G5EF47 (G5EF47_CAEEL) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Protein SMG-7 EMBL CCD62342.1

Submitted name:
SMG-7 EMBL AAD04156.1

Gene names

Name:	smg-7 WormBase WBGene00004885 WormBase Y73B6A.4 EMBL CCD62342.1
ORF Names:	CELE_Y73B6A.4 EMBL CCD62342.1

Organism

Caenorhabditis elegans [Reference proteome] EMBL AAD04156.1

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	458 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Technical term	3D-structure PDB 3ZHE Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Inferred from genetic interaction Ref.3. Source: WormBase
Cellular_component	cytoplasm Inferred from direct assay PubMed 16914455. Source: WormBase nucleus Inferred from direct assay PubMed 16914455. Source: WormBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	G5EF47 [UniParc]. Last modified December 14, 2011. Version 1. Checksum: AD7B83B041B80E47	FASTA	458	53,006
	10 20 30 40 50 60 MSDEWEQLTV ELRKIPRGTE AAPQYLRHLM KMFVADFETA VSKRFDVKFW NKLKSMMDEI 70 80 90 100 110 120 TKAMENDRLV NHNVQNLAIG FLTDLSLLVH YHYEIPNYGN DISKQLTWTP DVFLNRKPIK 130 140 150 160 170 180 SKKNSRVFMA YVLLRMGDLM RYKENYPKAQ EYYEQSCRIN PADGAVWNQL GLISSLGAKN 190 200 210 220 230 240 LESVYFHTRA LHATMEFPTA SGGLTNIFKN FANRDISRPM PIKDLYLSCL GRIHFLLEIE 250 260 270 280 290 300 DSSVHLQKIG EEAATSKEMI VPLMSVYKHL EDGTELEQRA VEYVKTIWCT AYRSLLKTLD 310 320 330 340 350 360 DYKEESKKLA DVPHLLHILA LLLCAPKLLR GIEDQTEDEV TSICEWLLCA NCDEKIKDSD 370 380 390 400 410 420 AFGYFHCLQR IQYPLTRTQL AQKLVEIEDE DESKDSDQST IPEEDQKSLS TDTSRIQNED 430 440 450 SEPESESESS DEEVLQRGRR RGRNPNLDES VETDEDEF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." Caenorhabditis elegans Sequencing Consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2 EMBL CCD62342.1.
[2]	Cali B.C., Latham J.R., Kuchma S., Anderson R.P. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: N2 EMBL AAD04156.1.
[3]	"smg-7 is required for mRNA surveillance in Caenorhabditis elegans." Cali B.M., Kuchma S.L., Latham J., Anderson P. Genetics 151:605-616(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: N2 EMBL AAD04156.1.
[4]	WormBase Consortium Becker M., Graves T., Shafer S. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Bristol N2 EMBL CCD62342.1.
[5]	"An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay." Jonas S., Weichenrieder O., Izaurralde E. Genes Dev. 27:211-225(2013) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 1-395.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF089729 mRNA. Translation: AAD04156.1.
FO080249 Genomic DNA. Translation: CCD62342.1.

PIR

T43643.

RefSeq

NP_501033.1. NM_068632.4.

UniGene

Cel.19545.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3ZHE	X-ray	3.00	B/D	1-395	[»]

SMR

G5EF47. Positions 31-348.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblMetazoa

Y73B6A.4; Y73B6A.4; Y73B6A.4.

GeneID

177435.

KEGG

cel:CELE_Y73B6A.4.

Organism-specific databases

CTD

177435.

WormBase

Y73B6A.4; CE25584; WBGene00004885; smg-7.

Phylogenomic databases

KO

K14409.

OMA

SRVFMAY.

Family and domain databases

Gene3D

1.25.40.10. 1 hit.

InterPro

IPR018834. DNA/RNA-bd_Est1-type.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR019734. TPR_repeat.
[Graphical view]

Pfam

PF10373. EST1_DNA_bind. 1 hit.
[Graphical view]

PROSITE

PS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

896806.

Entry information

Entry name

G5EF47_CAEEL

Accession

Primary (citable) accession number: G5EF47

Entry history

Integrated into UniProtKB/TrEMBL:	December 14, 2011
Last sequence update:	December 14, 2011
Last modified:	May 1, 2013
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)