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Protein
Submitted name:

EGF-containing fibulin-like extracellular matrix protein 2

Gene

Efemp2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

CalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
EGF-containing fibulin-like extracellular matrix protein 2Imported
Submitted name:
Epidermal growth factor-containing fibulin-like extracellular matrix protein 2, isoform CRA_cImported
Gene namesi
Name:Efemp2Imported
ORF Names:mCG_11764Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1891209. Efemp2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • proteinaceous extracellular matrix Source: MGI
  • vesicle Source: MGI
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064719.

Family & Domainsi

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118806.
OMAiQECHNLP.
TreeFamiTF317514.

Family and domain databases

InterProiIPR026823. cEGF.
IPR026824. Efemp2.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view]
PANTHERiPTHR24048:SF2. PTHR24048:SF2. 1 hit.
PfamiPF12662. cEGF. 2 hits.
PF07645. EGF_CA. 3 hits.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
SM00179. EGF_CA. 4 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 4 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G5E8D6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGAVAETPD FCPPPPSLRM LPFASCLPGS LLLWAFLLLL LGAASPQDPE
60 70 80 90 100
EPDSYTECTD GYEWDADSQH CRDVNECLTI PEACKGEMKC INHYGGYLCL
110 120 130 140 150
PRSAAVISDL HGEGPPPPAA HAQQPNPCPQ GYEPDEQESC VDVDECTQAL
160 170 180 190 200
HDCRPSQDCH NLPGSYQCTC PDGYRKIGPE CVDIDECRYR YCQHRCVNLP
210 220 230 240 250
GSFRCQCEPG FQLGPNNRSC VDVNECDMGA PCEQRCFNSY GTFLCRCNQG
260 270 280 290 300
YELHRDGFSC SDIDECGYSS YLCQYRCVNE PGRFSCHCPQ GYQLLATRLC
310 320 330 340 350
QDIDECETGA HQCSEAQTCV NFHGGYRCVD TNRCVEPYVQ VSDNRCLCPA
360 370 380 390 400
SNPLCREQPS SIVHRYMSIT SERSVPADVF QIQATSVYPG AYNAFQIRSG
410 420 430 440 450
NTQGDFYIRQ INNVSAMLVL ARPVTGPREY VLDLEMVTMN SLMSYRASSV
460
LRLTVFVGAY TF
Length:462
Mass (Da):51,350
Last modified:December 14, 2011 - v1
Checksum:i4A85A5A9191AF8C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126029 Genomic DNA. No translation available.
CH466612 Genomic DNA. Translation: EDL33141.1.
RefSeqiNP_001157824.1. NM_001164352.1.
UniGeneiMm.276367.

Genome annotation databases

EnsembliENSMUST00000070118; ENSMUSP00000064719; ENSMUSG00000024909.
GeneIDi58859.
KEGGimmu:58859.
UCSCiuc012bgy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126029 Genomic DNA. No translation available.
CH466612 Genomic DNA. Translation: EDL33141.1.
RefSeqiNP_001157824.1. NM_001164352.1.
UniGeneiMm.276367.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064719.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070118; ENSMUSP00000064719; ENSMUSG00000024909.
GeneIDi58859.
KEGGimmu:58859.
UCSCiuc012bgy.1. mouse.

Organism-specific databases

CTDi30008.
MGIiMGI:1891209. Efemp2.

Phylogenomic databases

GeneTreeiENSGT00760000118806.
OMAiQECHNLP.
TreeFamiTF317514.

Miscellaneous databases

ChiTaRSiEfemp2. mouse.
NextBioi314408.
SOURCEiSearch...

Family and domain databases

InterProiIPR026823. cEGF.
IPR026824. Efemp2.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view]
PANTHERiPTHR24048:SF2. PTHR24048:SF2. 1 hit.
PfamiPF12662. cEGF. 2 hits.
PF07645. EGF_CA. 3 hits.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
SM00179. EGF_CA. 4 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 4 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (OCT-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiG5E8D6_MOUSE
AccessioniPrimary (citable) accession number: G5E8D6
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: June 24, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.