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G4VFR8

- G4VFR8_SCHMA

UniProt

G4VFR8 - G4VFR8_SCHMA

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Protein

Kynureninase

Gene
Smp_023470
Organism
Schistosoma mansoni (Blood fluke)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei159 – 1591Pyridoxal phosphate; via amide nitrogen By similarityUniRule annotation
Binding sitei160 – 1601Pyridoxal phosphate By similarityUniRule annotation
Binding sitei273 – 2731Pyridoxal phosphate By similarityUniRule annotation
Binding sitei276 – 2761Pyridoxal phosphate By similarityUniRule annotation
Binding sitei298 – 2981Pyridoxal phosphate By similarityUniRule annotation
Binding sitei353 – 3531Pyridoxal phosphate By similarityUniRule annotation
Binding sitei381 – 3811Pyridoxal phosphate By similarityUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolase
Gene namesi
ORF Names:Smp_023470Imported
OrganismiSchistosoma mansoni (Blood fluke)Imported
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma
ProteomesiUP000008854: Chromosome 3

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei299 – 2991N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliG4VFR8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni187 – 1904Pyridoxal phosphate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK01556.
OMAiGWYGGDK.
PhylomeDBiG4VFR8.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 2 hits.

Sequencei

Sequence statusi: Complete.

G4VFR8-1 [UniParc]FASTAAdd to Basket

« Hide

MIQFLLVPLH YIVMSSSMEE LRYLANKYQV DMDSIDFAIK LDEHDLLQSY    50
QSEFYLPNYK EVMKTIQSNF TEPNPSLTDI NDENHSKKII YFCGNSMGLQ 100
PKRLHAYLDG ILNQWRNLGV LAYHYGELPA SYCDQQLSID CAQWIVNSKS 150
SEVTMTCNLT VNMHTLIAKF YRPKGERCCI LIEDGIFPSD YYVLESQINW 200
HGLNPNDCII KLKPHINEYC LRNEDILQEI QKNQHRIALI WLPGIQYVTG 250
QLFNMKLITE WGHQYCKCPV GWDLAHAVGN IPLYLHDWDV DMAVWCSYKY 300
LNGSPGAIGG LFIHEKHHHQ ESSYGPKFNE FNNINSSDNT IINDISGPQL 350
TGWWSHRTET RFNYTGNMEL AKGADAYRLS NPPLLLAAAL TVSISIIKSC 400
GGMNNLREKS IKLTNYLEYL ITESSLALNS DRYCIVTPSS PEERGAQLTL 450
CFNNVKIEKL YENLLRLGVI CDYRLPNFLR ITPIPLYNSF EDVYMFVKYL 500
RQALYDTESV 510
Length:510
Mass (Da):58,857
Last modified:December 14, 2011 - v1
Checksum:i57FD2462DC29D02A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601626 Genomic DNA. Translation: CCD78777.1.

Genome annotation databases

EnsemblMetazoaiSmp_023470.1; Smp_023470.1:pep; Smp_023470.
KEGGismm:Smp_023470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601626 Genomic DNA. Translation: CCD78777.1 .

3D structure databases

ProteinModelPortali G4VFR8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai Smp_023470.1 ; Smp_023470.1:pep ; Smp_023470 .
KEGGi smm:Smp_023470.

Phylogenomic databases

KOi K01556.
OMAi GWYGGDK.
PhylomeDBi G4VFR8.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Puerto Rican.

Entry informationi

Entry nameiG4VFR8_SCHMA
AccessioniPrimary (citable) accession number: G4VFR8
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: September 3, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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