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G5EDB7

- G5EDB7_CAEEL

UniProt

G5EDB7 - G5EDB7_CAEEL

Protein
Submitted name:

Glutamic acid decarboxylase

Gene

unc-25

Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (14 Dec 2011)
      Previous versions | rss
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    Functioni

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glutamate decarboxylase activity Source: WormBase
    2. pyridoxal phosphate binding Source: WormBase

    GO - Biological processi

    1. gamma-aminobutyric acid biosynthetic process Source: WormBase
    2. synaptic transmission, GABAergic Source: WormBase

    Keywords - Molecular functioni

    LyaseUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    ReactomeiREACT_183019. GABA synthesis, release, reuptake and degradation.
    REACT_183178. GABA synthesis.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Glutamic acid decarboxylaseImported
    Submitted name:
    Protein UNC-25, isoform aImported
    Gene namesi
    Name:unc-25Imported
    ORF Names:CELE_Y37D8A.23Imported, Y37D8A.23Imported
    OrganismiCaenorhabditis elegansImported
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiY37D8A.23a; CE20226; WBGene00006762; unc-25.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: WormBase
    2. inhibitory synapse Source: WormBase
    3. neuronal cell body Source: WormBase
    4. synaptic vesicle Source: WormBase

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00730000110441.
    KOiK01580.
    OMAiEYLYTKI.
    OrthoDBiEOG7H1JM3.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    G5EDB7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSAAADESD AVLENLIAKE ILPQTGNWEG TEEFLNRIVQ VLLKYIKDQN    50
    DRDQKILEFH HPDKMQMLMD LSIPEKPESL LKLVKSCEDV LRLGVRTGHP 100
    RFFNQISCGL DLVSMAGEWL TATANTNMFT YEIAPVFILM EKSVMARMWE 150
    AVGWDPEKAD GIFAPGGAIA NLYAMNAARH QLWPRSKHLG MKDIPTLCCF 200
    TSEDSHYSIK SASAVLGIGA DYCFNIPTDK NGKMIPEALE AKIIECKKEG 250
    LTPFFACCTA GSTVYGAFDP LERVANICER HKLWFHVDAA WGGGMLLSPE 300
    HRYKLAGIER ANSVTWNPHK LMGALLQCSA CLFRQDGLLF QCNQMSADYL 350
    FQQDKPYDVS FDTGDKAIQC GRHNDVFKLW LMWKSKGMEG YRQQINKLMD 400
    LANYFTRRIK ETEGFELIIE NPEFLNICFW YVPSKIRNLE PAEMRARLEK 450
    IAPKIKAGMM QRGTTMVGYQ PDKQRPNFFR MIISNQAITR EDLDFLIKEI 500
    VDIGESLE 508
    Length:508
    Mass (Da):57,793
    Last modified:December 14, 2011 - v1
    Checksum:i592DE1381ADF02AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF109378 mRNA. Translation: AAD19958.1.
    AL032626 Genomic DNA. Translation: CAA21537.1.
    PIRiT26636.
    RefSeqiNP_499689.1. NM_067288.4.
    UniGeneiCel.7826.

    Genome annotation databases

    EnsemblMetazoaiY37D8A.23a; Y37D8A.23a; WBGene00006762.
    GeneIDi176713.
    KEGGicel:CELE_Y37D8A.23.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF109378 mRNA. Translation: AAD19958.1 .
    AL032626 Genomic DNA. Translation: CAA21537.1 .
    PIRi T26636.
    RefSeqi NP_499689.1. NM_067288.4.
    UniGenei Cel.7826.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai Y37D8A.23a ; Y37D8A.23a ; WBGene00006762 .
    GeneIDi 176713.
    KEGGi cel:CELE_Y37D8A.23.

    Organism-specific databases

    CTDi 176713.
    WormBasei Y37D8A.23a ; CE20226 ; WBGene00006762 ; unc-25.

    Phylogenomic databases

    GeneTreei ENSGT00730000110441.
    KOi K01580.
    OMAi EYLYTKI.
    OrthoDBi EOG7H1JM3.

    Enzyme and pathway databases

    Reactomei REACT_183019. GABA synthesis, release, reuptake and degradation.
    REACT_183178. GABA synthesis.

    Miscellaneous databases

    NextBioi 893696.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      Caenorhabditis elegans Sequencing Consortium
      Science 282:2012-2018(1998)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Bristol N2Imported.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2Imported.
    3. WormBase Consortium
      Barlow K.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Bristol N2Imported.
    4. "The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development."
      Jin Y., Jorgensen E., Hartwieg E., Horvitz H.R.
      J. Neurosci. 19:539-548(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BristolImported.

    Entry informationi

    Entry nameiG5EDB7_CAEEL
    AccessioniPrimary (citable) accession number: G5EDB7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 14, 2011
    Last sequence update: December 14, 2011
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3