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G5KRT8

- G5KRT8_ECOLX

UniProt

G5KRT8 - G5KRT8_ECOLX

Protein

4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase

Gene

kduI

Organism
Escherichia coli cloneA_i1
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 15 (01 Oct 2014)
      Sequence version 1 (25 Jan 2012)
      Previous versions | rss
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    Functioni

    Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.UniRule annotationSAAS annotation

    Catalytic activityi

    5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi196 – 1961ZincUniRule annotation
    Metal bindingi198 – 1981ZincUniRule annotation
    Metal bindingi203 – 2031ZincUniRule annotation
    Metal bindingi245 – 2451ZincUniRule annotation

    GO - Molecular functioni

    1. 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pectin catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    UniPathwayiUPA00545; UER00826.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-deoxy-L-threo-5-hexosulose-uronate ketol-isomeraseUniRule annotation (EC:5.3.1.17UniRule annotation)
    Alternative name(s):
    5-keto-4-deoxyuronate isomeraseUniRule annotation
    DKI isomeraseUniRule annotation
    Gene namesi
    Name:kduIUniRule annotation
    ORF Names:i01_03932Imported
    OrganismiEscherichia coli cloneA_i1Imported
    Taxonomic identifieri993513 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

    Interactioni

    Subunit structurei

    Homohexamer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliG5KRT8.
    SMRiG5KRT8. Positions 1-277.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the KduI family.UniRule annotation

    Family and domain databases

    Gene3Di2.60.120.500. 1 hit.
    2.60.120.520. 1 hit.
    HAMAPiMF_00687. KduI.
    InterProiIPR007045. KduI.
    IPR021120. KduI/IolB_isomerase.
    IPR027447. KduI_C.
    IPR027449. KduI_N.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PfamiPF04962. KduI. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006625. KduI. 1 hit.
    SUPFAMiSSF51182. SSF51182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    G5KRT8-1 [UniParc]FASTAAdd to Basket

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    MDVRQSIHSA HAKTLDTQGL RNEFLVEKVF VADEYTMVYS HIDRIIVGGI    50
    MPVTKTVSVG GEVGKQLGVS YFLERRELGV INIGGAGTIT VDGQCYEIGH 100
    RDALYVGKGA KEVVFASIDT ATPAKFYYNC APAHTTYPTK KVTPDEVSPV 150
    TLGDNLTSNR RTINKYFVPD VLETCQLSMG LTELAPGNLW NTMPCHTHER 200
    RMEVYFYFNM DDDACVFHMM GQPQETRHIV MHNEQAVISP SWSIHSGVGT 250
    KAYTFIWGMV GENQVFDDMD HVAVKDLR 278
    Length:278
    Mass (Da):31,076
    Last modified:January 25, 2012 - v1
    Checksum:i7AF3DD98DE74D597
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AEYT01000035 Genomic DNA. Translation: EHG00043.1.

    Genome annotation databases

    EnsemblBacteriaiEHG00043; EHG00043; i01_03932.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AEYT01000035 Genomic DNA. Translation: EHG00043.1 .

    3D structure databases

    ProteinModelPortali G5KRT8.
    SMRi G5KRT8. Positions 1-277.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai EHG00043 ; EHG00043 ; i01_03932 .

    Enzyme and pathway databases

    UniPathwayi UPA00545 ; UER00826 .

    Family and domain databases

    Gene3Di 2.60.120.500. 1 hit.
    2.60.120.520. 1 hit.
    HAMAPi MF_00687. KduI.
    InterProi IPR007045. KduI.
    IPR021120. KduI/IolB_isomerase.
    IPR027447. KduI_C.
    IPR027449. KduI_N.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    Pfami PF04962. KduI. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006625. KduI. 1 hit.
    SUPFAMi SSF51182. SSF51182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Rates of mutation and host transmission for an Escherichia coli clone over 3 years."
      Reeves P.R., Liu B., Zhou Z., Li D., Guo D., Ren Y., Clabots C., Lan R., Johnson J.R., Wang L.
      PLoS ONE 6:E26907-E26907(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: CloneA_i1Imported.

    Entry informationi

    Entry nameiG5KRT8_ECOLX
    AccessioniPrimary (citable) accession number: G5KRT8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 25, 2012
    Last sequence update: January 25, 2012
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

    External Data

    Dasty 3