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Protein
Submitted name:

Tight junction protein 1 (Zona occludens 1), isoform CRA_e

Gene

TJP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Tight junction protein 1 (Zona occludens 1), isoform CRA_eImported
Submitted name:
Tight junction protein ZO-1Imported
Gene namesi
Name:TJP1Imported
ORF Names:hCG_27621Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:11827. TJP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiG5E9E7.
MaxQBiG5E9E7.
PeptideAtlasiG5E9E7.

Expressioni

Gene expression databases

BgeeiENSG00000104067.

Structurei

3D structure databases

SMRiG5E9E7. Positions 22-114, 189-268, 424-806, 1553-1692.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 11488PDZ (DHR)InterPro annotationAdd
BLAST
Domaini190 – 26879PDZ (DHR)InterPro annotationAdd
BLAST
Domaini425 – 50682PDZ (DHR)InterPro annotationAdd
BLAST
Domaini520 – 58869SH3InterPro annotationAdd
BLAST
Domaini694 – 795102Guanylate kinase-likeInterPro annotationAdd
BLAST
Domaini1556 – 1668113ZU5InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 3 PDZ (DHR) domains.UniRule annotation
Contains SH3 domain.SAAS annotation

Keywords - Domaini

SH3 domainSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00840000129793.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
3.40.50.300. 1 hit.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR005417. ZO.
IPR005418. ZO-1.
IPR000906. ZU5_dom.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 3 hits.
PF07653. SH3_2. 1 hit.
PF00791. ZU5. 1 hit.
[Graphical view]
PRINTSiPR01597. ZONOCCLUDNS.
PR01598. ZONOCCLUDNS1.
SMARTiSM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
SM00218. ZU5. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
PS51145. ZU5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G5E9E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERNTFSMDC HSKSTAMEET AIWEQHTVTL HRAPGFGFGI AISGGRDNPH
60 70 80 90 100
FQSGETSIVI SDVLKGGPAE GQLQENDRVA MVNGVSMDNV EHAFAVQQLR
110 120 130 140 150
KSGKNAKITI RRKKKVQIPV SRPDPEPVSD NEEDSYDEEI HDPRSGRSGV
160 170 180 190 200
VNRRSEKIWP RDRSASRERS LSPRSDRRSV ASSQPAKPTK VTLVKSRKNE
210 220 230 240 250
EYGLRLASHI FVKEISQDSL AARDGNIQEG DVVLKINGTV TENMSLTDAK
260 270 280 290 300
TLIERSKGKL KMVVQRDERA TLLNVPDLSD SIHSANASER DDISEIQSLA
310 320 330 340 350
SDHSGRSHDR PPRRSRSRSP DQRSEPSDHS RHSPQQPSNG SLRSRDEERI
360 370 380 390 400
SKPGAVSTPV KHADDHTPKT VEEVTVERNE KQTPSLPEPK PVYAQVGQPD
410 420 430 440 450
VDLPVSPSDG VLPNSTHEDG ILRPSMKLVK FRKGDSVGLR LAGGNDVGIF
460 470 480 490 500
VAGVLEDSPA AKEGLEEGDQ ILRVNNVDFT NIIREEAVLF LLDLPKGEEV
510 520 530 540 550
TILAQKKKDV YRRIVESDVG DSFYIRTHFE YEKESPYGLS FNKGEVFRVV
560 570 580 590 600
DTLYNGKLGS WLAIRIGKNH KEVERGIIPN KNRAEQLASV QYTLPKTAGG
610 620 630 640 650
DRADFWRFRG LRSSKRNLRK SREDLSAQPV QTKFPAYERV VLREAGFLRP
660 670 680 690 700
VTIFGPIADV AREKLAREEP DIYQIAKSEP RDAGTDQRSS GIIRLHTIKQ
710 720 730 740 750
IIDQDKHALL DVTPNAVDRL NYAQWYPIVV FLNPDSKQGV KTMRMRLCPE
760 770 780 790 800
SRKSARKLYE RSHKLRKNNH HLFTTTINLN SMNDGWYGAL KEAIQQQQNQ
810 820 830 840 850
LVWVSEGKAD GATSDDLDLH DDRLSYLSAP GSEYSMYSTD SRHTSDYEDT
860 870 880 890 900
DTEGGAYTDQ ELDETLNDEV GTPPESAITR SSEPVREDSS GMHHENQTYP
910 920 930 940 950
PYSPQAQPQP IHRIDSPGFK PASQQVYRKD PYPEEMMRQN HVLKQPAVSH
960 970 980 990 1000
PGHRPDKEPN LTYEPQLPYV EKQASRDLEQ PTYRYESSSY TDQFSRNYEH
1010 1020 1030 1040 1050
RLRYEDRVPM YEEQWSYYDD KQPYPSRPPF DNQHSQDLDS RQHPEESSER
1060 1070 1080 1090 1100
GYFPRFEEPA PLSYDSRPRY EQAPRASALR HEEQPAPGYD THGRLRPEAQ
1110 1120 1130 1140 1150
PHPSAGPKPA ESKQYFEQYS RSYEQVPPQG FTSRAGHFEP LHGAAAVPPL
1160 1170 1180 1190 1200
IPSSQHKPEA LPSNTKPLPP PPTQTEEEED PAMKPQSVLT RVKMFENKRS
1210 1220 1230 1240 1250
ASLETKKDVN DTGSFKPPEV ASKPSGAPII GPKPTSQNQF SEHDKTLYRI
1260 1270 1280 1290 1300
PEPQKPQLKP PEDIVRSNHY DPEEDEEYYR KQLSYFDRRS FENKPPAHIA
1310 1320 1330 1340 1350
ASHLSEPAKP AHSQNQSNFS SYSSKGKPPE ADGVDRSFGE KRYEPIQATP
1360 1370 1380 1390 1400
PPPPLPSQYA QPSQPVTSAS LHIHSKGAHG EGNSVSLDFQ NSLVSKPDPP
1410 1420 1430 1440 1450
PSQNKPATFR PPNREDTAQA AFYPQKSFPD KAPVNGTEQT QKTVTPAYNR
1460 1470 1480 1490 1500
FTPKPYTSSA RPFERKFESP KFNHNLLPSE TAHKPDLSSK TPTSPKTLVK
1510 1520 1530 1540 1550
SHSLAQPPEF DSGVETFSIH AEKPKYQINN ISTVPKAIPV SPSAVEEDED
1560 1570 1580 1590 1600
EDGHTVVATA RGIFNSNGGV LSSIETGVSI IIPQGAIPEG VEQEIYFKVC
1610 1620 1630 1640 1650
RDNSILPPLD KEKGETLLSP LVMCGPHGLK FLKPVELRLP HCASMTPDGW
1660 1670 1680 1690
SFALKSSDSS SGDPKTWQNK CLPGDPNYLV GANCVSVLID HF
Length:1,692
Mass (Da):189,676
Last modified:December 14, 2011 - v1
Checksum:iA425468CB02037DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022613 Genomic DNA. No translation available.
AC087455 Genomic DNA. No translation available.
AC243587 Genomic DNA. No translation available.
AC244165 Genomic DNA. No translation available.
KF511213 Genomic DNA. No translation available.
CH471205 Genomic DNA. Translation: EAW51510.1.
RefSeqiNP_001287955.1. NM_001301026.1.
UniGeneiHs.743990.

