Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Prohormone convertase 2

Gene

egl-3

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • serine-type endopeptidase activity Source: WormBase

GO - Biological processi

  • determination of adult lifespan Source: UniProtKB
  • insulin processing Source: WormBase
  • larval feeding behavior Source: UniProtKB
  • negative regulation of dense core granule transport Source: UniProtKB
  • negative regulation of turning behavior involved in mating Source: WormBase
  • regulation of eating behavior Source: UniProtKB
  • regulation of locomotion involved in locomotory behavior Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Protein family/group databases

MEROPSiS08.109.

Names & Taxonomyi

Protein namesi
Submitted name:
Prohormone convertase 2Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:egl-3Imported
Synonyms:pc2Imported
ORF Names:C51E3.7Imported, CELE_C51E3.7Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC51E3.7a; CE08940; WBGene00001172; egl-3.

Subcellular locationi

GO - Cellular componenti

  • axon Source: WormBase
  • extracellular space Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500876233023 – 652Sequence analysisAdd BLAST630

Expressioni

Gene expression databases

BgeeiWBGene00001172.

Interactioni

Protein-protein interaction databases

STRINGi6239.C51E3.7a.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 107S8_pro-domainInterPro annotationAdd BLAST79
Domaini165 – 423Peptidase S8InterPro annotationAdd BLAST259
Domaini532 – 618P_proproteinInterPro annotationAdd BLAST87

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3525. Eukaryota.
KOG3526. Eukaryota.
COG1404. LUCA.
COG4935. LUCA.
GeneTreeiENSGT00750000117358.
OMAiIWHSSIT.
OrthoDBiEOG091G05HI.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.30.70.850. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Propept_inh.
IPR002884. PrprotnconvertsP.
IPR032815. S8_pro-domain.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 3 hits.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF16470. S8_pro-domain. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G5ECN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNTHVDLIC VFLSIFIGIG EAVDVYTNHF HVHLKEGGGL EDAHRIAKRH
60 70 80 90 100
GFINRGQVAA SDNEYHFVQP ALVHARTRRS AGHHAKLHND DEVLHVEQLK
110 120 130 140 150
GYTRTKRGYR PLEQRLESQF DFSAVMSPSD PLYGYQWYLK NTGQAGGKAR
160 170 180 190 200
LDLNVERAWA MGFTGKNITT AIMDDGVDYM HPDIKNNFNA EASYDFSSND
210 220 230 240 250
PFPYPRYTDD WFNSHGTRCA GEIVAARDNG VCGVGVAYDG KVAGIRMLDQ
260 270 280 290 300
PYMTDLIEAN SMGHEPSKIH IYSASWGPTD DGKTVDGPRN ATMRAIVRGV
310 320 330 340 350
NEGRNGLGSI FVWASGDGGE DDDCNCDGYA ASMWTISINS AINNGENAHY
360 370 380 390 400
DESCSSTLAS TFSNGGRNPE TGVATTDLYG RCTRSHSGTS AAAPEAAGVF
410 420 430 440 450
ALALEANPSL TWRDLQHLTV LTSSRNSLFD GRCRDFPSLG INDNHRDSHG
460 470 480 490 500
NCSHFEWQMN GVGLEYNHLF GFGVLDAAEM VMLAMAWKTS PPRYHCTAGL
510 520 530 540 550
IDTPHEIPAD GNLILEINTD GCAGSQFEVR YLEHVQAVVS FNSTRRGDTT
560 570 580 590 600
LYLISPMGTR TMILSRRPKD DDSKDGFTNW PFMTTHTWGE NPTGKWRLVA
610 620 630 640 650
RFQGPGAHAG TLKKFELMLH GTREAPYNLI EPIVGQTNKK LDTVQKAHKR

SH
Length:652
Mass (Da):72,046
Last modified:December 14, 2011 - v1
Checksum:i39E378E75C081A2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04995 mRNA. Translation: AAA56868.1.
BX284605 Genomic DNA. Translation: CAB01635.1.
PIRiT20131.
RefSeqiNP_001023732.1. NM_001028561.3.
UniGeneiCel.18027.

Genome annotation databases

EnsemblMetazoaiC51E3.7a; C51E3.7a; WBGene00001172.
GeneIDi179412.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04995 mRNA. Translation: AAA56868.1.
BX284605 Genomic DNA. Translation: CAB01635.1.
PIRiT20131.
RefSeqiNP_001023732.1. NM_001028561.3.
UniGeneiCel.18027.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C51E3.7a.

Protein family/group databases

MEROPSiS08.109.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC51E3.7a; C51E3.7a; WBGene00001172.
GeneIDi179412.

Organism-specific databases

CTDi179412.
WormBaseiC51E3.7a; CE08940; WBGene00001172; egl-3.

Phylogenomic databases

eggNOGiKOG3525. Eukaryota.
KOG3526. Eukaryota.
COG1404. LUCA.
COG4935. LUCA.
GeneTreeiENSGT00750000117358.
OMAiIWHSSIT.
OrthoDBiEOG091G05HI.

Gene expression databases

BgeeiWBGene00001172.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.30.70.850. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Propept_inh.
IPR002884. PrprotnconvertsP.
IPR032815. S8_pro-domain.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 3 hits.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF16470. S8_pro-domain. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG5ECN9_CAEEL
AccessioniPrimary (citable) accession number: G5ECN9
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: November 30, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.