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G5ELM3

- G5ELM3_SERMA

UniProt

G5ELM3 - G5ELM3_SERMA

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Protein
Submitted name:

Metallo-beta-lactamase

Gene
SMB-1
Organism
Serratia marcescens
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei24 – 241Sulfate 1
Binding sitei64 – 641Sulfate 1
Binding sitei74 – 741Sulfate 2
Metal bindingi88 – 881Sodium; via carbonyl oxygenImported
Metal bindingi89 – 891Sodium; via carbonyl oxygenImported
Metal bindingi90 – 901Zinc 1; via tele nitrogenImported
Metal bindingi92 – 921Zinc 1; via pros nitrogenImported
Metal bindingi94 – 941Zinc 2Imported
Metal bindingi95 – 951Zinc 2; via tele nitrogenImported
Metal bindingi113 – 1131Sodium; via amide nitrogenImported
Metal bindingi168 – 1681Zinc 1; via tele nitrogenImported
Metal bindingi171 – 1711Sodium; via carbonyl oxygenImported
Binding sitei194 – 1941Acetate 1; via amide nitrogen
Binding sitei198 – 1981Acetate 2; via amide nitrogen
Metal bindingi233 – 2331Zinc 2; via tele nitrogenImported
Binding sitei237 – 2371Acetate 3
Binding sitei242 – 2421Acetate 3
Binding sitei274 – 2741Acetate 2

GO - Molecular functioni

  1. hydrolase activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Metal-bindingImported, SodiumImported, ZincImported

Names & Taxonomyi

Protein namesi
Submitted name:
Metallo-beta-lactamaseImported
Gene namesi
Name:SMB-1Imported
OrganismiSerratia marcescensImported
Taxonomic identifieri615 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VPEX-ray1.60A19-280[»]
3VQZX-ray2.20A19-280[»]

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni80 – 812Sulfate 2 binding
Regioni207 – 2104Sulfate 3 binding

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Beta-lactamas-like.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.

Sequencei

Sequence statusi: Complete.

G5ELM3-1 [UniParc]FASTAAdd to Basket

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MKIIASLILA AFASVAQAQD RDWSSPQQPF TIYGNTHYVG TGGISAVLLS    50
SPQGHILVDG TTEKGAQVVA ANIRAMGFKL SDVKYILSTH SHEDHAGGIS 100
AMQKLTGATV LAGAANVDTL RTGVSPKSDP QFGSLSNFPG SAKVRAVADG 150
ELVKLGPLAV KAHATPGHTE GGITWTWQSC EQGKCKDVVF ADSLTAVSAD 200
SYRFSDHPEV VASLRGSFEA VEKLSCDIAI AAHPEVNDMW TRQQRAAKEG 250
NSAYVDNGAC RAIAAAGRKR LETRLASEKR 280
Length:280
Mass (Da):29,518
Last modified:January 25, 2012 - v1
Checksum:i9F3E9CE4F4EFCBBD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB636283 Genomic DNA. Translation: BAL14456.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB636283 Genomic DNA. Translation: BAL14456.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3VPE X-ray 1.60 A 19-280 [» ]
3VQZ X-ray 2.20 A 19-280 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.60.15.10. 1 hit.
InterProi IPR001279. Beta-lactamas-like.
[Graphical view ]
Pfami PF00753. Lactamase_B. 1 hit.
[Graphical view ]
SMARTi SM00849. Lactamase_B. 1 hit.
[Graphical view ]
SUPFAMi SSF56281. SSF56281. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "SMB-1, a Novel Subclass B3 Metallo-beta-Lactamase, Associated with ISCR1 and a Class 1 Integron, from a Carbapenem-Resistant Serratia marcescens Clinical Isolate."
    Wachino J., Yoshida H., Yamane K., Suzuki S., Matsui M., Yamagishi T., Tsutsui A., Konda T., Shibayama K., Arakawa Y.
    Antimicrob. Agents Chemother. 55:5143-5149(2011)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 148Imported.
  2. "Structural insights into the subclass B3 metallo-?-lactamase SMB-1 and the mode of inhibition by the common metallo-?-lactamase inhibitor mercaptoacetate."
    Wachino J., Yamaguchi Y., Mori S., Kurosaki H., Arakawa Y., Shibayama K.
    Antimicrob. Agents Chemother. 57:101-109(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 19-280 IN COMPLEX WITH SODIUM AND ZINC.

Entry informationi

Entry nameiG5ELM3_SERMA
AccessioniPrimary (citable) accession number: G5ELM3
Entry historyi
Integrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: September 3, 2014
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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