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G5ECN9

- G5ECN9_CAEEL

UniProt

G5ECN9 - G5ECN9_CAEEL

Protein
Submitted name:

Prohormone convertase 2

Gene

egl-3

Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (14 Dec 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: RefGenome

    GO - Biological processi

    1. negative regulation of turning behavior involved in mating Source: WormBase

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

    Protein family/group databases

    MEROPSiS08.109.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Prohormone convertase 2Imported
    Submitted name:
    Protein EGL-3, isoform aImported
    Gene namesi
    Name:egl-3Imported
    Synonyms:pc2Imported
    ORF Names:C51E3.7Imported, CELE_C51E3.7Imported
    OrganismiCaenorhabditis elegansImported
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome V

    Organism-specific databases

    WormBaseiC51E3.7a; CE08940; WBGene00001172; egl-3.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: WormBase
    2. extracellular space Source: RefGenome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S8 family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117358.
    KOiK01360.
    OMAiHKIQSGN.
    OrthoDBiEOG7BW0JD.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    3.40.50.200. 1 hit.
    InterProiIPR008979. Galactose-bd-like.
    IPR000209. Peptidase_S8/S53_dom.
    IPR023827. Peptidase_S8_Asp-AS.
    IPR022398. Peptidase_S8_His-AS.
    IPR023828. Peptidase_S8_Ser-AS.
    IPR015500. Peptidase_S8_subtilisin-rel.
    IPR009020. Prot_inh_propept.
    IPR002884. PrprotnconvertsP.
    [Graphical view]
    PANTHERiPTHR10795. PTHR10795. 1 hit.
    PfamiPF01483. P_proprotein. 1 hit.
    PF00082. Peptidase_S8. 1 hit.
    [Graphical view]
    PRINTSiPR00723. SUBTILISIN.
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF52743. SSF52743. 1 hit.
    SSF54897. SSF54897. 1 hit.
    PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
    PS00137. SUBTILASE_HIS. 1 hit.
    PS00138. SUBTILASE_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G5ECN9-1 [UniParc]FASTAAdd to Basket

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    MKNTHVDLIC VFLSIFIGIG EAVDVYTNHF HVHLKEGGGL EDAHRIAKRH    50
    GFINRGQVAA SDNEYHFVQP ALVHARTRRS AGHHAKLHND DEVLHVEQLK 100
    GYTRTKRGYR PLEQRLESQF DFSAVMSPSD PLYGYQWYLK NTGQAGGKAR 150
    LDLNVERAWA MGFTGKNITT AIMDDGVDYM HPDIKNNFNA EASYDFSSND 200
    PFPYPRYTDD WFNSHGTRCA GEIVAARDNG VCGVGVAYDG KVAGIRMLDQ 250
    PYMTDLIEAN SMGHEPSKIH IYSASWGPTD DGKTVDGPRN ATMRAIVRGV 300
    NEGRNGLGSI FVWASGDGGE DDDCNCDGYA ASMWTISINS AINNGENAHY 350
    DESCSSTLAS TFSNGGRNPE TGVATTDLYG RCTRSHSGTS AAAPEAAGVF 400
    ALALEANPSL TWRDLQHLTV LTSSRNSLFD GRCRDFPSLG INDNHRDSHG 450
    NCSHFEWQMN GVGLEYNHLF GFGVLDAAEM VMLAMAWKTS PPRYHCTAGL 500
    IDTPHEIPAD GNLILEINTD GCAGSQFEVR YLEHVQAVVS FNSTRRGDTT 550
    LYLISPMGTR TMILSRRPKD DDSKDGFTNW PFMTTHTWGE NPTGKWRLVA 600
    RFQGPGAHAG TLKKFELMLH GTREAPYNLI EPIVGQTNKK LDTVQKAHKR 650
    SH 652
    Length:652
    Mass (Da):72,046
    Last modified:December 14, 2011 - v1
    Checksum:i39E378E75C081A2B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U04995 mRNA. Translation: AAA56868.1.
    Z78410 Genomic DNA. Translation: CAB01635.1.
    PIRiT20131.
    RefSeqiNP_001023732.1. NM_001028561.3.
    UniGeneiCel.18027.

    Genome annotation databases

    EnsemblMetazoaiC51E3.7a; C51E3.7a; WBGene00001172.
    GeneIDi179412.
    KEGGicel:CELE_C51E3.7.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U04995 mRNA. Translation: AAA56868.1 .
    Z78410 Genomic DNA. Translation: CAB01635.1 .
    PIRi T20131.
    RefSeqi NP_001023732.1. NM_001028561.3.
    UniGenei Cel.18027.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S08.109.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C51E3.7a ; C51E3.7a ; WBGene00001172 .
    GeneIDi 179412.
    KEGGi cel:CELE_C51E3.7.

    Organism-specific databases

    CTDi 179412.
    WormBasei C51E3.7a ; CE08940 ; WBGene00001172 ; egl-3.

    Phylogenomic databases

    GeneTreei ENSGT00750000117358.
    KOi K01360.
    OMAi HKIQSGN.
    OrthoDBi EOG7BW0JD.

    Miscellaneous databases

    NextBioi 905280.
    PROi G5ECN9.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    3.40.50.200. 1 hit.
    InterProi IPR008979. Galactose-bd-like.
    IPR000209. Peptidase_S8/S53_dom.
    IPR023827. Peptidase_S8_Asp-AS.
    IPR022398. Peptidase_S8_His-AS.
    IPR023828. Peptidase_S8_Ser-AS.
    IPR015500. Peptidase_S8_subtilisin-rel.
    IPR009020. Prot_inh_propept.
    IPR002884. PrprotnconvertsP.
    [Graphical view ]
    PANTHERi PTHR10795. PTHR10795. 1 hit.
    Pfami PF01483. P_proprotein. 1 hit.
    PF00082. Peptidase_S8. 1 hit.
    [Graphical view ]
    PRINTSi PR00723. SUBTILISIN.
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF52743. SSF52743. 1 hit.
    SSF54897. SSF54897. 1 hit.
    PROSITEi PS00136. SUBTILASE_ASP. 1 hit.
    PS00137. SUBTILASE_HIS. 1 hit.
    PS00138. SUBTILASE_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of CELPC2, a cDNA that encodes a putative Kex2-like prohormone convertase in C. elegans."
      Gomez-Saladin E., Wilson D.L., Dickerson I.M.
      Worm Breed. Gaz. 13:51-51(1993)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BA713Imported.
      Tissue: Whole organismImported.
    2. "Isolation and in situ localization of a cDNA encoding a Kex2-like prohormone convertase in the nematode Caenorhabditis elegans."
      Gomez-Saladin E., Wilson D.L., Dickerson I.M.
      Cell. Mol. Neurobiol. 14:9-25(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BA713Imported.
      Tissue: Whole organismImported.
    3. WormBase Consortium
      Wilkinson J.
      Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Bristol N2Imported.
    4. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2Imported.
    5. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      Caenorhabditis elegans Sequencing Consortium
      Science 282:2012-2018(1998)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Bristol N2Imported.

    Entry informationi

    Entry nameiG5ECN9_CAEEL
    AccessioniPrimary (citable) accession number: G5ECN9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 14, 2011
    Last sequence update: December 14, 2011
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3