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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Clostridioides difficile 050-P50-2011
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processAntibiotic resistanceUniRule annotationSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
ORF Names:HMPREF1123_03210Imported
OrganismiClostridioides difficile 050-P50-2011Imported
Taxonomic identifieri997828 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000004108 Componenti: Unassembled WGS sequence

Subcellular locationi

G6BMH0:
  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 34HelicalUniRule annotationAdd BLAST23
Transmembranei54 – 76HelicalUniRule annotationAdd BLAST23
Transmembranei97 – 116HelicalUniRule annotationAdd BLAST20
Transmembranei122 – 143HelicalUniRule annotationAdd BLAST22
Transmembranei155 – 176HelicalUniRule annotationAdd BLAST22
Transmembranei196 – 218HelicalUniRule annotationAdd BLAST23
Transmembranei230 – 251HelicalUniRule annotationAdd BLAST22
Transmembranei263 – 280HelicalUniRule annotationAdd BLAST18

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotationSAAS annotation, Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

OrthoDBiPOG091H00ZR.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiView protein in InterPro
IPR003824. UppP.
PANTHERiPTHR30622. PTHR30622. 1 hit.
PfamiView protein in Pfam
PF02673. BacA. 1 hit.
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

G6BMH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYWRYFDLET FSLLEIFKAV ILGIVQGITE WLPVSSTGHM ILVDEFIKLN
60 70 80 90 100
FSNTFISTFL VVIQFGSILA VLVIFFRKLN PFDSAKNIKQ KKETVRLWLK
110 120 130 140 150
VIIAVIPSGV IGILFEDDID RLFFNSTVVA IALIVYGIIM IGLEKRNKRP
160 170 180 190 200
KYKDFSQVTY KLALCIGLFQ CLALIPGTSR SGSTIIGAVL LGTSRYVAAE
210 220 230 240 250
FSFFLAIPTM LGASALKLLK AGFGFTGFEW LILGVGSVVA FVVSIVVIKF
260 270 280
FMDYIKKHDF KVFGYYRIVL GIVVLAYFFL L
Length:281
Mass (Da):31,604
Last modified:January 25, 2012 - v1
Checksum:i67D45203E167AF7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGAB01000076 Genomic DNA. Translation: EHJ25991.1.

Genome annotation databases

EnsemblBacteriaiEHJ25991; EHJ25991; HMPREF1123_03210.
PATRICifig|997828.4.peg.3131.

Similar proteinsi

Entry informationi

Entry nameiG6BMH0_CLODI
AccessioniPrimary (citable) accession number: G6BMH0
Entry historyiIntegrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: September 27, 2017
This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported