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Protein
Submitted name:

SMG-7

Gene

smg-7

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: WormBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
SMG-7Imported
Submitted name:
Y73B6A.4Imported
Gene namesi
Name:smg-7Imported
ORF Names:CELE_Y73B6A.4Imported, Y73B6A.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiY73B6A.4; CE25584; WBGene00004885; smg-7.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: WormBase
  • nucleus Source: WormBase
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi6239.Y73B6A.4.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZHEX-ray3.00B/D1-395[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK14409.
OMAiNELYLAC.
OrthoDBiEOG708VZ1.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR018834. DNA/RNA-bd_Est1-type.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF10373. EST1_DNA_bind. 1 hit.
[Graphical view]
PROSITEiPS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G5EF47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDEWEQLTV ELRKIPRGTE AAPQYLRHLM KMFVADFETA VSKRFDVKFW
60 70 80 90 100
NKLKSMMDEI TKAMENDRLV NHNVQNLAIG FLTDLSLLVH YHYEIPNYGN
110 120 130 140 150
DISKQLTWTP DVFLNRKPIK SKKNSRVFMA YVLLRMGDLM RYKENYPKAQ
160 170 180 190 200
EYYEQSCRIN PADGAVWNQL GLISSLGAKN LESVYFHTRA LHATMEFPTA
210 220 230 240 250
SGGLTNIFKN FANRDISRPM PIKDLYLSCL GRIHFLLEIE DSSVHLQKIG
260 270 280 290 300
EEAATSKEMI VPLMSVYKHL EDGTELEQRA VEYVKTIWCT AYRSLLKTLD
310 320 330 340 350
DYKEESKKLA DVPHLLHILA LLLCAPKLLR GIEDQTEDEV TSICEWLLCA
360 370 380 390 400
NCDEKIKDSD AFGYFHCLQR IQYPLTRTQL AQKLVEIEDE DESKDSDQST
410 420 430 440 450
IPEEDQKSLS TDTSRIQNED SEPESESESS DEEVLQRGRR RGRNPNLDES

VETDEDEF
Length:458
Mass (Da):53,006
Last modified:December 14, 2011 - v1
Checksum:iAD7B83B041B80E47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089729 mRNA. Translation: AAD04156.1.
BX284604 Genomic DNA. Translation: CCD62342.1.
PIRiT43643.
RefSeqiNP_501033.1. NM_068632.4.
UniGeneiCel.19545.

Genome annotation databases

EnsemblMetazoaiY73B6A.4; Y73B6A.4; WBGene00004885.
GeneIDi177435.
KEGGicel:CELE_Y73B6A.4.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089729 mRNA. Translation: AAD04156.1.
BX284604 Genomic DNA. Translation: CCD62342.1.
PIRiT43643.
RefSeqiNP_501033.1. NM_068632.4.
UniGeneiCel.19545.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZHEX-ray3.00B/D1-395[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.Y73B6A.4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY73B6A.4; Y73B6A.4; WBGene00004885.
GeneIDi177435.
KEGGicel:CELE_Y73B6A.4.

Organism-specific databases

CTDi177435.
WormBaseiY73B6A.4; CE25584; WBGene00004885; smg-7.

Phylogenomic databases

KOiK14409.
OMAiNELYLAC.
OrthoDBiEOG708VZ1.

Miscellaneous databases

NextBioi896806.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR018834. DNA/RNA-bd_Est1-type.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF10373. EST1_DNA_bind. 1 hit.
[Graphical view]
PROSITEiPS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.
  3. Cali B.C., Latham J.R., Kuchma S., Anderson R.P.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: N2Imported.
  4. "smg-7 is required for mRNA surveillance in Caenorhabditis elegans."
    Cali B.M., Kuchma S.L., Latham J., Anderson P.
    Genetics 151:605-616(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: N2Imported.
  5. "An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay."
    Jonas S., Weichenrieder O., Izaurralde E.
    Genes Dev. 27:211-225(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 1-395.
  6. WormBase Consortium
    Barlow K.
    Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiG5EF47_CAEEL
AccessioniPrimary (citable) accession number: G5EF47
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: June 24, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.