Pak1

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
collagen binding Source: Ensembl
protein kinase binding Source: Ensembl
protein serine/threonine kinase activity Source: Ensembl

GO - Biological processⁱ

actin cytoskeleton reorganization Source: Ensembl
branching morphogenesis of an epithelial tube Source: Ensembl
cellular response to insulin stimulus Source: Ensembl
cerebellum development Source: Ensembl
establishment of cell polarity Source: Ensembl
hepatocyte growth factor receptor signaling pathway Source: Ensembl
negative regulation of cell growth involved in cardiac muscle cell development Source: Ensembl
negative regulation of cell proliferation involved in contact inhibition Source: Ensembl
neuron projection morphogenesis Source: Ensembl
positive regulation of axon extension Source: Ensembl
positive regulation of fibroblast migration Source: Ensembl
positive regulation of glucose import in response to insulin stimulus Source: Ensembl
positive regulation of intracellular estrogen receptor signaling pathway Source: Ensembl
positive regulation of JUN kinase activity Source: Ensembl
positive regulation of microtubule polymerization Source: Ensembl
positive regulation of peptidyl-serine phosphorylation Source: Ensembl
positive regulation of protein targeting to membrane Source: Ensembl
positive regulation of stress fiber assembly Source: Ensembl
positive regulation of vascular associated smooth muscle cell migration Source: Ensembl
positive regulation of vascular smooth muscle cell proliferation Source: Ensembl
protein autophosphorylation Source: Ensembl
response to hypoxia Source: Ensembl
wound healing Source: Ensembl

Keywordsⁱ

Molecular function	KinaseSAAS annotationImported, Transferase
Ligand	ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-202433. Generation of second messenger molecules. R-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation. R-MMU-2871796. FCERI mediated MAPK activation. R-MMU-376172. DSCAM interactions. R-MMU-389359. CD28 dependent Vav1 pathway. R-MMU-3928662. EPHB-mediated forward signaling. R-MMU-3928664. Ephrin signaling. R-MMU-399954. Sema3A PAK dependent Axon repulsion. R-MMU-4420097. VEGFA-VEGFR2 Pathway. R-MMU-445144. Signal transduction by L1. R-MMU-5218920. VEGFR2 mediated vascular permeability. R-MMU-5621575. CD209 (DC-SIGN) signaling. R-MMU-5627123. RHO GTPases activate PAKs. R-MMU-5687128. MAPK6/MAPK4 signaling.

Reactomeⁱ

R-MMU-202433. Generation of second messenger molecules.
R-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-2871796. FCERI mediated MAPK activation.
R-MMU-376172. DSCAM interactions.
R-MMU-389359. CD28 dependent Vav1 pathway.
R-MMU-3928662. EPHB-mediated forward signaling.
R-MMU-3928664. Ephrin signaling.
R-MMU-399954. Sema3A PAK dependent Axon repulsion.
R-MMU-4420097. VEGFA-VEGFR2 Pathway.
R-MMU-445144. Signal transduction by L1.
R-MMU-5218920. VEGFR2 mediated vascular permeability.
R-MMU-5621575. CD209 (DC-SIGN) signaling.
R-MMU-5627123. RHO GTPases activate PAKs.
R-MMU-5687128. MAPK6/MAPK4 signaling.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Serine/threonine-protein kinase PAK 1Imported Submitted name: p21 (CDKN1A)-activated kinase 1, isoform CRA_bImported
Gene namesⁱ	Name:Pak1Imported ORF Names:mCG_7049Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:1339975. Pak1.

Subcellular locationⁱ

GO - Cellular componentⁱ

axon Source: Ensembl
cytosol Source: Ensembl
dendrite Source: Ensembl
intercalated disc Source: Ensembl
invadopodium Source: Ensembl
lamellipodium Source: Ensembl
nuclear membrane Source: Ensembl
plasma membrane Source: Ensembl
protein complex Source: Ensembl
ruffle Source: Ensembl
Z disc Source: Ensembl

Complete GO annotation...

