ID   G5AZ59_HETGA            Unreviewed;       456 AA.
AC   G5AZ59;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   24-JAN-2024, entry version 47.
DE   SubName: Full=Transcription factor Dp-2 {ECO:0000313|EMBL:EHB02320.1};
GN   ORFNames=GW7_20191 {ECO:0000313|EMBL:EHB02320.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB02320.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB02320.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA   Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA   Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of the
RT   naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003796}.
CC   -!- SIMILARITY: Belongs to the E2F/DP family.
CC       {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
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DR   EMBL; JH167593; EHB02320.1; -; Genomic_DNA.
DR   AlphaFoldDB; G5AZ59; -.
DR   STRING; 10181.G5AZ59; -.
DR   InParanoid; G5AZ59; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd14458; DP_DD; 1.
DR   Gene3D; 1.20.140.80; Transcription factor DP; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR037241; E2F-DP_heterodim.
DR   InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR   InterPro; IPR038168; TF_DP_C_sf.
DR   InterPro; IPR014889; Transc_factor_DP_C.
DR   InterPro; IPR015648; Transcrpt_fac_DP.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12548; TRANSCRIPTION FACTOR DP; 1.
DR   PANTHER; PTHR12548:SF5; TRANSCRIPTION FACTOR DP-2; 1.
DR   Pfam; PF08781; DP; 2.
DR   Pfam; PF02319; E2F_TDP; 1.
DR   PIRSF; PIRSF009404; Transcription_factor_DP; 3.
DR   SMART; SM01138; DP; 1.
DR   SMART; SM01372; E2F_TDP; 1.
DR   SUPFAM; SSF144074; E2F-DP heterodimerization region; 2.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|RuleBase:RU003796};
KW   Nucleus {ECO:0000256|RuleBase:RU003796};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Transcription {ECO:0000256|RuleBase:RU003796};
KW   Transcription regulation {ECO:0000256|RuleBase:RU003796}.
FT   DOMAIN          101..182
FT                   /note="E2F/DP family winged-helix DNA-binding"
FT                   /evidence="ECO:0000259|SMART:SM01372"
FT   DOMAIN          189..369
FT                   /note="Transcription factor DP C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01138"
FT   REGION          419..456
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        419..436
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        440..456
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   456 AA;  50329 MW;  FA4E912654F98E77 CRC64;
     MRKMSSVLTW NLREVIHNGK GIIENSEDSP VVDHRWIIST PQRLASSGSV LIGSPYTPAP
     AMVTQTHIAE ATSWVPGDRK RAREFIESDF SESKRSKKGD KNGKGLRHFS MKVCEKVQRK
     GTTSYNEVAD ELVSEFTNSN NHLAADSAYD QKNIRRRVYD ALNVLMAMNI ISKEKKEIKW
     IGLPTNSAQE CQNLEQIAFK NLVQRNRQNE QQNQGPPALN STIQLPFIII NTSRKTVIDC
     SISSDKRKMV TLQGWLLWAM GNSSSARVLP SASVTPSLTL LSWSRPGPVP GTLLLPVMCV
     SQPKLFEYLF NFDNTFEIHD DIEVLKRMGM SFGLESGKCS LEDLKLAKSL VPKALESYIT
     DISTGPSWLN QGLLLNSAQS ASNLDLTTGA TLPQSSVNQG LCLDAEVALA TGQFLAPNSH
     QSSSAASHCS ESRGETPCSF NDEDEEDDEE DSSSPE
//