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Protein
Submitted name:

Neuroendocrine convertase 1

Gene

PCSK1

Organism
Heterocephalus glaber (Naked mole rat)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Protein family/group databases

MEROPSiS08.072

Names & Taxonomyi

Protein namesi
Submitted name:
Neuroendocrine convertase 1Imported
Submitted name:
Neuroendocrine convertase 1 isoform 1 preproproteinImported
Gene namesi
Name:PCSK1Imported
ORF Names:GW7_03746Imported
OrganismiHeterocephalus glaber (Naked mole rat)Imported
Taxonomic identifieri10181 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaBathyergidaeHeterocephalus
Proteomesi
  • UP000006813 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_500766098528 – 755Sequence analysisAdd BLAST728

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliG5BU25
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini460 – 597P/Homo BInterPro annotationAdd BLAST138

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

InParanoidiG5BU25
KOiK01359

Family and domain databases

CDDicd04059 Peptidases_S8_Protein_converta, 1 hit
Gene3Di2.60.120.2601 hit
3.30.70.8501 hit
3.40.50.2001 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR034182 Kexin/furin
IPR002884 P_dom
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR022005 Proho_convert
IPR032815 S8_pro-domain
IPR038466 S8_pro-domain_sf
PfamiView protein in Pfam
PF01483 P_proprotein, 1 hit
PF00082 Peptidase_S8, 1 hit
PF12177 Proho_convert, 1 hit
PF16470 S8_pro-domain, 1 hit
PRINTSiPR00723 SUBTILISIN
SUPFAMiSSF49785 SSF49785, 1 hit
SSF52743 SSF52743, 1 hit
PROSITEiView protein in PROSITE
PS51829 P_HOMO_B, 1 hit
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

G5BU25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERRAWSLQG AAFALFCSWC ALNSVKAKRQ FVNEWAAEVP GGPEAASAIA
60 70 80 90 100
EELGYDLLGQ IGSLENYYLF KHKNHPQRSR RSASHITKRL SDDDRVIWAE
110 120 130 140 150
QQYEKKRSKR SALRDSALNL FNDPMWNQQW YLQDTRMTAA LPKLDLHVIP
160 170 180 190 200
VWEKGITGKG VVLTILDDGL EWNHTDIYAN YDPEASYDFN DNDHDPFPRY
210 220 230 240 250
DPTNENKHGT RCAGEIAMQA NNRKCGVGVA YNSKVGGIRM LDGIVTDAIE
260 270 280 290 300
ASSIGFNPGH VDIYSASWGP NDDGKTVEGP GRLAQKAFEY GVKQGRQGKG
310 320 330 340 350
SIFVWASGNG GRQGDNCDCD GYTDSIYTIS ISSASQQGLS PWYAEKCSST
360 370 380 390 400
LATSYSSGDY TDQRITSADL HNDCTETHTG TSASAPLAAG IFALALEANP
410 420 430 440 450
NLTWRDMQHL VVWTSEYDPL ANNPGWKKNG AGLMVNSRFG FGLLNAKALV
460 470 480 490 500
DLADPRSWSS VPEKKQCVVK DNDFEPRALK ANGEVIIEIP TRACEGQENS
510 520 530 540 550
IKSLEHVQFE ATIEYSRRGD LHVTLTSAAG TNTVLLAERE RDTSPNGFKN
560 570 580 590 600
WDFMSVHTWG ENPVGTWTLR ITDMSGRVQN EGRIVNWKLI LHGTSSQPEH
610 620 630 640 650
MKQPRVYTSY NTVQNDRRGV EKMADAGEEQ PTQQNLNEDP LVSKSASSSS
660 670 680 690 700
SSVGDRWDEQ AEGAPSQAML RLLQSAFSKN STPKQSPKKS PSAKLNIPYE
710 720 730 740 750
NFYKALEKLN KPFQLKDSED SLYNDYVDVF YNTKPYKHRD DRLLQALVDI

LNEEN
Length:755
Mass (Da):84,179
Last modified:December 14, 2011 - v1
Checksum:i5717C74F5A6D62B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JH171888 Genomic DNA Translation: EHB12786.1
GEBF01005627 Transcribed RNA Translation: JAN98005.1
RefSeqiXP_004841764.1, XM_004841707.2

Genome annotation databases

EnsembliENSHGLT00000010602; ENSHGLP00000010486; ENSHGLG00000007524
ENSHGLT00100024876; ENSHGLP00100024623; ENSHGLG00100018081
GeneIDi101704290
KEGGihgl:101704290

Similar proteinsi

Entry informationi

Entry nameiG5BU25_HETGA
AccessioniPrimary (citable) accession number: G5BU25
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: March 28, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported