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Protein
Submitted name:

LIM and calponin homology domains-containing protein 1

Gene

LIMCH1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
LIM and calponin homology domains-containing protein 1Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:LIMCH1Imported
Synonyms:DKFZP686A01247Imported
ORF Names:hCG_33090Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:29191. LIMCH1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000316891.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1395 – 146167LIM zinc-bindingInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili739 – 78042Sequence analysisAdd
BLAST
Coiled coili794 – 82431Sequence analysisAdd
BLAST
Coiled coili1166 – 120742Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 LIM zinc-binding domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, LIM domainUniRule annotation

Phylogenomic databases

eggNOGiENOG410INGA. Eukaryota.
ENOG410XQB9. LUCA.
GeneTreeiENSGT00530000063559.
OMAiINIPRTH.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
InterProiIPR031865. DUF4757.
IPR029980. LIMCH1.
IPR001781. Znf_LIM.
[Graphical view]
PANTHERiPTHR15551:SF3. PTHR15551:SF3. 3 hits.
PfamiPF15949. DUF4757. 2 hits.
PF00412. LIM. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 1 hit.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G5EA03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKDTDDIES PKRSIRDSGY IDCWDSERSD SLSPPRHGRD DSFDSLDSFG
60 70 80 90 100
SRSRQTPSPD VVLRGSSDGR GSDSESDLPH RKLPDVKKDD MSARRTSHGE
110 120 130 140 150
PKSAVPFNQY LPNKSNQTAY VPAPLRKKKA EREEYRKSWS TATSPLGGER
160 170 180 190 200
PFSFPETIEE EGSEVGSAGE DNPAGQMNPG WKPSDGGCEL PDGSGKEHPS
210 220 230 240 250
SDGAVVAPAP KSEEKDAAEI QKRKRLEQAG IKVMPAAQRF ASQKQLSEEK
260 270 280 290 300
EAIRDIVLRK ENSFLTHQHG NDSEAEGEVV CRLPDLEKDD FAARRARMNQ
310 320 330 340 350
TKPMVPLNQL LYGPYPKKGA EKSDGSKQLS KGISKKRSLE YKRNQGHTEE
360 370 380 390 400
VKLIVTCNMR AQESEPVEGG LRKVPDLHKD DLAQQRIQGS LAPHREPPSF
410 420 430 440 450
ITLSNITEAD LETWERLKVS EKARDGDVQH ICASEPSPEI KAETAIRDDF
460 470 480 490 500
ANRKARASKK ASSPRQKFVH FGPVTELDQQ KWKRLSIGKA GPREDEEEVI
510 520 530 540 550
CHGSKIQMDS VSPVSAATSS LKGHQIFNRQ NDCRTMNCGR GDYCRRASWL
560 570 580 590 600
APVPESQEEW VCSLGECPRG TEEVTSKQLP QDGKEETESA PRDSERLSKA
610 620 630 640 650
ERSEDSSQPL VCPLASECEA SGTEEKLEKM TAPAWSGSGL KGQRKLDDSR
660 670 680 690 700
KDDMMARRTG MSLRHTGSNP NQFLPVPFAK QQDVEESSKG LPMKDQRYGP
710 720 730 740 750
RTPVSDDAES TSMFDMRCEE EAAVQPHSRA RQEQLQLINN QLREEDDKWQ
760 770 780 790 800
DDLARWKSRR RSVSQDLIKK EEERKKMEKL LAGEDGTSER RKSIKTYREI
810 820 830 840 850
VQEKERRERE LHEAYKNARS QEEAEGILQQ YIERFTISEA VLERLEMPKI
860 870 880 890 900
LERSHSTEPN LSSFLNDPNP MKYLRQQSLP PPKFTATVET TIARASVLDT
910 920 930 940 950
SMSAGSGSPS KTVTPKAVPM LTPKPYSQPK NSQDVLKTFK VDGKVSVNGE
960 970 980 990 1000
TVHREEEKER ECPTVAPAHS LTKSQMFEGV ARVHGSPLEL KQDNGSIEIN
1010 1020 1030 1040 1050
IKKPNSVPQE LAATTEKTEP NSQEDKNDGG KSRKGNIELA SSEPQHFTTT
1060 1070 1080 1090 1100
VTRCSPTVAF VEFPSSPQLK NDVSEEKDQK KPENEMSGKV ELVLSQKVVK
1110 1120 1130 1140 1150
PKSPEPEATL TFPFLDKMPE ANQLHLPNLN SQVDSPSSEK SPVMTPFKFW
1160 1170 1180 1190 1200
AWDPEEERRR QEKWQQEQER LLQERYQKEQ DKLKEEWEKA QKEVEEEERR
1210 1220 1230 1240 1250
YYEEERKIIE DTVVPFTVSS SSADQLSTSS SMTEGSGTMN KIDLGNCQDE
1260 1270 1280 1290 1300
KQDRRWKKSF QGDDSDLLLK TRESDRLEEK GSLTEGALAH SGNPVSKGVH
1310 1320 1330 1340 1350
EDHQLDTEAG APHCGTNPQL AQDPSQNQQT SNPTHSSEDV KPKTLPLDKS
1360 1370 1380 1390 1400
INHQIESPSE RRKKSPREHF QAGPFSPCSP TPPGQSPNRS ISGKKLCSSC
1410 1420 1430 1440 1450
GLPLGKGAAM IIETLNLYFH IQCFRCGICK GQLGDAVSGT DVRIRNGLLN
1460
CNDCYMRSRS AGQPTTL
Length:1,467
Mass (Da):164,439
Last modified:December 14, 2011 - v1
Checksum:i05BD7752B1C4D4C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC095043 Genomic DNA. No translation available.
AC105389 Genomic DNA. No translation available.
AC108050 Genomic DNA. No translation available.
AC121159 Genomic DNA. No translation available.
AC124009 Genomic DNA. No translation available.
CH471069 Genomic DNA. Translation: EAW92986.1.
RefSeqiXP_005248124.1. XM_005248067.1.
UniGeneiHs.335163.

Genome annotation databases

EnsembliENST00000503057; ENSP00000425631; ENSG00000064042.
GeneIDi22998.
UCSCiuc003gvz.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC095043 Genomic DNA. No translation available.
AC105389 Genomic DNA. No translation available.
AC108050 Genomic DNA. No translation available.
AC121159 Genomic DNA. No translation available.
AC124009 Genomic DNA. No translation available.
CH471069 Genomic DNA. Translation: EAW92986.1.
RefSeqiXP_005248124.1. XM_005248067.1.
UniGeneiHs.335163.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000316891.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000503057; ENSP00000425631; ENSG00000064042.
GeneIDi22998.
UCSCiuc003gvz.5. human.

Organism-specific databases

CTDi22998.
HGNCiHGNC:29191. LIMCH1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INGA. Eukaryota.
ENOG410XQB9. LUCA.
GeneTreeiENSGT00530000063559.
OMAiINIPRTH.

Miscellaneous databases

ChiTaRSiLIMCH1. human.
GenomeRNAii22998.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
InterProiIPR031865. DUF4757.
IPR029980. LIMCH1.
IPR001781. Znf_LIM.
[Graphical view]
PANTHERiPTHR15551:SF3. PTHR15551:SF3. 3 hits.
PfamiPF15949. DUF4757. 2 hits.
PF00412. LIM. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 1 hit.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE.
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Ensembl
    Submitted (OCT-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  12. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiG5EA03_HUMAN
AccessioniPrimary (citable) accession number: G5EA03
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: July 6, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.