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G5EDB7

- G5EDB7_CAEEL

UniProt

G5EDB7 - G5EDB7_CAEEL

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Protein
Submitted name:

Glutamic acid decarboxylase

Gene

unc-25

Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Cofactori

Note: Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: WormBase
  2. pyridoxal phosphate binding Source: WormBase

GO - Biological processi

  1. gamma-aminobutyric acid biosynthetic process Source: WormBase
  2. synaptic transmission, GABAergic Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_183178. GABA synthesis.

Names & Taxonomyi

Protein namesi
Submitted name:
Glutamic acid decarboxylaseImported
Submitted name:
Protein UNC-25, isoform aImported
Gene namesi
Name:unc-25Imported
ORF Names:CELE_Y37D8A.23Imported, Y37D8A.23Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiY37D8A.23a; CE20226; WBGene00006762; unc-25.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: WormBase
  2. inhibitory synapse Source: WormBase
  3. neuronal cell body Source: WormBase
  4. synaptic vesicle Source: WormBase
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119205.
KOiK01580.
OMAiEYLYTKI.
OrthoDBiEOG7H1JM3.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

G5EDB7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSAAADESD AVLENLIAKE ILPQTGNWEG TEEFLNRIVQ VLLKYIKDQN
60 70 80 90 100
DRDQKILEFH HPDKMQMLMD LSIPEKPESL LKLVKSCEDV LRLGVRTGHP
110 120 130 140 150
RFFNQISCGL DLVSMAGEWL TATANTNMFT YEIAPVFILM EKSVMARMWE
160 170 180 190 200
AVGWDPEKAD GIFAPGGAIA NLYAMNAARH QLWPRSKHLG MKDIPTLCCF
210 220 230 240 250
TSEDSHYSIK SASAVLGIGA DYCFNIPTDK NGKMIPEALE AKIIECKKEG
260 270 280 290 300
LTPFFACCTA GSTVYGAFDP LERVANICER HKLWFHVDAA WGGGMLLSPE
310 320 330 340 350
HRYKLAGIER ANSVTWNPHK LMGALLQCSA CLFRQDGLLF QCNQMSADYL
360 370 380 390 400
FQQDKPYDVS FDTGDKAIQC GRHNDVFKLW LMWKSKGMEG YRQQINKLMD
410 420 430 440 450
LANYFTRRIK ETEGFELIIE NPEFLNICFW YVPSKIRNLE PAEMRARLEK
460 470 480 490 500
IAPKIKAGMM QRGTTMVGYQ PDKQRPNFFR MIISNQAITR EDLDFLIKEI

VDIGESLE
Length:508
Mass (Da):57,793
Last modified:December 14, 2011 - v1
Checksum:i592DE1381ADF02AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109378 mRNA. Translation: AAD19958.1.
AL032626 Genomic DNA. Translation: CAA21537.1.
PIRiT26636.
RefSeqiNP_499689.1. NM_067288.4.
UniGeneiCel.7826.

Genome annotation databases

EnsemblMetazoaiY37D8A.23a; Y37D8A.23a; WBGene00006762.
GeneIDi176713.
KEGGicel:CELE_Y37D8A.23.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109378 mRNA. Translation: AAD19958.1 .
AL032626 Genomic DNA. Translation: CAA21537.1 .
PIRi T26636.
RefSeqi NP_499689.1. NM_067288.4.
UniGenei Cel.7826.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai Y37D8A.23a ; Y37D8A.23a ; WBGene00006762 .
GeneIDi 176713.
KEGGi cel:CELE_Y37D8A.23.

Organism-specific databases

CTDi 176713.
WormBasei Y37D8A.23a ; CE20226 ; WBGene00006762 ; unc-25.

Phylogenomic databases

GeneTreei ENSGT00760000119205.
KOi K01580.
OMAi EYLYTKI.
OrthoDBi EOG7H1JM3.

Enzyme and pathway databases

Reactomei REACT_183178. GABA synthesis.

Miscellaneous databases

NextBioi 893696.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00282. Pyridoxal_deC. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Science 282:2012-2018(1998)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.
  3. WormBase Consortium
    Barlow K.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.
  4. "The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development."
    Jin Y., Jorgensen E., Hartwieg E., Horvitz H.R.
    J. Neurosci. 19:539-548(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BristolImported.

Entry informationi

Entry nameiG5EDB7_CAEEL
AccessioniPrimary (citable) accession number: G5EDB7
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: November 26, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3