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Protein
Submitted name:

Nonsense-mediated mRNA decay protein

Gene

smg-5

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • DEAD/H-box RNA helicase binding Source: WormBase
  • protein phosphatase 2A binding Source: WormBase
  • protein phosphatase type 2A regulator activity Source: WormBase
  • ribonuclease activity Source: WormBase

GO - Biological processi

  • embryonic genitalia morphogenesis Source: WormBase
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: WormBase
  • regulation of protein phosphatase type 2A activity Source: GOC
  • RNA interference Source: WormBase
  • RNA phosphodiester bond hydrolysis Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Nonsense-mediated mRNA decay proteinImported
Submitted name:
W02D3.8Imported
Gene namesi
Name:smg-5Imported
ORF Names:CELE_W02D3.8Imported, W02D3.8Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiW02D3.8; CE25134; WBGene00004883; smg-5.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: WormBase
  • nucleus Source: WormBase
Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZHEX-ray3.00A/C1-420[»]
ProteinModelPortaliG5ECF1.
SMRiG5ECF1. Positions 2-400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

OMAiINKLWIV.
OrthoDBiEOG73FQRH.

Family and domain databases

InterProiIPR002716. PIN_dom.
[Graphical view]
SMARTiSM00670. PINc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G5ECF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKSDEVTEK FKRYCNQLEK YGQTENVHSP VMAMLRRKGR KQLIEIMKRD
60 70 80 90 100
GDCTSSINKL WIVGYYHPFQ FFIRDKEKNM AIAVLLTMFC GELQEMLSLP
110 120 130 140 150
DDKYPALWNM YIGDFHRYMP DEEIQKCLAV GYYSRAIDLD PNQGRAFHVL
160 170 180 190 200
AGLRADLNVA QKLRLMILGQ LADAPYKKGT ELLEYLKFPQ KESTDKLMVD
210 220 230 240 250
FVIWALNEKS KRMDYQMTGI KIVNEFKAEI EQKLEFDWSL IMSTCRLASK
260 270 280 290 300
LAMKKFGFQQ FYNCFDTIST LYITIYSRTI SSKCLLAEAI SWISDSAEIL
310 320 330 340 350
GHLDEQKNEP HFQKLSVFAK TKWNELNDLV MNHINSVFTS MSLTINPSIS
360 370 380 390 400
MTSFLLNGPI SEPNVEFLSQ LINYLVSVEF PPMEIIHDRE ESGPLLRRIN
410 420 430 440 450
QSEQKRLDIQ IKTQNDEVNR EDWRPVYVLM DYDVIVDKIR IALKIWDIDD
460 470 480 490 500
FICILPSTVL DELDYQKTKN RAVRPVIRAL MELQAEGKIV LKKCDNERSC
510 520 530 540
AEQLVQSARR SAEDHKHIVA FLCKNPSEQK EMEGVTFYDI DQFYMKYLE
Length:549
Mass (Da):64,173
Last modified:December 14, 2011 - v1
Checksum:i304B9C6C05A3EC08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64440 Genomic DNA. Translation: AAB06456.1.
U64441 mRNA. Translation: AAB06457.1.
BX284601 Genomic DNA. Translation: CCD68991.1.
RefSeqiNP_491929.1. NM_059528.6.
UniGeneiCel.19712.

Genome annotation databases

EnsemblMetazoaiW02D3.8; W02D3.8; WBGene00004883.
GeneIDi172391.
KEGGicel:CELE_W02D3.8.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64440 Genomic DNA. Translation: AAB06456.1.
U64441 mRNA. Translation: AAB06457.1.
BX284601 Genomic DNA. Translation: CCD68991.1.
RefSeqiNP_491929.1. NM_059528.6.
UniGeneiCel.19712.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZHEX-ray3.00A/C1-420[»]
ProteinModelPortaliG5ECF1.
SMRiG5ECF1. Positions 2-400.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiW02D3.8; W02D3.8; WBGene00004883.
GeneIDi172391.
KEGGicel:CELE_W02D3.8.

Organism-specific databases

CTDi172391.
WormBaseiW02D3.8; CE25134; WBGene00004883; smg-5.

Phylogenomic databases

OMAiINKLWIV.
OrthoDBiEOG73FQRH.

Miscellaneous databases

NextBioi875313.

Family and domain databases

InterProiIPR002716. PIN_dom.
[Graphical view]
SMARTiSM00670. PINc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "smg-5: A gene required for nonsense-mediated mRNA decay in Caenorhabditis elegans."
    Anders K.R., Anderson P.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.
  3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.
  4. "An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay."
    Jonas S., Weichenrieder O., Izaurralde E.
    Genes Dev. 27:211-225(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 1-420.
  5. WormBase Consortium
    Barlow K.
    Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiG5ECF1_CAEEL
AccessioniPrimary (citable) accession number: G5ECF1
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: May 27, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.