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Protein
Submitted name:

EGF-containing fibulin-like extracellular matrix protein 2

Gene

Efemp2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
EGF-containing fibulin-like extracellular matrix protein 2Imported
Submitted name:
Epidermal growth factor-containing fibulin-like extracellular matrix protein 2, isoform CRA_cImported
Gene namesi
Name:Efemp2Imported
ORF Names:mCG_11764Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1891209 Efemp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 46Sequence analysisAdd BLAST46
ChainiPRO_501409196947 – 462Sequence analysisAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi226 ↔ 236PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

MaxQBiG5E8D6
PeptideAtlasiG5E8D6

Expressioni

Gene expression databases

BgeeiENSMUSG00000024909

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini142 – 182EGF-likeInterPro annotationAdd BLAST41
Domaini183 – 221EGF-likeInterPro annotationAdd BLAST39
Domaini222 – 257EGF-likeInterPro annotationAdd BLAST36
Domaini262 – 301EGF-likeInterPro annotationAdd BLAST40

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IR6U Eukaryota
ENOG410ZNNG LUCA
GeneTreeiENSGT00760000118806
OMAiQECHNLP
OrthoDBiEOG091G04QP
TreeFamiTF317514

Family and domain databases

InterProiView protein in InterPro
IPR026823 cEGF
IPR026824 Efemp2
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR037287 Fibulin_3/4/5
IPR009030 Growth_fac_rcpt_cys_sf
PANTHERiPTHR44074 PTHR44074, 1 hit
PTHR44074:SF3 PTHR44074:SF3, 1 hit
PfamiView protein in Pfam
PF12662 cEGF, 2 hits
PF07645 EGF_CA, 3 hits
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00179 EGF_CA, 6 hits
SUPFAMiSSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 4 hits
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 2 hits

Sequencei

Sequence statusi: Complete.

G5E8D6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGAVAETPD FCPPPPSLRM LPFASCLPGS LLLWAFLLLL LGAASPQDPE
60 70 80 90 100
EPDSYTECTD GYEWDADSQH CRDVNECLTI PEACKGEMKC INHYGGYLCL
110 120 130 140 150
PRSAAVISDL HGEGPPPPAA HAQQPNPCPQ GYEPDEQESC VDVDECTQAL
160 170 180 190 200
HDCRPSQDCH NLPGSYQCTC PDGYRKIGPE CVDIDECRYR YCQHRCVNLP
210 220 230 240 250
GSFRCQCEPG FQLGPNNRSC VDVNECDMGA PCEQRCFNSY GTFLCRCNQG
260 270 280 290 300
YELHRDGFSC SDIDECGYSS YLCQYRCVNE PGRFSCHCPQ GYQLLATRLC
310 320 330 340 350
QDIDECETGA HQCSEAQTCV NFHGGYRCVD TNRCVEPYVQ VSDNRCLCPA
360 370 380 390 400
SNPLCREQPS SIVHRYMSIT SERSVPADVF QIQATSVYPG AYNAFQIRSG
410 420 430 440 450
NTQGDFYIRQ INNVSAMLVL ARPVTGPREY VLDLEMVTMN SLMSYRASSV
460
LRLTVFVGAY TF
Length:462
Mass (Da):51,350
Last modified:December 14, 2011 - v1
Checksum:i4A85A5A9191AF8C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126029 Genomic DNA No translation available.
CH466612 Genomic DNA Translation: EDL33141.1
RefSeqiNP_001157824.1, NM_001164352.1
UniGeneiMm.276367

Genome annotation databases

EnsembliENSMUST00000070118; ENSMUSP00000064719; ENSMUSG00000024909
GeneIDi58859
UCSCiuc012bgy.1 mouse

Similar proteinsi

Entry informationi

Entry nameiG5E8D6_MOUSE
AccessioniPrimary (citable) accession number: G5E8D6
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: April 25, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported