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G5ECF1

- G5ECF1_CAEEL

UniProt

G5ECF1 - G5ECF1_CAEEL

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Protein
Submitted name: Nonsense-mediated mRNA decay protein
Gene
smg-5, CELE_W02D3.8, W02D3.8
Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. DEAD/H-box RNA helicase binding Source: WormBase
  2. protein binding Source: WormBase
  3. protein phosphatase 2A binding Source: WormBase
  4. protein phosphatase type 2A regulator activity Source: WormBase
  5. ribonuclease activity Source: WormBase

GO - Biological processi

  1. RNA interference Source: WormBase
  2. RNA phosphodiester bond hydrolysis Source: GOC
  3. embryonic genitalia morphogenesis Source: WormBase
  4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: WormBase
  5. regulation of catalytic activity Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Nonsense-mediated mRNA decay proteinImported
Submitted name:
Protein SMG-5Imported
Gene namesi
Name:smg-5Imported
ORF Names:CELE_W02D3.8Imported, W02D3.8Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiW02D3.8; CE25134; WBGene00004883; smg-5.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: WormBase
  2. nucleus Source: WormBase
Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZHEX-ray3.00A/C1-420[»]

Family & Domainsi

Phylogenomic databases

OMAiINKLWIV.
OrthoDBiEOG73FQRH.

Family and domain databases

InterProiIPR002716. PIN_dom.
[Graphical view]
SMARTiSM00670. PINc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G5ECF1-1 [UniParc]FASTAAdd to Basket

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MQKSDEVTEK FKRYCNQLEK YGQTENVHSP VMAMLRRKGR KQLIEIMKRD    50
GDCTSSINKL WIVGYYHPFQ FFIRDKEKNM AIAVLLTMFC GELQEMLSLP 100
DDKYPALWNM YIGDFHRYMP DEEIQKCLAV GYYSRAIDLD PNQGRAFHVL 150
AGLRADLNVA QKLRLMILGQ LADAPYKKGT ELLEYLKFPQ KESTDKLMVD 200
FVIWALNEKS KRMDYQMTGI KIVNEFKAEI EQKLEFDWSL IMSTCRLASK 250
LAMKKFGFQQ FYNCFDTIST LYITIYSRTI SSKCLLAEAI SWISDSAEIL 300
GHLDEQKNEP HFQKLSVFAK TKWNELNDLV MNHINSVFTS MSLTINPSIS 350
MTSFLLNGPI SEPNVEFLSQ LINYLVSVEF PPMEIIHDRE ESGPLLRRIN 400
QSEQKRLDIQ IKTQNDEVNR EDWRPVYVLM DYDVIVDKIR IALKIWDIDD 450
FICILPSTVL DELDYQKTKN RAVRPVIRAL MELQAEGKIV LKKCDNERSC 500
AEQLVQSARR SAEDHKHIVA FLCKNPSEQK EMEGVTFYDI DQFYMKYLE 549
Length:549
Mass (Da):64,173
Last modified:December 14, 2011 - v1
Checksum:i304B9C6C05A3EC08
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U64440 Genomic DNA. Translation: AAB06456.1.
U64441 mRNA. Translation: AAB06457.1.
FO081084 Genomic DNA. Translation: CCD68991.1.
RefSeqiNP_491929.1. NM_059528.6.
UniGeneiCel.19712.

Genome annotation databases

EnsemblMetazoaiW02D3.8; W02D3.8; WBGene00004883.
GeneIDi172391.
KEGGicel:CELE_W02D3.8.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U64440 Genomic DNA. Translation: AAB06456.1 .
U64441 mRNA. Translation: AAB06457.1 .
FO081084 Genomic DNA. Translation: CCD68991.1 .
RefSeqi NP_491929.1. NM_059528.6.
UniGenei Cel.19712.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ZHE X-ray 3.00 A/C 1-420 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai W02D3.8 ; W02D3.8 ; WBGene00004883 .
GeneIDi 172391.
KEGGi cel:CELE_W02D3.8.

Organism-specific databases

CTDi 172391.
WormBasei W02D3.8 ; CE25134 ; WBGene00004883 ; smg-5.

Phylogenomic databases

OMAi INKLWIV.
OrthoDBi EOG73FQRH.

Miscellaneous databases

NextBioi 875313.

Family and domain databases

InterProi IPR002716. PIN_dom.
[Graphical view ]
SMARTi SM00670. PINc. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "smg-5: A gene required for nonsense-mediated mRNA decay in Caenorhabditis elegans."
    Anders K.R., Anderson P.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. WormBase Consortium
    Le T., Weinstock L., Rifkin L.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.
  3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  4. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Science 282:2012-2018(1998)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.
  5. "An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay."
    Jonas S., Weichenrieder O., Izaurralde E.
    Genes Dev. 27:211-225(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 1-420.

Entry informationi

Entry nameiG5ECF1_CAEEL
AccessioniPrimary (citable) accession number: G5ECF1
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: July 9, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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