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Protein

Mitogen-activated protein kinase

Gene

Smp_140700

Organism
Schistosoma mansoni (Blood fluke)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseUniRule annotationSAAS annotation (EC:2.7.11.24UniRule annotationSAAS annotation)
Gene namesi
ORF Names:Smp_140700Imported
OrganismiSchistosoma mansoni (Blood fluke)Imported
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma
ProteomesiUP000008854 Componenti: Chromosome 2

Structurei

3D structure databases

ProteinModelPortaliG4VEG6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.UniRule annotation
Contains 1 protein kinase domain.UniRule annotation

Phylogenomic databases

InParanoidiG4VEG6.
OMAiHRSHANI.
PhylomeDBiG4VEG6.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G4VEG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVPINFPYS AETYQKQFLN PSTPLPGSLS VFPNVLHYSE KVAAMFNGLQ
60 70 80 90 100
IGPSLRCANL IPQKGPQHII GGPVLAVVKS TFSPVGYGNS QRLENGFTFQ
110 120 130 140 150
PSLTQKVYMP EKSLGFGAFG VVWLVVDPRT GDQVALKRIP NIFESIVSAK
160 170 180 190 200
RAYRELKLLF SLRHSNIVRL IDVVKVSSSS LFSEVSVLCE YMDTDLHKII
210 220 230 240 250
VSTQYLSLEH VKLFVYQILR GLKYLHSAGV IHRDLKPGNL LVNSDCLLKI
260 270 280 290 300
CDFGLARSVP SFDVESPSNP LTLEVVTQFY RPPELLLGSN FYTAAVDQWS
310 320 330 340 350
VGCILGELLC RQILFQSSSS FRQLDMIFNL LGSPNAMELI DLVGFPSSSI
360 370 380 390 400
DFIRNCPVRP FNHAAVSRIL VPANTQYFQS STENPPDPDL VNLFTGLLSF
410 420 430 440 450
SSSKRLTAEQ ALDSPFLIGG RARFHTCLCS CCPPRNQNSI INDSSSHWRN
460 470 480 490 500
VTNQVNRHHL VAVGSVGTLS SSGGTPPSSL HSSMLSQSRD ITLRIPLFLS
510 520 530 540 550
PHLMVPTSLI RYRRINLEPT FQDIHEYTYI NTEIQMNNLF EAKQILWNLI
560 570
QQYFQRDPNR TRVVINNSSP NFQSFIK
Length:577
Mass (Da):64,576
Last modified:December 14, 2011 - v1
Checksum:iCE5D690895F93156
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601625 Genomic DNA. Translation: CCD77182.1.

Genome annotation databases

EnsemblMetazoaiSmp_140700.1; Smp_140700.1:pep; Smp_140700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601625 Genomic DNA. Translation: CCD77182.1.

3D structure databases

ProteinModelPortaliG4VEG6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiSmp_140700.1; Smp_140700.1:pep; Smp_140700.

Phylogenomic databases

InParanoidiG4VEG6.
OMAiHRSHANI.
PhylomeDBiG4VEG6.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Puerto RicanImported.

Entry informationi

Entry nameiG4VEG6_SCHMA
AccessioniPrimary (citable) accession number: G4VEG6
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: April 29, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.