Genome annotation databases

EnsembliENST00000400011; ENSP00000382890; ENSG00000104067.
ENST00000612628; ENSP00000482697; ENSG00000277401.
GeneIDi7082.
UCSCiuc001zcq.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022613 Genomic DNA. No translation available.
AC087455 Genomic DNA. No translation available.
AC243587 Genomic DNA. No translation available.
AC244165 Genomic DNA. No translation available.
KF511213 Genomic DNA. No translation available.
CH471205 Genomic DNA. Translation: EAW51510.1.
RefSeqiNP_001287955.1. NM_001301026.1.
UniGeneiHs.743990.

3D structure databases

SMRiG5E9E7. Positions 22-114, 189-268, 424-806, 1553-1692.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiG5E9E7.
MaxQBiG5E9E7.
PeptideAtlasiG5E9E7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400011; ENSP00000382890; ENSG00000104067.
ENST00000612628; ENSP00000482697; ENSG00000277401.
GeneIDi7082.
UCSCiuc001zcq.4. human.

Organism-specific databases

CTDi7082.
HGNCiHGNC:11827. TJP1.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00840000129793.

Miscellaneous databases

ChiTaRSiTJP1. human.
GenomeRNAii7082.

Gene expression databases

BgeeiENSG00000104067.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
3.40.50.300. 1 hit.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR005417. ZO.
IPR005418. ZO-1.
IPR000906. ZU5_dom.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 3 hits.
PF07653. SH3_2. 1 hit.
PF00791. ZU5. 1 hit.
[Graphical view]
PRINTSiPR01597. ZONOCCLUDNS.
PR01598. ZONOCCLUDNS1.
SMARTiSM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
SM00218. ZU5. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
PS51145. ZU5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG5E9E7_HUMAN
AccessioniPrimary (citable) accession number: G5E9E7
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: September 7, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.