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G5ECF1

- G5ECF1_CAEEL

UniProt

G5ECF1 - G5ECF1_CAEEL

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Protein
Submitted name:

Nonsense-mediated mRNA decay protein

Gene

smg-5

Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. DEAD/H-box RNA helicase binding Source: WormBase
  2. protein phosphatase 2A binding Source: WormBase
  3. protein phosphatase type 2A regulator activity Source: WormBase
  4. ribonuclease activity Source: WormBase

GO - Biological processi

  1. embryonic genitalia morphogenesis Source: WormBase
  2. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: WormBase
  3. regulation of catalytic activity Source: GOC
  4. RNA interference Source: WormBase
  5. RNA phosphodiester bond hydrolysis Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Nonsense-mediated mRNA decay proteinImported
Submitted name:
Protein SMG-5Imported
Gene namesi
Name:smg-5Imported
ORF Names:CELE_W02D3.8Imported, W02D3.8Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiW02D3.8; CE25134; WBGene00004883; smg-5.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: WormBase
  2. nucleus Source: WormBase
Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZHEX-ray3.00A/C1-420[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

OMAiINKLWIV.
OrthoDBiEOG73FQRH.

Family and domain databases

InterProiIPR002716. PIN_dom.
[Graphical view]
SMARTiSM00670. PINc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G5ECF1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQKSDEVTEK FKRYCNQLEK YGQTENVHSP VMAMLRRKGR KQLIEIMKRD
60 70 80 90 100
GDCTSSINKL WIVGYYHPFQ FFIRDKEKNM AIAVLLTMFC GELQEMLSLP
110 120 130 140 150
DDKYPALWNM YIGDFHRYMP DEEIQKCLAV GYYSRAIDLD PNQGRAFHVL
160 170 180 190 200
AGLRADLNVA QKLRLMILGQ LADAPYKKGT ELLEYLKFPQ KESTDKLMVD
210 220 230 240 250
FVIWALNEKS KRMDYQMTGI KIVNEFKAEI EQKLEFDWSL IMSTCRLASK
260 270 280 290 300
LAMKKFGFQQ FYNCFDTIST LYITIYSRTI SSKCLLAEAI SWISDSAEIL
310 320 330 340 350
GHLDEQKNEP HFQKLSVFAK TKWNELNDLV MNHINSVFTS MSLTINPSIS
360 370 380 390 400
MTSFLLNGPI SEPNVEFLSQ LINYLVSVEF PPMEIIHDRE ESGPLLRRIN
410 420 430 440 450
QSEQKRLDIQ IKTQNDEVNR EDWRPVYVLM DYDVIVDKIR IALKIWDIDD
460 470 480 490 500
FICILPSTVL DELDYQKTKN RAVRPVIRAL MELQAEGKIV LKKCDNERSC
510 520 530 540
AEQLVQSARR SAEDHKHIVA FLCKNPSEQK EMEGVTFYDI DQFYMKYLE
Length:549
Mass (Da):64,173
Last modified:December 14, 2011 - v1
Checksum:i304B9C6C05A3EC08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64440 Genomic DNA. Translation: AAB06456.1.
U64441 mRNA. Translation: AAB06457.1.
FO081084 Genomic DNA. Translation: CCD68991.1.
RefSeqiNP_491929.1. NM_059528.6.
UniGeneiCel.19712.

Genome annotation databases

EnsemblMetazoaiW02D3.8; W02D3.8; WBGene00004883.
GeneIDi172391.
KEGGicel:CELE_W02D3.8.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64440 Genomic DNA. Translation: AAB06456.1 .
U64441 mRNA. Translation: AAB06457.1 .
FO081084 Genomic DNA. Translation: CCD68991.1 .
RefSeqi NP_491929.1. NM_059528.6.
UniGenei Cel.19712.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ZHE X-ray 3.00 A/C 1-420 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai W02D3.8 ; W02D3.8 ; WBGene00004883 .
GeneIDi 172391.
KEGGi cel:CELE_W02D3.8.

Organism-specific databases

CTDi 172391.
WormBasei W02D3.8 ; CE25134 ; WBGene00004883 ; smg-5.

Phylogenomic databases

OMAi INKLWIV.
OrthoDBi EOG73FQRH.

Miscellaneous databases

NextBioi 875313.

Family and domain databases

InterProi IPR002716. PIN_dom.
[Graphical view ]
SMARTi SM00670. PINc. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "smg-5: A gene required for nonsense-mediated mRNA decay in Caenorhabditis elegans."
    Anders K.R., Anderson P.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. WormBase Consortium
    Le T., Weinstock L., Rifkin L.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.
  3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.
  4. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Science 282:2012-2018(1998)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.
  5. "An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay."
    Jonas S., Weichenrieder O., Izaurralde E.
    Genes Dev. 27:211-225(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 1-420.

Entry informationi

Entry nameiG5ECF1_CAEEL
AccessioniPrimary (citable) accession number: G5ECF1
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: October 29, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3