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G5EB45

- G5EB45_EMENI

UniProt

G5EB45 - G5EB45_EMENI

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Protein
Alpha-amylase
Gene
AN2018.2, ANIA_02018
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi134 – 1341Calcium 1 By similarityUniRule annotation
Metal bindingi175 – 1751Calcium 1; via carbonyl oxygen By similarityUniRule annotation
Metal bindingi188 – 1881Calcium 1 By similarityUniRule annotation
Active sitei219 – 2191Nucleophile By similarityUniRule annotation
Metal bindingi219 – 2191Calcium 2 By similarityUniRule annotation
Metal bindingi223 – 2231Calcium 1; via carbonyl oxygen By similarityUniRule annotation
Active sitei243 – 2431Proton donor By similarityUniRule annotation
Metal bindingi243 – 2431Calcium 2 By similarityUniRule annotation
Sitei310 – 3101Transition state stabilizer By similarityUniRule annotation

GO - Molecular functioni

  1. alpha-amylase activity Source: InterPro
  2. calcium ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. carbohydrate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Keywords - Biological processi

Carbohydrate metabolismUniRule annotation

Keywords - Ligandi

CalciumUniRule annotation, Metal-bindingUniRule annotation

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-amylaseUniRule annotation (EC:3.2.1.1UniRule annotation)
Gene namesi
ORF Names:AN2018.2Imported, ANIA_02018Imported
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)Imported
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome VII

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi163 ↔ 177 By similarityUniRule annotation
Disulfide bondi253 ↔ 296 By similarityUniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000165530.
KOiK01176.
OMAiNQTQVED.
OrthoDBiEOG7RBZJ4.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR013777. A-amylase_fun.
IPR015340. A_amylase_DUF1966_C.
IPR006046. Alpha_amylase.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
PF09260. DUF1966. 1 hit.
[Graphical view]
PIRSFiPIRSF001024. Alph-amyl_fung. 1 hit.
PRINTSiPR00110. ALPHAAMYLASE.
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

G5EB45-1 [UniParc]FASTAAdd to Basket

« Hide

MRSPLFLSFA ATVLAATPAE WRSQSIYFLL TDRFARTDNS TTAECDTSAK    50
YCGGTWQGII NQLDYIQGMG FTAIWITPVT ANLEDGQHGE AYHGYWQQDI 100
YALNPHFGTQ DDLRALSDAL HDRGMYLMVD VVANHFGYDA PAASVDYSAF 150
NPFNSADYFH TPCDITDYDN QTQVEDCWLY TDAVSLPDVD TTNEEVKEIW 200
YDWVGDLVSD YSIDGLRIDT ARHVQKDFWR DYNDAAGVYC VGEVFQGDPD 250
YTCGYQEVMD GVLNYPIYYP LLRAFSSTSG SLSDLANMIE TVKYTCSDAT 300
LLGNFIENHD NPRFASYTDD ISLAKNVAAF VILSDGIPII YAGQEQHYSG 350
AGDPANREAT WLSGYDSTSE LYQFISKTNQ IRNHAIWQNE TYLSYKNYAI 400
YNENNVLAMR KGFDGSQIIT ILTNAGADAG SSTVSVPNTG FTAGAAVTEI 450
YTCEDITVSG SGEVSVPMES GLPRVLYPKA KLEGSGICGL 490
Length:490
Mass (Da):54,250
Last modified:December 14, 2011 - v1
Checksum:iA891C4ACEAEB5305
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BN001307 Genomic DNA. Translation: CBF86021.1.
AACD01000032 Genomic DNA. Translation: EAA64850.1.
RefSeqiXP_659622.1. XM_654530.1.

Genome annotation databases

EnsemblFungiiCADANIAT00008686; CADANIAP00008686; CADANIAG00008686.
GeneIDi2875021.
KEGGiani:AN2018.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BN001307 Genomic DNA. Translation: CBF86021.1 .
AACD01000032 Genomic DNA. Translation: EAA64850.1 .
RefSeqi XP_659622.1. XM_654530.1.

3D structure databases

ModBasei Search...

Protein family/group databases

CAZyi GH13. Glycoside Hydrolase Family 13.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00008686 ; CADANIAP00008686 ; CADANIAG00008686 .
GeneIDi 2875021.
KEGGi ani:AN2018.2.

Phylogenomic databases

HOGENOMi HOG000165530.
KOi K01176.
OMAi NQTQVED.
OrthoDBi EOG7RBZJ4.

Family and domain databases

Gene3Di 2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR013777. A-amylase_fun.
IPR015340. A_amylase_DUF1966_C.
IPR006046. Alpha_amylase.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10357. PTHR10357. 1 hit.
Pfami PF00128. Alpha-amylase. 1 hit.
PF09260. DUF1966. 1 hit.
[Graphical view ]
PIRSFi PIRSF001024. Alph-amyl_fung. 1 hit.
PRINTSi PR00110. ALPHAAMYLASE.
SMARTi SM00642. Aamy. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "The 2008 update of the Aspergillus nidulans genome annotation: A community effort."
    Russo Wortman J., Mabey Gilsenan J., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J.M., Durek P., Espeso E., Fekete E., Flipphi M., Garcia Estrada C.
    , Geysens S., Goldman G., de Groot P.W.J., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A.K.W., Kim J-M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., MacCabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Posci I., Punt P.J., Ram A.F.J., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van der Vondervoot P.J.I., de Vries R.P., Walton J., Xiang X., Xiong Y., Ping Zeng A., Brandt B.W., Cornell M.J., van den Hondel C.A.M.J.J., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-S13(2009)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: FGSC A4Imported.

Entry informationi

Entry nameiG5EB45_EMENI
AccessioniPrimary (citable) accession number: G5EB45
Secondary accession number(s): C8VLE6
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: September 3, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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