G5ECL2 (G5ECL2_CAEEL) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Protein UNC-26, isoform b EMBL CAC70096.1

Submitted name:
Synaptojanin UNC-26A EMBL AAG18574.1

Gene names

Name:	unc-26 EMBL CAC70096.1 WormBase WBGene00006763 WormBase JC8.10b
ORF Names:	CELE_JC8.10 EMBL CAC70096.1, JC8.10 WormBase WBGene00006763

Organism

Caenorhabditis elegans [Reference proteome] EMBL AAG18574.1

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	1119 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Golgi vesicle uncoating Inferred from mutant phenotype Ref.3. Source: WormBase acetylcholine transport Inferred from mutant phenotype Ref.3. Source: WormBase cytoskeleton organization Inferred from mutant phenotype Ref.3. Source: WormBase endosome organization Inferred from mutant phenotype Ref.3. Source: WormBase gamma-aminobutyric acid transport Inferred from mutant phenotype Ref.3. Source: WormBase locomotion Inferred from mutant phenotype PubMed 2381425. Source: WormBase muscle contraction Inferred from mutant phenotype PubMed 2381425. Source: WormBase phosphatidylinositol phosphorylation Inferred from electronic annotation. Source: InterPro positive regulation of multicellular organism growth Inferred from mutant phenotype Ref.3. Source: WormBase positive regulation of muscle contraction Inferred from mutant phenotype Ref.3. Source: WormBase positive regulation of necrotic cell death Inferred from genetic interaction PubMed 22157748. Source: WormBase positive regulation of neurotransmitter secretion Inferred from mutant phenotype Ref.3. Source: WormBase protein localization to synapse Inferred from genetic interaction PubMed 22446320. Source: WormBase regulation of backward locomotion Inferred from mutant phenotype Ref.3. Source: WormBase regulation of forward locomotion Inferred from mutant phenotype Ref.3. Source: WormBase synaptic vesicle budding from presynaptic membrane Inferred from mutant phenotype Ref.3. Source: WormBase synaptic vesicle uncoating Inferred from mutant phenotype Ref.3. Source: WormBase
Cellular_component	synaptic vesicle Inferred from sequence or structural similarity Ref.3. Source: WormBase
Molecular_function	nucleotide binding Inferred from electronic annotation. Source: InterPro phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity Inferred from sequence or structural similarity Ref.3. Source: WormBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	G5ECL2 [UniParc]. Last modified December 14, 2011. Version 1. Checksum: 37004D0B646EF394	FASTA	1,119	124,209
	10 20 30 40 50 60 MSVRGIRIWR RNDARFQPSI LVEKNGLDGS LLFQGGAIAT LDSDSTDVER RSYQKIVDAY 70 80 90 100 110 120 GILGVLAITK DEAVLVAVTG VLSVGQLYGA DILKITNVEF ISLRTFGSVE NVDSRIIDLQ 130 140 150 160 170 180 RLLSSQMFYF SSLQSYDLTR SAQHRDSHDC SDARFFWNRS LHFSFQRYGI DTDNWLLKCM 190 200 210 220 230 240 AGSVLVRVVY VGANTGRVAL ISRLSCERVG TRFNVRGANY LGNVANFVET EQLLLFDEKE 250 260 270 280 290 300 CSLLQIRGSI PLFWEQPGVN VGSHKVKLRA FETSLPAYHR HLSQLQHRYG EFAIVNLLGR 310 320 330 340 350 360 KEGERVLGDA FKTQHKSSHF APLVDFIDFD YHAQMKISKE