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G5KRT8 (G5KRT8_ECOLX) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase HAMAP-Rule MF_00687

EC=5.3.1.17 HAMAP-Rule MF_00687
Alternative name(s):
5-keto-4-deoxyuronate isomerase HAMAP-Rule MF_00687
DKI isomerase HAMAP-Rule MF_00687
Gene names
Name:kduI HAMAP-Rule MF_00687
ORF Names:i01_03932 EMBL EHG00043.1
OrganismEscherichia coli cloneA_i1 EMBL EHG00043.1
Taxonomic identifier993513 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate By similarity. HAMAP-Rule MF_00687 SAAS SAAS007045

Catalytic activity

5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate. HAMAP-Rule MF_00687 SAAS SAAS007045

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00687 SAAS SAAS007045

Pathway

Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 4/5. HAMAP-Rule MF_00687 SAAS SAAS007045

Subunit structure

Homohexamer By similarity. HAMAP-Rule MF_00687

Sequence similarities

Belongs to the KduI family. HAMAP-Rule MF_00687

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. EMBL EHG00043.1

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding1961Zinc By similarity HAMAP-Rule MF_00687
Metal binding1981Zinc By similarity HAMAP-Rule MF_00687
Metal binding2031Zinc By similarity HAMAP-Rule MF_00687
Metal binding2451Zinc By similarity HAMAP-Rule MF_00687

Sequences

Sequence LengthMass (Da)Tools
G5KRT8 [UniParc].

Last modified January 25, 2012. Version 1.
Checksum: 7AF3DD98DE74D597

FASTA27831,076
        10         20         30         40         50         60 
MDVRQSIHSA HAKTLDTQGL RNEFLVEKVF VADEYTMVYS HIDRIIVGGI MPVTKTVSVG 

        70         80         90        100        110        120 
GEVGKQLGVS YFLERRELGV INIGGAGTIT VDGQCYEIGH RDALYVGKGA KEVVFASIDT 

       130        140        150        160        170        180 
ATPAKFYYNC APAHTTYPTK KVTPDEVSPV TLGDNLTSNR RTINKYFVPD VLETCQLSMG 

       190        200        210        220        230        240 
LTELAPGNLW NTMPCHTHER RMEVYFYFNM DDDACVFHMM GQPQETRHIV MHNEQAVISP 

       250        260        270 
SWSIHSGVGT KAYTFIWGMV GENQVFDDMD HVAVKDLR 

« Hide

References

[1]"Rates of Mutation and Host Transmission for an Escherichia coli Clone over 3 Years."
Reeves P.R., Liu B., Zhou Z., Li D., Guo D., Ren Y., Clabots C., Lan R., Johnson J.R., Wang L.
PLoS ONE 6:E26907-E26907(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: CloneA_i1 EMBL EHG00043.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AEYT01000035 Genomic DNA. Translation: EHG00043.1.

3D structure databases

ProteinModelPortalG5KRT8.
SMRG5KRT8. Positions 1-277.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEHG00043; EHG00043; i01_03932.

Enzyme and pathway databases

UniPathwayUPA00545; UER00826.

Family and domain databases

Gene3D2.60.120.500. 1 hit.
2.60.120.520. 1 hit.
HAMAPMF_00687. KduI.
InterProIPR007045. KduI.
IPR021120. KduI/IolB_isomerase.
IPR027447. KduI_C.
IPR027449. KduI_N.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamPF04962. KduI. 1 hit.
[Graphical view]
PIRSFPIRSF006625. KduI. 1 hit.
SUPFAMSSF51182. SSF51182. 1 hit.
ProtoNetSearch...

Entry information

Entry nameG5KRT8_ECOLX
AccessionPrimary (citable) accession number: G5KRT8
Entry history
Integrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: February 19, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)