Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

G5ECF1

- G5ECF1_CAEEL

UniProt

G5ECF1 - G5ECF1_CAEEL

Protein
Submitted name:

Nonsense-mediated mRNA decay protein

Gene

smg-5

Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (14 Dec 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. DEAD/H-box RNA helicase binding Source: WormBase
    2. protein binding Source: WormBase
    3. protein phosphatase 2A binding Source: WormBase
    4. protein phosphatase type 2A regulator activity Source: WormBase
    5. ribonuclease activity Source: WormBase

    GO - Biological processi

    1. embryonic genitalia morphogenesis Source: WormBase
    2. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: WormBase
    3. regulation of catalytic activity Source: GOC
    4. RNA interference Source: WormBase
    5. RNA phosphodiester bond hydrolysis Source: GOC

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Nonsense-mediated mRNA decay proteinImported
    Submitted name:
    Protein SMG-5Imported
    Gene namesi
    Name:smg-5Imported
    ORF Names:CELE_W02D3.8Imported, W02D3.8Imported
    OrganismiCaenorhabditis elegansImported
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome I

    Organism-specific databases

    WormBaseiW02D3.8; CE25134; WBGene00004883; smg-5.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: WormBase
    2. nucleus Source: WormBase

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3ZHEX-ray3.00A/C1-420[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    OMAiINKLWIV.
    OrthoDBiEOG73FQRH.

    Family and domain databases

    InterProiIPR002716. PIN_dom.
    [Graphical view]
    SMARTiSM00670. PINc. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G5ECF1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKSDEVTEK FKRYCNQLEK YGQTENVHSP VMAMLRRKGR KQLIEIMKRD    50
    GDCTSSINKL WIVGYYHPFQ FFIRDKEKNM AIAVLLTMFC GELQEMLSLP 100
    DDKYPALWNM YIGDFHRYMP DEEIQKCLAV GYYSRAIDLD PNQGRAFHVL 150
    AGLRADLNVA QKLRLMILGQ LADAPYKKGT ELLEYLKFPQ KESTDKLMVD 200
    FVIWALNEKS KRMDYQMTGI KIVNEFKAEI EQKLEFDWSL IMSTCRLASK 250
    LAMKKFGFQQ FYNCFDTIST LYITIYSRTI SSKCLLAEAI SWISDSAEIL 300
    GHLDEQKNEP HFQKLSVFAK TKWNELNDLV MNHINSVFTS MSLTINPSIS 350
    MTSFLLNGPI SEPNVEFLSQ LINYLVSVEF PPMEIIHDRE ESGPLLRRIN 400
    QSEQKRLDIQ IKTQNDEVNR EDWRPVYVLM DYDVIVDKIR IALKIWDIDD 450
    FICILPSTVL DELDYQKTKN RAVRPVIRAL MELQAEGKIV LKKCDNERSC 500
    AEQLVQSARR SAEDHKHIVA FLCKNPSEQK EMEGVTFYDI DQFYMKYLE 549
    Length:549
    Mass (Da):64,173
    Last modified:December 14, 2011 - v1
    Checksum:i304B9C6C05A3EC08
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U64440 Genomic DNA. Translation: AAB06456.1.
    U64441 mRNA. Translation: AAB06457.1.
    FO081084 Genomic DNA. Translation: CCD68991.1.
    RefSeqiNP_491929.1. NM_059528.6.
    UniGeneiCel.19712.

    Genome annotation databases

    EnsemblMetazoaiW02D3.8; W02D3.8; WBGene00004883.
    GeneIDi172391.
    KEGGicel:CELE_W02D3.8.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U64440 Genomic DNA. Translation: AAB06456.1 .
    U64441 mRNA. Translation: AAB06457.1 .
    FO081084 Genomic DNA. Translation: CCD68991.1 .
    RefSeqi NP_491929.1. NM_059528.6.
    UniGenei Cel.19712.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3ZHE X-ray 3.00 A/C 1-420 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai W02D3.8 ; W02D3.8 ; WBGene00004883 .
    GeneIDi 172391.
    KEGGi cel:CELE_W02D3.8.

    Organism-specific databases

    CTDi 172391.
    WormBasei W02D3.8 ; CE25134 ; WBGene00004883 ; smg-5.

    Phylogenomic databases

    OMAi INKLWIV.
    OrthoDBi EOG73FQRH.

    Miscellaneous databases

    NextBioi 875313.

    Family and domain databases

    InterProi IPR002716. PIN_dom.
    [Graphical view ]
    SMARTi SM00670. PINc. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "smg-5: A gene required for nonsense-mediated mRNA decay in Caenorhabditis elegans."
      Anders K.R., Anderson P.
      Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. WormBase Consortium
      Le T., Weinstock L., Rifkin L.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Bristol N2Imported.
    3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      Caenorhabditis elegans Sequencing Consortium
      Science 282:2012-2018(1998)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Bristol N2Imported.
    4. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2Imported.
    5. "An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay."
      Jonas S., Weichenrieder O., Izaurralde E.
      Genes Dev. 27:211-225(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 1-420.

    Entry informationi

    Entry nameiG5ECF1_CAEEL
    AccessioniPrimary (citable) accession number: G5ECF1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 14, 2011
    Last sequence update: December 14, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3