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Protein

Kynureninase

Gene

Smp_023470

Organism
Schistosoma mansoni (Blood fluke)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-kynurenine degradation

This protein is involved in step 1 of the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Kynureninase (Smp_023470)
This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Kynureninase (Smp_023470)
  3. no protein annotated in this organism
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei159Pyridoxal phosphate; via amide nitrogenUniRule annotation1
Binding sitei160Pyridoxal phosphateUniRule annotation1
Binding sitei273Pyridoxal phosphateUniRule annotation1
Binding sitei276Pyridoxal phosphateUniRule annotation1
Binding sitei298Pyridoxal phosphateUniRule annotation1
Binding sitei353Pyridoxal phosphateUniRule annotation1
Binding sitei381Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
Biological processPyridine nucleotide biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329
UPA00334; UER00455

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
ORF Names:Smp_023470Imported
OrganismiSchistosoma mansoni (Blood fluke)Imported
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma
Proteomesi
  • UP000008854 Componenti: Chromosome 3

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei299N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi6183.Smp_023470__mRNA

Structurei

3D structure databases

ProteinModelPortaliG4VFR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini234 – 320Aminotran_5InterPro annotationAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni187 – 190Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3846 Eukaryota
COG3844 LUCA
InParanoidiG4VFR8
KOiK01556
OMAiGWYGGDK
OrthoDBiEOG091G077R
PhylomeDBiG4VFR8

Family and domain databases

Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 2 hits
HAMAPiMF_01970 Kynureninase, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR010111 Kynureninase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR14084 PTHR14084, 1 hit
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PIRSFiPIRSF038800 KYNU, 1 hit
SUPFAMiSSF53383 SSF53383, 2 hits

Sequencei

Sequence statusi: Complete.

G4VFR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQFLLVPLH YIVMSSSMEE LRYLANKYQV DMDSIDFAIK LDEHDLLQSY
60 70 80 90 100
QSEFYLPNYK EVMKTIQSNF TEPNPSLTDI NDENHSKKII YFCGNSMGLQ
110 120 130 140 150
PKRLHAYLDG ILNQWRNLGV LAYHYGELPA SYCDQQLSID CAQWIVNSKS
160 170 180 190 200
SEVTMTCNLT VNMHTLIAKF YRPKGERCCI LIEDGIFPSD YYVLESQINW
210 220 230 240 250
HGLNPNDCII KLKPHINEYC LRNEDILQEI QKNQHRIALI WLPGIQYVTG
260 270 280 290 300
QLFNMKLITE WGHQYCKCPV GWDLAHAVGN IPLYLHDWDV DMAVWCSYKY
310 320 330 340 350
LNGSPGAIGG LFIHEKHHHQ ESSYGPKFNE FNNINSSDNT IINDISGPQL
360 370 380 390 400
TGWWSHRTET RFNYTGNMEL AKGADAYRLS NPPLLLAAAL TVSISIIKSC
410 420 430 440 450
GGMNNLREKS IKLTNYLEYL ITESSLALNS DRYCIVTPSS PEERGAQLTL
460 470 480 490 500
CFNNVKIEKL YENLLRLGVI CDYRLPNFLR ITPIPLYNSF EDVYMFVKYL
510
RQALYDTESV
Length:510
Mass (Da):58,857
Last modified:December 14, 2011 - v1
Checksum:i57FD2462DC29D02A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601626 Genomic DNA Translation: CCD78777.1
RefSeqiXP_018651385.1, XM_018799614.1

Genome annotation databases

EnsemblMetazoaiSmp_023470.1; Smp_023470.1:pep; Smp_023470
GeneDBiSmp_023470.1:pep
GeneIDi8346127
KEGGismm:Smp_023470

Similar proteinsi

Entry informationi

Entry nameiG4VFR8_SCHMA
AccessioniPrimary (citable) accession number: G4VFR8
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: March 28, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health