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G5ED33

- G5ED33_CAEEL

UniProt

G5ED33 - G5ED33_CAEEL

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Protein
Submitted name: Epidermal growth factor receptor pathway substrate 8 splice variant A
Gene
eps-8, CELE_Y57G11C.24, Y57G11C.24
Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. actin filament binding Source: WormBase
  2. cytoskeletal protein binding Source: WormBase
  3. protein binding Source: IntAct

GO - Biological processi

  1. actin filament bundle assembly Source: WormBase
  2. barbed-end actin filament capping Source: WormBase
  3. digestive tract morphogenesis Source: WormBase
  4. embryonic morphogenesis Source: WormBase
  5. epidermis morphogenesis Source: WormBase
  6. intermediate filament organization Source: WormBase
  7. maintenance of protein location Source: WormBase
  8. nematode larval development Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Epidermal growth factor receptor pathway substrate 8 splice variant AImported
Submitted name:
Protein EPS-8, isoform gImported
Gene namesi
Name:eps-8Imported
ORF Names:CELE_Y57G11C.24Imported, Y57G11C.24Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiY57G11C.24g; CE39450; WBGene00001330; eps-8.

Subcellular locationi

GO - Cellular componenti

  1. apical part of cell Source: WormBase
  2. brush border Source: WormBase
  3. extracellular matrix Source: WormBase
Complete GO annotation...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000003646.
KOiK17277.
OMAiMLCVNEE.

Family and domain databases

InterProiIPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR013761. SAM/pointed.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G5ED33-1 [UniParc]FASTAAdd to Basket

« Hide

MRRGGSMGPP SGDPYQSRPS PGGYYYNRST PGGQPAPSPS HSQQSASSHH    50
PRGVPMSQPI ARRSDYRTGS EQMTPRSDHR GPSMGYGNGG SVDQRVDDVT 100
PSYYVEHLAT FAVGRQFGLT FPADGIRKLK QMEKNSAIWA QPLILRFRHN 150
AVTVEDDNGE LVEQFPLELI EQPTAHVSND SRETYNNVLL FVVREDRKRM 200
STPTEMHIFQ CIRVSATDVA EDLKNYVQGQ FRRVRNGRRT AAPTHLQAQQ 250
QQMPFYPPDD ASISSETSEM FERDVNTLNR CFDDIERFVA RIQSAALAQR 300
EIEQQNHRYR TANRRDKKNQ QPPDPNGILF MRAQLPLESE FVDILKKFKL 350
SFNLLAKLKN HIHEPNAPEL LHFLFTPLAV ILEACHWGLG RNVAPTVASP 400
LLSLEARELM QNCLTSHESD IWMSLGEAWR TPPEDWTKPL PPPYRPIFND 450
GFAPYGVADR AMATPNQIHR GHSAPPEHFR QPPPRERNMV DTLEFDRLTL 500
ERERLEFEKA KIMERESRLR HEEKQIEDEK RRMHAEKDLI TKETTQPVPP 550
PAAVVTHQPI TKRYDPPISI SPPPQRNNYS HVKVTVDSDT SPRQQAFIDD 600
IVAKGGKLAV VTYDRGGQNT KELTVHKGEY LEVIFDERNW WECKNMHQRV 650
GYVPHTILSM VPFEQQQYAS PNHHNNSSST GGYNNGHHQG PAQNVYRPPP 700
PPLVSDAGVQ VEIRREHVAP PPPPVVIPPP PPPVRTPTME ELLRMQQQQQ 750
QKQRKPPVEE PVYQPQPAQR AGLEIWRRNQ NPQLIQEVTE TVGQHSGDIL 800
RPAMQRATRV AINEKSSPED VTRWLQEKGF SPRVIDLLDG QDGANLFSLS 850
KLHLQQACGR DEGGYLYSQL LVQKKRSGFR THTGDELKAI LNHRRTHVEL 900
SNEAAADEPV FTINPIL 917
Length:917
Mass (Da):104,365
Last modified:December 14, 2011 - v1
Checksum:i4BC021037B43E170
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY611484 mRNA. Translation: AAT37523.1.
Z99281 Genomic DNA. Translation: CAJ44243.1.
RefSeqiNP_001041047.1. NM_001047582.3.
UniGeneiCel.17206.

Genome annotation databases

EnsemblMetazoaiY57G11C.24g; Y57G11C.24g; WBGene00001330.
GeneIDi178411.
KEGGicel:CELE_Y57G11C.24.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY611484 mRNA. Translation: AAT37523.1 .
Z99281 Genomic DNA. Translation: CAJ44243.1 .
RefSeqi NP_001041047.1. NM_001047582.3.
UniGenei Cel.17206.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai Y57G11C.24g ; Y57G11C.24g ; WBGene00001330 .
GeneIDi 178411.
KEGGi cel:CELE_Y57G11C.24.

Organism-specific databases

CTDi 178411.
WormBasei Y57G11C.24g ; CE39450 ; WBGene00001330 ; eps-8.

Phylogenomic databases

GeneTreei ENSGT00390000003646.
KOi K17277.
OMAi MLCVNEE.

Miscellaneous databases

NextBioi 901024.

Family and domain databases

InterProi IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR013761. SAM/pointed.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF08416. PTB. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view ]
SMARTi SM00462. PTB. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEi PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. WormBase Consortium
    McMurray A.A.
    Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Science 282:2012-2018(1998)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.
  3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  4. "A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans."
    Croce A., Cassata G., Disanza A., Gagliani M.C., Tacchetti C., Malabarba M.G., Carlier M.F., Scita G., Baumeister R., Di Fiore P.P.
    Nat. Cell Biol. 6:1173-1179(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: N2Imported.

Entry informationi

Entry nameiG5ED33_CAEEL
AccessioniPrimary (citable) accession number: G5ED33
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: September 3, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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