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G5EC49

- G5EC49_CAEEL

UniProt

G5EC49 - G5EC49_CAEEL

Protein
Submitted name:

Cytoplasmic signalling transducer

Gene

mig-5

Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (14 Dec 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. signal transducer activity Source: InterPro

    GO - Biological processi

    1. canonical Wnt signaling pathway Source: RefGenome
    2. cell fate determination Source: WormBase
    3. cell fate specification involved in pattern specification Source: WormBase
    4. cell migration Source: WormBase
    5. embryonic morphogenesis Source: WormBase
    6. endodermal cell fate specification Source: WormBase
    7. epidermis morphogenesis Source: WormBase
    8. establishment of mitotic spindle orientation Source: WormBase
    9. inductive cell migration Source: WormBase
    10. intracellular signal transduction Source: InterPro
    11. neuron migration Source: WormBase
    12. regulation of establishment or maintenance of cell polarity Source: WormBase
    13. regulation of signaling Source: RefGenome
    14. signal transduction involved in regulation of gene expression Source: WormBase
    15. Wnt signaling pathway, planar cell polarity pathway Source: WormBase
    16. Wnt signaling pathway, regulating spindle positioning Source: WormBase

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cytoplasmic signalling transducerImported
    Submitted name:
    Protein MIG-5, isoform bImported
    Gene namesi
    Name:mig-5Imported
    ORF Names:CELE_T05C12.6Imported, T05C12.6Imported
    OrganismiCaenorhabditis elegansImported
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiT05C12.6b; CE25100; WBGene00003241; mig-5.

    Subcellular locationi

    GO - Cellular componenti

    1. cell cortex Source: WormBase
    2. cytoplasm Source: WormBase

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 PDZ (DHR) domain.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000013552.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.30.42.10. 1 hit.
    InterProiIPR000591. DEP_dom.
    IPR001158. DIX.
    IPR026542. Dsh.
    IPR015506. Dsh/Dvl-rel.
    IPR001478. PDZ.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PANTHERiPTHR10878. PTHR10878. 1 hit.
    PTHR10878:SF19. PTHR10878:SF19. 1 hit.
    PfamiPF00610. DEP. 1 hit.
    PF00778. DIX. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view]
    SMARTiSM00021. DAX. 1 hit.
    SM00049. DEP. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50186. DEP. 1 hit.
    PS50841. DIX. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G5EC49-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPPCTSDCS QIKVFYYLDD ETTPYVSVIE AREGVATLGN FKNSFTKRGY    50
    KYYAKELDPD IQREVKVELT TDSDRLRKSQ NGFYEIFLVS TPGYGTLPRN 100
    SGTMTRPQRT ALDKRRRRSA DFDATPYSDA SLAPSTIVSR RAGEHLAELY 150
    TSNSEDPYQY DEHTRRTGDD SSLYEPLAAR DMNKIYDDDR RRKKQKKERF 200
    RRPYVPSTIS SATESSVNSG LPRILEIYLP MKNVPYLGLS VCTIDGHIFV 250
    SEIAPEGAVE KDGRVNVGDQ ILQVNRVSFE ELSGPQAVRS LREAASSKRP 300
    ITLYISKFAR GAPSEYDDPL ASMASETMPL DVGVWVETAV QNTEKMKALG 350
    LDPQEQTATT IDDGTLPFTS TASDDEERML YDQRRNGIPR ALIEEAERKR 400
    ENEQNEKIEQ LTEMIDPIIV VRSMARPDSG LAVKNRKWLK ILVPMSFIGR 450
    DLVDWLVDHM ADIHNRKKAR IYAARLLAAG LIRHVVSKLT FTEKCYYVFG 500
    DGILGNDRNS TDTTGTSGTT MRVEATTEVT YVGSPAPHAL AARVGRNIPH 550
    RLETTTLSPV AHDQTWLRRR RDCESPMTND YASMVGESQI GMNPVGNYHV 600
    FGTKNNHRQV PAPSQVTSSS LTNVTNSRKW WLRRPSADSS IQYYGSSSFS 650
    DSVAERSQPR FRRGEQ 666
    Length:666
    Mass (Da):75,091
    Last modified:December 14, 2011 - v1
    Checksum:i21C4EB2D673ACD1F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF063244 mRNA. Translation: AAC16434.1.
    Z66500 Genomic DNA. Translation: CAB61022.1.
    PIRiT43171.
    RefSeqiNP_001022317.1. NM_001027146.2.
    UniGeneiCel.18251.

    Genome annotation databases

    EnsemblMetazoaiT05C12.6b; T05C12.6b; WBGene00003241.
    GeneIDi174317.
    KEGGicel:CELE_T05C12.6.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF063244 mRNA. Translation: AAC16434.1 .
    Z66500 Genomic DNA. Translation: CAB61022.1 .
    PIRi T43171.
    RefSeqi NP_001022317.1. NM_001027146.2.
    UniGenei Cel.18251.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai T05C12.6b ; T05C12.6b ; WBGene00003241 .
    GeneIDi 174317.
    KEGGi cel:CELE_T05C12.6.

    Organism-specific databases

    CTDi 174317.
    WormBasei T05C12.6b ; CE25100 ; WBGene00003241 ; mig-5.

    Phylogenomic databases

    GeneTreei ENSGT00390000013552.

    Miscellaneous databases

    NextBioi 883496.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.30.42.10. 1 hit.
    InterProi IPR000591. DEP_dom.
    IPR001158. DIX.
    IPR026542. Dsh.
    IPR015506. Dsh/Dvl-rel.
    IPR001478. PDZ.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    PANTHERi PTHR10878. PTHR10878. 1 hit.
    PTHR10878:SF19. PTHR10878:SF19. 1 hit.
    Pfami PF00610. DEP. 1 hit.
    PF00778. DIX. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view ]
    SMARTi SM00021. DAX. 1 hit.
    SM00049. DEP. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50186. DEP. 1 hit.
    PS50841. DIX. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mig-5, a gene that controls cell fate determination and cell migration in c.elegans, is a member of the dsh family."
      Guo C.
      Thesis (1995), The Johns Hopkins University
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: N2Imported.
    2. WormBase Consortium
      Burton J.
      Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Bristol N2Imported.
    3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      Caenorhabditis elegans Sequencing Consortium
      Science 282:2012-2018(1998)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Bristol N2Imported.
    4. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2Imported.
    5. Guo C., Li N., Hedgecock E.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: N2Imported.

    Entry informationi

    Entry nameiG5EC49_CAEEL
    AccessioniPrimary (citable) accession number: G5EC49
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 14, 2011
    Last sequence update: December 14, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3