Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

EGF-containing fibulin-like extracellular matrix protein 2

Gene

Efemp2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandCalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
EGF-containing fibulin-like extracellular matrix protein 2Imported
Submitted name:
Epidermal growth factor-containing fibulin-like extracellular matrix protein 2, isoform CRA_cImported
Gene namesi
Name:Efemp2Imported
ORF Names:mCG_11764Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1891209. Efemp2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 46Sequence analysisAdd BLAST46
ChainiPRO_501120688447 – 462Sequence analysisAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi226 ↔ 236PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000024909.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini142 – 182EGF-likeInterPro annotationAdd BLAST41
Domaini183 – 221EGF-likeInterPro annotationAdd BLAST39
Domaini222 – 257EGF-likeInterPro annotationAdd BLAST36
Domaini262 – 301EGF-likeInterPro annotationAdd BLAST40

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IR6U. Eukaryota.
ENOG410ZNNG. LUCA.
GeneTreeiENSGT00760000118806.
OMAiQECHNLP.
OrthoDBiEOG091G04QP.
TreeFamiTF317514.

Family and domain databases

InterProiView protein in InterPro
IPR026823. cEGF.
IPR026824. Efemp2.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR037287. Fibulin_3/4/5.
IPR009030. Growth_fac_rcpt_cys_sf.
PANTHERiPTHR44074. PTHR44074. 1 hit.
PTHR44074:SF3. PTHR44074:SF3. 1 hit.
PfamiView protein in Pfam
PF12662. cEGF. 2 hits.
PF07645. EGF_CA. 3 hits.
SMARTiView protein in SMART
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 6 hits.
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 4 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 2 hits.

Sequencei

Sequence statusi: Complete.

G5E8D6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGAVAETPD FCPPPPSLRM LPFASCLPGS LLLWAFLLLL LGAASPQDPE
60 70 80 90 100
EPDSYTECTD GYEWDADSQH CRDVNECLTI PEACKGEMKC INHYGGYLCL
110 120 130 140 150
PRSAAVISDL HGEGPPPPAA HAQQPNPCPQ GYEPDEQESC VDVDECTQAL
160 170 180 190 200
HDCRPSQDCH NLPGSYQCTC PDGYRKIGPE CVDIDECRYR YCQHRCVNLP
210 220 230 240 250
GSFRCQCEPG FQLGPNNRSC VDVNECDMGA PCEQRCFNSY GTFLCRCNQG
260 270 280 290 300
YELHRDGFSC SDIDECGYSS YLCQYRCVNE PGRFSCHCPQ GYQLLATRLC
310 320 330 340 350
QDIDECETGA HQCSEAQTCV NFHGGYRCVD TNRCVEPYVQ VSDNRCLCPA
360 370 380 390 400
SNPLCREQPS SIVHRYMSIT SERSVPADVF QIQATSVYPG AYNAFQIRSG
410 420 430 440 450
NTQGDFYIRQ INNVSAMLVL ARPVTGPREY VLDLEMVTMN SLMSYRASSV
460
LRLTVFVGAY TF
Length:462
Mass (Da):51,350
Last modified:December 14, 2011 - v1
Checksum:i4A85A5A9191AF8C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126029 Genomic DNA. No translation available.
CH466612 Genomic DNA. Translation: EDL33141.1.
RefSeqiNP_001157824.1. NM_001164352.1.
UniGeneiMm.276367.

Genome annotation databases

EnsembliENSMUST00000070118; ENSMUSP00000064719; ENSMUSG00000024909.
GeneIDi58859.
UCSCiuc012bgy.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiG5E8D6_MOUSE
AccessioniPrimary (citable) accession number: G5E8D6
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: November 22, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported