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Protein
Submitted name:

Tight junction protein 1 (Zona occludens 1), isoform CRA_e

Gene

TJP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Tight junction protein 1 (Zona occludens 1), isoform CRA_eImported
Submitted name:
Tight junction protein ZO-1Imported
Gene namesi
Name:TJP1Imported
ORF Names:hCG_27621Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000104067.16
HGNCiHGNC:11827 TJP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104067

PTM / Processingi

Proteomic databases

MaxQBiG5E9E7
PeptideAtlasiG5E9E7
PRIDEiG5E9E7

Expressioni

Gene expression databases

BgeeiENSG00000104067
ExpressionAtlasiG5E9E7 baseline and differential

Structurei

3D structure databases

SMRiG5E9E7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 114PDZInterPro annotationAdd BLAST88
Domaini190 – 268PDZInterPro annotationAdd BLAST79
Domaini425 – 506PDZInterPro annotationAdd BLAST82
Domaini520 – 588SH3InterPro annotationAdd BLAST69
Domaini694 – 795Guanylate kinase-likeInterPro annotationAdd BLAST102
Domaini1558 – 1692ZU5InterPro annotationAdd BLAST135

Sequence similaritiesi

Belongs to the MAGUK family.SAAS annotation

Keywords - Domaini

SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118866

Family and domain databases

CDDicd12026 SH3_ZO-1, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR005417 ZO
IPR005418 ZO-1
IPR035597 ZO-1_SH3
IPR000906 ZU5_dom
PANTHERiPTHR13865:SF25 PTHR13865:SF25, 2 hits
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 3 hits
PF07653 SH3_2, 1 hit
PF00791 ZU5, 1 hit
PRINTSiPR01597 ZONOCCLUDNS
PR01598 ZONOCCLUDNS1
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 3 hits
SM00218 ZU5, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 3 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 3 hits
PS50002 SH3, 1 hit
PS51145 ZU5, 1 hit

Sequencei

Sequence statusi: Complete.

