Setdb1

Functionⁱ

Catalytic activityⁱ

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N₆-methyl-L-lysine-[histone].PROSITE-ProRule annotationSAAS annotation

GO - Molecular functionⁱ

DNA binding Source: InterPro
histone-lysine N-methyltransferase activity Source: UniProtKB-UniRule
zinc ion binding Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	MethyltransferasePROSITE-ProRule annotationSAAS annotation, Transferase
Ligand	S-adenosyl-L-methioninePROSITE-ProRule annotationSAAS annotation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3214841. PKMTs methylate histone lysines.

Reactomeⁱ

R-MMU-3214841. PKMTs methylate histone lysines.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesⁱ	Name:Setdb1Imported ORF Names:mCG_16729Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 3

Organism-specific databases

MGIⁱ	MGI:1934229. Setdb1.

Subcellular locationⁱ

Chromosome
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00563877

Nucleus
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00574581

GO - Cellular componentⁱ

chromosome Source: UniProtKB-SubCell
nucleus Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

ChromosomeSAAS annotation, NucleusSAAS annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000015697.

Bgeeⁱ

ENSMUSG00000015697.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	611 – 682	MBD (methyl-CpG-binding)InterPro annotationAdd BLAST	72
Domainⁱ	744 – 817	Pre-SETInterPro annotationAdd BLAST	74
Domainⁱ	820 – 1282	SETInterPro annotationAdd BLAST	463
Domainⁱ	1291 – 1307	Post-SETInterPro annotationAdd BLAST	17

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	37 – 64	Sequence analysisAdd BLAST		28

Sequence similaritiesⁱ

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG1141. Eukaryota. COG2940. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00780000121845.

Family and domain databases

InterProⁱ	View protein in InterPro IPR016177. DNA-bd_dom. IPR025796. Hist-Lys_N-MeTrfase_SETDB1. IPR001739. Methyl_CpG_DNA-bd. IPR003616. Post-SET_dom. IPR007728. Pre-SET_dom. IPR001214. SET_dom. IPR002999. Tudor.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01429. MBD. 1 hit. PF05033. Pre-SET. 1 hit. PF00856. SET. 1 hit.
SMARTⁱ	View protein in SMART SM00391. MBD. 1 hit. SM00468. PreSET. 1 hit. SM00317. SET. 1 hit. SM00333. TUDOR. 2 hits.
SUPFAMⁱ	SSF54171. SSF54171. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50982. MBD. 1 hit. PS50868. POST_SET. 1 hit. PS50867. PRE_SET. 1 hit. PS51573. SAM_MT43_SUVAR39_1. 1 hit. PS50280. SET. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

G5E8N3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSLPGCMSL AAAPAAADSA EIAELQQAVV EELGISMEEL RQYIDEELEK 
        60         70         80         90        100
MDCIQQRKKQ LAELETWVLQ KESEVAYVDR LFDDASREVT NCESLVKDFY 
       110        120        130        140        150
SKLGLQYHDS SSEDEASRPT EIIEIPDEDD DVLSIDSGDA GSRTPKDQKL 
       160        170        180        190        200
REAMAALRKS AQDVQKFMDA VNKKSSSQDL HKGTLGQVSG ELSKDGDLIV 
       210        220        230        240        250
SMRILGKKRT KTWHKGTLIA IQTVGLGKKY KVKFDNKGKS LLSGNHIAYD 
       260        270        280        290        300
YHPPADKLFV GSRVVAKYKD GNQVWLYAGI VAETPNVKNK LRFLIFFDDG 
       310        320        330        340        350
YASYVTQSEL YPICRPLKKT WEDIEDSSCR DFIEEYITAY PNRPMVLLKS 
       360        370        380        390        400
GQLIKTEWEG TWWKSRVEEV DGSLVRILFL DDKRCEWIYR GSTRLEPMFS 
       410        420        430        440        450
MKTSSASAME KKQGGQLRTR PNMGAVRSKG PVVQYTQDLT GTGIQFKPME 
       460        470        480        490        500
PLQPIAPPAP LPIPPLSPQA ADTDLESQLA QSRKQVAKKS TSFRPGSVGS 
       510        520        530        540        550
GHSSPTSSTL SENVSAGKLG INQTYRSPLA SVTSTPASAA PPVPPVPPGP 
       560        570        580        590        600
PTPPGPPAPP GPLAPPAFHG MLERAPAEPS YRAPMEKLFY LPHVCSYTCL 
       610        620        630        640        650
SRIRPMRNEQ YRGKNPLLVP LLYDFRRMTA RRRVNRKMGF HVIYKTPCGL 
       660        670        680        690        700
CLRTMQEIER YLFETGCDFL FLEMFCLDPY VLVDRKFQPF KPFYYILDIT 
       710        720        730        740        750
YGKEDVPLSC VNEIDTTPPP QVAYSKERIP GKGVFINTGP EFLVGCDCKD 
       760        770        780        790        800
GCRDKSKCAC HQLTIQATAC TPGGQVNPNS GYQYKRLEEC LPTGVYECNK 
       810        820        830        840        850
RCNCDPNMCT NRLVQHGLQV RLQLFKTQNK GWGIRCLDDI AKGSFVCIYA 
       860        870        880        890        900
GKILTDDFAD KEGLEMGDEY FANLDHIESV ENFKEGYESD VPTSSDSSGV 
       910        920        930        940        950
DMKDQEDGNS GSEDPEESND DSSDDNFCKD EDFSTSSVWR SYATRRQTRG 
       960        970        980        990       1000
QKENELSEMT SKDSRPPDLG PPHVPIPSSV SVGGCNPPSS EETPKNKVAS 
      1010       1020       1030       1040       1050
WLSCNSVSEG GFADSDSRSS FKTSEGGDGR AGGGRGEAER ASTSGLSFKD 
      1060       1070       1080       1090       1100
EGDNKQPKKE DPENRNKMPV VTEGSQNHGH NPPMKSEGLR RSASKMSVLQ 
      1110       1120       1130       1140       1150
SQRVVTSTQS NPDDILTLSS STESEGESGT SRKPTAGHTS ATAVDSDDIQ 
      1160       1170       1180       1190       1200
TISSGSDGDD FEDKKNLSGP TKRQVAVKST RGFALKSTHG IAIKSTNMAS 
      1210       1220       1230       1240       1250
VDKGESAPVR KNTRQFYDGE ESCYIIDAKL EGNLGRYLNH SCSPNLFVQN 
      1260       1270       1280       1290       1300
VFVDTHDLRF PWVAFFASKR IRAGTELTWD YNYEVGSVEG KELLCCCGAI 

