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G5ELM3

- G5ELM3_SERMA

UniProt

G5ELM3 - G5ELM3_SERMA

Protein
Submitted name:

Metallo-beta-lactamase

Gene

SMB-1

Organism
Serratia marcescens
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 11 (01 Oct 2014)
      Sequence version 1 (25 Jan 2012)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei24 – 241Sulfate 1
    Binding sitei64 – 641Sulfate 1
    Binding sitei74 – 741Sulfate 2
    Metal bindingi90 – 901Zinc 1; via tele nitrogenImported
    Metal bindingi92 – 921Zinc 1; via pros nitrogenImported
    Metal bindingi94 – 941Zinc 2Imported
    Metal bindingi95 – 951Zinc 2; via tele nitrogenImported
    Metal bindingi168 – 1681Zinc 1; via tele nitrogenImported
    Binding sitei194 – 1941Acetate 1; via amide nitrogen
    Binding sitei198 – 1981Acetate 2; via amide nitrogen
    Metal bindingi233 – 2331Zinc 2; via tele nitrogenImported
    Binding sitei237 – 2371Acetate 3
    Binding sitei242 – 2421Acetate 3
    Binding sitei274 – 2741Acetate 2

    GO - Molecular functioni

    1. hydrolase activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    Metal-bindingImported, ZincImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Metallo-beta-lactamaseImported
    Gene namesi
    Name:SMB-1Imported
    OrganismiSerratia marcescensImported
    Taxonomic identifieri615 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3VPEX-ray1.60A19-280[»]
    3VQZX-ray2.20A19-280[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni80 – 812Sulfate 2 binding
    Regioni207 – 2104Sulfate 3 binding

    Family and domain databases

    Gene3Di3.60.15.10. 1 hit.
    InterProiIPR001279. Beta-lactamas-like.
    [Graphical view]
    PfamiPF00753. Lactamase_B. 1 hit.
    [Graphical view]
    SMARTiSM00849. Lactamase_B. 1 hit.
    [Graphical view]
    SUPFAMiSSF56281. SSF56281. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    G5ELM3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIIASLILA AFASVAQAQD RDWSSPQQPF TIYGNTHYVG TGGISAVLLS    50
    SPQGHILVDG TTEKGAQVVA ANIRAMGFKL SDVKYILSTH SHEDHAGGIS 100
    AMQKLTGATV LAGAANVDTL RTGVSPKSDP QFGSLSNFPG SAKVRAVADG 150
    ELVKLGPLAV KAHATPGHTE GGITWTWQSC EQGKCKDVVF ADSLTAVSAD 200
    SYRFSDHPEV VASLRGSFEA VEKLSCDIAI AAHPEVNDMW TRQQRAAKEG 250
    NSAYVDNGAC RAIAAAGRKR LETRLASEKR 280
    Length:280
    Mass (Da):29,518
    Last modified:January 25, 2012 - v1
    Checksum:i9F3E9CE4F4EFCBBD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB636283 Genomic DNA. Translation: BAL14456.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB636283 Genomic DNA. Translation: BAL14456.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3VPE X-ray 1.60 A 19-280 [» ]
    3VQZ X-ray 2.20 A 19-280 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.60.15.10. 1 hit.
    InterProi IPR001279. Beta-lactamas-like.
    [Graphical view ]
    Pfami PF00753. Lactamase_B. 1 hit.
    [Graphical view ]
    SMARTi SM00849. Lactamase_B. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56281. SSF56281. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "SMB-1, a Novel Subclass B3 Metallo-beta-Lactamase, Associated with ISCR1 and a Class 1 Integron, from a Carbapenem-Resistant Serratia marcescens Clinical Isolate."
      Wachino J., Yoshida H., Yamane K., Suzuki S., Matsui M., Yamagishi T., Tsutsui A., Konda T., Shibayama K., Arakawa Y.
      Antimicrob. Agents Chemother. 55:5143-5149(2011)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 148Imported.
    2. "Structural insights into the subclass B3 metallo-?-lactamase SMB-1 and the mode of inhibition by the common metallo-?-lactamase inhibitor mercaptoacetate."
      Wachino J., Yamaguchi Y., Mori S., Kurosaki H., Arakawa Y., Shibayama K.
      Antimicrob. Agents Chemother. 57:101-109(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 19-280 IN COMPLEX WITH ZINC.

    Entry informationi

    Entry nameiG5ELM3_SERMA
    AccessioniPrimary (citable) accession number: G5ELM3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 25, 2012
    Last sequence update: January 25, 2012
    Last modified: October 1, 2014
    This is version 11 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3