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Protein
Submitted name:

EGF-containing fibulin-like extracellular matrix protein 2

Gene

Efemp2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
EGF-containing fibulin-like extracellular matrix protein 2Imported
Submitted name:
Epidermal growth factor-containing fibulin-like extracellular matrix protein 2, isoform CRA_cImported
Gene namesi
Name:Efemp2Imported
ORF Names:mCG_11764Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1891209. Efemp2.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 46Sequence analysisAdd BLAST46
ChainiPRO_500969205047 – 462Sequence analysisAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi226 ↔ 236PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

MaxQBiG5E8D6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024909.
ExpressionAtlasiG5E8D6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064719.

Structurei

3D structure databases

ProteinModelPortaliG5E8D6.
SMRiG5E8D6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini142 – 182EGF-likeInterPro annotationAdd BLAST41
Domaini183 – 221EGF-likeInterPro annotationAdd BLAST39
Domaini222 – 257EGF-likeInterPro annotationAdd BLAST36
Domaini262 – 301EGF-likeInterPro annotationAdd BLAST40

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IR6U. Eukaryota.
ENOG410ZNNG. LUCA.
GeneTreeiENSGT00760000118806.
OMAiQECHNLP.
OrthoDBiEOG091G04QP.
TreeFamiTF317514.

Family and domain databases

InterProiView protein in InterPro
IPR026823. cEGF.
IPR026824. Efemp2.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
PANTHERiPTHR24044:SF379. PTHR24044:SF379. 1 hit.
PfamiView protein in Pfam
PF12662. cEGF. 2 hits.
PF07645. EGF_CA. 3 hits.
SMARTiView protein in SMART
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 6 hits.
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 4 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 2 hits.

Sequencei

Sequence statusi: Complete.

G5E8D6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGAVAETPD FCPPPPSLRM LPFASCLPGS LLLWAFLLLL LGAASPQDPE
60 70 80 90 100
EPDSYTECTD GYEWDADSQH CRDVNECLTI PEACKGEMKC INHYGGYLCL
110 120 130 140 150
PRSAAVISDL HGEGPPPPAA HAQQPNPCPQ GYEPDEQESC VDVDECTQAL
160 170 180 190 200
HDCRPSQDCH NLPGSYQCTC PDGYRKIGPE CVDIDECRYR YCQHRCVNLP
210 220 230 240 250
GSFRCQCEPG FQLGPNNRSC VDVNECDMGA PCEQRCFNSY GTFLCRCNQG
260 270 280 290 300
YELHRDGFSC SDIDECGYSS YLCQYRCVNE PGRFSCHCPQ GYQLLATRLC
310 320 330 340 350
QDIDECETGA HQCSEAQTCV NFHGGYRCVD TNRCVEPYVQ VSDNRCLCPA
360 370 380 390 400
SNPLCREQPS SIVHRYMSIT SERSVPADVF QIQATSVYPG AYNAFQIRSG
410 420 430 440 450
NTQGDFYIRQ INNVSAMLVL ARPVTGPREY VLDLEMVTMN SLMSYRASSV
460
LRLTVFVGAY TF
Length:462
Mass (Da):51,350
Last modified:December 14, 2011 - v1
Checksum:i4A85A5A9191AF8C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126029 Genomic DNA. No translation available.
CH466612 Genomic DNA. Translation: EDL33141.1.
RefSeqiNP_001157824.1. NM_001164352.1.
UniGeneiMm.276367.

Genome annotation databases

EnsembliENSMUST00000070118; ENSMUSP00000064719; ENSMUSG00000024909.
GeneIDi58859.
UCSCiuc012bgy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126029 Genomic DNA. No translation available.
CH466612 Genomic DNA. Translation: EDL33141.1.
RefSeqiNP_001157824.1. NM_001164352.1.
UniGeneiMm.276367.

3D structure databases

ProteinModelPortaliG5E8D6.
SMRiG5E8D6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064719.

Proteomic databases

MaxQBiG5E8D6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070118; ENSMUSP00000064719; ENSMUSG00000024909.
GeneIDi58859.
UCSCiuc012bgy.1. mouse.

Organism-specific databases

CTDi30008.
MGIiMGI:1891209. Efemp2.

Phylogenomic databases

eggNOGiENOG410IR6U. Eukaryota.
ENOG410ZNNG. LUCA.
GeneTreeiENSGT00760000118806.
OMAiQECHNLP.
OrthoDBiEOG091G04QP.
TreeFamiTF317514.

Miscellaneous databases

ChiTaRSiEfemp2. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024909.
ExpressionAtlasiG5E8D6. baseline and differential.

Family and domain databases

InterProiView protein in InterPro
IPR026823. cEGF.
IPR026824. Efemp2.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
PANTHERiPTHR24044:SF379. PTHR24044:SF379. 1 hit.
PfamiView protein in Pfam
PF12662. cEGF. 2 hits.
PF07645. EGF_CA. 3 hits.
SMARTiView protein in SMART
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 6 hits.
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 4 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiG5E8D6_MOUSE
AccessioniPrimary (citable) accession number: G5E8D6
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: April 12, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.