ECRGRLL

Length:1,307

Mass (Da):144,539

Last modified:December 14, 2011 - v1

Checksum:ⁱ6397C183402DB6F3

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC092202 Genomic DNA. No translation available. CH466620 Genomic DNA. Translation: EDL38807.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001157114.1. NM_001163642.1.
UniGeneⁱ	Mm.490259.

Genome annotation databases

Ensemblⁱ	ENSMUST00000107171; ENSMUSP00000102789; ENSMUSG00000015697.
GeneIDⁱ	84505.
UCSC genome browser More...UCSCⁱ	uc008qjn.2. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC092202 Genomic DNA. No translation available. CH466620 Genomic DNA. Translation: EDL38807.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001157114.1. NM_001163642.1.
UniGeneⁱ	Mm.490259.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000107171; ENSMUSP00000102789; ENSMUSG00000015697.
GeneIDⁱ	84505.
UCSC genome browser More...UCSCⁱ	uc008qjn.2. mouse.

Organism-specific databases

CTDⁱ	9869.
MGIⁱ	MGI:1934229. Setdb1.

Phylogenomic databases

eggNOGⁱ	KOG1141. Eukaryota. COG2940. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00780000121845.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3214841. PKMTs methylate histone lysines.

Reactomeⁱ

R-MMU-3214841. PKMTs methylate histone lysines.

Miscellaneous databases

ChiTaRSⁱ	Setdb1. mouse.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000015697.

Bgeeⁱ

ENSMUSG00000015697.

Family and domain databases

InterProⁱ	View protein in InterPro IPR016177. DNA-bd_dom. IPR025796. Hist-Lys_N-MeTrfase_SETDB1. IPR001739. Methyl_CpG_DNA-bd. IPR003616. Post-SET_dom. IPR007728. Pre-SET_dom. IPR001214. SET_dom. IPR002999. Tudor.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01429. MBD. 1 hit. PF05033. Pre-SET. 1 hit. PF00856. SET. 1 hit.
SMARTⁱ	View protein in SMART SM00391. MBD. 1 hit. SM00468. PreSET. 1 hit. SM00317. SET. 1 hit. SM00333. TUDOR. 2 hits.
SUPFAMⁱ	SSF54171. SSF54171. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50982. MBD. 1 hit. PS50868. POST_SET. 1 hit. PS50867. PRE_SET. 1 hit. PS51573. SAM_MT43_SUVAR39_1. 1 hit. PS50280. SET. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	G5E8N3_MOUSE
Accessionⁱ	G5E8N3Primary (citable) accession number: G5E8N3
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	December 14, 2011
	Last sequence update:	December 14, 2011
	Last modified:	July 5, 2017
	This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - G5E8N3 (G5E8N3_MOUSE)

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Histone-lysine N-methyltransferase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Expressionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