AIVQLKKKMS PHMTKHGFFY 370 380 390 400 410 420 SMGKEIVKRQ TGVIRTNCLD CLDRTNAVQT AIGLQMSHDQ VAFLNLNAGK VNVEQRVEEI 430 440 450 460 470 480 LRDLWQKNGD QCSTIYAGTG ALDGKSKLKD ASRSLARTIQ NNLMDGAKQE SFDLFLTGAA 490 500 510 520 530 540 YDPRLFDRAC NILPPSLIQE SYYYHEYADA VSQLVERSPE IAEPQSIKIF VGTWNVNGGK 550 560 570 580 590 600 NIHNVAFRNE SSLSHWIFAN SMTRLVSVED EQLADIVAIG VEELVDLNAS NMVKASTTNQ 610 620 630 640 650 660 RMWCESIRKT LSEKAPFVLI GSEQLVGVCL FLFARPRVSP YLKDFAVASV KTGMGGATGN 670 680 690 700 710 720 KGSVAFRIVV FSTSICFICS HFAAGQNEIR DRNEDFATTL KKIRFPLGRE IDSHDVIFWL 730 740 750 760 770 780 GDFNYRINLS GDEVKNAVRN GDYAKLVEND QLTQQKALGQ TFVGFNEGQL TFAPTYKYDT 790 800 810 820 830 840 FSDDYDTSEK CRAPAWTDRI LWKDQRKKGK TQLLSYDRSE LKTSDHRPVG AVFKVETFKV 850 860 870 880 890 900 GGRKCVELIE DVVESMGPPD GTIIVSIAGK PRFPPQMFPP IHEKLKELGA QVQLSKFDDG 910 920 930 940 950 960 DLWIVLNSGE MALAALSMDG LKIGGTDQIN VKLKSPDWAY ALKPHLSDFD LESFEVTAEE 970 980 990 1000 1010 1020 EALLGGTDGA VFEFADEDED AISVSSLTLT GSAPDRPRPP SARSEAISVA KLEWPTEQPN 1030 1040 1050 1060 1070 1080 VLSTSMPTRA SSASLANSSW YEHVPPLAPP QSNNNKSPPQ ACLFNPFTQS APSPAPPPST 1090 1100 1110 IPLPPTRGAS VGPGPPAVPV RKAPPPPPRP VIPPRPKNM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	WormBase Consortium Lightning J. Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Bristol N2 EMBL CAC70096.1.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." Caenorhabditis elegans Sequencing Consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2 EMBL CAC70096.1.
[3]	"Mutations in synaptojanin disrupt synaptic vesicle recycling." Harris T.W., Hartwieg E., Horvitz H.R., Jorgensen E.M. J. Cell Biol. 150:589-600(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF283322 mRNA. Translation: AAG18574.1. Z82274, AL132951 Genomic DNA. Translation: CAC70096.1.
PIR	C88883.
RefSeq	NP_001023266.1. NM_001028095.3.
UniGene	Cel.5211.
3D structure databases
HSSP	HSSP built from PDB template 1I9Z based on UniProtKB O43001.
SMR	G5ECL2. Positions 55-440, 525-835.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	JC8.10b; JC8.10b; JC8.10.
GeneID	178284.
KEGG	cel:CELE_JC8.10.
Organism-specific databases
CTD	178284.
WormBase	JC8.10b; CE29050; WBGene00006763; unc-26.
Phylogenomic databases
GeneTree	ENSGT00700000104268.
KO	K01099.
OMA	RTIQNNL.
Family and domain databases
Gene3D	3.30.70.330. 1 hit.
InterPro	IPR015047. DUF1866. IPR005135. Endo/exonuclease/phosphatase. IPR000300. IPPc. IPR012677. Nucleotide-bd_a/b_plait. IPR002013. Syja_N. [Graphical view]
Pfam	PF08952. DUF1866. 1 hit. PF03372. Exo_endo_phos. 1 hit. PF02383. Syja_N. 1 hit. [Graphical view]
SMART	SM00128. IPPc. 1 hit. [Graphical view]
SUPFAM	SSF56219. Exo_endo_phos. 1 hit.
PROSITE	PS50275. SAC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	900500.

Entry information

Entry name

G5ECL2_CAEEL

Accession

Primary (citable) accession number: G5ECL2

Entry history

Integrated into UniProtKB/TrEMBL:	December 14, 2011
Last sequence update:	December 14, 2011
Last modified:	May 1, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)