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Protein

DNA ligase

Gene

Smp_148660

Organism
Schistosoma mansoni (Blood fluke)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:Smp_148660Imported
OrganismiSchistosoma mansoni (Blood fluke)Imported
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma
ProteomesiUP000008854 Componenti: Chromosome 1

Structurei

3D structure databases

ProteinModelPortaliG4V907.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

InParanoidiG4V907.
OMAiISHFLCA.
PhylomeDBiG4V907.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR10459:SF7. PTHR10459:SF7. 1 hit.
PfamiPF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G4V907-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVIFESSRI AKNVSFTTYC RLLEKLASSD GVKTKEKILS RFVILWETQY
60 70 80 90 100
LALDSISQYP CGGRASLYLL LRLLIPSHDR SRKAFGLRGQ TLSRLIIKAI
110 120 130 140 150
GLAPNSLAAR KLSHIHPNSI HRQTDFADVA YTVLRARCRE DSVLSVKDLN
160 170 180 190 200
THLDELSTAE SYDMRLQVLR SLLQLTTALE QKWIIRLIVK RDSGCGLSGK
210 220 230 240 250
SILRCFHPAA VSVFEVTQDL LPLCERIANI PSPNTFMLTG YANNLSKSFD
260 270 280 290 300
VTLFVPFRPM LCERANSGDM LVNSALHLYG KQNQGDTKGL KLLFETKFDG
310 320 330 340 350
ERVQLHKSSN SYRYWSRNGL EWTASYGEDG TRDFDRLSAQ LHCGFAQHVT
360 370 380 390 400
DCILDGEMMI FSKWSNSIMS KSTKFDVKRS SYQNPEIDNY QPCFIVFDIL
410 420 430 440 450
YLNSQVCLSY PYHINDFKPI PIINGIMYVS KWYTASAHQT EVARAFNHLV
460 470 480 490 500
DNHQEGLIVK IANSPSLYLP GIRTDGGWWK IKPDYIQGLL EDLDCLIVGG
510 520 530 540 550
YFHHRGDKII TRVNHFLCAV RNDESYESTS EDNFTLTRFY TFCKVKSGLT
560 570 580 590 600
VKQLKEINQL LGKHWKVYDK KHPNSSSTEW LCVNSERPDV WIAPRSSLVL
610 620 630 640 650
QLHGAELIQS DSYSCGITLR FPRVVAIRHD KNWRDSLSMS ELIKLNTETE
660 670 680 690 700
GKLATKRLSI VPTFSGLADV EHQQSFPDIS SLNSSCSSTN QSSGYHTLNE
710 720 730 740 750
TTEQQTTELF INVDEPLATS SPIKQRKIDV CHEHLNYFEN HEICLWLSND
760 770 780 790 800
IELNKKLELE AIIRRYGGVV VQNPSESTFC IVADKLTLKL STSQETEFNI
810 820 830 840
WLNKNYSILN TWIRQFPRIP HFIKESWLTE CIMQSSWCSE LNHLIEIN
Length:848
Mass (Da):96,966
Last modified:December 13, 2011 - v1
Checksum:i48EA2647122EA354
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601624 Genomic DNA. Translation: CCD76233.1.

Genome annotation databases

EnsemblMetazoaiSmp_148660.1; Smp_148660.1:pep; Smp_148660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601624 Genomic DNA. Translation: CCD76233.1.

3D structure databases

ProteinModelPortaliG4V907.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiSmp_148660.1; Smp_148660.1:pep; Smp_148660.

Phylogenomic databases

InParanoidiG4V907.
OMAiISHFLCA.
PhylomeDBiG4V907.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR10459:SF7. PTHR10459:SF7. 1 hit.
PfamiPF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Puerto RicanImported.

Entry informationi

Entry nameiG4V907_SCHMA
AccessioniPrimary (citable) accession number: G4V907
Entry historyi
Integrated into UniProtKB/TrEMBL: December 13, 2011
Last sequence update: December 13, 2011
Last modified: January 6, 2015
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.