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G4V7G8

- G4V7G8_SCHMA

UniProt

G4V7G8 - G4V7G8_SCHMA

Protein
Submitted name:

Putative adenosine kinase

Gene

Smp_008360

Organism
Schistosoma mansoni (Blood fluke)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (14 Dec 2011)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi265 – 2673AMPImported

    GO - Molecular functioni

    1. adenosine kinase activity Source: UniProtKB-EC
    2. nucleotide binding Source: UniProtKB-KW
    3. phosphotransferase activity, alcohol group as acceptor Source: InterPro

    GO - Biological processi

    1. purine ribonucleoside salvage Source: InterPro

    Keywords - Molecular functioni

    KinaseImported, Transferase

    Keywords - Ligandi

    Nucleotide-bindingImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative adenosine kinaseImported (EC:2.7.1.20Imported)
    Gene namesi
    ORF Names:Smp_008360Imported
    OrganismiSchistosoma mansoni (Blood fluke)Imported
    Taxonomic identifieri6183 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma
    ProteomesiUP000008854: Chromosome 1

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3UQ6X-ray2.30A/B1-352[»]
    3UQ9X-ray2.34A/B1-352[»]
    3VAQX-ray2.44A/B1-352[»]
    3VASX-ray2.26A/B2-352[»]
    4DC3X-ray2.40A/B1-352[»]
    ProteinModelPortaliG4V7G8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    KOiK00856.
    OMAiCIANIEK.
    PhylomeDBiG4V7G8.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    InterProiIPR001805. Adenokinase.
    IPR002173. Carboh/pur_kinase_PfkB_CS.
    IPR011611. PfkB_dom.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PANTHERiPTHR10584:SF24. PTHR10584:SF24. 1 hit.
    PfamiPF00294. PfkB. 1 hit.
    [Graphical view]
    PRINTSiPR00989. ADENOKINASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.
    PROSITEiPS00584. PFKB_KINASES_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G4V7G8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHDLSEGYVF GMGNPLLDII VDADDFMYRK YNLKKDNIVL AEEKHMTIYD    50
    EIQKKKKLNY IAGGATLNTV KMIQWIIQKP FVCSYVGCIG ADIQGKYIKN 100
    DCSALDLVTE FQIAEEPLMT GKVAVLVSEK LRSMVTYLGA ACDLSLAHIE 150
    QPHVWSLVEK AQVYYIAGFV INTCYEGMLK IAKHSLENEK LFCFNLSAPF 200
    LSQFNTKEVD EMISYSNIVF GNESEAEAYG EVHGLLEDTV HATARYIADL 250
    PFADGKKRKR LVIITRGKNP LLYTDSSDSE IHQFMVEQFK DDQIIDTNGA 300
    GDAFAAGFIA DYIRGKPMIT SLHAAVKAAA YIICRSGFSL GSRDSYSLKI 350
    NK 352
    Length:352
    Mass (Da):39,392
    Last modified:December 14, 2011 - v1
    Checksum:i68B7BD774E7BBAD5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601624 Genomic DNA. Translation: CCD75963.1.
    UniGeneiSma.8196.

    Genome annotation databases

    EnsemblMetazoaiSmp_008360.1; Smp_008360.1:pep; Smp_008360.
    KEGGismm:Smp_008360.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601624 Genomic DNA. Translation: CCD75963.1 .
    UniGenei Sma.8196.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3UQ6 X-ray 2.30 A/B 1-352 [» ]
    3UQ9 X-ray 2.34 A/B 1-352 [» ]
    3VAQ X-ray 2.44 A/B 1-352 [» ]
    3VAS X-ray 2.26 A/B 2-352 [» ]
    4DC3 X-ray 2.40 A/B 1-352 [» ]
    ProteinModelPortali G4V7G8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai Smp_008360.1 ; Smp_008360.1:pep ; Smp_008360 .
    KEGGi smm:Smp_008360.

    Phylogenomic databases

    KOi K00856.
    OMAi CIANIEK.
    PhylomeDBi G4V7G8.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    InterProi IPR001805. Adenokinase.
    IPR002173. Carboh/pur_kinase_PfkB_CS.
    IPR011611. PfkB_dom.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    PANTHERi PTHR10584:SF24. PTHR10584:SF24. 1 hit.
    Pfami PF00294. PfkB. 1 hit.
    [Graphical view ]
    PRINTSi PR00989. ADENOKINASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    PROSITEi PS00584. PFKB_KINASES_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Puerto RicanImported.
    2. "Adenosine kinase from Schistosoma mansoni: structural basis for the differential incorporation of nucleoside analogues."
      Romanello L., Bachega J.F., Cassago A., Brandao-Neto J., DeMarco R., Garratt R.C., Pereira H.D.
      Acta Crystallogr. D 69:126-136(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS) OF 2-352 IN COMPLEX WITH AMP.

    Entry informationi

    Entry nameiG4V7G8_SCHMA
    AccessioniPrimary (citable) accession number: G4V7G8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 14, 2011
    Last sequence update: December 14, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3