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Protein
Submitted name:

Protein SKR-1

Gene

skr-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. positive regulation of apoptotic process Source: WormBase
  2. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_205379. SCF-beta-TrCP mediated degradation of Emi1.
REACT_219545. Cyclin D associated events in G1.
REACT_242668. Circadian Clock.
REACT_249811. Degradation of beta-catenin by the destruction complex.
REACT_254516. SCF(Skp2)-mediated degradation of p27/p21.
REACT_269089. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_270292. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_270666. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_271066. Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein SKR-1Imported
Gene namesi
Name:skr-1Imported
ORF Names:CELE_F46A9.5Imported, F46A9.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiF46A9.5; CE10580; WBGene00004807; skr-1.

Expressioni

Gene expression databases

ExpressionAtlasiG5ECU1. baseline.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
C14B1.3Q179623EBI-323117,EBI-2003707
dre-1Q942513EBI-323117,EBI-314286
F46F11.6P913053EBI-323117,EBI-2003766
fbxa-101G5EDX94EBI-323117,EBI-2003730
fbxa-164O171984EBI-323117,EBI-2412975
fbxa-196O165255EBI-323117,EBI-329491
fog-2Q2YS434EBI-323117,EBI-2417735
fsn-1Q182233EBI-323117,EBI-2003744
sel-10Q937945EBI-323117,EBI-323098

Protein-protein interaction databases

IntActiG5ECU1. 19 interactions.

Structurei

3D structure databases

ProteinModelPortaliG5ECU1.
SMRiG5ECU1. Positions 16-174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000012652.
InParanoidiG5ECU1.
KOiK03094.
OMAiDDIPSWD.
PhylomeDBiG5ECU1.

Family and domain databases

InterProiIPR011333. BTB/POZ_fold.
IPR016897. SKP1.
IPR001232. SKP1-like.
IPR016072. Skp1_comp_dimer.
IPR016073. Skp1_comp_POZ.
[Graphical view]
PfamiPF01466. Skp1. 1 hit.
PF03931. Skp1_POZ. 1 hit.
[Graphical view]
PIRSFiPIRSF028729. E3_ubiquit_lig_SCF_Skp. 1 hit.
SMARTiSM00512. Skp1. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
SSF81382. SSF81382. 1 hit.

Sequencei

Sequence statusi: Complete.

G5ECU1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADQKKVSEA AKEREIKISS SDNEIFLVPR NVIRLSNTIN TLLMDLGLDD
60 70 80 90 100
EEGTNAEPIP VQNVTASILK KVISWCNHHH SDPISTEDSD NREKRTDDIG
110 120 130 140 150
SWDVEFLKVD QGTLFELILA ANYLDIKGLL DVTCKTVANM IKGKSPEEIR
160 170
RTFNIKNDFT PEEEEQIRKE NAWCED
Length:176
Mass (Da):20,032
Last modified:December 14, 2011 - v1
Checksum:i3FCDC4D52BC2DF35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81084, Z81072 Genomic DNA. Translation: CAB03110.1.
PIRiT21573.
RefSeqiNP_492513.1. NM_060112.5.
UniGeneiCel.18311.

Genome annotation databases

EnsemblMetazoaiF46A9.5.1; F46A9.5.1; WBGene00004807.
F46A9.5.2; F46A9.5.2; WBGene00004807.
F46A9.5.3; F46A9.5.3; WBGene00004807.
GeneIDi172775.
KEGGicel:CELE_F46A9.5.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81084, Z81072 Genomic DNA. Translation: CAB03110.1.
PIRiT21573.
RefSeqiNP_492513.1. NM_060112.5.
UniGeneiCel.18311.

3D structure databases

ProteinModelPortaliG5ECU1.
SMRiG5ECU1. Positions 16-174.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiG5ECU1. 19 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF46A9.5.1; F46A9.5.1; WBGene00004807.
F46A9.5.2; F46A9.5.2; WBGene00004807.
F46A9.5.3; F46A9.5.3; WBGene00004807.
GeneIDi172775.
KEGGicel:CELE_F46A9.5.

Organism-specific databases

CTDi172775.
WormBaseiF46A9.5; CE10580; WBGene00004807; skr-1.

Phylogenomic databases

GeneTreeiENSGT00390000012652.
InParanoidiG5ECU1.
KOiK03094.
OMAiDDIPSWD.
PhylomeDBiG5ECU1.

Enzyme and pathway databases

ReactomeiREACT_205379. SCF-beta-TrCP mediated degradation of Emi1.
REACT_219545. Cyclin D associated events in G1.
REACT_242668. Circadian Clock.
REACT_249811. Degradation of beta-catenin by the destruction complex.
REACT_254516. SCF(Skp2)-mediated degradation of p27/p21.
REACT_269089. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_270292. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_270666. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_271066. Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling.

Miscellaneous databases

NextBioi876957.
PROiG5ECU1.

Gene expression databases

ExpressionAtlasiG5ECU1. baseline.

Family and domain databases

InterProiIPR011333. BTB/POZ_fold.
IPR016897. SKP1.
IPR001232. SKP1-like.
IPR016072. Skp1_comp_dimer.
IPR016073. Skp1_comp_POZ.
[Graphical view]
PfamiPF01466. Skp1. 1 hit.
PF03931. Skp1_POZ. 1 hit.
[Graphical view]
PIRSFiPIRSF028729. E3_ubiquit_lig_SCF_Skp. 1 hit.
SMARTiSM00512. Skp1. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
SSF81382. SSF81382. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiG5ECU1_CAEEL
AccessioniPrimary (citable) accession number: G5ECU1
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: February 4, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.