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G5ED33

- G5ED33_CAEEL

UniProt

G5ED33 - G5ED33_CAEEL

Protein
Submitted name:

Epidermal growth factor receptor pathway substrate 8 splice variant A

Gene

eps-8

Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (14 Dec 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. actin filament binding Source: WormBase
    2. cytoskeletal protein binding Source: WormBase
    3. protein binding Source: IntAct

    GO - Biological processi

    1. actin filament bundle assembly Source: WormBase
    2. barbed-end actin filament capping Source: WormBase
    3. digestive tract morphogenesis Source: WormBase
    4. embryonic morphogenesis Source: WormBase
    5. epidermis morphogenesis Source: WormBase
    6. intermediate filament organization Source: WormBase
    7. maintenance of protein location Source: WormBase
    8. nematode larval development Source: WormBase

    Keywords - Molecular functioni

    ReceptorImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Epidermal growth factor receptor pathway substrate 8 splice variant AImported
    Submitted name:
    Protein EPS-8, isoform gImported
    Gene namesi
    Name:eps-8Imported
    ORF Names:CELE_Y57G11C.24Imported, Y57G11C.24Imported
    OrganismiCaenorhabditis elegansImported
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome IV

    Organism-specific databases

    WormBaseiY57G11C.24g; CE39450; WBGene00001330; eps-8.

    Subcellular locationi

    GO - Cellular componenti

    1. apical part of cell Source: WormBase
    2. brush border Source: WormBase
    3. extracellular matrix Source: WormBase

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00390000003646.
    KOiK17277.
    OMAiMLCVNEE.

    Family and domain databases

    InterProiIPR013625. PTB.
    IPR006020. PTB/PI_dom.
    IPR013761. SAM/pointed.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF08416. PTB. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view]
    SMARTiSM00462. PTB. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEiPS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G5ED33-1 [UniParc]FASTAAdd to Basket

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    MRRGGSMGPP SGDPYQSRPS PGGYYYNRST PGGQPAPSPS HSQQSASSHH    50
    PRGVPMSQPI ARRSDYRTGS EQMTPRSDHR GPSMGYGNGG SVDQRVDDVT 100
    PSYYVEHLAT FAVGRQFGLT FPADGIRKLK QMEKNSAIWA QPLILRFRHN 150
    AVTVEDDNGE LVEQFPLELI EQPTAHVSND SRETYNNVLL FVVREDRKRM 200
    STPTEMHIFQ CIRVSATDVA EDLKNYVQGQ FRRVRNGRRT AAPTHLQAQQ 250
    QQMPFYPPDD ASISSETSEM FERDVNTLNR CFDDIERFVA RIQSAALAQR 300
    EIEQQNHRYR TANRRDKKNQ QPPDPNGILF MRAQLPLESE FVDILKKFKL 350
    SFNLLAKLKN HIHEPNAPEL LHFLFTPLAV ILEACHWGLG RNVAPTVASP 400
    LLSLEARELM QNCLTSHESD IWMSLGEAWR TPPEDWTKPL PPPYRPIFND 450
    GFAPYGVADR AMATPNQIHR GHSAPPEHFR QPPPRERNMV DTLEFDRLTL 500
    ERERLEFEKA KIMERESRLR HEEKQIEDEK RRMHAEKDLI TKETTQPVPP 550
    PAAVVTHQPI TKRYDPPISI SPPPQRNNYS HVKVTVDSDT SPRQQAFIDD 600
    IVAKGGKLAV VTYDRGGQNT KELTVHKGEY LEVIFDERNW WECKNMHQRV 650
    GYVPHTILSM VPFEQQQYAS PNHHNNSSST GGYNNGHHQG PAQNVYRPPP 700
    PPLVSDAGVQ VEIRREHVAP PPPPVVIPPP PPPVRTPTME ELLRMQQQQQ 750
    QKQRKPPVEE PVYQPQPAQR AGLEIWRRNQ NPQLIQEVTE TVGQHSGDIL 800
    RPAMQRATRV AINEKSSPED VTRWLQEKGF SPRVIDLLDG QDGANLFSLS 850
    KLHLQQACGR DEGGYLYSQL LVQKKRSGFR THTGDELKAI LNHRRTHVEL 900
    SNEAAADEPV FTINPIL 917
    Length:917
    Mass (Da):104,365
    Last modified:December 14, 2011 - v1
    Checksum:i4BC021037B43E170
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY611484 mRNA. Translation: AAT37523.1.
    Z99281 Genomic DNA. Translation: CAJ44243.1.
    RefSeqiNP_001041047.1. NM_001047582.3.
    UniGeneiCel.17206.

    Genome annotation databases

    EnsemblMetazoaiY57G11C.24g; Y57G11C.24g; WBGene00001330.
    GeneIDi178411.
    KEGGicel:CELE_Y57G11C.24.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY611484 mRNA. Translation: AAT37523.1 .
    Z99281 Genomic DNA. Translation: CAJ44243.1 .
    RefSeqi NP_001041047.1. NM_001047582.3.
    UniGenei Cel.17206.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai Y57G11C.24g ; Y57G11C.24g ; WBGene00001330 .
    GeneIDi 178411.
    KEGGi cel:CELE_Y57G11C.24.

    Organism-specific databases

    CTDi 178411.
    WormBasei Y57G11C.24g ; CE39450 ; WBGene00001330 ; eps-8.

    Phylogenomic databases

    GeneTreei ENSGT00390000003646.
    KOi K17277.
    OMAi MLCVNEE.

    Miscellaneous databases

    NextBioi 901024.

    Family and domain databases

    InterProi IPR013625. PTB.
    IPR006020. PTB/PI_dom.
    IPR013761. SAM/pointed.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF08416. PTB. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view ]
    SMARTi SM00462. PTB. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEi PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. WormBase Consortium
      McMurray A.A.
      Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Bristol N2Imported.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      Caenorhabditis elegans Sequencing Consortium
      Science 282:2012-2018(1998)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Bristol N2Imported.
    3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2Imported.
    4. "A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans."
      Croce A., Cassata G., Disanza A., Gagliani M.C., Tacchetti C., Malabarba M.G., Carlier M.F., Scita G., Baumeister R., Di Fiore P.P.
      Nat. Cell Biol. 6:1173-1179(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: N2Imported.

    Entry informationi

    Entry nameiG5ED33_CAEEL
    AccessioniPrimary (citable) accession number: G5ED33
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 14, 2011
    Last sequence update: December 14, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3