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Protein

Kynureninase

Gene

Smp_023470

Organism
Schistosoma mansoni (Blood fluke)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei159 – 1591Pyridoxal phosphate; via amide nitrogenUniRule annotation
Binding sitei160 – 1601Pyridoxal phosphateUniRule annotation
Binding sitei273 – 2731Pyridoxal phosphateUniRule annotation
Binding sitei276 – 2761Pyridoxal phosphateUniRule annotation
Binding sitei298 – 2981Pyridoxal phosphateUniRule annotation
Binding sitei353 – 3531Pyridoxal phosphateUniRule annotation
Binding sitei381 – 3811Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  4. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
ORF Names:Smp_023470Imported
OrganismiSchistosoma mansoni (Blood fluke)Imported
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma
ProteomesiUP000008854 Componenti: Chromosome 3

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei299 – 2991N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliG4VFR8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni187 – 1904Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

InParanoidiG4VFR8.
OMAiGWYGGDK.
PhylomeDBiG4VFR8.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 2 hits.

Sequencei

Sequence statusi: Complete.

G4VFR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQFLLVPLH YIVMSSSMEE LRYLANKYQV DMDSIDFAIK LDEHDLLQSY
60 70 80 90 100
QSEFYLPNYK EVMKTIQSNF TEPNPSLTDI NDENHSKKII YFCGNSMGLQ
110 120 130 140 150
PKRLHAYLDG ILNQWRNLGV LAYHYGELPA SYCDQQLSID CAQWIVNSKS
160 170 180 190 200
SEVTMTCNLT VNMHTLIAKF YRPKGERCCI LIEDGIFPSD YYVLESQINW
210 220 230 240 250
HGLNPNDCII KLKPHINEYC LRNEDILQEI QKNQHRIALI WLPGIQYVTG
260 270 280 290 300
QLFNMKLITE WGHQYCKCPV GWDLAHAVGN IPLYLHDWDV DMAVWCSYKY
310 320 330 340 350
LNGSPGAIGG LFIHEKHHHQ ESSYGPKFNE FNNINSSDNT IINDISGPQL
360 370 380 390 400
TGWWSHRTET RFNYTGNMEL AKGADAYRLS NPPLLLAAAL TVSISIIKSC
410 420 430 440 450
GGMNNLREKS IKLTNYLEYL ITESSLALNS DRYCIVTPSS PEERGAQLTL
460 470 480 490 500
CFNNVKIEKL YENLLRLGVI CDYRLPNFLR ITPIPLYNSF EDVYMFVKYL
510
RQALYDTESV
Length:510
Mass (Da):58,857
Last modified:December 14, 2011 - v1
Checksum:i57FD2462DC29D02A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601626 Genomic DNA. Translation: CCD78777.1.

Genome annotation databases

EnsemblMetazoaiSmp_023470.1; Smp_023470.1:pep; Smp_023470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601626 Genomic DNA. Translation: CCD78777.1.

3D structure databases

ProteinModelPortaliG4VFR8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiSmp_023470.1; Smp_023470.1:pep; Smp_023470.

Phylogenomic databases

InParanoidiG4VFR8.
OMAiGWYGGDK.
PhylomeDBiG4VFR8.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Puerto RicanImported.

Entry informationi

Entry nameiG4VFR8_SCHMA
AccessioniPrimary (citable) accession number: G4VFR8
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: April 1, 2015
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.