G5EFA4 (G5EFA4_CAEEL) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
KIN-4 protein EMBL CAJ31105.1
EC=2.7.1.37 EMBL CAJ31105.1

Submitted name:
Protein KIN-4, isoform a EMBL CAB05684.2

Gene names

Name:	kin-4 WormBase WBGene00002192 WormBase C10C6.1a EMBL CAB05684.2
ORF Names:	C10C6.1 EMBL CAJ31105.1, CELE_C10C6.1 EMBL CAB05684.2

Organism

Caenorhabditis elegans [Reference proteome] EMBL CAB05684.2

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	1565 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 PDZ (DHR) domain. RuleBase RU003354

Ontologies

Keywords
Molecular function	Transferase EMBL CAJ31105.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	G5EFA4 [UniParc]. Last modified December 14, 2011. Version 1. Checksum: B47054B5917B0176	FASTA	1,565	169,787
	10 20 30 40 50 60 MIPPRRSFHR PQGGGGNDSS DSNSNVERLL KRNRRRTMAI HGVETEPGQT AASTGWTSAS 70 80 90 100 110 120 MTNLCRVRSS LGHSDPQLSS SSTNSFNTST SSLHPATKSS TTALSSFSTS SANRSPANRP 130 140 150 160 170 180 SLHSSTSPVT LQRCRSPMRV PQRSTSSSHN FGAAGAGPSS SGSSVHSGTI TLRTYSARNG 190 200 210 220 230 240 SSLMAPVQDT RRWSLASLPS TSGYGTPGTG SNSGVSSQYS SSEQIGEMLD QTRISGPVRQ 250 260 270 280 290 300 NSSRFDSNDS YDDMASHQQA AAQNAFLNRP RSRSLTSPMK FLNEYNIEMV NRTSVYKERF 310 320 330 340 350 360 PRAKLQMEER LNAFVAENGP LSGGISQQSA RDDTDRVDDL SARQSGSSSG LKAKDSVEEA 370 380 390 400 410 420 VMRSRRSTVL EAESYADRSL LRLIGDGATR FLHHQIVEIA LDCLGKSKDD LITCSYFCEM 430 440 450 460 470 480 SQRLEETLNE AQMKTSPESL EYLSKLVKKL LMIVSRPARL LECLEFDPDE FYHLLEEAEG 490 500 510 520 530 540 VVREQLGSGT ARVPDLPQYI IGKLGLDRDP LIDSTEHVDS SENTHATTSG TTSAKGAGSA 550 560 570 580 590 600 WQETNRAPCE DDFDTIRLVS NGAYGAVYLV RHRETRQRFA LKKMNKQTLM LRNQVDQVFA 610 620 630 640 650 660 ERDILTMADN PFVVSFYGSF ETRQYLCMLM EYVEGGDCAA LLKSAGTLPV ELVRLYVAET 670 680 690 700 710 720 ILAIEYLHSY GIVHRDLKPD NLLITAMGHI KLTDFGLSKI GLMNRTTLVA EGYDAVVETQ 730 740 750 760 770 780 QFQDKQLCGT PEYIAPEVIL RRGYGKPVDW WALGIILYEF LVGIVPFFGE TPEALFSKVI 790 800 810 820 830 840 SEDVEYPEED EALPPEAADL CRRLLEKNPA ERLGTLNGAA QLMAHEFFIL LDFTSLLRQK 850 860 870 880 890 900 AEFVPQLDNE EDTSYFDTRT DRYNHEAESC GEEEIVGSSA ASSMMFHSFS TASPRHSIVS 910 920 930 940 950 960 IDPAHLPHLL STANAAAKEI ERSHSVSMSS RPETRPERSY STGQAPPELF KVGDDNTSTA 970 980 990 1000 1010 1020 VNLRRRFSAQ RHNVSTTSSS GTGSGTCFAT AASSTDSSID ASSLPLFQPP SRSSIAERGS 1030 1040 1050 1060 1070 1080 RSPLPKFSIS CEGEAGVSRS GDDHDDLDDS RNSTIVSTAS SGGADETVRF RRQSSGRTPA 1090 1100 1110 1120 1130 1140 SQLQLVIPSI SSSQSSQSAE PARETCYVMY PSGPSTSVGS QLSPGGASVS SASSSNDVGS 1150 1160 1170 1180 1190 1200 PHPLPLHHEH PLTSHDSSAA SSSTAPSKTI TIRKGPFGFG FTLKSVRVYL GEHSEYYTIE 1210 1220 1230 1240 1250 1260 HIVTAVVEGS PAFHANLQAE DMITHVNGHP VHNLTHPQLM HRLLANGNEL ILRLVPLANT 1270 1280 1290 1300 1310 1320 SIREGAARRT VGKMARKKPK RPQRRVVPLE KKTRKPSALL RRLSGKRATN DIVPGSSSQK 1330 1340 1350 1360 1370 1380 QAFMPRSASS QDGCILTHLP GTSKISQQEA SQEPSTSSQG MVRRSVNEIE TNRPSSLRST 1390 1400 1410 1420 1430 1440 SNSHHHHHHP ASTSSVASAP ATLPSTTPSN LSRMASSSPS SSASNSGTSS PAATSSGISI 1450 1460 1470 1480 1490 1500 VKQKSQSIAV SPLARDTRMR SPSPSHLHHR PASSSYTTRP DGVVTPATSS SPNNSGFVQD 1510 1520 1530 1540 1550 1560 LISSRQSPNL SARRRSYQPT TTTSMIVPPT THHLRGFSAA AQSAQDLLNR LLPKQDNNSD SGSKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	WormBase Consortium White S. Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Bristol N2 EMBL CAB05684.2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." Caenorhabditis elegans Sequencing Consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2 EMBL CAB05684.2.
[3]	"KIN-4 is a novel Diacylglycerol Kinase 1 (DGK-1) binding protein required for efficient dopamine and serotonin signaling in Caenorhabditis elegans." Morrison P.R., McMullan R., Pitcher J., Nurrish S.J. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: N2 EMBL CAJ31105.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z83217 Genomic DNA. Translation: CAB05684.2. AM086627 mRNA. Translation: CAJ31105.1.
PIR	T19188.
RefSeq	NP_001255557.1. NM_001268628.1.
UniGene	Cel.22672.
3D structure databases
SMR	G5EFA4. Positions 345-459, 477-895, 1179-1260.
ModBase	Search...
Protein-protein interaction databases
IntAct	G5EFA4. 13 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	C10C6.1a; C10C6.1a; C10C6.1.
GeneID	178068.
KEGG	cel:CELE_C10C6.1.
Organism-specific databases
CTD	178068.
WormBase	C10C6.1a; CE39132; WBGene00002192; kin-4.
Phylogenomic databases
GeneTree	ENSGT00530000063286.
Family and domain databases
Gene3D	1.20.1480.20. 2 hits.
InterPro	IPR011009. Kinase-like_dom. IPR015022. MA_Ser/Thr_Kinase_dom. IPR023142. MAST_pre-PK_dom. IPR001478. PDZ. IPR000719. Prot_kinase_cat_dom. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF08926. DUF1908. 2 hits. PF00595. PDZ. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00228. PDZ. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit. SSF50156. PDZ. 1 hit. SSF140482. SSF140482. 1 hit.
PROSITE	PS50106. PDZ. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	899580.

Entry information

Entry name

G5EFA4_CAEEL

Accession

Primary (citable) accession number: G5EFA4

Entry history

Integrated into UniProtKB/TrEMBL:	December 14, 2011
Last sequence update:	December 14, 2011
Last modified:	May 1, 2013
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)