Skip Header

Contribute Send feedback
Read comments (?) or add your own

G5E843 (G5E843_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesSubmitted name:
Roundabout homolog 1 Ensembl ENSMUSP00000023600
Submitted name:
Roundabout homolog 1 (Drosophila) EMBL EDK98262.1
Gene names
Name:Robo1 EMBL EDK98262.1 Ensembl ENSMUSP00000023600 MGI 1274781
ORF Names:mCG_142127 EMBL EDK98262.1
OrganismMus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000023600
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length1612 AA.
Sequence statusComplete.
Protein existencePredicted

Ontologies

Keywords
   Cellular componentMembrane
   DomainRepeat SAAS SAAS013098
Transmembrane
Transmembrane helix SAAS SAAS003596
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRoundabout signaling pathway

Inferred from electronic annotation. Source: Compara

activation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from electronic annotation. Source: Compara

axon guidance

Inferred from mutant phenotype PubMed 15084255. Source: MGI

cell migration involved in sprouting angiogenesis

Inferred from electronic annotation. Source: Compara

chemorepulsion involved in postnatal olfactory bulb interneuron migration

Inferred from electronic annotation. Source: Compara

homophilic cell adhesion

Inferred from electronic annotation. Source: Compara

mammary duct terminal end bud growth

Inferred from mutant phenotype PubMed 16439476. Source: MGI

negative regulation of cell proliferation

Inferred from mutant phenotype PubMed 18829537. Source: MGI

negative regulation of chemokine-mediated signaling pathway

Inferred from electronic annotation. Source: Compara

negative regulation of mammary gland epithelial cell proliferation

Inferred from electronic annotation. Source: Compara

negative regulation of negative chemotaxis

Inferred from electronic annotation. Source: Compara

positive regulation of axonogenesis

Inferred from electronic annotation. Source: Compara

   Cellular_componentaxolemma

Inferred from direct assay PubMed 15084255. Source: MGI

cell surface

Inferred from electronic annotation. Source: Compara

cytoplasm

Inferred from electronic annotation. Source: Compara

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
G5E843 [UniParc].

Last modified December 14, 2011. Version 1.
Checksum: A82C1750A10BC0A7

FASTA1,612176,375
        10         20         30         40         50         60 
MIAEPARFYL FGLICLCSGS RLRQEDFPPR IVEHPSDLIV SKGEPATLNC KAEGRPTPTI 

        70         80         90        100        110        120 
EWYKGGERVE TDKDDPRSHR MLLPSGSLFF LRIVHGRKSR PDEGVYICVA RNYLGEAVSH 

       130        140        150        160        170        180 
NASLEVAILR DDFRQNPSDV MVAVGEPAVM ECQPPRGHPE PTISWKKDGS PLDDKDERIT 

       190        200        210        220        230        240 
IRGGKLMITY TRKSDAGKYV CVGTNMVGER ESEVAELTVL ERPSFVKRPS NLAVTVDDSA 

       250        260        270        280        290        300 
EFKCEARGDP VPTVRWRKDD GELPKSRYEI RDDHTLKIRK VTAGDMGSYT CVAENMVGKA 

       310        320        330        340        350        360 
EASATLTVQE PPHFVVKPRD QVVALGRTVT FQCEATGNPQ PAIFWRREGS QNLLFSYQPP 

       370        380        390        400        410        420 
QSSSRFSVSQ TGDLTITNVQ RSDVGYYICQ TLNVAGSIIT KAYLEVTDVI ADRPPPVIRQ 

       430        440        450        460        470        480 
GPVNQTVAVD GTLILSCVAT GSPAPTILWR KDGVLVSTQD SRIKQLESGV LQIRYAKLGD 

       490        500        510        520        530        540 
TGRYTCTAST PSGEATWSAY IEVQEFGVPV QPPRPTDPNL IPSAPSKPEV TDVSKNTVTL 

       550        560        570        580        590        600 
SWQPNLNSGA TPTSYIIEAF SHASGSSWQT AAENVKTETF AIKGLKPNAI YLFLVRAANA 

       610        620        630        640        650        660 
YGISDPSQIS DPVKTQDVPP TSQGVDHKQV QRELGNVVLH LHNPTILSSS SVEVHWTVDQ 

       670        680        690        700        710        720 
QSQYIQGYKI LYRPSGASHG ESEWLVFEVR TPTKNSVVIP DLRKGVNYEI KARPFFNEFQ 

