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Protein
Submitted name:

Lamina-associated polypeptide 2, isoforms beta/gamma

Gene

TMPO

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Lamina-associated polypeptide 2, isoforms beta/gammaImported
Submitted name:
Thymopoietin, isoform CRA_dImported
Gene namesi
Name:TMPOImported
ORF Names:hCG_2015322Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:11875. TMPO.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei373 – 394HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000120802.

Expressioni

Gene expression databases

BgeeiENSG00000120802.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000266732.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 48LEM-likeInterPro annotationAdd BLAST44
Domaini109 – 153LEMInterPro annotationAdd BLAST45

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IT7C. Eukaryota.
ENOG4111J0N. LUCA.
GeneTreeiENSGT00510000048934.

Family and domain databases

Gene3Di1.10.720.40. 1 hit.
InterProiView protein in InterPro
IPR013146. LEM-like_dom.
IPR011015. LEM/LEM-like_dom.
IPR003887. LEM_dom.
PfamiView protein in Pfam
PF03020. LEM. 1 hit.
PF08198. Thymopoietin. 1 hit.
SMARTiView protein in SMART
SM00540. LEM. 1 hit.
SM01261. Thymopoietin. 1 hit.
SUPFAMiSSF63451. SSF63451. 2 hits.
PROSITEiView protein in PROSITE
PS50954. LEM. 1 hit.
PS50955. LEM_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

G5E972-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEFLEDPSV LTKDKLKSEL VANNVTLPAG EQRKDVYVQL YLQHLTARNR
60 70 80 90 100
PPLPAGTNSK GPPDFSSDEE REPTPVLGSG AAAAGRSRAA VGRKATKKTD
110 120 130 140 150
KPRQEDKDDL DVTELTNEDL LDQLVKYGVN PGPIVGTTRK LYEKKLLKLR
160 170 180 190 200
EQGTESRSST PLPTISSSAE NTRQNGSNDS DRYSDNEEDS KIELKLEKRE
210 220 230 240 250
PLKGRAKTPV TLKQRRVEHN QVETSEHFRI DGPVISESTP IAETIMASSN
260 270 280 290 300
ESLVVNRVTG NFKHASPILP ITEFSDIPRR APKKPLTRAE VGEKTEERRV
310 320 330 340 350
ERDILKEMFP YEASTPTGIS ASCRRPIKGA AGRPLELSDF RMEESFSSKY
360 370 380 390 400
VPKYVPLADV KSEKTKKGRS IPVWIKILLF VVVAVFLFLV YQAMETNQVN
410
PFSNFLHVDP RKSN
Length:414
Mass (Da):46,306
Last modified:December 14, 2011 - v1
Checksum:iD36CC78A5EEE7679
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013418 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97592.1.
RefSeqiNP_001294904.1. NM_001307975.1.
UniGeneiHs.11355.

Genome annotation databases

EnsembliENST00000343315; ENSP00000340251; ENSG00000120802.
GeneIDi7112.
UCSCiuc058scd.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013418 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97592.1.
RefSeqiNP_001294904.1. NM_001307975.1.
UniGeneiHs.11355.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000266732.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343315; ENSP00000340251; ENSG00000120802.
GeneIDi7112.
UCSCiuc058scd.1. human.

Organism-specific databases

CTDi7112.
HGNCiHGNC:11875. TMPO.
OpenTargetsiENSG00000120802.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IT7C. Eukaryota.
ENOG4111J0N. LUCA.
GeneTreeiENSGT00510000048934.

Miscellaneous databases

ChiTaRSiTMPO. human.
GenomeRNAii7112.

Gene expression databases

BgeeiENSG00000120802.

Family and domain databases

Gene3Di1.10.720.40. 1 hit.
InterProiView protein in InterPro
IPR013146. LEM-like_dom.
IPR011015. LEM/LEM-like_dom.
IPR003887. LEM_dom.
PfamiView protein in Pfam
PF03020. LEM. 1 hit.
PF08198. Thymopoietin. 1 hit.
SMARTiView protein in SMART
SM00540. LEM. 1 hit.
SM01261. Thymopoietin. 1 hit.
SUPFAMiSSF63451. SSF63451. 2 hits.
PROSITEiView protein in PROSITE
PS50954. LEM. 1 hit.
PS50955. LEM_LIKE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiG5E972_HUMAN
AccessioniPrimary (citable) accession number: G5E972
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: April 12, 2017
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.