G5E9E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERNTFSMDC HSKSTAMEET AIWEQHTVTL HRAPGFGFGI AISGGRDNPH
60 70 80 90 100
FQSGETSIVI SDVLKGGPAE GQLQENDRVA MVNGVSMDNV EHAFAVQQLR
110 120 130 140 150
KSGKNAKITI RRKKKVQIPV SRPDPEPVSD NEEDSYDEEI HDPRSGRSGV
160 170 180 190 200
VNRRSEKIWP RDRSASRERS LSPRSDRRSV ASSQPAKPTK VTLVKSRKNE
210 220 230 240 250
EYGLRLASHI FVKEISQDSL AARDGNIQEG DVVLKINGTV TENMSLTDAK
260 270 280 290 300
TLIERSKGKL KMVVQRDERA TLLNVPDLSD SIHSANASER DDISEIQSLA
310 320 330 340 350
SDHSGRSHDR PPRRSRSRSP DQRSEPSDHS RHSPQQPSNG SLRSRDEERI
360 370 380 390 400
SKPGAVSTPV KHADDHTPKT VEEVTVERNE KQTPSLPEPK PVYAQVGQPD
410 420 430 440 450
VDLPVSPSDG VLPNSTHEDG ILRPSMKLVK FRKGDSVGLR LAGGNDVGIF
460 470 480 490 500
VAGVLEDSPA AKEGLEEGDQ ILRVNNVDFT NIIREEAVLF LLDLPKGEEV
510 520 530 540 550
TILAQKKKDV YRRIVESDVG DSFYIRTHFE YEKESPYGLS FNKGEVFRVV
560 570 580 590 600
DTLYNGKLGS WLAIRIGKNH KEVERGIIPN KNRAEQLASV QYTLPKTAGG
610 620 630 640 650
DRADFWRFRG LRSSKRNLRK SREDLSAQPV QTKFPAYERV VLREAGFLRP
660 670 680 690 700
VTIFGPIADV AREKLAREEP DIYQIAKSEP RDAGTDQRSS GIIRLHTIKQ
710 720 730 740 750
IIDQDKHALL DVTPNAVDRL NYAQWYPIVV FLNPDSKQGV KTMRMRLCPE
760 770 780 790 800
SRKSARKLYE RSHKLRKNNH HLFTTTINLN SMNDGWYGAL KEAIQQQQNQ
810 820 830 840 850
LVWVSEGKAD GATSDDLDLH DDRLSYLSAP GSEYSMYSTD SRHTSDYEDT
860 870 880 890 900
DTEGGAYTDQ ELDETLNDEV GTPPESAITR SSEPVREDSS GMHHENQTYP
910 920 930 940 950
PYSPQAQPQP IHRIDSPGFK PASQQVYRKD PYPEEMMRQN HVLKQPAVSH
960 970 980 990 1000
PGHRPDKEPN LTYEPQLPYV EKQASRDLEQ PTYRYESSSY TDQFSRNYEH
1010 1020 1030 1040 1050
RLRYEDRVPM YEEQWSYYDD KQPYPSRPPF DNQHSQDLDS RQHPEESSER
1060 1070 1080 1090 1100
GYFPRFEEPA PLSYDSRPRY EQAPRASALR HEEQPAPGYD THGRLRPEAQ
1110 1120 1130 1140 1150
PHPSAGPKPA ESKQYFEQYS RSYEQVPPQG FTSRAGHFEP LHGAAAVPPL
1160 1170 1180 1190 1200
IPSSQHKPEA LPSNTKPLPP PPTQTEEEED PAMKPQSVLT RVKMFENKRS
1210 1220 1230 1240 1250
ASLETKKDVN DTGSFKPPEV ASKPSGAPII GPKPTSQNQF SEHDKTLYRI
1260 1270 1280 1290 1300
PEPQKPQLKP PEDIVRSNHY DPEEDEEYYR KQLSYFDRRS FENKPPAHIA
1310 1320 1330 1340 1350
ASHLSEPAKP AHSQNQSNFS SYSSKGKPPE ADGVDRSFGE KRYEPIQATP
1360 1370 1380 1390 1400
PPPPLPSQYA QPSQPVTSAS LHIHSKGAHG EGNSVSLDFQ NSLVSKPDPP
1410 1420 1430 1440 1450
PSQNKPATFR PPNREDTAQA AFYPQKSFPD KAPVNGTEQT QKTVTPAYNR
1460 1470 1480 1490 1500
FTPKPYTSSA RPFERKFESP KFNHNLLPSE TAHKPDLSSK TPTSPKTLVK
1510 1520 1530 1540 1550
SHSLAQPPEF DSGVETFSIH AEKPKYQINN ISTVPKAIPV SPSAVEEDED
1560 1570 1580 1590 1600
EDGHTVVATA RGIFNSNGGV LSSIETGVSI IIPQGAIPEG VEQEIYFKVC
1610 1620 1630 1640 1650
RDNSILPPLD KEKGETLLSP LVMCGPHGLK FLKPVELRLP HCASMTPDGW
1660 1670 1680 1690
SFALKSSDSS SGDPKTWQNK CLPGDPNYLV GANCVSVLID HF
Length:1,692
Mass (Da):189,676
Last modified:December 14, 2011 - v1
Checksum:iA425468CB02037DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022613 Genomic DNA No translation available.
AC087455 Genomic DNA No translation available.
AC243587 Genomic DNA No translation available.
AC244165 Genomic DNA No translation available.
KF511213 Genomic DNA No translation available.
CH471205 Genomic DNA Translation: EAW51510.1
RefSeqiNP_001287955.1, NM_001301026.1
UniGeneiHs.743990

Genome annotation databases

EnsembliENST00000400011; ENSP00000382890; ENSG00000104067
ENST00000612628; ENSP00000482697; ENSG00000277401
GeneIDi7082
UCSCiuc001zcq.4 human

Similar proteinsi

Entry informationi

Entry nameiG5E9E7_HUMAN
AccessioniPrimary (citable) accession number: G5E9E7
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health