G5ECF1 (G5ECF1_CAEEL) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Nonsense-mediated mRNA decay protein EMBL AAB06456.1

Submitted name:
Protein SMG-5 EMBL CCD68991.1

Gene names

Name:	smg-5 WormBase W02D3.8 EMBL CCD68991.1 WormBase WBGene00004883
ORF Names:	CELE_W02D3.8 EMBL CCD68991.1

Organism

Caenorhabditis elegans [Reference proteome] EMBL CCD68991.1

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	549 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Technical term	3D-structure PDB 3ZHE Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA interference Inferred from mutant phenotype PubMed 10988072. Source: WormBase embryonic genitalia morphogenesis Inferred from mutant phenotype PubMed 2583479. Source: WormBase nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Inferred from genetic interaction PubMed 2583479. Source: WormBase
Cellular_component	cytoplasm Inferred from direct assay PubMed 16914455. Source: WormBase nucleus Inferred from direct assay PubMed 16914455. Source: WormBase
Molecular_function	protein phosphatase type 2A regulator activity Non-traceable author statement PubMed 11672865. Source: WormBase ribonuclease activity Inferred from sequence or structural similarity PubMed 11137022. Source: WormBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	G5ECF1 [UniParc]. Last modified December 14, 2011. Version 1. Checksum: 304B9C6C05A3EC08	FASTA	549	64,173
	10 20 30 40 50 60 MQKSDEVTEK FKRYCNQLEK YGQTENVHSP VMAMLRRKGR KQLIEIMKRD GDCTSSINKL 70 80 90 100 110 120 WIVGYYHPFQ FFIRDKEKNM AIAVLLTMFC GELQEMLSLP DDKYPALWNM YIGDFHRYMP 130 140 150 160 170 180 DEEIQKCLAV GYYSRAIDLD PNQGRAFHVL AGLRADLNVA QKLRLMILGQ LADAPYKKGT 190 200 210 220 230 240 ELLEYLKFPQ KESTDKLMVD FVIWALNEKS KRMDYQMTGI KIVNEFKAEI EQKLEFDWSL 250 260 270 280 290 300 IMSTCRLASK LAMKKFGFQQ FYNCFDTIST LYITIYSRTI SSKCLLAEAI SWISDSAEIL 310 320 330 340 350 360 GHLDEQKNEP HFQKLSVFAK TKWNELNDLV MNHINSVFTS MSLTINPSIS MTSFLLNGPI 370 380 390 400 410 420 SEPNVEFLSQ LINYLVSVEF PPMEIIHDRE ESGPLLRRIN QSEQKRLDIQ IKTQNDEVNR 430 440 450 460 470 480 EDWRPVYVLM DYDVIVDKIR IALKIWDIDD FICILPSTVL DELDYQKTKN RAVRPVIRAL 490 500 510 520 530 540 MELQAEGKIV LKKCDNERSC AEQLVQSARR SAEDHKHIVA FLCKNPSEQK EMEGVTFYDI DQFYMKYLE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"smg-5: A gene required for nonsense-mediated mRNA decay in Caenorhabditis elegans." Anders K.R., Anderson P. Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	WormBase Consortium Le T., Weinstock L., Rifkin L. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Bristol N2 EMBL CCD68991.1.
[3]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." Caenorhabditis elegans Sequencing Consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2 EMBL CCD68991.1.
[4]	"An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay." Jonas S., Weichenrieder O., Izaurralde E. Genes Dev. 27:211-225(2013) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 1-420.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U64440 Genomic DNA. Translation: AAB06456.1.
U64441 mRNA. Translation: AAB06457.1.
FO081084 Genomic DNA. Translation: CCD68991.1.

RefSeq

NP_491929.1. NM_059528.6.

UniGene

Cel.19712.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3ZHE	X-ray	3.00	A/C	1-420	[»]

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblMetazoa

W02D3.8; W02D3.8; W02D3.8.

GeneID

172391.

KEGG

cel:CELE_W02D3.8.

Organism-specific databases

CTD

172391.

WormBase

W02D3.8; CE25134; WBGene00004883; smg-5.

Phylogenomic databases

OMA

INKLWIV.

Family and domain databases

InterPro

IPR006596. PINc_nuc-bd.
[Graphical view]

SMART

SM00670. PINc. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

875313.

Entry information

Entry name

G5ECF1_CAEEL

Accession

Primary (citable) accession number: G5ECF1

Entry history

Integrated into UniProtKB/TrEMBL:	December 14, 2011
Last sequence update:	December 14, 2011
Last modified:	May 1, 2013
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)