       730        740        750        760        770        780 
GADSEIKFAK TLEEAPSAPP RSVTVSKNDG NGTAILVTWQ PPPEDTQNGM VQEYKVWCLG 

       790        800        810        820        830        840 
NETKYHINKT VDGSTFSVVI PSLVPGIRYS VEVAASTGAG PGVKSEPQFI QLDSHGNPVS 

       850        860        870        880        890        900 
PEDQVSLAQQ ISDVVRQPAF IAGIGAACWI ILMVFSIWLY RHRKKRNGLT STYAGIRKVP 

       910        920        930        940        950        960 
SFTFTPTVTY QRGGEAVSSG GRPGLLNISE PATQPWLADT WPNTGNNHND CSINCCTAGN 

       970        980        990       1000       1010       1020 
GNSDSNLTTY SRPADCIANY NNQLDNKQTN LMLPESTVYG DVDLSNKINE MKTFNSPNLK 

      1030       1040       1050       1060       1070       1080 
DGRFVNPSGQ PTPYATTQLI QANLSNNMNN GAGDSSEKHW KPPGQQKPEV APIQYNIMEQ 

      1090       1100       1110       1120       1130       1140 
NKLNKDYRAN DTIPPTIPYN QSYDQNTGGS YNSSDRGSST SGSQGHKKGA RTPKAPKQGG 

      1150       1160       1170       1180       1190       1200 
MNWADLLPPP PAHPPPHSNS EEYNMSVDES YDQEMPCPVP PARMYLQQDE LEEEEDERGP 

      1210       1220       1230       1240       1250       1260 
TPPVRGAASS PAAVSYSHQS TATLTPSPQE ELQPMLQDCP EDLGHMPHPP DRRRQPVSPP 

      1270       1280       1290       1300       1310       1320 
PPPRPISPPH TYGYISGPLV SDMDTDAPEE EEDEADMEVA KMQTRRLLLR GLEQTPASSV 

      1330       1340       1350       1360       1370       1380 
GDLESSVTGS MINGWGSASE EDNISSGRSS VSSSDGSFFT DADFAQAVAA AAEYAGLKVA 

      1390       1400       1410       1420       1430       1440 
RRQMQDAAGR RHFHASQCPR PTSPVSTDSN MSAVVIQKAR PAKKQKHQPG HLRREAYADD 

      1450       1460       1470       1480       1490       1500 
LPPPPVPPPA IKSPTVQSKA QLEVRPVMVP KLASIEARTD RSSDRKGGSY KGREALDGRQ 

      1510       1520       1530       1540       1550       1560 
VTDLRTNPSD PREAQEQPND GKGRGTKAAK RDLPPAKTHL GQEDILPYCR PTFPTSNNPR 

      1570       1580       1590       1600       1610 
DPSSSSSMSS RGSGSRQREQ ANVGRRNMAE MQVLGGFERG DENNEELEET ES

« Hide

References

« Hide 'large scale' references
[1]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDK98262.1.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDK98262.1.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000023600.
[4]Ensembl
Submitted (OCT-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000023600.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AC124726 Genomic DNA. No translation available.
AC134431 Genomic DNA. No translation available.
AC164551 Genomic DNA. No translation available.
CH466521 Genomic DNA. Translation: EDK98262.1.
RefSeqNP_062286.2. NM_019413.2.
UniGeneMm.310772.

3D structure databases

SMRG5E843. Positions 22-227, 415-525.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023600; ENSMUSP00000023600; ENSMUSG00000022883.
GeneID19876.
KEGGmmu:19876.

Organism-specific databases

CTD6091.
MGIMGI:1274781. Robo1.

Phylogenomic databases

GeneTreeENSGT00660000095158.
KOK06753.
OMANSDSNLT.

Family and domain databases

Gene3D2.60.40.10. 9 hits.
InterProIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamPF00041. fn3. 3 hits.
PF07679. I-set. 5 hits.
[Graphical view]
SMARTSM00060. FN3. 3 hits.
SM00408. IGc2. 4 hits.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMSSF49265. FN_III-like. 3 hits.
PROSITEPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio297362.
SOURCESearch...

Entry information

Entry nameG5E843_MOUSE
AccessionPrimary (citable) accession number: G5E843
Entry history
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: April 3, 2013
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry info