Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Neurexin 2, isoform CRA_a

Gene

NRXN2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Neurexin 2, isoform CRA_aImported
Submitted name:
Neurexin-2Imported
Gene namesi
Name:NRXN2Imported
ORF Names:hCG_1810991Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8009. NRXN2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1631 – 165121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 17051677Sequence analysisPRO_5007661211Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlasiG5E9G7.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000265459.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 206179LAM_G_DOMAINInterPro annotationAdd
BLAST
Domaini202 – 24241EGF-likeInterPro annotationAdd
BLAST
Domaini289 – 479191LAM_G_DOMAINInterPro annotationAdd
BLAST
Domaini486 – 679194LAM_G_DOMAINInterPro annotationAdd
BLAST
Domaini683 – 72038EGF-likeInterPro annotationAdd
BLAST
Domaini725 – 897173LAM_G_DOMAINInterPro annotationAdd
BLAST
Domaini911 – 1086176LAM_G_DOMAINInterPro annotationAdd
BLAST
Domaini1089 – 112638EGF-likeInterPro annotationAdd
BLAST
Domaini1130 – 1338209LAM_G_DOMAINInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3514. Eukaryota.
ENOG410XNU6. LUCA.
GeneTreeiENSGT00760000118991.

Family and domain databases

Gene3Di2.60.120.200. 6 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
IPR027160. NRXN2.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERiPTHR10127:SF593. PTHR10127:SF593. 2 hits.
PfamiPF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 5 hits.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 7 hits.
PROSITEiPS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G5E9G7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGSRWRPT PPPLLLLLLL ALAARADGLE FGGGPGQWAR YARWAGAASS
60 70 80 90 100
GELSFSLRTN ATRALLLYLD DGGDCDFLEL LLVDGRLRLR FTLSCAEPAT
110 120 130 140 150
LQLDTPVADD RWHMVLLTRD ARRTALAVDG EARAAEVRSK RREMQVASDL
160 170 180 190 200
FVGGIPPDVR LSALTLSTVK YEPPFRGLLA NLKLGERPPA LLGSQGLRGA
210 220 230 240 250
TADPLCAPAR NPCANGGLCT VLAPGEVGCD CSHTGFGGKF CSEEEHPMEG
260 270 280 290 300
PAHLTLNSEV GSLLFSEGGA GRGGAGDVHQ PTKGKEEFVA TFKGNEFFCY
310 320 330 340 350
DLSHNPIQSS TDEITLAFRT LQRNGLMLHT GKSADYVNLS LKSGAVWLVI
360 370 380 390 400
NLGSGAFEAL VEPVNGKFND NAWHDVRVTR NLRQHAGIGH AMVTISVDGI
410 420 430 440 450
LTTTGYTQED YTMLGSDDFF YIGGSPNTAD LPGSPVSNNF MGCLKDVVYK
460 470 480 490 500
NNDFKLELSR LAKEGDPKMK LQGDLSFRCE DVAALDPVTF ESPEAFVALP
510 520 530 540 550
RWSAKRTGSI SLDFRTTEPN GLLLFSQGRR AGGGAGSHSS AQRADYFAME
560 570 580 590 600
LLDGHLYLLL DMGSGGIKLR ASSRKVNDGE WCHVDFQRDG RKGSISVNSR
610 620 630 640 650
STPFLATGDS EILDLESELY LGGLPEGGRV DLPLPPEVWT AALRAGYVGC
660 670 680 690 700
VRDLFIDGRS RDLRGLAEAQ GAVGVAPFCS RETLKQCASA PCRNGGVCRE
710 720 730 740 750
GWNRFICDCI GTGFLGRVCE REATVLSYDG SMYMKIMLPN AMHTEAEDVS
760 770 780 790 800
LRFMSQRAYG LMMATTSRES ADTLRLELDG GQMKLTVNLD CLRVGCAPSK
810 820 830 840 850
GPETLFAGHK LNDNEWHTVR VVRRGKSLQL SVDNVTVEGQ MAGAHMRLEF
860 870 880 890 900
HNIETGIMTE RRFISVVPSN FIGHLSGLVF NGQPYMDQCK DGDITYCELN
910 920 930 940 950
ARFGLRAIVA DPVTFKSRSS YLALATLQAY ASMHLFFQFK TTAPDGLLLF
960 970 980 990 1000
NSGNGNDFIV IELVKGYIHY VFDLGNGPSL MKGNSDKPVN DNQWHNVVVS
1010 1020 1030 1040 1050
RDPGNVHTLK IDSRTVTQHS NGARNLDLKG ELYIGGLSKN MFSNLPKLVA
1060 1070 1080 1090 1100
SRDGFQGCLA SVDLNGRLPD LIADALHRIG QVERGCDGPS TTCTEESCAN
1110 1120 1130 1140 1150
QGVCLQQWDG FTCDCTMTSY GGPVCNDPGT TYIFGKGGAL ITYTWPPNDR
1160 1170 1180 1190 1200
PSTRMDRLAV GFSTHQRSAV LVRVDSASGL GDYLQLHIDQ GTVGVIFNVG
1210 1220 1230 1240 1250
TDDITIDEPN AIVSDGKYHV VRFTRSGGNA TLQVDSWPVN ERYPAGNFDN
1260 1270 1280 1290 1300
ERLAIARQRI PYRLGRVVDE WLLDKGRQLT IFNSQAAIKI GGRDQGRPFQ
1310 1320 1330 1340 1350
GQVSGLYYNG LKVLALAAES DPNVRTEGHL RLVGEGPSVL LSAETTATTL
1360 1370 1380 1390 1400
LADMATTIME TTTTMATTTT RRGRSPTLRD STTQNTDDLL VASAECPSDD
1410 1420 1430 1440 1450
EDLEECEPST GGELILPIIT EDSLDPPPVA TRSPFVPPPP TFYPFLTGVG
1460 1470 1480 1490 1500
ATQDTLPPPA ARRPPSGGPC QAERDDSDCE EPIEASGFAS GEVFDSSLPP
1510 1520 1530 1540 1550
TDDEDFYTTF PLVTDRTTLL SPRKPAPRPN LRTDGATGAP GVLFAPSAPA
1560 1570 1580 1590 1600
PNLPAGKMNH RDPLQPLLEN PPLGPGAPTS FEPRRPPPLR PGVTSAPGFP
1610 1620 1630 1640 1650
HLPTANPTGP GERGPPGAVE VIRESSSTTG MVVGIVAAAA LCILILLYAM
1660 1670 1680 1690 1700
YKYRNRDEGS YQVDQSRNYI SNSAQSNGAV VKEKAPAAPK TPSKAKKNKD

