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Protein

Integrin beta

Gene

Itgb5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinUniRule annotationSAAS annotationImported
Biological processCell adhesionUniRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-1236973. Cross-presentation of particulate exogenous antigens (phagosomes).
R-MMU-2129379. Molecules associated with elastic fibres.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-3000170. Syndecan interactions.
R-MMU-3000178. ECM proteoglycans.
R-MMU-445355. Smooth Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin betaUniRule annotation
Gene namesi
Name:Itgb5Imported
ORF Names:mCG_127131Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:96614. Itgb5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei720 – 742HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_501109124425 – 816Integrin betaSequence analysisAdd BLAST792

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 46UniRule annotation
Disulfide bondi39 ↔ 75UniRule annotation
Disulfide bondi49 ↔ 64UniRule annotation
Disulfide bondi202 ↔ 211UniRule annotation
Disulfide bondi259 ↔ 300UniRule annotation
Disulfide bondi401 ↔ 413UniRule annotation
Disulfide bondi433 ↔ 682UniRule annotation
Disulfide bondi461 ↔ 465UniRule annotation
Disulfide bondi484 ↔ 522UniRule annotation
Disulfide bondi489 ↔ 498UniRule annotation
Disulfide bondi500 ↔ 513UniRule annotation
Disulfide bondi528 ↔ 533UniRule annotation
Disulfide bondi530 ↔ 563UniRule annotation
Disulfide bondi535 ↔ 548UniRule annotation
Disulfide bondi550 ↔ 555UniRule annotation
Disulfide bondi569 ↔ 574UniRule annotation
Disulfide bondi571 ↔ 602UniRule annotation
Disulfide bondi576 ↔ 585UniRule annotation
Disulfide bondi608 ↔ 613UniRule annotation
Disulfide bondi610 ↔ 657UniRule annotation
Disulfide bondi615 ↔ 625UniRule annotation
Disulfide bondi628 ↔ 631UniRule annotation
Disulfide bondi635 ↔ 644UniRule annotation
Disulfide bondi641 ↔ 714UniRule annotation
Disulfide bondi661 ↔ 690UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000022817.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 76PSIInterPro annotationAdd BLAST50
Domaini35 – 463INBInterPro annotationAdd BLAST429
Domaini137 – 372VWFAInterPro annotationAdd BLAST236
Domaini635 – 719Integrin_B_tailInterPro annotationAdd BLAST85

Sequence similaritiesi

Belongs to the integrin beta chain family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
OMAiPDACSTK.
OrthoDBiEOG091G029W.
TreeFamiTF105392.

Family and domain databases

Gene3Di1.20.5.100. 1 hit.
1.20.5.630. 1 hit.
InterProiView protein in InterPro
IPR021157. Cyt_c1_TM_anchor_C.
IPR027067. Integrin_beta-5.
IPR033760. Integrin_beta_N.
IPR015812. Integrin_bsu.
IPR037076. Integrin_bsu_cyt_dom_sf.
IPR012896. Integrin_bsu_tail.
IPR036349. Integrin_bsu_tail_dom_sf.
IPR002369. Integrin_bsu_VWA.
IPR032695. Integrin_dom.
IPR016201. PSI.
IPR002035. VWF_A.
IPR036465. vWFA_dom_sf.
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF26. PTHR10082:SF26. 1 hit.
PfamiView protein in Pfam
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
PF17205. PSI_integrin. 1 hit.
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiView protein in SMART
SM00187. INB. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 1 hit.
SSF69687. SSF69687. 1 hit.

Sequencei

Sequence statusi: Complete.

G5E8F8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRVPATLYA CLLGLCALVP RLAGLNICTS GSATSCEECL LIHPKCAWCS
60 70 80 90 100
KEYFGNPRSI TSRCDLKANL IRNGCEGEIE SPASSTHVLR NLPLSSKGSS
110 120 130 140 150
ATGSDVIQMT PQEIAVSLRP GEQTTFQLQV RQVEDYPVDL YYLMDLSLSM
160 170 180 190 200
KDDLENIRSL GTKLAEEMRK LTSNFRLGFG SFVDKDISPF SYTAPRYQTN
210 220 230 240 250
PCIGYKLFPN CVPSFGFRHL LPLTDRVDSF NEEVRKQRVS RNRDAPEGGF
260 270 280 290 300
DAVLQAAVCK EKIGWRKDAL HLLVFTTDDV PHIALDGKLG GLVQPHDGQC
310 320 330 340 350
HLNEANEYTA SNQMDYPSLA LLGEKLAENN INLIFAVTKN HYMLYKNFTA
360 370 380 390 400
LIPGTTVEIL HGDSKNIIQL IINAYSSIRA KVELSVWDQP EDLNLFFTAT
410 420 430 440 450
CQDGISYPGQ RKCEGLKIGD TASFEVSVEA RSCPGRQAAQ SFTLRPVGFR
460 470 480 490 500
DSLQVEVAYN CTCGCSTGLE PNSARCSGNG TYTCGLCECD PGYLGTRCEC
510 520 530 540 550
QEGENQSGYQ NLCREAEGKP LCSGRGECSC NQCSCFESEF GRIYGPFCEC
560 570 580 590 600
DSFSCARNKG VLCSGHGECH CGECKCHAGY IGDNCNCSTD VSTCRAKDGQ
610 620 630 640 650
ICSDRGRCVC GQCQCTEPGA FGETCEKCPT CPDACSSKRD CVECLLLHQG
660 670 680 690 700
KPDNQTCHHQ CKDEVITWVD TIVKDDQEAV LCFYKTAKDC VMMFSYTELP
710 720 730 740 750
NGRSNLTVLR EPECGSAPNA MTILLAVVGS ILLIGMALLA IWKLLVTIHD
760 770 780 790 800
RREFAKFQSL KPPVQKAHLH THCRFRLQQV QQILQWLSGL RLLDGWRGTK
810
DEDSGVPWTS WTICSR
Length:816
Mass (Da):90,063
Last modified:December 14, 2011 - v1
Checksum:iC4784C3738970717
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC155268 Genomic DNA. No translation available.
AC165079 Genomic DNA. No translation available.
CH466521 Genomic DNA. Translation: EDK97856.1.
RefSeqiNP_034710.2. NM_010580.2.
UniGeneiMm.6424.

Genome annotation databases

EnsembliENSMUST00000069345; ENSMUSP00000069416; ENSMUSG00000022817.
GeneIDi16419.
UCSCiuc007zan.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiG5E8F8_MOUSE
AccessioniPrimary (citable) accession number: G5E8F8
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: October 25, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported