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Protein
Submitted name:

C46A5.9

Gene

hcf-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • transcription factor binding Source: WormBase

GO - Biological processi

  • dauer exit Source: WormBase
  • determination of adult lifespan Source: WormBase
  • negative regulation of transcription by transcription factor localization Source: WormBase
  • response to cadmium ion Source: WormBase
  • response to oxidative stress Source: WormBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
C46A5.9Imported
Submitted name:
Host cell factor 1Imported
Gene namesi
Name:hcf-1Imported
ORF Names:C46A5.9Imported, CELE_C46A5.9Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC46A5.9; CE26914; WBGene00001827; hcf-1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: WormBase
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliG5EC23.
SMRiG5EC23. Positions 384-418, 553-752.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000119086.
KOiK14966.
OMAiDETCALP.
OrthoDBiEOG790G05.
PhylomeDBiG5EC23.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
2.130.10.80. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR013783. Ig-like_fold.
IPR015915. Kelch-typ_b-propeller.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.

Sequencei

Sequence statusi: Complete.

G5EC23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEDVGLEAT NYSRGDESRS EEQEKNVVRW RIVQQSTGPN PKPRHGHRAV
60 70 80 90 100
VLKELIVIFG GGNEGMIDEL HAYNTQKREW TAPQCCGDVP TPAAAFGAIS
110 120 130 140 150
LGNKIYRFGG MTEYGKYTND LYELQSTRWE WRRLNPRVHS NGHLPCPRIG
160 170 180 190 200
HSFVVSQKSQ KAYVFGGLSN DLNDPKRNVP HYLDDLYVIN LSGPQHLIWE
210 220 230 240 250
KLNATGPGPI SRESHTAVIY EKDSISRMVV YGGMNGVRLG DLWYLNLNTL
260 270 280 290 300
HWTEIKFDDP RTGIPPMPRS LHSSVLIGDK MFVYGGWVPL LEHASTEQQT
310 320 330 340 350
EKEWKCTSSL GCWNITEDRW VPLHLYCSDE DTIPRGRAGH CAAAVGDRMY
360 370 380 390 400
IWSGRDGYRK AWSNQVCCRD MWLLDTILPE QPGKVQLGRA GFNSLEISWP
410 420 430 440 450
IVQGASGYFL QIGFGDAKEQ SVSPIKRATT SPRKQPSIVP PSQKETEQSP
460 470 480 490 500
KKPQGTAPSI ISTQGTTYTA PADPKPATDE GGLPQDLFED TEKNETASPK
510 520 530 540 550
RSNDAQSADS STCEQKKTDE SGLEEDSEKD QKPSDAGETD EMKEENGDDD
560 570 580 590 600
LPWFDVGIID KATINVTHYF NDRQQSLEKQ LNDLIDHNAF KCVNDSVFTT
610 620 630 640 650
EDKIPLINGQ SYRFRVSAIN GLGKGAWSET ASCKTCVPGY PSAPSSIRIT
660 670 680 690 700
KSHEGAQLTW EPPSNTNISG KIIEYSVYLA VKNQSANSAD SQLAFMRVYC
710 720 730 740 750
GPQADCQVLQ SNLGTAFVDQ TNKPAIIFRI AARNEKGYGP ATQVRWLQDQ
760 770 780
QKIPVRTNYP NNSGFIYQQH GGQQKRARFD HQ
Length:782
Mass (Da):87,359
Last modified:December 14, 2011 - v1
Checksum:i1DF7775CA82B8309
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072907 mRNA. Translation: AAD12580.1.
BX284604 Genomic DNA. Translation: CCD66593.1.
PIRiT29816.
T43277.
RefSeqiNP_501279.1. NM_068878.4.
UniGeneiCel.17455.

Genome annotation databases

EnsemblMetazoaiC46A5.9; C46A5.9; WBGene00001827.
GeneIDi177560.
KEGGicel:CELE_C46A5.9.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072907 mRNA. Translation: AAD12580.1.
BX284604 Genomic DNA. Translation: CCD66593.1.
PIRiT29816.
T43277.
RefSeqiNP_501279.1. NM_068878.4.
UniGeneiCel.17455.

3D structure databases

ProteinModelPortaliG5EC23.
SMRiG5EC23. Positions 384-418, 553-752.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC46A5.9; C46A5.9; WBGene00001827.
GeneIDi177560.
KEGGicel:CELE_C46A5.9.

Organism-specific databases

CTDi177560.
WormBaseiC46A5.9; CE26914; WBGene00001827; hcf-1.

Phylogenomic databases

GeneTreeiENSGT00760000119086.
KOiK14966.
OMAiDETCALP.
OrthoDBiEOG790G05.
PhylomeDBiG5EC23.

Miscellaneous databases

NextBioi897368.
PROiG5EC23.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
2.130.10.80. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR013783. Ig-like_fold.
IPR015915. Kelch-typ_b-propeller.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.
  3. "Selected elements of herpes simplex virus accessory factor HCF are highly conserved in Caenorhabditis elegans."
    Liu Y., Hengartner M.O., Herr W.
    Mol. Cell. Biol. 19:909-915(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. WormBase Consortium
    Barlow K.
    Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiG5EC23_CAEEL
AccessioniPrimary (citable) accession number: G5EC23
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: May 27, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.