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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Streptococcus urinalis 2285-97
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei258ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotation, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotationImported
ORF Names:STRUR_0183Imported
OrganismiStreptococcus urinalis 2285-97Imported
Taxonomic identifieri764291 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000005388 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi764291.STRUR_0183.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 326tRNA-synt_1cInterPro annotationAdd BLAST322

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 21"HIGH" regionUniRule annotationAdd BLAST11
Motifi255 – 259"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20. Bacteria.
COG0008. LUCA.
OrthoDBiPOG091H021W.

Family and domain databases

CDDicd00808. GluRS_core. 1 hit.
Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022. Glu_tRNA_synth_type1. 1 hit.
InterProiView protein in InterPro
IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR033910. GluRS_core.
IPR014729. Rossmann-like_a/b/a_fold.
PfamiView protein in Pfam
PF00749. tRNA-synt_1c. 1 hit.
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

G5KH90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKPIRVRYA PSPTGLLHIG NARTALFNYL YARHHNGTFV IRIEDTDRKR
60 70 80 90 100
HVEDGERSQL ENLRWLGIDW DESPETHEKY RQSERLDLYQ KYIDQLLAEG
110 120 130 140 150
KAYKSYTTEE ELAAERERQE AAGETPRYIN EFIGMSEAEK SAYIAEREAK
160 170 180 190 200
GIIPTVRLSV NESGIYKWHD IVKGDIEFEG GNIGGDWVIQ KKDGYPTYNF
210 220 230 240 250
AVVIDDHDMQ ISHVIRGDDH IANTPKQLMV YEALGWEAPE FGHMTLIINS
260 270 280 290 300
ETGKKLSKRD TNTLQFIEDY RKKGYMPEAV FNFIALLGWN PGGEDEIFSR
310 320 330 340 350
QELITLFDET RLSKSPAAFD QKKMDWMSNE YIKNADFETV FNLCKPFLEE
360 370 380 390 400
AGRLTDKAEK LVELYQPQLK SADEIVTLTD LFFTDFPALT EAEKEVMAGE
410 420 430 440 450
TVPTVLEAFK AKLEAMSDDD FQPENIFPQI KAVQKDTGIK GKNLFMPIRI
460 470 480
AVSGEMHGPE LPNTIYLLGK EKSIEHIENM LAKLV
Length:485
Mass (Da):55,600
Last modified:January 25, 2012 - v1
Checksum:i9C8699923E9BF9E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEUZ02000001 Genomic DNA. Translation: EHJ57329.1.
RefSeqiWP_006740043.1. NZ_AEUZ02000001.1.

Genome annotation databases

EnsemblBacteriaiEHJ57329; EHJ57329; STRUR_0183.

Similar proteinsi

Entry informationi

Entry nameiG5KH90_9STRE
AccessioniPrimary (citable) accession number: G5KH90
Entry historyiIntegrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: January 31, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported