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Protein

Cactin

Gene

cacn-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role during early embryonic development. Required for the distal tip cell migration at the end of larval development and for gonad morphogenesis.1 Publication

GO - Molecular functioni

  • RNA binding Source: WormBase

GO - Biological processi

  • gonad development Source: UniProtKB
  • positive regulation of cell migration Source: UniProtKB
  • regulation of cell migration Source: WormBase
  • regulation of gene expression Source: UniProtKB
  • regulation of Wnt signaling pathway Source: WormBase

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Cactin
Gene namesi
Name:cacn-1
ORF Names:W03H9.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiW03H9.4a; CE46363; WBGene00012230; cacn-1.
W03H9.4b; CE46257; WBGene00012230; cacn-1.
W03H9.4c; CE45519; WBGene00012230; cacn-1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004192671 – 657CactinAdd BLAST657

Proteomic databases

EPDiG5EG14.
PaxDbiG5EG14.
PeptideAtlasiG5EG14.
PRIDEiG5EG14.

Expressioni

Tissue specificityi

Expressed in pharynx, intestine, vulva and spermatheca (at protein level).1 Publication

Developmental stagei

Expressed in migrating distal tip cells throughout larval development (at protein level).1 Publication

Gene expression databases

BgeeiWBGene00012230.

Interactioni

Protein-protein interaction databases

BioGridi40348. 1 interactor.
STRINGi6239.W03H9.4a.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili23 – 77Sequence analysisAdd BLAST55
Coiled coili352 – 403Sequence analysisAdd BLAST52

Sequence similaritiesi

Belongs to the CACTIN family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2370. Eukaryota.
ENOG410XPKF. LUCA.
GeneTreeiENSGT00390000000097.
InParanoidiG5EG14.
OMAiNQTHYDT.
OrthoDBiEOG091G08BK.

Family and domain databases

InterProiView protein in InterPro
IPR019134. Cactin_C.
IPR018816. Cactin_central.
PfamiView protein in Pfam
PF10312. Cactin_mid. 1 hit.
PF09732. CactinC_cactus. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: G5EG14-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKDSKKHKK ERRRERSPST SDSDEERLQK RLAEQRSLKK DEKRRQKEEM
60 70 80 90 100
KKNESAEEKR ARRMEKKMRK DAKRKDADAE DTLIPPELNY TNLNNPFNDT
110 120 130 140 150
KLTQTFVWGK KLEREGKSGL TQDEITKQTS QRIRKNLHEA AEFKRIRDSR
160 170 180 190 200
AAAKEDMEMM KRDADLRAGQ ISDTKEREFQ MDQIKERTRI RIDQGRAKAI
210 220 230 240 250
DLLSRYARFA DENPHTAKIP DFELENPMEY LKASCKSVDD YEDLIEDIKT
260 270 280 290 300
YREVDGWAKN ETWWMDVTRI AEDEIQKKAA QNRGDVHASV QTEVQNMFKN
310 320 330 340 350
KSIDELLKLE DQMDAKIRGN SGNKGYWQDL DDQLKVFIAR KRLREHHGRV
360 370 380 390 400
LRLQLAIIKE EQKKEIQQQE SEELLPVAEV PPQVKIQKEE EEEEEEDEDD
410 420 430 440 450
EKISKKVRRK IDVQTLDDPE LDEPERERKW RALTGDQLDD VTRELYRIGC
460 470 480 490 500
YSPTYISADD TMPGIEILDE QADVDNLTER RNRNRGTLPS SSAASSGAPQ
510 520 530 540 550
GASSKMMAIA REGMEADESI FGAEEQLAAQ RHLWSDKYRP RKPTYLNRVQ
560 570 580 590 600
TGFDWNKYNQ THYDQDNPPP KIVQGYKFNI FYPDLLDMTV APRFGLTSCE
610 620 630 640 650
DPDFAIIRFK AGPPYEDIAF KVVNREWETL HKNGYKCQFQ NGVFQLWFMF

KKYRYRR
Length:657
Mass (Da):77,418
Last modified:December 14, 2011 - v1
Checksum:iD86210EC02C767E2
GO
Isoform b (identifier: G5EG14-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-312: Missing.

Note: No experimental confirmation available.
Show »
Length:345
Mass (Da):40,449
Checksum:i1845FA431495EC9A
GO
Isoform c (identifier: G5EG14-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-461: Missing.

Note: No experimental confirmation available.
Show »
Length:196
Mass (Da):22,807
Checksum:i7526F77A5EC98D2E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0441431 – 461Missing in isoform c. CuratedAdd BLAST461
Alternative sequenceiVSP_0441441 – 312Missing in isoform b. CuratedAdd BLAST312

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z82067, Z83234 Genomic DNA. Translation: CAB76738.2.
Z83234 Genomic DNA. Translation: CBY25190.2.
Z83234 Genomic DNA. Translation: CBY25191.1.
RefSeqiNP_001254420.1. NM_001267491.1. [G5EG14-2]
NP_001254421.1. NM_001267492.1. [G5EG14-3]
NP_001254422.1. NM_001267493.1. [G5EG14-1]
UniGeneiCel.7464.

Genome annotation databases

EnsemblMetazoaiW03H9.4a; W03H9.4a; WBGene00012230. [G5EG14-1]
GeneIDi175066.
KEGGicel:CELE_W03H9.4.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCATIN_CAEEL
AccessioniPrimary (citable) accession number: G5EG14
Secondary accession number(s): E5QCI6, E5QCI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: December 14, 2011
Last modified: June 7, 2017
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families