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Protein
Submitted name:

Putative adenosine kinase

Gene

Smp_008360

Organism
Schistosoma mansoni (Blood fluke)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi265 – 2673AMPCombined sources

GO - Molecular functioni

  1. adenosine kinase activity Source: UniProtKB-EC
  2. nucleotide binding Source: UniProtKB-KW
  3. phosphotransferase activity, alcohol group as acceptor Source: InterPro

GO - Biological processi

  1. purine ribonucleoside salvage Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Keywords - Ligandi

Nucleotide-bindingCombined sources

Enzyme and pathway databases

BRENDAi2.7.1.20. 5608.

Names & Taxonomyi

Protein namesi
Submitted name:
Putative adenosine kinaseImported (EC:2.7.1.20Imported)
Gene namesi
ORF Names:Smp_008360Imported
OrganismiSchistosoma mansoni (Blood fluke)Imported
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma
ProteomesiUP000008854 Componenti: Chromosome 1

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UQ6X-ray2.30A/B1-352[»]
3UQ9X-ray2.34A/B1-352[»]
3VAQX-ray2.44A/B1-352[»]
3VASX-ray2.26A/B2-352[»]
4DC3X-ray2.40A/B1-352[»]
ProteinModelPortaliG4V7G8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

InParanoidiG4V7G8.
OMAiHASAQNC.
PhylomeDBiG4V7G8.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR001805. Adenokinase.
IPR002173. Carboh/pur_kinase_PfkB_CS.
IPR011611. PfkB_dom.
IPR029056. Ribokinase-like.
[Graphical view]
PANTHERiPTHR10584:SF24. PTHR10584:SF24. 1 hit.
PfamiPF00294. PfkB. 1 hit.
[Graphical view]
PRINTSiPR00989. ADENOKINASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
PROSITEiPS00584. PFKB_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G4V7G8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHDLSEGYVF GMGNPLLDII VDADDFMYRK YNLKKDNIVL AEEKHMTIYD
60 70 80 90 100
EIQKKKKLNY IAGGATLNTV KMIQWIIQKP FVCSYVGCIG ADIQGKYIKN
110 120 130 140 150
DCSALDLVTE FQIAEEPLMT GKVAVLVSEK LRSMVTYLGA ACDLSLAHIE
160 170 180 190 200
QPHVWSLVEK AQVYYIAGFV INTCYEGMLK IAKHSLENEK LFCFNLSAPF
210 220 230 240 250
LSQFNTKEVD EMISYSNIVF GNESEAEAYG EVHGLLEDTV HATARYIADL
260 270 280 290 300
PFADGKKRKR LVIITRGKNP LLYTDSSDSE IHQFMVEQFK DDQIIDTNGA
310 320 330 340 350
GDAFAAGFIA DYIRGKPMIT SLHAAVKAAA YIICRSGFSL GSRDSYSLKI

NK
Length:352
Mass (Da):39,392
Last modified:December 14, 2011 - v1
Checksum:i68B7BD774E7BBAD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601624 Genomic DNA. Translation: CCD75963.1.

Genome annotation databases

EnsemblMetazoaiSmp_008360.1; Smp_008360.1:pep; Smp_008360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601624 Genomic DNA. Translation: CCD75963.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UQ6X-ray2.30A/B1-352[»]
3UQ9X-ray2.34A/B1-352[»]
3VAQX-ray2.44A/B1-352[»]
3VASX-ray2.26A/B2-352[»]
4DC3X-ray2.40A/B1-352[»]
ProteinModelPortaliG4V7G8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiSmp_008360.1; Smp_008360.1:pep; Smp_008360.

Phylogenomic databases

InParanoidiG4V7G8.
OMAiHASAQNC.
PhylomeDBiG4V7G8.

Enzyme and pathway databases

BRENDAi2.7.1.20. 5608.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR001805. Adenokinase.
IPR002173. Carboh/pur_kinase_PfkB_CS.
IPR011611. PfkB_dom.
IPR029056. Ribokinase-like.
[Graphical view]
PANTHERiPTHR10584:SF24. PTHR10584:SF24. 1 hit.
PfamiPF00294. PfkB. 1 hit.
[Graphical view]
PRINTSiPR00989. ADENOKINASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
PROSITEiPS00584. PFKB_KINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Puerto RicanImported.
  2. "Adenosine kinase from Schistosoma mansoni: structural basis for the differential incorporation of nucleoside analogues."
    Romanello L., Bachega J.F., Cassago A., Brandao-Neto J., DeMarco R., Garratt R.C., Pereira H.D.
    Acta Crystallogr. D 69:126-136(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS) OF 2-352 IN COMPLEX WITH AMP.

Entry informationi

Entry nameiG4V7G8_SCHMA
AccessioniPrimary (citable) accession number: G4V7G8
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: April 1, 2015
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.