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Protein
Submitted name:

Cytoplasmic signalling transducer

Gene

mig-5

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. cell fate determination Source: WormBase
  2. cell fate specification involved in pattern specification Source: WormBase
  3. cell migration Source: WormBase
  4. embryonic morphogenesis Source: WormBase
  5. endodermal cell fate specification Source: WormBase
  6. epidermis morphogenesis Source: WormBase
  7. establishment of mitotic spindle orientation Source: WormBase
  8. inductive cell migration Source: WormBase
  9. intracellular signal transduction Source: InterPro
  10. neuron migration Source: WormBase
  11. regulation of establishment or maintenance of cell polarity Source: WormBase
  12. signal transduction involved in regulation of gene expression Source: WormBase
  13. Wnt signaling pathway, planar cell polarity pathway Source: WormBase
  14. Wnt signaling pathway, regulating spindle positioning Source: WormBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198018. PCP/CE pathway.
REACT_229542. negative regulation of TCF-dependent signaling by DVL-interacting proteins.
REACT_251235. WNT mediated activation of DVL.
REACT_255237. degradation of DVL.
REACT_259595. WNT5A-dependent internalization of FZD4.

Names & Taxonomyi

Protein namesi
Submitted name:
Cytoplasmic signalling transducerImported
Submitted name:
Protein MIG-5, isoform bImported
Gene namesi
Name:mig-5Imported
ORF Names:CELE_T05C12.6Imported, T05C12.6Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiT05C12.6b; CE25100; WBGene00003241; mig-5.

Subcellular locationi

GO - Cellular componenti

  1. cell cortex Source: WormBase
  2. cytoplasm Source: WormBase
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliG5EC49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000013552.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR001158. DIX.
IPR026542. Dsh.
IPR015506. Dsh/Dvl-rel.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10878. PTHR10878. 1 hit.
PTHR10878:SF19. PTHR10878:SF19. 1 hit.
PfamiPF00610. DEP. 1 hit.
PF00778. DIX. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G5EC49-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPPCTSDCS QIKVFYYLDD ETTPYVSVIE AREGVATLGN FKNSFTKRGY
60 70 80 90 100
KYYAKELDPD IQREVKVELT TDSDRLRKSQ NGFYEIFLVS TPGYGTLPRN
110 120 130 140 150
SGTMTRPQRT ALDKRRRRSA DFDATPYSDA SLAPSTIVSR RAGEHLAELY
160 170 180 190 200
TSNSEDPYQY DEHTRRTGDD SSLYEPLAAR DMNKIYDDDR RRKKQKKERF
210 220 230 240 250
RRPYVPSTIS SATESSVNSG LPRILEIYLP MKNVPYLGLS VCTIDGHIFV
260 270 280 290 300
SEIAPEGAVE KDGRVNVGDQ ILQVNRVSFE ELSGPQAVRS LREAASSKRP
310 320 330 340 350
ITLYISKFAR GAPSEYDDPL ASMASETMPL DVGVWVETAV QNTEKMKALG
360 370 380 390 400
LDPQEQTATT IDDGTLPFTS TASDDEERML YDQRRNGIPR ALIEEAERKR
410 420 430 440 450
ENEQNEKIEQ LTEMIDPIIV VRSMARPDSG LAVKNRKWLK ILVPMSFIGR
460 470 480 490 500
DLVDWLVDHM ADIHNRKKAR IYAARLLAAG LIRHVVSKLT FTEKCYYVFG
510 520 530 540 550
DGILGNDRNS TDTTGTSGTT MRVEATTEVT YVGSPAPHAL AARVGRNIPH
560 570 580 590 600
RLETTTLSPV AHDQTWLRRR RDCESPMTND YASMVGESQI GMNPVGNYHV
610 620 630 640 650
FGTKNNHRQV PAPSQVTSSS LTNVTNSRKW WLRRPSADSS IQYYGSSSFS
660
DSVAERSQPR FRRGEQ
Length:666
Mass (Da):75,091
Last modified:December 14, 2011 - v1
Checksum:i21C4EB2D673ACD1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063244 mRNA. Translation: AAC16434.1.
Z66500 Genomic DNA. Translation: CAB61022.1.
PIRiT43171.
RefSeqiNP_001022317.1. NM_001027146.2.
UniGeneiCel.18251.

Genome annotation databases

EnsemblMetazoaiT05C12.6b; T05C12.6b; WBGene00003241.
GeneIDi174317.
KEGGicel:CELE_T05C12.6.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063244 mRNA. Translation: AAC16434.1.
Z66500 Genomic DNA. Translation: CAB61022.1.
PIRiT43171.
RefSeqiNP_001022317.1. NM_001027146.2.
UniGeneiCel.18251.

3D structure databases

ProteinModelPortaliG5EC49.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT05C12.6b; T05C12.6b; WBGene00003241.
GeneIDi174317.
KEGGicel:CELE_T05C12.6.

Organism-specific databases

CTDi174317.
WormBaseiT05C12.6b; CE25100; WBGene00003241; mig-5.

Phylogenomic databases

GeneTreeiENSGT00390000013552.

Enzyme and pathway databases

ReactomeiREACT_198018. PCP/CE pathway.
REACT_229542. negative regulation of TCF-dependent signaling by DVL-interacting proteins.
REACT_251235. WNT mediated activation of DVL.
REACT_255237. degradation of DVL.
REACT_259595. WNT5A-dependent internalization of FZD4.

Miscellaneous databases

NextBioi883496.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR001158. DIX.
IPR026542. Dsh.
IPR015506. Dsh/Dvl-rel.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10878. PTHR10878. 1 hit.
PTHR10878:SF19. PTHR10878:SF19. 1 hit.
PfamiPF00610. DEP. 1 hit.
PF00778. DIX. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mig-5, a gene that controls cell fate determination and cell migration in c.elegans, is a member of the dsh family."
    Guo C.
    Thesis (1995), The Johns Hopkins University
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: N2Imported.
  2. WormBase Consortium
    Burton J.
    Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.
  3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.
  4. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Science 282:2012-2018(1998)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.
  5. Guo C., Li N., Hedgecock E.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: N2Imported.

Entry informationi

Entry nameiG5EC49_CAEEL
AccessioniPrimary (citable) accession number: G5EC49
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: February 4, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.