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Protein
Submitted name:

UNC-45

Gene

unc-45

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • ubiquitin protein ligase binding Source: WormBase

GO - Biological processi

  • embryo development ending in birth or egg hatching Source: WormBase
  • locomotion Source: WormBase
  • oviposition Source: WormBase
  • sarcomere organization Source: WormBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
UNC-45Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:unc-45Imported
ORF Names:CELE_F30H5.1Imported, F30H5.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF30H5.1; CE01925; WBGene00006781; unc-45.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: WormBase
  • cleavage furrow Source: WormBase
  • plasma membrane Source: WormBase
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiWBGene00006781.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself8EBI-6675165,EBI-6675165
daf-21Q186885EBI-6675165,EBI-313329
hsp-1P094463EBI-6675165,EBI-322448
unc-54P025663EBI-6675165,EBI-329238

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • ubiquitin protein ligase binding Source: WormBase

Protein-protein interaction databases

STRINGi6239.F30H5.1.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I2WX-ray3.60A1-961[»]
4I2ZX-ray2.90A1-961[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 114TPR_REGIONInterPro annotationAdd BLAST107

Phylogenomic databases

eggNOGiENOG411001W. LUCA.
GeneTreeiENSGT00860000133805.
OMAiCLYGVVT.
OrthoDBiEOG091G02FM.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
1.25.40.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR024660. UCS_central_dom.
[Graphical view]
PfamiPF11701. UNC45-central. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF48452. SSF48452. 1 hit.
PROSITEiPS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G5EG62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVARVQTAEE IRDEGNAAVK DQDYIKADEL YTEALQLTTD EDKALRPVLY
60 70 80 90 100
RNRAMARLKR DDFEGAQSDC TKALEFDGAD VKALFRRSLA REQLGNVGPA
110 120 130 140 150
FQDAKEALRL SPNDKGIVEV LQRLVKANND KIKQTTSLAN KVTDMEKLAF
160 170 180 190 200
RGEAKDTEQK MTALNNLLVL CRESESGATG VWNQGALVPF VLNLINDASE
210 220 230 240 250
NEEVTVTAIR ILDETIKNSV RCMKFLAMHD PDGPKSVRFV CRLMCKKSTK
260 270 280 290 300
DFVDATGILV QRVFNAMAKM DRQKEMKPDP EVAEANKIWI IRVLLELQEM
310 320 330 340 350
LQDPKVGAVQ RETCIDLFLK NLMHMDGGIP RGWSWKFVEE RGLLALLDVA
360 370 380 390 400
SQIPELCEYP VSAETRQHVA ICLQRLEEDM VFDTKRTIFK EKVDMFFNAL
410 420 430 440 450
ISRCTNDDEG HKYRIKLSCF LITMLQGPVD IGINLITNDQ LTPIMLEMAA
460 470 480 490 500
SQDHLMQGIA AELIVATVSK HERAINMLKV GIPVLRALYD SEDPTVKVRA
510 520 530 540 550
LVGLCKIGAA GGDDISKATM KEEAVISLAK TCKKFLLETE KYSVDIRRYA
560 570 580 590 600
CEGLSYLSLD ADVKEWIVDD SLLLKALVLL AKKAGALCVY TLATIYANLS
610 620 630 640 650
NAFEKPKVDE EMVKLAQFAK HHVPETHPKD TEEYVEKRVR ALVEEGAVPA
660 670 680 690 700
CVAVSKTESK NALELIARSL LAFAEYEDLR GRIIAEGGTV LCLRLTKEAS
710 720 730 740 750
GEGKIKAGHA IAKLGAKADP MISFPGQRAY EVVKPLCDLL HPDVEGKANY
760 770 780 790 800
DSLLTLTNLA SVSDSIRGRI LKEKAIPKIE EFWFMTDHEH LRAAAAELLL
810 820 830 840 850
NLLFFEKFYE ETVAPGTDRL KLWVLYSAEV EEERLSRASA AGFAILTEDE
860 870 880 890 900
NACARIMDEI KSWPEVFKDI AMHEDAETQR RGLMGIANIM HSSNKLCSEI
910 920 930 940 950
VSSEVFRVLV AVTKLGTINQ ERAGSTEQAK RGLEAAEKFG LIKATDREIY
960
ERENQMSTIQ E
Length:961
Mass (Da):107,424
Last modified:December 14, 2011 - v1
Checksum:iDE9B7B8CC21B29E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034085 Genomic DNA. Translation: AAD01976.1.
BX284603 Genomic DNA. Translation: CCD69153.1.
PIRiT32493.
RefSeqiNP_497205.1. NM_064804.5.
UniGeneiCel.19943.

Genome annotation databases

EnsemblMetazoaiF30H5.1; F30H5.1; WBGene00006781.
GeneIDi175206.
KEGGicel:CELE_F30H5.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034085 Genomic DNA. Translation: AAD01976.1.
BX284603 Genomic DNA. Translation: CCD69153.1.
PIRiT32493.
RefSeqiNP_497205.1. NM_064804.5.
UniGeneiCel.19943.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I2WX-ray3.60A1-961[»]
4I2ZX-ray2.90A1-961[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F30H5.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF30H5.1; F30H5.1; WBGene00006781.
GeneIDi175206.
KEGGicel:CELE_F30H5.1.

Organism-specific databases

CTDi44910.
WormBaseiF30H5.1; CE01925; WBGene00006781; unc-45.

Phylogenomic databases

eggNOGiENOG411001W. LUCA.
GeneTreeiENSGT00860000133805.
OMAiCLYGVVT.
OrthoDBiEOG091G02FM.

Gene expression databases

BgeeiWBGene00006781.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
1.25.40.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR024660. UCS_central_dom.
[Graphical view]
PfamiPF11701. UNC45-central. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF48452. SSF48452. 1 hit.
PROSITEiPS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG5EG62_CAEEL
AccessioniPrimary (citable) accession number: G5EG62
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: November 30, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.