KEYYV
Length:1,705
Mass (Da):184,114
Last modified:December 14, 2011 - v1
Checksum:i3BD48907229A5A12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001092 Genomic DNA. No translation available.
AP001462 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74277.1.
RefSeqiXP_005274457.1. XM_005274400.3.
UniGeneiHs.372938.

Genome annotation databases

EnsembliENST00000409571; ENSP00000386416; ENSG00000110076.
GeneIDi9379.
UCSCiuc058cyc.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001092 Genomic DNA. No translation available.
AP001462 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74277.1.
RefSeqiXP_005274457.1. XM_005274400.3.
UniGeneiHs.372938.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000265459.

Proteomic databases

PeptideAtlasiG5E9G7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409571; ENSP00000386416; ENSG00000110076.
GeneIDi9379.
UCSCiuc058cyc.1. human.

Organism-specific databases

CTDi9379.
HGNCiHGNC:8009. NRXN2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3514. Eukaryota.
ENOG410XNU6. LUCA.
GeneTreeiENSGT00760000118991.

Miscellaneous databases

ChiTaRSiNRXN2. human.
GenomeRNAii9379.

Family and domain databases

Gene3Di2.60.120.200. 6 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
IPR027160. NRXN2.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERiPTHR10127:SF593. PTHR10127:SF593. 2 hits.
PfamiPF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 5 hits.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 7 hits.
PROSITEiPS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Ensembl
    Submitted (OCT-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiG5E9G7_HUMAN
AccessioniPrimary (citable) accession number: G5E9G7
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: July 6, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.