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G5EC49 (G5EC49_CAEEL) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

Protein MIG-5, isoform b EMBL CAB61022.1
Gene names
Name:mig-5 EMBL CAB61022.1 WormBase T05C12.6b
ORF Names:CELE_T05C12.6 EMBL CAB61022.1, T05C12.6 WormBase T05C12.6b
OrganismCaenorhabditis elegans [Reference proteome] EMBL AAC16434.1
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length666 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 PDZ (DHR) domain. RuleBase RU003354

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway, planar cell polarity pathway

Inferred from genetic interaction PubMed 16631156. Source: WormBase

Wnt signaling pathway, regulating spindle positioning

Inferred from mutant phenotype PubMed 15572126. Source: WormBase

canonical Wnt signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

cell fate determination

Inferred from mutant phenotype PubMed 16899238. Source: WormBase

cell fate specification involved in pattern specification

Inferred from genetic interaction PubMed 19298786. Source: WormBase

cell migration

Inferred from mutant phenotype PubMed 16899238. Source: WormBase

embryonic morphogenesis

Inferred from mutant phenotype PubMed 16899238. Source: WormBase

endodermal cell fate specification

Inferred from genetic interaction PubMed 12110172PubMed 15572126. Source: WormBase

epidermis morphogenesis

Inferred from mutant phenotype PubMed 16899238. Source: WormBase

establishment of mitotic spindle orientation

Inferred from mutant phenotype PubMed 16899238. Source: WormBase

inductive cell migration

Inferred from mutant phenotype PubMed 16899238. Source: WormBase

intracellular signal transduction

Inferred from electronic annotation. Source: InterPro

neuron migration

Inferred from mutant phenotype PubMed 16899238. Source: WormBase

regulation of establishment or maintenance of cell polarity

Inferred from mutant phenotype PubMed 16631156. Source: WormBase

regulation of signaling

Inferred from Biological aspect of Ancestor. Source: RefGenome

signal transduction involved in regulation of gene expression

Inferred from genetic interaction PubMed 19298786. Source: WormBase

   Cellular_componentcell cortex

Inferred from direct assay PubMed 16899238. Source: WormBase

cytoplasm

Inferred from direct assay PubMed 16899238. Source: WormBase

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 17601533. Source: UniProtKB

signal transducer activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

abl-1P039493EBI-2315994,EBI-2315883

Sequences

Sequence LengthMass (Da)Tools
G5EC49 [UniParc].

Last modified December 14, 2011. Version 1.
Checksum: 21C4EB2D673ACD1F

FASTA66675,091
        10         20         30         40         50         60 
MEPPCTSDCS QIKVFYYLDD ETTPYVSVIE AREGVATLGN FKNSFTKRGY KYYAKELDPD 

        70         80         90        100        110        120 
IQREVKVELT TDSDRLRKSQ NGFYEIFLVS TPGYGTLPRN SGTMTRPQRT ALDKRRRRSA 

       130        140        150        160        170        180 
DFDATPYSDA SLAPSTIVSR RAGEHLAELY TSNSEDPYQY DEHTRRTGDD SSLYEPLAAR 

       190        200        210        220        230        240 
DMNKIYDDDR RRKKQKKERF RRPYVPSTIS SATESSVNSG LPRILEIYLP MKNVPYLGLS 

       250        260        270        280        290        300 
VCTIDGHIFV SEIAPEGAVE KDGRVNVGDQ ILQVNRVSFE ELSGPQAVRS LREAASSKRP 

       310        320        330        340        350        360 
ITLYISKFAR GAPSEYDDPL ASMASETMPL DVGVWVETAV QNTEKMKALG LDPQEQTATT 

       370        380        390        400        410        420 
IDDGTLPFTS TASDDEERML YDQRRNGIPR ALIEEAERKR ENEQNEKIEQ LTEMIDPIIV 

       430        440        450        460        470        480 
VRSMARPDSG LAVKNRKWLK ILVPMSFIGR DLVDWLVDHM ADIHNRKKAR IYAARLLAAG 

       490        500        510        520        530        540 
LIRHVVSKLT FTEKCYYVFG DGILGNDRNS TDTTGTSGTT MRVEATTEVT YVGSPAPHAL 

       550        560        570        580        590        600 
AARVGRNIPH RLETTTLSPV AHDQTWLRRR RDCESPMTND YASMVGESQI GMNPVGNYHV 

       610        620        630        640        650        660 
FGTKNNHRQV PAPSQVTSSS LTNVTNSRKW WLRRPSADSS IQYYGSSSFS DSVAERSQPR 


FRRGEQ 

« Hide

References

« Hide 'large scale' references
[1]"Mig-5, a gene that controls cell fate determination and cell migration in c.elegans, is a member of the dsh family."
Guo C.
Thesis (1995), The Johns Hopkins University
Cited for: NUCLEOTIDE SEQUENCE.
Strain: N2 EMBL AAC16434.1.
[2]WormBase Consortium
Burton J.
Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Bristol N2 EMBL CAB61022.1.
[3]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
Caenorhabditis elegans Sequencing Consortium
Science 282:2012-2018(1998)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Bristol N2 EMBL CAB61022.1.
[4]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[5]Guo C., Li N., Hedgecock E.
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: N2 EMBL AAC16434.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF063244 mRNA. Translation: AAC16434.1.
Z66500 Genomic DNA. Translation: CAB61022.1.
PIRT43171.
RefSeqNP_001022317.1. NM_001027146.2.
UniGeneCel.18251.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaT05C12.6b; T05C12.6b; WBGene00003241.
GeneID174317.
KEGGcel:CELE_T05C12.6.

Organism-specific databases

CTD174317.
WormBaseT05C12.6b; CE25100; WBGene00003241; mig-5.

Phylogenomic databases

GeneTreeENSGT00390000013552.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProIPR000591. DEP_dom.
IPR001158. DIX.
IPR026542. Dsh.
IPR015506. Dsh/Dvl-rel.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERPTHR10878. PTHR10878. 1 hit.
PTHR10878:SF19. PTHR10878:SF19. 1 hit.
PfamPF00610. DEP. 1 hit.
PF00778. DIX. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTSM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMSSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEPS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio883496.

Entry information

Entry nameG5EC49_CAEEL
AccessionPrimary (citable) accession number: G5EC49
Entry history
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: June 11, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)