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G4VFR8 (G4VFR8_SCHMA) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Kynureninase PIRNR PIRNR038800

EC=3.7.1.3 PIRNR PIRNR038800
Gene names
ORF Names:Smp_023470 EMBL CCD78777.1
OrganismSchistosoma mansoni (Blood fluke) [Reference proteome] EMBL CCD78777.1
Taxonomic identifier6183 [NCBI]
Taxonomic lineageEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

Protein attributes

Sequence length510 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800

Catalytic activity

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800

L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800

Cofactor

Pyridoxal phosphate By similarity. PIRNR PIRNR038800

Pathway

Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800

Subunit structure

Homodimer By similarity. PIRNR PIRNR038800

Subcellular location

Cytoplasm By similarity PIRNR PIRNR038800.

Sequence similarities

Belongs to the kynureninase family. PIRNR PIRNR038800

Sequences

Sequence LengthMass (Da)Tools
G4VFR8 [UniParc].

Last modified December 14, 2011. Version 1.
Checksum: 57FD2462DC29D02A

FASTA51058,857
        10         20         30         40         50         60 
MIQFLLVPLH YIVMSSSMEE LRYLANKYQV DMDSIDFAIK LDEHDLLQSY QSEFYLPNYK 

        70         80         90        100        110        120 
EVMKTIQSNF TEPNPSLTDI NDENHSKKII YFCGNSMGLQ PKRLHAYLDG ILNQWRNLGV 

       130        140        150        160        170        180 
LAYHYGELPA SYCDQQLSID CAQWIVNSKS SEVTMTCNLT VNMHTLIAKF YRPKGERCCI 

       190        200        210        220        230        240 
LIEDGIFPSD YYVLESQINW HGLNPNDCII KLKPHINEYC LRNEDILQEI QKNQHRIALI 

       250        260        270        280        290        300 
WLPGIQYVTG QLFNMKLITE WGHQYCKCPV GWDLAHAVGN IPLYLHDWDV DMAVWCSYKY 

       310        320        330        340        350        360 
LNGSPGAIGG LFIHEKHHHQ ESSYGPKFNE FNNINSSDNT IINDISGPQL TGWWSHRTET 

       370        380        390        400        410        420 
RFNYTGNMEL AKGADAYRLS NPPLLLAAAL TVSISIIKSC GGMNNLREKS IKLTNYLEYL 

       430        440        450        460        470        480 
ITESSLALNS DRYCIVTPSS PEERGAQLTL CFNNVKIEKL YENLLRLGVI CDYRLPNFLR 

       490        500        510 
ITPIPLYNSF EDVYMFVKYL RQALYDTESV 

« Hide

References

[1]"A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni."
Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A., De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C., Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J., Oliveira G., Otto T.D. expand/collapse author list , Parker-Manuel S.J., Quail M.A., Wilson R.A., Zerlotini A., Dunne D.W., Berriman M.
PLoS Negl. Trop. Dis. 6:E1455-E1455(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Puerto Rican.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE601626 Genomic DNA. Translation: CCD78777.1.
RefSeqXP_002573785.1. XM_002573739.1.

3D structure databases

ProteinModelPortalG4VFR8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaSmp_023470.1; Smp_023470.1:pep; Smp_023470.
GeneID8346127.
KEGGsmm:Smp_023470.

Organism-specific databases

CTD8346127.

Phylogenomic databases

KOK01556.
OMAGWYGGDK.
PhylomeDBG4VFR8.

Enzyme and pathway databases

UniPathwayUPA00253; UER00329.
UPA00334; UER00455.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPMF_01970. Kynureninase.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR14084. PTHR14084. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF038800. KYNU. 1 hit.
SUPFAMSSF53383. SSF53383. 2 hits.
ProtoNetSearch...

Entry information

Entry nameG4VFR8_SCHMA
AccessionPrimary (citable) accession number: G4VFR8
Entry history
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: February 19, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)