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Protein
Submitted name:

ERM-1B

Gene

erm-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural molecule activity Source: WormBase

GO - Biological processi

  • actin filament organization Source: WormBase
  • morphogenesis of an epithelium Source: WormBase
  • nematode larval development Source: WormBase
  • protein localization to basolateral plasma membrane Source: WormBase
  • tube formation Source: WormBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
ERM-1BImported
Submitted name:
Ezrin/Radixin/MoesinImported
Gene namesi
Name:erm-1Imported
ORF Names:C01G8.5Imported, CELE_C01G8.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiC01G8.5b; CE07806; WBGene00001333; erm-1.

Subcellular locationi

GO - Cellular componenti

  • apical cortex Source: WormBase
  • apical part of cell Source: WormBase
  • apical plasma membrane Source: WormBase
  • cell cortex Source: WormBase
  • cytoskeleton Source: InterPro
  • extrinsic component of membrane Source: InterPro
  • membrane-enclosed lumen Source: WormBase
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi6239.C01G8.5b.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 297291FERMInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili308 – 40497Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains FERM domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3529. Eukaryota.
ENOG410XQFP. LUCA.
GeneTreeiENSGT00830000128251.
OMAiEWERRIM.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR011174. ERM.
IPR011259. ERM_C_dom.
IPR000798. Ez/rad/moesin-like.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR008954. Moesin_tail.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00769. ERM. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
PIRSFiPIRSF002305. ERM. 1 hit.
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiSM00295. B41. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF48678. SSF48678. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G5EBK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAAGDINVR VTSMDSELEF AIQSSTTGKQ LFDQVVKTIG LREIWYFGLQ
60 70 80 90 100
YTDNKGFPTW LKLNKKVLSQ DVKKDPTLVF KFRAKFYPED VAEEIIQDVT
110 120 130 140 150
MRLFYLQVKD GILSDEIYCP PETSVLLASY AMQAKYGDYV PETHVAGCLT
160 170 180 190 200
ADRLLPQRVL GQFKLNSEEW ERRIMTWWAD HRATTREQAM LEYLKIAQDL
210 220 230 240 250
EMYGVNYFEI RNKKGTDLYL GVDALGLNIY DKADRLSPKV GFPWSEIRNI
260 270 280 290 300
SFNDKKFVIK PIDKKAHDFV FYAPRLRINK RILALCMGNH ELYMRRRKPD
310 320 330 340 350
TIEVQQMKQQ AREDRALKIA EQEKLTREMS AREEAEQRQR DAEKRMAQMQ
360 370 380 390 400
EDMERARLEL AEAHNTIHSL EAQLKQLQLA KQALEQKEYE LRELTAQLQS
410 420 430 440 450
EKAMSDGERR HLRDQVDARE REVFSMREEV ERQTTVTRQL QTQIHSQQHT
460 470 480 490 500
QHYSNSHHVS NGHAHDETAT DDEDNGATEL TNDADQNVPQ HELERVTAAE
510 520 530 540 550
KNIQIKNKLD MLTRELDSVK DQNAVTDYDV LHMENKKAGR DKYKTLRQIR
560
GGNTKRRIDQ YENM
Length:564
Mass (Da):66,000
Last modified:December 14, 2011 - v1
Checksum:i06E157B354BD3FA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB107269 mRNA. Translation: BAC98355.1.
AB107270 Genomic DNA. Translation: BAC98358.1.
BX284601 Genomic DNA. Translation: CCD62463.1.
PIRiT29263.
RefSeqiNP_491560.1. NM_059159.3.
UniGeneiCel.5070.

Genome annotation databases

EnsemblMetazoaiC01G8.5b; C01G8.5b; WBGene00001333.
GeneIDi172174.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB107269 mRNA. Translation: BAC98355.1.
AB107270 Genomic DNA. Translation: BAC98358.1.
BX284601 Genomic DNA. Translation: CCD62463.1.
PIRiT29263.
RefSeqiNP_491560.1. NM_059159.3.
UniGeneiCel.5070.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C01G8.5b.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC01G8.5b; C01G8.5b; WBGene00001333.
GeneIDi172174.

Organism-specific databases

CTDi172174.
WormBaseiC01G8.5b; CE07806; WBGene00001333; erm-1.

Phylogenomic databases

eggNOGiKOG3529. Eukaryota.
ENOG410XQFP. LUCA.
GeneTreeiENSGT00830000128251.
OMAiEWERRIM.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR011174. ERM.
IPR011259. ERM_C_dom.
IPR000798. Ez/rad/moesin-like.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR008954. Moesin_tail.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00769. ERM. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
PIRSFiPIRSF002305. ERM. 1 hit.
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiSM00295. B41. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF48678. SSF48678. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.
  2. Alber B.E., Fuchs G.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.
  3. "Genome structure, tissue expression and RNAi phenotype of erm-1, the C. elegans homolog of vertebrate moesin."
    Sakube Y., Kagawa H.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: N2Imported.
  4. WormBase Consortium
    WormBase
    Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiG5EBK3_CAEEL
AccessioniPrimary (citable) accession number: G5EBK3
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: July 6, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.