abendroth J., Edwards T.E., Sankaran B., Staker B.L.
    Submitted (OCT-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 2-350 IN COMPLEX WITH ZINC.

Entry informationi

Entry nameiG7CC99_MYCTH
AccessioniPrimary (citable) accession number: G7CC99
Entry historyi
Integrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: January 7, 2015
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.