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G4VFR8

- G4VFR8_SCHMA

UniProt

G4VFR8 - G4VFR8_SCHMA

Protein

Kynureninase

Gene

Smp_023470

Organism
Schistosoma mansoni (Blood fluke)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (14 Dec 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei159 – 1591Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei160 – 1601Pyridoxal phosphateUniRule annotation
    Binding sitei273 – 2731Pyridoxal phosphateUniRule annotation
    Binding sitei276 – 2761Pyridoxal phosphateUniRule annotation
    Binding sitei298 – 2981Pyridoxal phosphateUniRule annotation
    Binding sitei353 – 3531Pyridoxal phosphateUniRule annotation
    Binding sitei381 – 3811Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotationImported

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    L-kynurenine hydrolaseUniRule annotation
    Gene namesi
    ORF Names:Smp_023470Imported
    OrganismiSchistosoma mansoni (Blood fluke)Imported
    Taxonomic identifieri6183 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma
    ProteomesiUP000008854: Chromosome 3

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei299 – 2991N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliG4VFR8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni187 – 1904Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    KOiK01556.
    OMAiGWYGGDK.
    PhylomeDBiG4VFR8.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    G4VFR8-1 [UniParc]FASTAAdd to Basket

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    MIQFLLVPLH YIVMSSSMEE LRYLANKYQV DMDSIDFAIK LDEHDLLQSY    50
    QSEFYLPNYK EVMKTIQSNF TEPNPSLTDI NDENHSKKII YFCGNSMGLQ 100
    PKRLHAYLDG ILNQWRNLGV LAYHYGELPA SYCDQQLSID CAQWIVNSKS 150
    SEVTMTCNLT VNMHTLIAKF YRPKGERCCI LIEDGIFPSD YYVLESQINW 200
    HGLNPNDCII KLKPHINEYC LRNEDILQEI QKNQHRIALI WLPGIQYVTG 250
    QLFNMKLITE WGHQYCKCPV GWDLAHAVGN IPLYLHDWDV DMAVWCSYKY 300
    LNGSPGAIGG LFIHEKHHHQ ESSYGPKFNE FNNINSSDNT IINDISGPQL 350
    TGWWSHRTET RFNYTGNMEL AKGADAYRLS NPPLLLAAAL TVSISIIKSC 400
    GGMNNLREKS IKLTNYLEYL ITESSLALNS DRYCIVTPSS PEERGAQLTL 450
    CFNNVKIEKL YENLLRLGVI CDYRLPNFLR ITPIPLYNSF EDVYMFVKYL 500
    RQALYDTESV 510
    Length:510
    Mass (Da):58,857
    Last modified:December 14, 2011 - v1
    Checksum:i57FD2462DC29D02A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601626 Genomic DNA. Translation: CCD78777.1.

    Genome annotation databases

    EnsemblMetazoaiSmp_023470.1; Smp_023470.1:pep; Smp_023470.
    KEGGismm:Smp_023470.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601626 Genomic DNA. Translation: CCD78777.1 .

    3D structure databases

    ProteinModelPortali G4VFR8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai Smp_023470.1 ; Smp_023470.1:pep ; Smp_023470 .
    KEGGi smm:Smp_023470.

    Phylogenomic databases

    KOi K01556.
    OMAi GWYGGDK.
    PhylomeDBi G4VFR8.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Puerto RicanImported.

    Entry informationi

    Entry nameiG4VFR8_SCHMA
    AccessioniPrimary (citable) accession number: G4VFR8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 14, 2011
    Last sequence update: December 14, 2011
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3