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000030774.

Bgeeⁱ

ENSMUSG00000030774.

Interactionⁱ

GO - Molecular functionⁱ

collagen binding Source: Ensembl
protein kinase binding Source: Ensembl

Complete GO annotation...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	75 – 88	CRIBInterPro annotationAdd BLAST		14
Domainⁱ	269 – 520	Protein kinaseInterPro annotationAdd BLAST		252

Phylogenomic databases

eggNOGⁱ	KOG0578. Eukaryota. ENOG410XP4K. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133680.
KEGG Orthology (KO) More...KOⁱ	K04409.
OMAⁱ	AGTLNHG.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04H8.
TreeFamⁱ	TF105351.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01093. CRIB_PAK_like. 1 hit.
Gene3Dⁱ	3.90.810.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000095. CRIB_dom. IPR011009. Kinase-like_dom. IPR033923. PAK_BD. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00786. PBD. 1 hit. PF00069. Pkinase. 1 hit.
SMARTⁱ	View protein in SMART SM00285. PBD. 1 hit. SM00220. S_TKc. 1 hit.
SUPFAMⁱ	SSF56112. SSF56112. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50108. CRIB. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

G5E884-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSNNGVDIQD KPPAPPMRNT STMIGAGSKD TGTLNHGSKP LPPNPEEKKK 
        60         70         80         90        100
KDRFYRSILP GDKTNKKKEK ERPEISLPSD FEHTIHVGFD AVTGEFTGMP 
       110        120        130        140        150
EQWARLLQTS NITKSEQKKN PQAVLDVLEF YNSKKTSNSQ KYMSFTDKSA 
       160        170        180        190        200
EDYNSSNTLN VKTVSETPAV PPVSEDEDDD DDATPPPVIA PRPEHTKSVY 
       210        220        230        240        250
TRSVIEPLPV TPTRDVATSP ISPTENNTTP PDALTRNTEK QKKKPKMSDE 
       260        270        280        290        300
EILEKLRSIV SVGDPKKKYT RFEKIGQGAS GTVYTAMDVA TGQEVAIKQM 
       310        320        330        340        350
NLQQQPKKEL IINEILVMRE NKNPNIVNYL DSYLVGDELW VVMEYLAGGS 
       360        370        380        390        400
LTDVVTETCM DEGQIAAVCR ECLQALEFLH SNQVIHRDIK SDNILLGMDG 
       410        420        430        440        450
SVKLTDFGFC AQITPEQSKR STMVGTPYWM APEVVTRKAY GPKVDIWSLG 
       460        470        480        490        500
IMAIEMIEGE PPYLNENPLR ALYLIATNGT PELQNPEKLS AIFRDFLNRC 
       510        520        530        540 
LEMDVEKRGS AKELLQHQFL KIAKPLSSLT PLIAAAKEAT KNNH

Length:544

Mass (Da):60,608

Last modified:December 14, 2011 - v1

Checksum:ⁱ0CCA15802BEB5E5C

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC120438 Genomic DNA. No translation available. AC125323 Genomic DNA. No translation available. AC151477 Genomic DNA. No translation available. CH466531 Genomic DNA. Translation: EDL16323.1. CH466531 Genomic DNA. Translation: EDL16324.1. CH466531 Genomic DNA. Translation: EDL16326.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_035165.2. NM_011035.2. XP_017177517.1. XM_017322028.1.
UniGeneⁱ	Mm.260227.

