UniProtKB - G5ECR8 (GLCM3_CAEEL)
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Putative glucosylceramidase 3
gba-3
Functioni
Catalytic activityi
: sphingolipid metabolism Pathwayi
This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.View all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 259 | Proton donorBy similarity | 1 | |
Active sitei | 364 | NucleophileBy similarity | 1 |
GO - Molecular functioni
- glucosylceramidase activity Source: GO_Central
GO - Biological processi
- glucosylceramide catabolic process Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid metabolism, Sphingolipid metabolism |
Enzyme and pathway databases
UniPathwayi | UPA00222 |
Protein family/group databases
CAZyi | GH30 Glycoside Hydrolase Family 30 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:gba-3 ORF Names:F11E6.1 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | F11E6.1a ; CE20669 ; WBGene00008706 ; gba-3 F11E6.1b ; CE26698 ; WBGene00008706 ; gba-3 F11E6.1c ; CE31166 ; WBGene00008706 ; gba-3 F11E6.1d ; CE46394 ; WBGene00008706 ; gba-3 |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000421455 | 22 – 522 | Putative glucosylceramidase 3Add BLAST | 501 |
Proteomic databases
PaxDbi | G5ECR8 |
PeptideAtlasi | G5ECR8 |
Interactioni
Protein-protein interaction databases
BioGridi | 436101 interactor. |
IntActi | G5ECR8 1 interactor. |
MINTi | G5ECR8 |
STRINGi | 6239.F11E6.1d |
Structurei
3D structure databases
ProteinModelPortali | G5ECR8 |
SMRi | G5ECR8 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG2566 Eukaryota COG5520 LUCA |
GeneTreei | ENSGT00390000009464 |
HOGENOMi | HOG000270031 |
InParanoidi | G5ECR8 |
KOi | K01201 |
OMAi | PIMGDWF |
OrthoDBi | EOG091G06I4 |
PhylomeDBi | G5ECR8 |
Family and domain databases
Gene3Di | 2.60.40.11802 hits |
InterProi | View protein in InterPro IPR033452 GH30_C IPR001139 Glyco_hydro_30 IPR033453 Glyco_hydro_30_TIM-barrel IPR013780 Glyco_hydro_b IPR017853 Glycoside_hydrolase_SF |
PANTHERi | PTHR11069 PTHR11069, 1 hit |
Pfami | View protein in Pfam PF02055 Glyco_hydro_30, 1 hit PF17189 Glyco_hydro_30C, 1 hit |
PRINTSi | PR00843 GLHYDRLASE30 |
SUPFAMi | SSF51445 SSF51445, 1 hit |
s (4)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MSRWKVVILC LLSFMFEIGH ASFQCNPKTY DGAFLNIVCV CNATFCDEIE
60 70 80 90 100
PIGEIAEGKA IVYRSSLDGD RLKRMSMKMK EKLRKNESVN VTITIDASER
110 120 130 140 150
FQNIFGFGGA FTDSAGDQFV SLSETLQNYI VDSYFGKNGL EYNIGRVPIA
160 170 180 190 200
SCDFSTHEYS YDDVHDDFEL KHFALPDEDL KLKIPFIKKA IEKTEGNIQL
210 220 230 240 250
FASPWSAPGW MKVTGRMRGG GAMRNDKRVY QAYADYFFKF FEAYSSHAIT
260 270 280 290 300
FWGLTIQNEP STGADMAWRW QTMNYTAETM RDFLKKYLGP KLKENKLTET
310 320 330 340 350
LKVMVLDDGR GLLPGWADTI FNDPEATKYA DGVAVHWYGN LYSPAVLLDI
360 370 380 390 400
TQRHHPTKFI FGTEACAGYF GHHGPIMGDW FRAESYADDI ITDLNHHVTG
410 420 430 440 450
WTDWNLCLDE TGGPNWAYNV VDSPIIVNRT AQEFYKQPMF YALGHFSKFL
460 470 480 490 500
PRGSTRVFTK IEGNLAVSAT SVVIEGGRRA TVILSKASNS LLTRIVDSST
510 520
GFSIVLNLPP RSIHTVIWKK RK
The sequence of this isoform differs from the canonical sequence as follows:
370-371: FG → AI
376-376: I → L
382-382: R → T
385-385: S → N
388-388: D → S
392-392: T → S
398-398: V → F
410-411: ET → DM
415-420: NWAYNV → TWVDNF
431-431: A → G
443-443: L → M
The sequence of this isoform differs from the canonical sequence as follows:
370-371: FG → AI
376-376: I → L
382-382: R → T
385-385: S → N
388-388: D → S
392-392: T → S
398-398: V → F
410-411: ET → DM
415-420: NWAYNV → TWVDNF
431-431: A → G
443-443: L → M
447-458: SKFLPRGSTRVF → RHVLATLDIMVQ
459-522: Missing.
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045725 | 1 – 18 | MSRWK…FMFEI → MAFFSVRSSKIVFGLERSEE K in isoform d. CuratedAdd BLAST | 18 | |
Alternative sequenceiVSP_045726 | 370 – 371 | FG → AI in isoform b and isoform c. Curated | 2 | |
Alternative sequenceiVSP_045727 | 376 | I → L in isoform b and isoform c. Curated | 1 | |
Alternative sequenceiVSP_045728 | 382 | R → T in isoform b and isoform c. Curated | 1 | |
Alternative sequenceiVSP_045729 | 385 | S → N in isoform b and isoform c. Curated | 1 | |
Alternative sequenceiVSP_045730 | 388 | D → S in isoform b and isoform c. Curated | 1 | |
Alternative sequenceiVSP_045731 | 392 | T → S in isoform b and isoform c. Curated | 1 | |
Alternative sequenceiVSP_045732 | 398 | V → F in isoform b and isoform c. Curated | 1 | |
Alternative sequenceiVSP_045733 | 410 – 411 | ET → DM in isoform b and isoform c. Curated | 2 | |
Alternative sequenceiVSP_045734 | 415 – 420 | NWAYNV → TWVDNF in isoform b and isoform c. Curated | 6 | |
Alternative sequenceiVSP_045735 | 431 | A → G in isoform b and isoform c. Curated | 1 | |
Alternative sequenceiVSP_045736 | 443 | L → M in isoform b and isoform c. Curated | 1 | |
Alternative sequenceiVSP_045737 | 447 – 458 | SKFLP…STRVF → RHVLATLDIMVQ in isoform c. CuratedAdd BLAST | 12 | |
Alternative sequenceiVSP_045738 | 459 – 522 | Missing in isoform c. CuratedAdd BLAST | 64 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z81058, AL031254 Genomic DNA Translation: CCD31056.1 Z81058, AL031254 Genomic DNA Translation: CAB02924.1 Z81058, AL031254 Genomic DNA Translation: CAC35813.1 Z81058 Genomic DNA Translation: CAD42642.1 |
PIRi | T18583 |
RefSeqi | NP_001255965.1, NM_001269036.1 [G5ECR8-4] NP_503118.1, NM_070717.3 [G5ECR8-2] NP_503119.1, NM_070718.3 [G5ECR8-1] |
UniGenei | Cel.13150 |
Genome annotation databases
EnsemblMetazoai | F11E6.1a; F11E6.1a; WBGene00008706 [G5ECR8-1] |
GeneIDi | 178535 |
KEGGi | cel:CELE_F11E6.1 |
UCSCi | F11E6.1a c. elegans |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | GLCM3_CAEEL | |
Accessioni | G5ECR8Primary (citable) accession number: G5ECR8 Secondary accession number(s): G5EEA6, G5EFK0, Q8MQ76 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 6, 2013 |
Last sequence update: | December 14, 2011 | |
Last modified: | February 28, 2018 | |
This is version 46 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |