G5EDB7 (G5EDB7_CAEEL) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Glutamic acid decarboxylase EMBL AAD19958.1

Submitted name:
Protein UNC-25, isoform a EMBL CAA21537.1

Gene names

Name:	unc-25 WormBase Y37D8A.23a WormBase WBGene00006762 EMBL CAA21537.1
ORF Names:	CELE_Y37D8A.23 EMBL CAA21537.1, Y37D8A.23 WormBase WBGene00006762

Organism

Caenorhabditis elegans [Reference proteome] EMBL AAD19958.1

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	508 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Cofactor	Pyridoxal phosphate By similarity. RuleBase RU000382
Sequence similarities	Belongs to the group II decarboxylase family. RuleBase RU000382

Ontologies

Keywords
Ligand	Pyridoxal phosphate RuleBase RU000382
Molecular function	Lyase RuleBase RU000382
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	gamma-aminobutyric acid biosynthetic process Inferred from sequence or structural similarity Ref.3. Source: WormBase synaptic transmission, GABAergic Inferred from genetic interaction PubMed 16996038. Source: WormBase
Cellular_component	axon Inferred from direct assay Ref.3. Source: WormBase inhibitory synapse Inferred from direct assay Ref.3. Source: WormBase neuronal cell body Inferred from direct assay Ref.3. Source: WormBase synaptic vesicle Inferred from direct assay Ref.3. Source: WormBase
Molecular_function	glutamate decarboxylase activity Inferred from sequence or structural similarity Ref.3. Source: WormBase pyridoxal phosphate binding Inferred from sequence or structural similarity Ref.3. Source: WormBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	G5EDB7 [UniParc]. Last modified December 14, 2011. Version 1. Checksum: 592DE1381ADF02AB	FASTA	508	57,793
	10 20 30 40 50 60 MSSAAADESD AVLENLIAKE ILPQTGNWEG TEEFLNRIVQ VLLKYIKDQN DRDQKILEFH 70 80 90 100 110 120 HPDKMQMLMD LSIPEKPESL LKLVKSCEDV LRLGVRTGHP RFFNQISCGL DLVSMAGEWL 130 140 150 160 170 180 TATANTNMFT YEIAPVFILM EKSVMARMWE AVGWDPEKAD GIFAPGGAIA NLYAMNAARH 190 200 210 220 230 240 QLWPRSKHLG MKDIPTLCCF TSEDSHYSIK SASAVLGIGA DYCFNIPTDK NGKMIPEALE 250 260 270 280 290 300 AKIIECKKEG LTPFFACCTA GSTVYGAFDP LERVANICER HKLWFHVDAA WGGGMLLSPE 310 320 330 340 350 360 HRYKLAGIER ANSVTWNPHK LMGALLQCSA CLFRQDGLLF QCNQMSADYL FQQDKPYDVS 370 380 390 400 410 420 FDTGDKAIQC GRHNDVFKLW LMWKSKGMEG YRQQINKLMD LANYFTRRIK ETEGFELIIE 430 440 450 460 470 480 NPEFLNICFW YVPSKIRNLE PAEMRARLEK IAPKIKAGMM QRGTTMVGYQ PDKQRPNFFR 490 500 MIISNQAITR EDLDFLIKEI VDIGESLE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." Caenorhabditis elegans Sequencing Consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2 EMBL CAA21537.1.
[2]	WormBase Consortium Barlow K. Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Bristol N2 EMBL CAA21537.1.
[3]	"The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development." Jin Y., Jorgensen E., Hartwieg E., Horvitz H.R. J. Neurosci. 19:539-548(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Bristol EMBL AAD19958.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF109378 mRNA. Translation: AAD19958.1. AL032626 Genomic DNA. Translation: CAA21537.1.
PIR	T26636.
RefSeq	NP_499689.1. NM_067288.4.
UniGene	Cel.7826.
3D structure databases
SMR	G5EDB7. Positions 13-507.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	Y37D8A.23a; Y37D8A.23a; Y37D8A.23.
GeneID	176713.
KEGG	cel:CELE_Y37D8A.23.
Organism-specific databases
CTD	176713.
WormBase	Y37D8A.23a; CE20226; WBGene00006762; unc-25.
Phylogenomic databases
GeneTree	ENSGT00550000074275.
KO	K01580.
OMA	ISMAGEW.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 1 hit.
InterPro	IPR002129. PyrdxlP-dep_de-COase. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Pfam	PF00282. Pyridoxal_deC. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...
Other
NextBio	893696.

Entry information

Entry name

G5EDB7_CAEEL

Accession

Primary (citable) accession number: G5EDB7

Entry history

Integrated into UniProtKB/TrEMBL:	December 14, 2011
Last sequence update:	December 14, 2011
Last modified:	May 1, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)