Genome annotation databases

Ensemblⁱ	ENSMUST00000033040; ENSMUSP00000033040; ENSMUSG00000030774. ENSMUST00000206984; ENSMUSP00000146055; ENSMUSG00000030774.
GeneIDⁱ	18479.
KEGGⁱ	mmu:18479.
UCSC genome browser More...UCSCⁱ	uc009ijv.1. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC120438 Genomic DNA. No translation available. AC125323 Genomic DNA. No translation available. AC151477 Genomic DNA. No translation available. CH466531 Genomic DNA. Translation: EDL16323.1. CH466531 Genomic DNA. Translation: EDL16324.1. CH466531 Genomic DNA. Translation: EDL16326.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_035165.2. NM_011035.2. XP_017177517.1. XM_017322028.1.
UniGeneⁱ	Mm.260227.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000033040; ENSMUSP00000033040; ENSMUSG00000030774. ENSMUST00000206984; ENSMUSP00000146055; ENSMUSG00000030774.
GeneIDⁱ	18479.
KEGGⁱ	mmu:18479.
UCSC genome browser More...UCSCⁱ	uc009ijv.1. mouse.

Organism-specific databases

CTDⁱ	5058.
MGIⁱ	MGI:1339975. Pak1.

Phylogenomic databases

eggNOGⁱ	KOG0578. Eukaryota. ENOG410XP4K. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133680.
KEGG Orthology (KO) More...KOⁱ	K04409.
OMAⁱ	AGTLNHG.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04H8.
TreeFamⁱ	TF105351.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-202433. Generation of second messenger molecules. R-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation. R-MMU-2871796. FCERI mediated MAPK activation. R-MMU-376172. DSCAM interactions. R-MMU-389359. CD28 dependent Vav1 pathway. R-MMU-3928662. EPHB-mediated forward signaling. R-MMU-3928664. Ephrin signaling. R-MMU-399954. Sema3A PAK dependent Axon repulsion. R-MMU-4420097. VEGFA-VEGFR2 Pathway. R-MMU-445144. Signal transduction by L1. R-MMU-5218920. VEGFR2 mediated vascular permeability. R-MMU-5621575. CD209 (DC-SIGN) signaling. R-MMU-5627123. RHO GTPases activate PAKs. R-MMU-5687128. MAPK6/MAPK4 signaling.

Reactomeⁱ

R-MMU-202433. Generation of second messenger molecules.
R-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-2871796. FCERI mediated MAPK activation.
R-MMU-376172. DSCAM interactions.
R-MMU-389359. CD28 dependent Vav1 pathway.
R-MMU-3928662. EPHB-mediated forward signaling.
R-MMU-3928664. Ephrin signaling.
R-MMU-399954. Sema3A PAK dependent Axon repulsion.
R-MMU-4420097. VEGFA-VEGFR2 Pathway.
R-MMU-445144. Signal transduction by L1.
R-MMU-5218920. VEGFR2 mediated vascular permeability.
R-MMU-5621575. CD209 (DC-SIGN) signaling.
R-MMU-5627123. RHO GTPases activate PAKs.
R-MMU-5687128. MAPK6/MAPK4 signaling.

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030774.

Bgeeⁱ

ENSMUSG00000030774.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01093. CRIB_PAK_like. 1 hit.
Gene3Dⁱ	3.90.810.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000095. CRIB_dom. IPR011009. Kinase-like_dom. IPR033923. PAK_BD. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00786. PBD. 1 hit. PF00069. Pkinase. 1 hit.
SMARTⁱ	View protein in SMART SM00285. PBD. 1 hit. SM00220. S_TKc. 1 hit.
SUPFAMⁱ	SSF56112. SSF56112. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50108. CRIB. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	G5E884_MOUSE
Accessionⁱ	G5E884Primary (citable) accession number: G5E884
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	December 14, 2011
	Last sequence update:	December 14, 2011
	Last modified:	July 5, 2017
	This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB - G5E884 (G5E884_MOUSE)

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Serine/threonine-protein kinase PAK 1

Select a section on the left to see content.

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

GO - Cellular componentⁱ

Expressionⁱ

Gene expression databases

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - G5E884 (G5E884_MOUSE)

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Serine/threonine-protein kinase PAK 1

Pak1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