ID   G5E846_MOUSE            Unreviewed;       475 AA.
AC   G5E846;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   27-MAR-2024, entry version 82.
DE   SubName: Full=Peripherin {ECO:0000313|Ensembl:ENSMUSP00000024249.4};
GN   Name=Prph {ECO:0000313|Ensembl:ENSMUSP00000024249.4,
GN   ECO:0000313|MGI:MGI:97774};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000024249.4, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000024249.4, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000024249.4,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000024249.4}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000024249.4};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; NP_001157061.1; NM_001163589.1.
DR   AlphaFoldDB; G5E846; -.
DR   SMR; G5E846; -.
DR   jPOST; G5E846; -.
DR   MaxQB; G5E846; -.
DR   PeptideAtlas; G5E846; -.
DR   ProteomicsDB; 332987; -.
DR   Antibodypedia; 3724; 597 antibodies from 39 providers.
DR   DNASU; 19132; -.
DR   Ensembl; ENSMUST00000024249.5; ENSMUSP00000024249.4; ENSMUSG00000023484.15.
DR   GeneID; 19132; -.
DR   UCSC; uc007xoo.2; mouse.
DR   AGR; MGI:97774; -.
DR   CTD; 5630; -.
DR   MGI; MGI:97774; Prph.
DR   VEuPathDB; HostDB:ENSMUSG00000023484; -.
DR   GeneTree; ENSGT00940000160203; -.
DR   OrthoDB; 4640531at2759; -.
DR   BioGRID-ORCS; 19132; 1 hit in 77 CRISPR screens.
DR   Proteomes; UP000000589; Chromosome 15.
DR   Bgee; ENSMUSG00000023484; Expressed in trigeminal ganglion and 104 other cell types or tissues.
DR   ExpressionAtlas; G5E846; baseline and differential.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0007010; P:cytoskeleton organization; IEA:UniProt.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR006821; Intermed_filament_DNA-bd.
DR   InterPro; IPR002957; Keratin_I.
DR   PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR   PANTHER; PTHR45652:SF14; PERIPHERIN; 1.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF04732; Filament_head; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685};
KW   Proteomics identification {ECO:0007829|MaxQB:G5E846,
KW   ECO:0007829|PeptideAtlas:G5E846};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN          101..411
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          453..475
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          91..253
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          298..389
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..29
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   475 AA;  54298 MW;  EE731821091742E4 CRC64;
     MPSSASMSHH HSSGLRSSIS STSYRRTFGP PPSLSPGAFS YSSSSRFSSS RLLGSGSPSS
     SARLGSFRAP RAGALRLPSE RLDFSMAEAL NQEFLATRSN EKQELQELND RFANFIEKVR
     FLEQQNAALR GELSQARGQE PARADQLCQQ ELRELRRELE LLGRERDRVQ VERDGLAEDL
     AALKQRLEEE TRKREDAEHN LVLFRKDVDD ATLSRLELER KIESLMDEIE FLKKLHEEEL
     RDLQVSVESQ QVQQVEVEAT VKPELTAALR DIRAQYENIA AKNLQEAEEW YKSKYADLSD
     AANRNHEALR QAKQEMNESR RQIQSLMCEV DGLRGTNEAL LRQLRELEEQ FALEAGGYQA
     GAARLEEELR QLKEEMARHL REYQELLNVK MALDIEIATY RKLLEGEESR ISVPVHSFAS
     LSLKTTVPEM EPLQDSHSKK MVLIRTIETR DGEKVVTESQ KEQHSDLDKS SIHSY
//