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Protein

Integrin beta

Gene

Itgb5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IntegrinUniRule annotationSAAS annotationImported

Keywords - Biological processi

Cell adhesionUniRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-1236973. Cross-presentation of particulate exogenous antigens (phagosomes).
R-MMU-2129379. Molecules associated with elastic fibres.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-3000170. Syndecan interactions.
R-MMU-3000178. ECM proteoglycans.
R-MMU-445355. Smooth Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin betaUniRule annotation
Gene namesi
Name:Itgb5Imported
ORF Names:mCG_127131Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:96614. Itgb5.

Subcellular locationi

  • Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei720 – 742HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500876227625 – 816Integrin betaSequence analysisAdd BLAST792

Expressioni

Gene expression databases

BgeeiENSMUSG00000022817.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069416.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 76PSIInterPro annotationAdd BLAST50
Domaini35 – 463INBInterPro annotationAdd BLAST429
Domaini137 – 372VWFAInterPro annotationAdd BLAST236
Domaini635 – 719Integrin_B_tailInterPro annotationAdd BLAST85

Sequence similaritiesi

Belongs to the integrin beta chain family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
OMAiPDACSTK.
OrthoDBiEOG091G029W.
TreeFamiTF105392.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR033760. Integin_beta_N.
IPR027067. Integrin_beta-5.
IPR015812. Integrin_bsu.
IPR012896. Integrin_bsu_tail.
IPR002369. Integrin_bsu_VWA.
IPR032695. Integrin_dom.
IPR016201. PSI.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF26. PTHR10082:SF26. 1 hit.
PfamiPF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
PF17205. PSI_integrin. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 1 hit.
SSF69687. SSF69687. 1 hit.

Sequencei

Sequence statusi: Complete.

G5E8F8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRVPATLYA CLLGLCALVP RLAGLNICTS GSATSCEECL LIHPKCAWCS
60 70 80 90 100
KEYFGNPRSI TSRCDLKANL IRNGCEGEIE SPASSTHVLR NLPLSSKGSS
110 120 130 140 150
ATGSDVIQMT PQEIAVSLRP GEQTTFQLQV RQVEDYPVDL YYLMDLSLSM
160 170 180 190 200
KDDLENIRSL GTKLAEEMRK LTSNFRLGFG SFVDKDISPF SYTAPRYQTN
210 220 230 240 250
PCIGYKLFPN CVPSFGFRHL LPLTDRVDSF NEEVRKQRVS RNRDAPEGGF
260 270 280 290 300
DAVLQAAVCK EKIGWRKDAL HLLVFTTDDV PHIALDGKLG GLVQPHDGQC
310 320 330 340 350
HLNEANEYTA SNQMDYPSLA LLGEKLAENN INLIFAVTKN HYMLYKNFTA
360 370 380 390 400
LIPGTTVEIL HGDSKNIIQL IINAYSSIRA KVELSVWDQP EDLNLFFTAT
410 420 430 440 450
CQDGISYPGQ RKCEGLKIGD TASFEVSVEA RSCPGRQAAQ SFTLRPVGFR
460 470 480 490 500
DSLQVEVAYN CTCGCSTGLE PNSARCSGNG TYTCGLCECD PGYLGTRCEC
510 520 530 540 550
QEGENQSGYQ NLCREAEGKP LCSGRGECSC NQCSCFESEF GRIYGPFCEC
560 570 580 590 600
DSFSCARNKG VLCSGHGECH CGECKCHAGY IGDNCNCSTD VSTCRAKDGQ
610 620 630 640 650
ICSDRGRCVC GQCQCTEPGA FGETCEKCPT CPDACSSKRD CVECLLLHQG
660 670 680 690 700
KPDNQTCHHQ CKDEVITWVD TIVKDDQEAV LCFYKTAKDC VMMFSYTELP
710 720 730 740 750
NGRSNLTVLR EPECGSAPNA MTILLAVVGS ILLIGMALLA IWKLLVTIHD
760 770 780 790 800
RREFAKFQSL KPPVQKAHLH THCRFRLQQV QQILQWLSGL RLLDGWRGTK
810
DEDSGVPWTS WTICSR
Length:816
Mass (Da):90,063
Last modified:December 14, 2011 - v1
Checksum:iC4784C3738970717
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC155268 Genomic DNA. No translation available.
AC165079 Genomic DNA. No translation available.
CH466521 Genomic DNA. Translation: EDK97856.1.
RefSeqiNP_034710.2. NM_010580.2.
UniGeneiMm.6424.

Genome annotation databases

EnsembliENSMUST00000069345; ENSMUSP00000069416; ENSMUSG00000022817.
GeneIDi16419.
UCSCiuc007zan.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC155268 Genomic DNA. No translation available.
AC165079 Genomic DNA. No translation available.
CH466521 Genomic DNA. Translation: EDK97856.1.
RefSeqiNP_034710.2. NM_010580.2.
UniGeneiMm.6424.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069416.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069345; ENSMUSP00000069416; ENSMUSG00000022817.
GeneIDi16419.
UCSCiuc007zan.2. mouse.

Organism-specific databases

CTDi3693.
MGIiMGI:96614. Itgb5.

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
OMAiPDACSTK.
OrthoDBiEOG091G029W.
TreeFamiTF105392.

Enzyme and pathway databases

ReactomeiR-MMU-1236973. Cross-presentation of particulate exogenous antigens (phagosomes).
R-MMU-2129379. Molecules associated with elastic fibres.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-3000170. Syndecan interactions.
R-MMU-3000178. ECM proteoglycans.
R-MMU-445355. Smooth Muscle Contraction.

Miscellaneous databases

ChiTaRSiItgb5. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022817.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR033760. Integin_beta_N.
IPR027067. Integrin_beta-5.
IPR015812. Integrin_bsu.
IPR012896. Integrin_bsu_tail.
IPR002369. Integrin_bsu_VWA.
IPR032695. Integrin_dom.
IPR016201. PSI.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF26. PTHR10082:SF26. 1 hit.
PfamiPF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
PF17205. PSI_integrin. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 1 hit.
SSF69687. SSF69687. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiG5E8F8_MOUSE
AccessioniPrimary (citable) accession number: G5E8F8
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: November 30, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.