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Protein
Submitted name:

Sema domain, transmembrane domain (TM), and cytoplasmic domain, (Semaphorin) 6C, isoform CRA_a

Gene

Sema6c

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • chemorepellent activity Source: GO_Central
  • semaphorin receptor binding Source: MGI

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Sema domain, transmembrane domain (TM), and cytoplasmic domain, (Semaphorin) 6C, isoform CRA_aImported
Submitted name:
Semaphorin-6CImported
Gene namesi
Name:Sema6cImported
ORF Names:mCG_13711Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1338032. Sema6c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei598 – 62225HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 923898Sequence analysisPRO_5005915347Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 477447SemaInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains Sema domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00760000119134.
TreeFamiTF316102.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015514. Semaphorin_6C.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 2 hits.
PTHR11036:SF11. PTHR11036:SF11. 2 hits.
PfamiPF01403. Sema. 2 hits.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G5E8N4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRAPHSMPL LLLLLLLSSL PQAQAAFPQD PTPLLTSDLQ GASPSSWFRG
60 70 80 90 100
LEDDAVAAEL GLDFQRFLTL NRTLLVAARD HVFSFDLQAQ EEGEGLVPNK
110 120 130 140 150
FLTWRSQDME NCAVRGKLTD ECYNYIRVLV PWNSQTLLAC GTNSFSPMCR
160 170 180 190 200
SYGITSLQQE GEELSGQARC PFDATQSTVA IFAEPHFVYA LEHGEHVYFF
210 220 230 240 250
FREVSVEDAR LGRVQFSRVA RVCKRDMGGS PRALDRHWTS FLKLRLNCSV
260 270 280 290 300
PGDSTFYFDV LQSLTGPVNL HGRSALFGVF TTQTNSIPGS AVCAFYLDDI
310 320 330 340 350
ERGFEGKFKE QRSLDGAWTP VSEDKVPSPR PGSCAGVGAA ASFSSSQDLP
360 370 380 390 400
DDVLLFIKAH PLLDPAVPPA THQPLLTLTS RALLTQVAVD GMAGPHRNTT
410 420 430 440 450
VLFLGSNDGT VLKVLPPGGQ SLGSEPIVLE EIDAYSHARC SGKRSPRAAR
460 470 480 490 500
RIIGLELDTE GHRLFVAFPG CIVYLSLSRC ARHGACQRSC LASLDPYCGW
510 520 530 540 550
HRSRGCMSIR GPGGTDVDLT GNQESTEHGD CQDGATGSQS GPGDSAYVLL
560 570 580 590 600
GPGPSPETPS SPSDAQQGPQ SSTLGAHTQG VRRDLSPASA SRSIPIPLLL
610 620 630 640 650
ACVAAAFALG ASVSGLLVSC ACRRANRRRS KDIETPGLPR PLSLRSLARL
660 670 680 690 700
HGGGPEPPPP PKDGDAAQTP QLYTTFLPPP DGGSPPELAC LPTPETTPEL
710 720 730 740 750
PVKHLRASGG PWEWNQNGNN ASEGPGRPPR GCSGAGGPAP RVLVRPPPPG
760 770 780 790 800
CPGQAVEVTT LEELLRYLHG PQPPRKGSEP LASAPFTSRP PASEPGASLF
810 820 830 840 850
VDSSPMPRDG VPPLRLDVPP EGKRAAPSGR PALSAPAPRL GVGGSRRLPF
860 870 880 890 900
PTHRAPPGLL TRVPSGGPAR YSGGPGRHLL YLGRPEGHRG RSLKRVDVKS
910 920
PLSPKPPLAS PPQPAPHGGH FNF
Length:923
Mass (Da):98,264
Last modified:December 14, 2011 - v1
Checksum:i1B081DD77BE428E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131769 Genomic DNA. No translation available.
AC140190 Genomic DNA. No translation available.
CH466620 Genomic DNA. Translation: EDL38780.1.
UniGeneiMm.23662.

Genome annotation databases

EnsembliENSMUST00000107217; ENSMUSP00000102835; ENSMUSG00000038777.
UCSCiuc008qil.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131769 Genomic DNA. No translation available.
AC140190 Genomic DNA. No translation available.
CH466620 Genomic DNA. Translation: EDL38780.1.
UniGeneiMm.23662.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107217; ENSMUSP00000102835; ENSMUSG00000038777.
UCSCiuc008qil.2. mouse.

Organism-specific databases

MGIiMGI:1338032. Sema6c.

Phylogenomic databases

GeneTreeiENSGT00760000119134.
TreeFamiTF316102.

Miscellaneous databases

NextBioi35561218.
SOURCEiSearch...

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015514. Semaphorin_6C.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 2 hits.
PTHR11036:SF11. PTHR11036:SF11. 2 hits.
PfamiPF01403. Sema. 2 hits.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (OCT-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiG5E8N4_MOUSE
AccessioniPrimary (citable) accession number: G5E8N4
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: January 20, 2016
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.