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Protein
Submitted name:

Epidermal growth factor receptor pathway substrate 8 splice variant A

Gene

eps-8

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. actin filament binding Source: WormBase
  2. cytoskeletal protein binding Source: WormBase

GO - Biological processi

  1. actin filament bundle assembly Source: WormBase
  2. barbed-end actin filament capping Source: WormBase
  3. digestive tract morphogenesis Source: WormBase
  4. embryonic morphogenesis Source: WormBase
  5. epidermis morphogenesis Source: WormBase
  6. intermediate filament organization Source: WormBase
  7. maintenance of protein location Source: WormBase
  8. nematode larval development Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Epidermal growth factor receptor pathway substrate 8 splice variant AImported
Submitted name:
Protein EPS-8, isoform gImported
Gene namesi
Name:eps-8Imported
ORF Names:CELE_Y57G11C.24Imported, Y57G11C.24Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiY57G11C.24g; CE39450; WBGene00001330; eps-8.

Subcellular locationi

GO - Cellular componenti

  1. apical part of cell Source: WormBase
  2. brush border Source: WormBase
  3. extracellular matrix Source: WormBase
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliG5ED33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000003646.
KOiK17277.
OMAiMLCVNEE.

Family and domain databases

InterProiIPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR013761. SAM/pointed.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G5ED33-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRRGGSMGPP SGDPYQSRPS PGGYYYNRST PGGQPAPSPS HSQQSASSHH
60 70 80 90 100
PRGVPMSQPI ARRSDYRTGS EQMTPRSDHR GPSMGYGNGG SVDQRVDDVT
110 120 130 140 150
PSYYVEHLAT FAVGRQFGLT FPADGIRKLK QMEKNSAIWA QPLILRFRHN
160 170 180 190 200
AVTVEDDNGE LVEQFPLELI EQPTAHVSND SRETYNNVLL FVVREDRKRM
210 220 230 240 250
STPTEMHIFQ CIRVSATDVA EDLKNYVQGQ FRRVRNGRRT AAPTHLQAQQ
260 270 280 290 300
QQMPFYPPDD ASISSETSEM FERDVNTLNR CFDDIERFVA RIQSAALAQR
310 320 330 340 350
EIEQQNHRYR TANRRDKKNQ QPPDPNGILF MRAQLPLESE FVDILKKFKL
360 370 380 390 400
SFNLLAKLKN HIHEPNAPEL LHFLFTPLAV ILEACHWGLG RNVAPTVASP
410 420 430 440 450
LLSLEARELM QNCLTSHESD IWMSLGEAWR TPPEDWTKPL PPPYRPIFND
460 470 480 490 500
GFAPYGVADR AMATPNQIHR GHSAPPEHFR QPPPRERNMV DTLEFDRLTL
510 520 530 540 550
ERERLEFEKA KIMERESRLR HEEKQIEDEK RRMHAEKDLI TKETTQPVPP
560 570 580 590 600
PAAVVTHQPI TKRYDPPISI SPPPQRNNYS HVKVTVDSDT SPRQQAFIDD
610 620 630 640 650
IVAKGGKLAV VTYDRGGQNT KELTVHKGEY LEVIFDERNW WECKNMHQRV
660 670 680 690 700
GYVPHTILSM VPFEQQQYAS PNHHNNSSST GGYNNGHHQG PAQNVYRPPP
710 720 730 740 750
PPLVSDAGVQ VEIRREHVAP PPPPVVIPPP PPPVRTPTME ELLRMQQQQQ
760 770 780 790 800
QKQRKPPVEE PVYQPQPAQR AGLEIWRRNQ NPQLIQEVTE TVGQHSGDIL
810 820 830 840 850
RPAMQRATRV AINEKSSPED VTRWLQEKGF SPRVIDLLDG QDGANLFSLS
860 870 880 890 900
KLHLQQACGR DEGGYLYSQL LVQKKRSGFR THTGDELKAI LNHRRTHVEL
910
SNEAAADEPV FTINPIL
Length:917
Mass (Da):104,365
Last modified:December 14, 2011 - v1
Checksum:i4BC021037B43E170
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY611484 mRNA. Translation: AAT37523.1.
Z99281 Genomic DNA. Translation: CAJ44243.1.
RefSeqiNP_001041047.1. NM_001047582.3.
UniGeneiCel.17206.

Genome annotation databases

EnsemblMetazoaiY57G11C.24g; Y57G11C.24g; WBGene00001330.
GeneIDi178411.
KEGGicel:CELE_Y57G11C.24.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY611484 mRNA. Translation: AAT37523.1.
Z99281 Genomic DNA. Translation: CAJ44243.1.
RefSeqiNP_001041047.1. NM_001047582.3.
UniGeneiCel.17206.

3D structure databases

ProteinModelPortaliG5ED33.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY57G11C.24g; Y57G11C.24g; WBGene00001330.
GeneIDi178411.
KEGGicel:CELE_Y57G11C.24.

Organism-specific databases

CTDi178411.
WormBaseiY57G11C.24g; CE39450; WBGene00001330; eps-8.

Phylogenomic databases

GeneTreeiENSGT00390000003646.
KOiK17277.
OMAiMLCVNEE.

Miscellaneous databases

NextBioi901024.

Family and domain databases

InterProiIPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR013761. SAM/pointed.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. WormBase Consortium
    McMurray A.A.
    Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.
  3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Science 282:2012-2018(1998)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.
  4. "A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans."
    Croce A., Cassata G., Disanza A., Gagliani M.C., Tacchetti C., Malabarba M.G., Carlier M.F., Scita G., Baumeister R., Di Fiore P.P.
    Nat. Cell Biol. 6:1173-1179(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: N2Imported.

Entry informationi

Entry nameiG5ED33_CAEEL
AccessioniPrimary (citable) accession number: G5ED33
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: February 4, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.