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Protein

L-lactate dehydrogenase

Gene

Smp_038950

Organism
Schistosoma mansoni (Blood fluke)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (Smp_038950), L-lactate dehydrogenase (Smp_038960)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106SubstrateUniRule annotation1
Binding sitei138SubstrateUniRule annotation1
Binding sitei169SubstrateUniRule annotation1
Active sitei193Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
ORF Names:Smp_038950Imported
OrganismiSchistosoma mansoni (Blood fluke)Imported
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma
Proteomesi
  • UP000008854 Componenti: Chromosome W

Subcellular locationi

Interactioni

Protein-protein interaction databases

STRINGi6183.Smp_038950__mRNA.

Structurei

3D structure databases

ProteinModelPortaliG4VQZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 160Ldh_1_NInterPro annotationAdd BLAST137
Domaini163 – 328Ldh_1_CInterPro annotationAdd BLAST166

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1495. Eukaryota.
COG0039. LUCA.
InParanoidiG4VQZ5.
OMAiDQWKNIH.
OrthoDBiEOG091G0HME.
PhylomeDBiG4VQZ5.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiView protein in PROSITE
PS00064. L_LDH. 1 hit.

Sequencei

Sequence statusi: Complete.

G4VQZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSICDALLK PVAPTDIEPR SRSKVTVIGV GMVGMAAAFS TMQVAGELVL
60 70 80 90 100
IDVVADKVKG EVLDLQHGQQ FFGRCKIDGG TDYKYSANSD IVVITAGARQ
110 120 130 140 150
NEGESRLNLV QRNVDIFKKI IPNIVKYSPK CIIVVVSNPV DILTYVARKL
160 170 180 190 200
SGFEAHRVIG TGTMLDSARF RFLLGEKLGV SANSVHGYVI GEHGDSSVAV
210 220 230 240 250
WSNVNVAGVR LSSLNPKIGC KDDPENFEEI HKQVVQSAYD IIRLKGYTSW
260 270 280 290 300
AIGLTCRSLC NALLNNLHTV YPLSVPVKGI HGINEDVYLS LPCLVTSSGI
310 320 330
SHLIPLELGD DELCKLRKSA ATLNEVITGI KW
Length:332
Mass (Da):35,963
Last modified:December 14, 2011 - v1
Checksum:i43314A62CDF387AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601631 Genomic DNA. Translation: CCD82636.1.
RefSeqiXP_018655219.1. XM_018789814.1.

Genome annotation databases

EnsemblMetazoaiSmp_038950.1; Smp_038950.1:pep; Smp_038950.
GeneDBiSmp_038950.1:pep.
GeneIDi8355539.

Similar proteinsi

Entry informationi

Entry nameiG4VQZ5_SCHMA
AccessioniPrimary (citable) accession number: G4VQZ5
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: November 22, 2017
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported