Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

G5EF47

- G5EF47_CAEEL

UniProt

G5EF47 - G5EF47_CAEEL

Protein
Submitted name:

Protein SMG-7

Gene

smg-7

Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (14 Dec 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. protein binding Source: WormBase

    GO - Biological processi

    1. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: WormBase

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein SMG-7Imported
    Submitted name:
    SMG-7Imported
    Gene namesi
    Name:smg-7Imported
    ORF Names:CELE_Y73B6A.4Imported, Y73B6A.4Imported
    OrganismiCaenorhabditis elegansImported
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome IV

    Organism-specific databases

    WormBaseiY73B6A.4; CE25584; WBGene00004885; smg-7.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: WormBase
    2. nucleus Source: WormBase

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3ZHEX-ray3.00B/D1-395[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    KOiK14409.
    OMAiDESVETD.
    OrthoDBiEOG708VZ1.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR018834. DNA/RNA-bd_Est1-type.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR019734. TPR_repeat.
    [Graphical view]
    PfamiPF10373. EST1_DNA_bind. 1 hit.
    [Graphical view]
    PROSITEiPS50005. TPR. 1 hit.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G5EF47-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDEWEQLTV ELRKIPRGTE AAPQYLRHLM KMFVADFETA VSKRFDVKFW    50
    NKLKSMMDEI TKAMENDRLV NHNVQNLAIG FLTDLSLLVH YHYEIPNYGN 100
    DISKQLTWTP DVFLNRKPIK SKKNSRVFMA YVLLRMGDLM RYKENYPKAQ 150
    EYYEQSCRIN PADGAVWNQL GLISSLGAKN LESVYFHTRA LHATMEFPTA 200
    SGGLTNIFKN FANRDISRPM PIKDLYLSCL GRIHFLLEIE DSSVHLQKIG 250
    EEAATSKEMI VPLMSVYKHL EDGTELEQRA VEYVKTIWCT AYRSLLKTLD 300
    DYKEESKKLA DVPHLLHILA LLLCAPKLLR GIEDQTEDEV TSICEWLLCA 350
    NCDEKIKDSD AFGYFHCLQR IQYPLTRTQL AQKLVEIEDE DESKDSDQST 400
    IPEEDQKSLS TDTSRIQNED SEPESESESS DEEVLQRGRR RGRNPNLDES 450
    VETDEDEF 458
    Length:458
    Mass (Da):53,006
    Last modified:December 14, 2011 - v1
    Checksum:iAD7B83B041B80E47
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF089729 mRNA. Translation: AAD04156.1.
    FO080249 Genomic DNA. Translation: CCD62342.1.
    PIRiT43643.
    RefSeqiNP_501033.1. NM_068632.4.
    UniGeneiCel.19545.

    Genome annotation databases

    EnsemblMetazoaiY73B6A.4; Y73B6A.4; WBGene00004885.
    GeneIDi177435.
    KEGGicel:CELE_Y73B6A.4.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF089729 mRNA. Translation: AAD04156.1 .
    FO080249 Genomic DNA. Translation: CCD62342.1 .
    PIRi T43643.
    RefSeqi NP_501033.1. NM_068632.4.
    UniGenei Cel.19545.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3ZHE X-ray 3.00 B/D 1-395 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai Y73B6A.4 ; Y73B6A.4 ; WBGene00004885 .
    GeneIDi 177435.
    KEGGi cel:CELE_Y73B6A.4.

    Organism-specific databases

    CTDi 177435.
    WormBasei Y73B6A.4 ; CE25584 ; WBGene00004885 ; smg-7.

    Phylogenomic databases

    KOi K14409.
    OMAi DESVETD.
    OrthoDBi EOG708VZ1.

    Miscellaneous databases

    NextBioi 896806.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR018834. DNA/RNA-bd_Est1-type.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR019734. TPR_repeat.
    [Graphical view ]
    Pfami PF10373. EST1_DNA_bind. 1 hit.
    [Graphical view ]
    PROSITEi PS50005. TPR. 1 hit.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2Imported.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      Caenorhabditis elegans Sequencing Consortium
      Science 282:2012-2018(1998)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Bristol N2Imported.
    3. Cali B.C., Latham J.R., Kuchma S., Anderson R.P.
      Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: N2Imported.
    4. "smg-7 is required for mRNA surveillance in Caenorhabditis elegans."
      Cali B.M., Kuchma S.L., Latham J., Anderson P.
      Genetics 151:605-616(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: N2Imported.
    5. WormBase Consortium
      Becker M., Graves T., Shafer S.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Bristol N2Imported.
    6. "An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay."
      Jonas S., Weichenrieder O., Izaurralde E.
      Genes Dev. 27:211-225(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 1-395.

    Entry informationi

    Entry nameiG5EF47_CAEEL
    AccessioniPrimary (citable) accession number: G5EF47
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 14, 2011
    Last sequence update: December 14, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3