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G4V7G8

- G4V7G8_SCHMA

UniProt

G4V7G8 - G4V7G8_SCHMA

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Protein
Submitted name:

Putative adenosine kinase

Gene

Smp_008360

Organism
Schistosoma mansoni (Blood fluke)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi265 – 2673AMPImported

GO - Molecular functioni

  1. adenosine kinase activity Source: UniProtKB-EC
  2. nucleotide binding Source: UniProtKB-KW
  3. phosphotransferase activity, alcohol group as acceptor Source: InterPro

GO - Biological processi

  1. purine ribonucleoside salvage Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Keywords - Ligandi

Nucleotide-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
Putative adenosine kinaseImported (EC:2.7.1.20Imported)
Gene namesi
ORF Names:Smp_008360Imported
OrganismiSchistosoma mansoni (Blood fluke)Imported
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma
ProteomesiUP000008854: Chromosome 1

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UQ6X-ray2.30A/B1-352[»]
3UQ9X-ray2.34A/B1-352[»]
3VAQX-ray2.44A/B1-352[»]
3VASX-ray2.26A/B2-352[»]
4DC3X-ray2.40A/B1-352[»]
ProteinModelPortaliG4V7G8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

InParanoidiG4V7G8.
KOiK00856.
OMAiCIANIEK.
PhylomeDBiG4V7G8.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR001805. Adenokinase.
IPR002173. Carboh/pur_kinase_PfkB_CS.
IPR011611. PfkB_dom.
IPR029056. Ribokinase-like.
[Graphical view]
PANTHERiPTHR10584:SF24. PTHR10584:SF24. 1 hit.
PfamiPF00294. PfkB. 1 hit.
[Graphical view]
PRINTSiPR00989. ADENOKINASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
PROSITEiPS00584. PFKB_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G4V7G8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHDLSEGYVF GMGNPLLDII VDADDFMYRK YNLKKDNIVL AEEKHMTIYD
60 70 80 90 100
EIQKKKKLNY IAGGATLNTV KMIQWIIQKP FVCSYVGCIG ADIQGKYIKN
110 120 130 140 150
DCSALDLVTE FQIAEEPLMT GKVAVLVSEK LRSMVTYLGA ACDLSLAHIE
160 170 180 190 200
QPHVWSLVEK AQVYYIAGFV INTCYEGMLK IAKHSLENEK LFCFNLSAPF
210 220 230 240 250
LSQFNTKEVD EMISYSNIVF GNESEAEAYG EVHGLLEDTV HATARYIADL
260 270 280 290 300
PFADGKKRKR LVIITRGKNP LLYTDSSDSE IHQFMVEQFK DDQIIDTNGA
310 320 330 340 350
GDAFAAGFIA DYIRGKPMIT SLHAAVKAAA YIICRSGFSL GSRDSYSLKI

NK
Length:352
Mass (Da):39,392
Last modified:December 14, 2011 - v1
Checksum:i68B7BD774E7BBAD5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601624 Genomic DNA. Translation: CCD75963.1.

Genome annotation databases

EnsemblMetazoaiSmp_008360.1; Smp_008360.1:pep; Smp_008360.
KEGGismm:Smp_008360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601624 Genomic DNA. Translation: CCD75963.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3UQ6 X-ray 2.30 A/B 1-352 [» ]
3UQ9 X-ray 2.34 A/B 1-352 [» ]
3VAQ X-ray 2.44 A/B 1-352 [» ]
3VAS X-ray 2.26 A/B 2-352 [» ]
4DC3 X-ray 2.40 A/B 1-352 [» ]
ProteinModelPortali G4V7G8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai Smp_008360.1 ; Smp_008360.1:pep ; Smp_008360 .
KEGGi smm:Smp_008360.

Phylogenomic databases

InParanoidi G4V7G8.
KOi K00856.
OMAi CIANIEK.
PhylomeDBi G4V7G8.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
InterProi IPR001805. Adenokinase.
IPR002173. Carboh/pur_kinase_PfkB_CS.
IPR011611. PfkB_dom.
IPR029056. Ribokinase-like.
[Graphical view ]
PANTHERi PTHR10584:SF24. PTHR10584:SF24. 1 hit.
Pfami PF00294. PfkB. 1 hit.
[Graphical view ]
PRINTSi PR00989. ADENOKINASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
PROSITEi PS00584. PFKB_KINASES_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Puerto RicanImported.
  2. "Adenosine kinase from Schistosoma mansoni: structural basis for the differential incorporation of nucleoside analogues."
    Romanello L., Bachega J.F., Cassago A., Brandao-Neto J., DeMarco R., Garratt R.C., Pereira H.D.
    Acta Crystallogr. D 69:126-136(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS) OF 2-352 IN COMPLEX WITH AMP.

Entry informationi

Entry nameiG4V7G8_SCHMA
AccessioniPrimary (citable) accession number: G4V7G8
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: October 29, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3