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Protein
Submitted name:

Glycine receptor subunit alpha-3

Gene

Glra3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotation, ReceptorImported

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-975298. Ligand-gated ion channel transport.

Names & Taxonomyi

Protein namesi
Submitted name:
Glycine receptor subunit alpha-3Imported
Submitted name:
Glycine receptor, alpha 3 subunitImported
Gene namesi
Name:Glra3Imported
ORF Names:mCG_4607Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:95749. Glra3.

Subcellular locationi

  • Cell junctionsynapse SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4321HelicalSequence analysisAdd
BLAST
Transmembranei271 – 29323HelicalSequence analysisAdd
BLAST
Transmembranei334 – 35724HelicalSequence analysisAdd
BLAST
Transmembranei450 – 47021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, SynapseSAAS annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000038257.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000275.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 269208Neur_chan_LBDInterPro annotationAdd
BLAST
Domaini276 – 36994Neur_chan_membInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3643. Eukaryota.
ENOG410XPWH. LUCA.
GeneTreeiENSGT00760000118821.
KOiK05195.
OMAiPKNSDEM.
OrthoDBiEOG091G0805.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008127. Glycine_rcpt_A.
IPR008130. Glycine_rcpt_A3.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01673. GLYRALPHA.
PR01676. GLYRALPHA3.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G5E811-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPWIRLLSGS WISFRIMAHV RHFRTLVSGF YFWEAALLLS LVATKETNSA
60 70 80 90 100
RSRSAPMSPS DFLDKLMGRT SGYDARIRPN FKGPPVNVTC NIFINSFGSI
110 120 130 140 150
AETTMDYRVN IFLRQKWNDP RLAYSEYPDD SLDLDPSMLD SIWKPDLFFA
160 170 180 190 200
NEKGANFHEV TTDNKLLRIF KNGNVLYSIR LTLTLSCPMD LKNFPMDVQT
210 220 230 240 250
CIMQLESFGY TMNDLIFEWQ DEAPVQVAEG LTLPQFLLKE EKDLRYCTKH
260 270 280 290 300
YNTGKFTCIE VRFHLERQMG YYLIQMYIPS LLIVILSWVS FWINMDAAPA
310 320 330 340 350
RVALGITTVL TMTTQSSGSR ASLPKVSYVK AIDIWMAVCL LFVFSALLEY
360 370 380 390 400
AAVNFVSRQH KELLRFRRKR KNKTEAFALE KFYRFSDTDD EVRESRFSFT
410 420 430 440 450
AYGMGPCLQA KDGVVPKGPN HAVQVMPKSP DEMRKVFIDR AKKIDTISRA
460 470 480
CFPLAFLIFN IFYWVIYKIL RHEDIHQQQD
Length:480
Mass (Da):55,654
Last modified:December 14, 2011 - v1
Checksum:iFE164C5C486A4507
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117729 Genomic DNA. No translation available.
AC119900 Genomic DNA. No translation available.
CH466569 Genomic DNA. Translation: EDL28601.1.
RefSeqiNP_536686.2. NM_080438.2.
UniGeneiMm.307061.

Genome annotation databases

EnsembliENSMUST00000000275; ENSMUSP00000000275; ENSMUSG00000038257.
GeneIDi110304.
KEGGimmu:110304.
UCSCiuc009lsn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117729 Genomic DNA. No translation available.
AC119900 Genomic DNA. No translation available.
CH466569 Genomic DNA. Translation: EDL28601.1.
RefSeqiNP_536686.2. NM_080438.2.
UniGeneiMm.307061.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000275.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000275; ENSMUSP00000000275; ENSMUSG00000038257.
GeneIDi110304.
KEGGimmu:110304.
UCSCiuc009lsn.1. mouse.

Organism-specific databases

CTDi8001.
MGIiMGI:95749. Glra3.

Phylogenomic databases

eggNOGiKOG3643. Eukaryota.
ENOG410XPWH. LUCA.
GeneTreeiENSGT00760000118821.
KOiK05195.
OMAiPKNSDEM.
OrthoDBiEOG091G0805.
TreeFamiTF315453.

Enzyme and pathway databases

ReactomeiR-MMU-975298. Ligand-gated ion channel transport.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038257.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008127. Glycine_rcpt_A.
IPR008130. Glycine_rcpt_A3.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01673. GLYRALPHA.
PR01676. GLYRALPHA3.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG5E811_MOUSE
AccessioniPrimary (citable) accession number: G5E811
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: September 7, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.