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Protein
Submitted name:

SeRPin

Gene

srp-6

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, ProteaseImported

Enzyme and pathway databases

ReactomeiR-CEL-114608. Platelet degranulation.
R-CEL-140837. Intrinsic Pathway of Fibrin Clot Formation.
R-CEL-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-CEL-5694530. Cargo concentration in the ER.
R-CEL-75205. Dissolution of Fibrin Clot.

Protein family/group databases

MEROPSiI04.081.

Names & Taxonomyi

Protein namesi
Submitted name:
SeRPinImported
Submitted name:
Serine or cysteine protease inhibitorImported
Gene namesi
Name:srp-6Imported
ORF Names:C03G6.19Imported, CELE_C03G6.19Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC03G6.19; CE27579; WBGene00005647; srp-6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi6239.C03G6.19.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 372351SERPINInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the serpin family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00840000129734.
OrthoDBiEOG7327PB.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G5EFH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSSSDEKM GLLLHSETDF GLSLLRQQNL TESFVFSPLS IALALSLVHV
60 70 80 90 100
AAKGETRDEI RKALLNGATD EELEQHFSNI SAGLLVAEKG TEVNVANHIF
110 120 130 140 150
SRKTFTIKKL YLNDVKKLYN AGASQLNFED QEASAEAINN FVSENTKGHI
160 170 180 190 200
KKIINPDSIS EELVAVLTNA FYFKANWQTK FKKESTYKRE FFSSENSKRE
210 220 230 240 250
TEFLHSRNSN RKYSENGQFQ VLSLPYKDTS FALSIFLPKT RFGLSEALQN
260 270 280 290 300
LDSVTIQQLM SNTSNTLVNI AMPKWKIETA LGLNRALMAV GIEKAFTDSA
310 320 330 340 350
DLSNFADGIY ISQAAHKALI EVDEDGTVAA AATTISFSLT SVFIPAEEPI
360 370
EFTADHPFLF ILSKDNHPLF IGIHN
Length:375
Mass (Da):41,696
Last modified:December 14, 2011 - v1
Checksum:iBEFE7D31BEF0275E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY525082 mRNA. Translation: AAS13530.1.
BX284605 Genomic DNA. Translation: CCD62703.1.
PIRiT25504.
RefSeqiNP_504890.1. NM_072489.5.
UniGeneiCel.23464.

Genome annotation databases

EnsemblMetazoaiC03G6.19; C03G6.19; WBGene00005647.
GeneIDi179125.
KEGGicel:CELE_C03G6.19.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY525082 mRNA. Translation: AAS13530.1.
BX284605 Genomic DNA. Translation: CCD62703.1.
PIRiT25504.
RefSeqiNP_504890.1. NM_072489.5.
UniGeneiCel.23464.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C03G6.19.

Protein family/group databases

MEROPSiI04.081.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC03G6.19; C03G6.19; WBGene00005647.
GeneIDi179125.
KEGGicel:CELE_C03G6.19.

Organism-specific databases

CTDi179125.
WormBaseiC03G6.19; CE27579; WBGene00005647; srp-6.

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00840000129734.
OrthoDBiEOG7327PB.

Enzyme and pathway databases

ReactomeiR-CEL-114608. Platelet degranulation.
R-CEL-140837. Intrinsic Pathway of Fibrin Clot Formation.
R-CEL-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-CEL-5694530. Cargo concentration in the ER.
R-CEL-75205. Dissolution of Fibrin Clot.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.
  2. Alber B.E., Fuchs G.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.
  3. "SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins."
    Pak S.C., Kumar V., Tsu C., Luke C.J., Askew Y.S., Askew D.J., Mills D.R., Bromme D., Silverman G.A.
    J. Biol. Chem. 279:15448-15459(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. WormBase Consortium
    WormBase
    Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiG5EFH4_CAEEL
AccessioniPrimary (citable) accession number: G5EFH4
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: July 6, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.