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Protein
Submitted name:

Glutamic acid decarboxylase

Gene

unc-25

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: WormBase
  2. pyridoxal phosphate binding Source: WormBase

GO - Biological processi

  1. gamma-aminobutyric acid biosynthetic process Source: WormBase
  2. synaptic transmission, GABAergic Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_301589. GABA synthesis.

Names & Taxonomyi

Protein namesi
Submitted name:
Glutamic acid decarboxylaseImported
Submitted name:
UNC-25, isoform aImported
Gene namesi
Name:unc-25Imported
ORF Names:CELE_Y37D8A.23Imported, Y37D8A.23Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiY37D8A.23a; CE20226; WBGene00006762; unc-25.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: WormBase
  2. inhibitory synapse Source: WormBase
  3. neuronal cell body Source: WormBase
  4. synaptic vesicle Source: WormBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiG5EDB7.

Expressioni

Gene expression databases

ExpressionAtlasiG5EDB7. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliG5EDB7.
SMRiG5EDB7. Positions 13-505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119205.
InParanoidiG5EDB7.
KOiK01580.
OMAiEYLYTKI.
OrthoDBiEOG7H1JM3.
PhylomeDBiG5EDB7.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

G5EDB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAAADESD AVLENLIAKE ILPQTGNWEG TEEFLNRIVQ VLLKYIKDQN
60 70 80 90 100
DRDQKILEFH HPDKMQMLMD LSIPEKPESL LKLVKSCEDV LRLGVRTGHP
110 120 130 140 150
RFFNQISCGL DLVSMAGEWL TATANTNMFT YEIAPVFILM EKSVMARMWE
160 170 180 190 200
AVGWDPEKAD GIFAPGGAIA NLYAMNAARH QLWPRSKHLG MKDIPTLCCF
210 220 230 240 250
TSEDSHYSIK SASAVLGIGA DYCFNIPTDK NGKMIPEALE AKIIECKKEG
260 270 280 290 300
LTPFFACCTA GSTVYGAFDP LERVANICER HKLWFHVDAA WGGGMLLSPE
310 320 330 340 350
HRYKLAGIER ANSVTWNPHK LMGALLQCSA CLFRQDGLLF QCNQMSADYL
360 370 380 390 400
FQQDKPYDVS FDTGDKAIQC GRHNDVFKLW LMWKSKGMEG YRQQINKLMD
410 420 430 440 450
LANYFTRRIK ETEGFELIIE NPEFLNICFW YVPSKIRNLE PAEMRARLEK
460 470 480 490 500
IAPKIKAGMM QRGTTMVGYQ PDKQRPNFFR MIISNQAITR EDLDFLIKEI

VDIGESLE
Length:508
Mass (Da):57,793
Last modified:December 14, 2011 - v1
Checksum:i592DE1381ADF02AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109378 mRNA. Translation: AAD19958.1.
BX284603 Genomic DNA. Translation: CAA21537.1.
PIRiT26636.
RefSeqiNP_499689.1. NM_067288.4.
UniGeneiCel.7826.

Genome annotation databases

EnsemblMetazoaiY37D8A.23a; Y37D8A.23a; WBGene00006762.
GeneIDi176713.
KEGGicel:CELE_Y37D8A.23.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109378 mRNA. Translation: AAD19958.1.
BX284603 Genomic DNA. Translation: CAA21537.1.
PIRiT26636.
RefSeqiNP_499689.1. NM_067288.4.
UniGeneiCel.7826.

3D structure databases

ProteinModelPortaliG5EDB7.
SMRiG5EDB7. Positions 13-505.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiG5EDB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY37D8A.23a; Y37D8A.23a; WBGene00006762.
GeneIDi176713.
KEGGicel:CELE_Y37D8A.23.

Organism-specific databases

CTDi176713.
WormBaseiY37D8A.23a; CE20226; WBGene00006762; unc-25.

Phylogenomic databases

GeneTreeiENSGT00760000119205.
InParanoidiG5EDB7.
KOiK01580.
OMAiEYLYTKI.
OrthoDBiEOG7H1JM3.
PhylomeDBiG5EDB7.

Enzyme and pathway databases

ReactomeiREACT_301589. GABA synthesis.

Miscellaneous databases

NextBioi893696.

Gene expression databases

ExpressionAtlasiG5EDB7. baseline and differential.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1997)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.
  3. "The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development."
    Jin Y., Jorgensen E., Hartwieg E., Horvitz H.R.
    J. Neurosci. 19:539-548(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BristolImported.
  4. WormBase Consortium
    Barlow K.
    Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiG5EDB7_CAEEL
AccessioniPrimary (citable) accession number: G5EDB7
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: April 1, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.