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G5EF47

- G5EF47_CAEEL

UniProt

G5EF47 - G5EF47_CAEEL

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Protein
Submitted name:

Protein SMG-7

Gene

smg-7

Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: WormBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Protein SMG-7Imported
Submitted name:
SMG-7Imported
Gene namesi
Name:smg-7Imported
ORF Names:CELE_Y73B6A.4Imported, Y73B6A.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiY73B6A.4; CE25584; WBGene00004885; smg-7.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: WormBase
  2. nucleus Source: WormBase
Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZHEX-ray3.00B/D1-395[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK14409.
OMAiDESVETD.
OrthoDBiEOG708VZ1.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR018834. DNA/RNA-bd_Est1-type.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF10373. EST1_DNA_bind. 1 hit.
[Graphical view]
PROSITEiPS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G5EF47-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDEWEQLTV ELRKIPRGTE AAPQYLRHLM KMFVADFETA VSKRFDVKFW
60 70 80 90 100
NKLKSMMDEI TKAMENDRLV NHNVQNLAIG FLTDLSLLVH YHYEIPNYGN
110 120 130 140 150
DISKQLTWTP DVFLNRKPIK SKKNSRVFMA YVLLRMGDLM RYKENYPKAQ
160 170 180 190 200
EYYEQSCRIN PADGAVWNQL GLISSLGAKN LESVYFHTRA LHATMEFPTA
210 220 230 240 250
SGGLTNIFKN FANRDISRPM PIKDLYLSCL GRIHFLLEIE DSSVHLQKIG
260 270 280 290 300
EEAATSKEMI VPLMSVYKHL EDGTELEQRA VEYVKTIWCT AYRSLLKTLD
310 320 330 340 350
DYKEESKKLA DVPHLLHILA LLLCAPKLLR GIEDQTEDEV TSICEWLLCA
360 370 380 390 400
NCDEKIKDSD AFGYFHCLQR IQYPLTRTQL AQKLVEIEDE DESKDSDQST
410 420 430 440 450
IPEEDQKSLS TDTSRIQNED SEPESESESS DEEVLQRGRR RGRNPNLDES

VETDEDEF
Length:458
Mass (Da):53,006
Last modified:December 14, 2011 - v1
Checksum:iAD7B83B041B80E47
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF089729 mRNA. Translation: AAD04156.1.
FO080249 Genomic DNA. Translation: CCD62342.1.
PIRiT43643.
RefSeqiNP_501033.1. NM_068632.4.
UniGeneiCel.19545.

Genome annotation databases

EnsemblMetazoaiY73B6A.4; Y73B6A.4; WBGene00004885.
GeneIDi177435.
KEGGicel:CELE_Y73B6A.4.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF089729 mRNA. Translation: AAD04156.1 .
FO080249 Genomic DNA. Translation: CCD62342.1 .
PIRi T43643.
RefSeqi NP_501033.1. NM_068632.4.
UniGenei Cel.19545.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ZHE X-ray 3.00 B/D 1-395 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai Y73B6A.4 ; Y73B6A.4 ; WBGene00004885 .
GeneIDi 177435.
KEGGi cel:CELE_Y73B6A.4.

Organism-specific databases

CTDi 177435.
WormBasei Y73B6A.4 ; CE25584 ; WBGene00004885 ; smg-7.

Phylogenomic databases

KOi K14409.
OMAi DESVETD.
OrthoDBi EOG708VZ1.

Miscellaneous databases

NextBioi 896806.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
InterProi IPR018834. DNA/RNA-bd_Est1-type.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view ]
Pfami PF10373. EST1_DNA_bind. 1 hit.
[Graphical view ]
PROSITEi PS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Science 282:2012-2018(1998)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.
  3. Cali B.C., Latham J.R., Kuchma S., Anderson R.P.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: N2Imported.
  4. "smg-7 is required for mRNA surveillance in Caenorhabditis elegans."
    Cali B.M., Kuchma S.L., Latham J., Anderson P.
    Genetics 151:605-616(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: N2Imported.
  5. WormBase Consortium
    Becker M., Graves T., Shafer S.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.
  6. "An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay."
    Jonas S., Weichenrieder O., Izaurralde E.
    Genes Dev. 27:211-225(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 1-395.

Entry informationi

Entry nameiG5EF47_CAEEL
AccessioniPrimary (citable) accession number: G5EF47
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: October 29, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3