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G5AY81

- HYAS2_HETGA

UniProt

G5AY81 - HYAS2_HETGA

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Protein

Hyaluronan synthase 2

Gene
Has2
Organism
Heterocephalus glaber (Naked mole rat)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix.1 Publication

Catalytic activityi

UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan).
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan).

Cofactori

Magnesium.

Pathwayi

GO - Molecular functioni

  1. hyaluronan synthase activity Source: UniProtKB

GO - Biological processi

  1. atrioventricular canal development Source: UniProtKB
  2. endocardial cushion to mesenchymal transition Source: UniProtKB
  3. extracellular matrix assembly Source: UniProtKB
  4. extracellular polysaccharide biosynthetic process Source: UniProtKB
  5. hyaluronan biosynthetic process Source: UniProtKB
  6. positive regulation of urine volume Source: UniProtKB
  7. renal water absorption Source: UniProtKB
  8. vasculogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00341.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan synthase 2 (EC:2.4.1.212)
Alternative name(s):
Hyaluronate synthase 2
Hyaluronic acid synthase 2
Gene namesi
Name:Has2
OrganismiHeterocephalus glaber (Naked mole rat)
Taxonomic identifieri10181 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiBathyergidaeHeterocephalus
ProteomesiUP000006813: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei12 – 3221Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini33 – 4513Extracellular Reviewed predictionAdd
BLAST
Transmembranei46 – 6621Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini67 – 374308Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei375 – 39521Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini396 – 4027Extracellular Reviewed prediction
Transmembranei403 – 42321Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini424 – 4296Cytoplasmic Reviewed prediction
Transmembranei430 – 45021Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini451 – 47525Extracellular Reviewed predictionAdd
BLAST
Transmembranei476 – 49621Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini497 – 51014Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei511 – 53121Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini532 – 55221Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 552552Hyaluronan synthase 2PRO_0000424266Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the NodC/HAS family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK00752.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001173. Glyco_trans_2-like.
IPR026107. HAS/NodC.
IPR028371. HAS2.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR22913. PTHR22913. 1 hit.
PTHR22913:SF7. PTHR22913:SF7. 1 hit.
PfamiPF00535. Glycos_transf_2. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 2 hits.

Sequencei

Sequence statusi: Complete.

G5AY81-1 [UniParc]FASTAAdd to Basket

« Hide

MHCERFLCIL RIIGTTLFGV SLLLGITAAY IVGYQFIQTD NYYFSFGLYG    50
AFLASHLIIQ SLFAFLEHRK MKKSLETPIK LNKTVALCIA AYQEDPDYLR 100
KCLQSVKRLT YPGIKVVMVI DGNSDDDLYM MDIFSEVMGR DKSATYIWKN 150
NFHEKGPGET DESHKESSQH VTQLVLSSKS VCIMQKWGGK REVMYTAFRA 200
LGRSVDYVQV CDSDTMLDPA SSVEMVKVLE EDPMVGGVGG DVQILNKYDS 250
WISFLSSVRY WMAFNIERAC QSYFGCVQCI SGPLGMYRNS LLHEFVEDWY 300
SQEFMGNQCS FGDDRHLTNR VLSLGYATKY TARSKCLTET PIEYLRWLNQ 350
QTRWSKSYFR EWLYNAMWFH KHHLWMTYEA VITGFFPFFL IATVIQLFYR 400
GKIWNILLFL LTVQLVGLIK SSFASCLRGN IVMVFMSLYS VLYMSSLLPA 450
KMFAIATINK AGWGTSGRKT IVVNFIGLIP VSVWFTILLG GVIFTIYKES 500
KKPFSESKQT VLIVGTLLYA CYWVMLLTLY VVLINKCGRR KKGQQYDMVL 550
DV 552
Length:552
Mass (Da):63,442
Last modified:December 14, 2011 - v1
Checksum:i36C8A97AD5E3729E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JH167500 Genomic DNA. Translation: EHB01992.1.
RefSeqiXP_004883180.1. XM_004883123.1.

Genome annotation databases

GeneIDi101724130.
KEGGihgl:101724130.

Cross-referencesi

Web resourcesi

Protein Spotlight

an unexpected turn of events - Issue 155 of December 2013

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JH167500 Genomic DNA. Translation: EHB01992.1 .
RefSeqi XP_004883180.1. XM_004883123.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101724130.
KEGGi hgl:101724130.

Organism-specific databases

CTDi 3037.

Phylogenomic databases

KOi K00752.

Enzyme and pathway databases

UniPathwayi UPA00341 .

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR001173. Glyco_trans_2-like.
IPR026107. HAS/NodC.
IPR028371. HAS2.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
PANTHERi PTHR22913. PTHR22913. 1 hit.
PTHR22913:SF7. PTHR22913:SF7. 1 hit.
Pfami PF00535. Glycos_transf_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat."
    Tian X., Azpurua J., Hine C., Vaidya A., Myakishev-Rempel M., Ablaeva J., Mao Z., Nevo E., Gorbunova V., Seluanov A.
    Nature 499:346-349(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiHYAS2_HETGA
AccessioniPrimary (citable) accession number: G5AY81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2013
Last sequence update: December 14, 2011
Last modified: June 11, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Via the strong production of high molecular mass hyaluronan (HMM-HA) may be in part responsible for the low susceptibility to cancers observed with those rodents (1 Publication).

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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