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Protein
Submitted name:

Neuroendocrine convertase 1

Gene

PCSK1

Organism
Heterocephalus glaber (Naked mole rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseSAAS annotation

Protein family/group databases

MEROPSiS08.072.

Names & Taxonomyi

Protein namesi
Submitted name:
Neuroendocrine convertase 1Imported
Submitted name:
Neuroendocrine convertase 1 isoform 1 preproproteinImported
Gene namesi
Name:PCSK1Imported
ORF Names:GW7_03746Imported
OrganismiHeterocephalus glaber (Naked mole rat)Imported
Taxonomic identifieri10181 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiBathyergidaeHeterocephalus
Proteomesi
  • UP000006813 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 755728Sequence analysisPRO_5007660985Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliG5BU25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 11077S8_pro-domainInterPro annotationAdd
BLAST
Domaini158 – 442285Peptidase S8InterPro annotationAdd
BLAST
Domaini504 – 59188P_proproteinInterPro annotationAdd
BLAST
Domaini716 – 75338Proho_convertInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S8 family.SAAS annotation
Contains peptidase S8 domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

InParanoidiG5BU25.
KOiK01359.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.30.70.850. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR022005. Proho_convert.
IPR009020. Propept_inh.
IPR002884. PrprotnconvertsP.
IPR032815. S8_pro-domain.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 2 hits.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF12177. Proho_convert. 1 hit.
PF16470. S8_pro-domain. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G5BU25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERRAWSLQG AAFALFCSWC ALNSVKAKRQ FVNEWAAEVP GGPEAASAIA
60 70 80 90 100
EELGYDLLGQ IGSLENYYLF KHKNHPQRSR RSASHITKRL SDDDRVIWAE
110 120 130 140 150
QQYEKKRSKR SALRDSALNL FNDPMWNQQW YLQDTRMTAA LPKLDLHVIP
160 170 180 190 200
VWEKGITGKG VVLTILDDGL EWNHTDIYAN YDPEASYDFN DNDHDPFPRY
210 220 230 240 250
DPTNENKHGT RCAGEIAMQA NNRKCGVGVA YNSKVGGIRM LDGIVTDAIE
260 270 280 290 300
ASSIGFNPGH VDIYSASWGP NDDGKTVEGP GRLAQKAFEY GVKQGRQGKG
310 320 330 340 350
SIFVWASGNG GRQGDNCDCD GYTDSIYTIS ISSASQQGLS PWYAEKCSST
360 370 380 390 400
LATSYSSGDY TDQRITSADL HNDCTETHTG TSASAPLAAG IFALALEANP
410 420 430 440 450
NLTWRDMQHL VVWTSEYDPL ANNPGWKKNG AGLMVNSRFG FGLLNAKALV
460 470 480 490 500
DLADPRSWSS VPEKKQCVVK DNDFEPRALK ANGEVIIEIP TRACEGQENS
510 520 530 540 550
IKSLEHVQFE ATIEYSRRGD LHVTLTSAAG TNTVLLAERE RDTSPNGFKN
560 570 580 590 600
WDFMSVHTWG ENPVGTWTLR ITDMSGRVQN EGRIVNWKLI LHGTSSQPEH
610 620 630 640 650
MKQPRVYTSY NTVQNDRRGV EKMADAGEEQ PTQQNLNEDP LVSKSASSSS
660 670 680 690 700
SSVGDRWDEQ AEGAPSQAML RLLQSAFSKN STPKQSPKKS PSAKLNIPYE
710 720 730 740 750
NFYKALEKLN KPFQLKDSED SLYNDYVDVF YNTKPYKHRD DRLLQALVDI

LNEEN
Length:755
Mass (Da):84,179
Last modified:December 14, 2011 - v1
Checksum:i5717C74F5A6D62B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JH171888 Genomic DNA. Translation: EHB12786.1.
GEBF01005627 Transcribed RNA. Translation: JAN98005.1.
RefSeqiXP_004841764.1. XM_004841707.2.

Genome annotation databases

GeneIDi101704290.
KEGGihgl:101704290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JH171888 Genomic DNA. Translation: EHB12786.1.
GEBF01005627 Transcribed RNA. Translation: JAN98005.1.
RefSeqiXP_004841764.1. XM_004841707.2.

3D structure databases

ProteinModelPortaliG5BU25.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS08.072.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101704290.
KEGGihgl:101704290.

Organism-specific databases

CTDi5122.

Phylogenomic databases

InParanoidiG5BU25.
KOiK01359.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.30.70.850. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR022005. Proho_convert.
IPR009020. Propept_inh.
IPR002884. PrprotnconvertsP.
IPR032815. S8_pro-domain.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 2 hits.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF12177. Proho_convert. 1 hit.
PF16470. S8_pro-domain. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG5BU25_HETGA
AccessioniPrimary (citable) accession number: G5BU25
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: July 6, 2016
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.