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Protein
Submitted name:

C51E3.7a

Gene

egl-3

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: WormBase

GO - Biological processi

  1. insulin processing Source: WormBase
  2. negative regulation of turning behavior involved in mating Source: WormBase
  3. regulation of locomotion involved in locomotory behavior Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Protein family/group databases

MEROPSiS08.109.

Names & Taxonomyi

Protein namesi
Submitted name:
C51E3.7aImported
Submitted name:
Prohormone convertase 2Imported
Gene namesi
Name:egl-3Imported
Synonyms:pc2Imported
ORF Names:C51E3.7Imported, CELE_C51E3.7Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC51E3.7a; CE08940; WBGene00001172; egl-3.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: WormBase
  2. extracellular space Source: GO_Central
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotation
Contains peptidase S8 domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00750000117358.
KOiK01360.
OMAiIWHSSIT.
OrthoDBiEOG7BW0JD.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G5ECN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNTHVDLIC VFLSIFIGIG EAVDVYTNHF HVHLKEGGGL EDAHRIAKRH
60 70 80 90 100
GFINRGQVAA SDNEYHFVQP ALVHARTRRS AGHHAKLHND DEVLHVEQLK
110 120 130 140 150
GYTRTKRGYR PLEQRLESQF DFSAVMSPSD PLYGYQWYLK NTGQAGGKAR
160 170 180 190 200
LDLNVERAWA MGFTGKNITT AIMDDGVDYM HPDIKNNFNA EASYDFSSND
210 220 230 240 250
PFPYPRYTDD WFNSHGTRCA GEIVAARDNG VCGVGVAYDG KVAGIRMLDQ
260 270 280 290 300
PYMTDLIEAN SMGHEPSKIH IYSASWGPTD DGKTVDGPRN ATMRAIVRGV
310 320 330 340 350
NEGRNGLGSI FVWASGDGGE DDDCNCDGYA ASMWTISINS AINNGENAHY
360 370 380 390 400
DESCSSTLAS TFSNGGRNPE TGVATTDLYG RCTRSHSGTS AAAPEAAGVF
410 420 430 440 450
ALALEANPSL TWRDLQHLTV LTSSRNSLFD GRCRDFPSLG INDNHRDSHG
460 470 480 490 500
NCSHFEWQMN GVGLEYNHLF GFGVLDAAEM VMLAMAWKTS PPRYHCTAGL
510 520 530 540 550
IDTPHEIPAD GNLILEINTD GCAGSQFEVR YLEHVQAVVS FNSTRRGDTT
560 570 580 590 600
LYLISPMGTR TMILSRRPKD DDSKDGFTNW PFMTTHTWGE NPTGKWRLVA
610 620 630 640 650
RFQGPGAHAG TLKKFELMLH GTREAPYNLI EPIVGQTNKK LDTVQKAHKR

SH
Length:652
Mass (Da):72,046
Last modified:December 14, 2011 - v1
Checksum:i39E378E75C081A2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04995 mRNA. Translation: AAA56868.1.
BX284605 Genomic DNA. Translation: CAB01635.1.
PIRiT20131.
RefSeqiNP_001023732.1. NM_001028561.3.
UniGeneiCel.18027.

Genome annotation databases

EnsemblMetazoaiC51E3.7a; C51E3.7a; WBGene00001172.
GeneIDi179412.
KEGGicel:CELE_C51E3.7.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04995 mRNA. Translation: AAA56868.1.
BX284605 Genomic DNA. Translation: CAB01635.1.
PIRiT20131.
RefSeqiNP_001023732.1. NM_001028561.3.
UniGeneiCel.18027.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS08.109.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC51E3.7a; C51E3.7a; WBGene00001172.
GeneIDi179412.
KEGGicel:CELE_C51E3.7.

Organism-specific databases

CTDi179412.
WormBaseiC51E3.7a; CE08940; WBGene00001172; egl-3.

Phylogenomic databases

GeneTreeiENSGT00750000117358.
KOiK01360.
OMAiIWHSSIT.
OrthoDBiEOG7BW0JD.

Miscellaneous databases

NextBioi905280.
PROiG5ECN9.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of CELPC2, a cDNA that encodes a putative Kex2-like prohormone convertase in C. elegans."
    Gomez-Saladin E., Wilson D.L., Dickerson I.M.
    Worm Breed. Gaz. 13:51-51(1993)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BA713Imported.
    Tissue: Whole organismImported.
  2. "Isolation and in situ localization of a cDNA encoding a Kex2-like prohormone convertase in the nematode Caenorhabditis elegans."
    Gomez-Saladin E., Wilson D.L., Dickerson I.M.
    Cell. Mol. Neurobiol. 14:9-25(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BA713Imported.
    Tissue: Whole organismImported.
  3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.
  4. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.
  5. WormBase Consortium
    Barlow K.
    Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiG5ECN9_CAEEL
AccessioniPrimary (citable) accession number: G5ECN9
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: April 29, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.